Welcome to the official database of the IUPHAR Committee on Receptor Nomenclature and Drug Classification.
Incorporating detailed pharmacological, functional and pathophysiological information on G Protein-Coupled Receptors, Voltage-Gated and Ligand-Gated Ion Channels.
Database content as of October 2009:
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There are 356 human genes encoding GPCRs, of which 131 are designated as orphans*, including
- 277 Class A GPCRs, of which 93 are orphans;
- 49 Class B GPCRs, of which 34 are orphans;
- 19 Class C GPCRs, of which 7 are orphans;
- 11 Frizzled Class GPCRs.
- There are 141 human genes encoding Voltage-gated Ion Channel subunits.
- There are 52 human genes encoding Ligand-gated Ion Channel subunits.
- There are 2364 unique ligand molecules.
* Orphans are defined as proteins having similarity to receptors but whose endogenous ligands have not yet been conclusively identified.
Recent updates include:
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October 2009: all database URLs have changed - please update links and bookmarks!
- The IUPHAR Database has undergone behind-the-scenes restructuring, resulting in the GPCRs and Ion Channels being combined in a new database. The webpage addresses have changed to reflect the new structure, so we ask that all users please update their bookmarks and links into IUPHAR-DB from other resources. In the meantime all previous page addresses will automatically redirect. Please see the Linking to us page for further details.
- The IUPHAR Database has undergone behind-the-scenes restructuring, resulting in the GPCRs and Ion Channels being combined in a new database. The webpage addresses have changed to reflect the new structure, so we ask that all users please update their bookmarks and links into IUPHAR-DB from other resources. In the meantime all previous page addresses will automatically redirect. Please see the Linking to us page for further details.
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NEW list of all ligands in IUPHAR-DB
- The complete list of ligand molecules described in the database is now available to browse via the side bar - click on Ligand List.
- The complete list of ligand molecules described in the database is now available to browse via the side bar - click on Ligand List.
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Annotation of an orphan GPCR, GPR3
- Detailed annotation of an orphan class A G protein-coupled receptor, GPR3, has been added to the database.
- Detailed annotation of an orphan class A G protein-coupled receptor, GPR3, has been added to the database.
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June 2009 data release:
- Ion channel updates: detailed pharmacological and functional annotation added to the database for 7 voltage-gated and 3 ligand-gated ion channel families:
- GPCR updates:
- Detailed annotation and an introduction have been added for the Melanin-concentrating hormone receptor family.
- The P2Y receptor family data and introduction have been updated.
- An introduction has been added for the Estrogen G protein-coupled receptor.
Useful links
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HUGO Gene Nomenclature committee |
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Pharmacological reviews |
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IUPHAR Career Centre |
We welcome all questions, comments and suggestions - Email us: curators@iuphar-db.org
© IUPHAR 2009
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Page last updated 30th October 2009
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