Latest news from the International Union of Basic and Clinical Pharmacology database of G protein-coupled receptors (GPCRs), voltage-gated and ligand-gated ion channels. http://www.iuphar-db.org/ The orphan receptor CMKOR1 (commonly referred to in the literature as CXCR7) binds the CXC chemokines CXCL11 and CXCL12/SDF-1 with high affinity. http://www.iuphar-db.org/PRODGPCR/latestPairings.jsp#CMKOR1-CXCL11+CXCL12 http://www.iuphar-db.org/PRODGPCR/latestPairings.jsp#CMKOR1-CXCL11+CXCL12 Schertler and colleagues report the crystal structure of a beta1-adrenergic receptor in complex with the antagonist cyanopindolol. http://www.iuphar-db.org/hotTopics.jsp#beta1-adrenergicReceptor http://www.iuphar-db.org/hotTopics.jsp#beta1-adrenergicReceptor Three papers in Science and Nature report the structure of the human beta2-adrenergic receptor http://www.iuphar-db.org/hotTopics.jsp#beta2-adrenergicReceptor http://www.iuphar-db.org/hotTopics.jsp#beta2-adrenergicReceptor Initial release includes detailed pharmacological and functional annotation for Transient Receptor Potential Channels. More families coming soon. http://www.iuphar-db.org/IC/ReceptorFamiliesForward Initial VGIC Release Neuropeptide FF/neuropeptide AF receptors have been added to the GPCR database http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1340 GPCR chapter=1340 Cholecystokinin receptors have been added to the GPCR database http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1281 GPCR chapter=1281 Calcitonin receptors have been updated http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1358 GPCR chapter=1358