IUPHAR DATABASE OF RECEPTORS AND ION CHANNELS

Welcome to the official database of the IUPHAR Committee on Receptor Nomenclature and Drug Classification.

Incorporating detailed pharmacological, functional and pathophysiological information on G Protein-Coupled Receptors, Voltage-Gated Ion Channels, Ligand-Gated Ion Channels and Nuclear Hormone Receptors.

Database content:

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* Orphans are defined as proteins having similarity to receptors but whose endogenous ligands have not yet been conclusively identified.

[Cite the database] [About]

Latest news:

NC-IUPHAR and DiscoveRx form an alliance to accelerate GPCR deorphanization efforts
- NC-IUPHAR and DiscoveRx have announced that they will form an alliance to accelerate progress on understanding the functions of orphan G Protein-coupled receptors (GPCRs) and their signalling mechanisms, which will be communicated through the IUPHAR Database. Read more about the goals of this unprecedented industry-academia alliance.
Spotlight on IUPHAR-DB in the September edition of orphaNews Europe
- A spotlight on IUPHAR-DB and interview with NC-IUPHAR database chair Professor Tony Harmar has been published in the September edition of orphaNews Europe, the newsletter of the European Union Committee of Experts on Rare Diseases. Click here to read the article online.
Viewpoint article on IUPHAR-DB published in ACS Chemical Neuroscience
- A Viewpoint article about IUPHAR-DB has been published in the journal ACS Chemical Neuroscience (1). Click here to access the article online.
  
  (1) Sharman JL, Mpamhanga CP. (2011) IUPHAR-DB: An Open-Access, Expert-Curated Resource for Receptor and Ion Channel Research. ACS Chemical Neuroscience, 2 (5): 232-235.

Recent database updates (September 2011) include:

New annotation for GPCRs:
- Links to DiscoveRx PathHunter® assays and cell lines have been added to orphan pages, for example see the GPR6 receptor page;
- Updated annotation and introduction for the VIP and PACAP receptors;
- Annotation added for a Frizzled family receptor: FZD₆.
New annotation for LGICs:
- Introductory chapter and full annotation of all Nicotinic acetylcholine receptor subunits.
New database links and other datasets:
- Further 3D structures for GPCRs (in particular, class B) have been added to the database;
- Links from ligand pages to ChemSpider - the free chemical database;
- New 'Radio analogues' tab on ligand pages providing information on radio-labelled versions of unlabelled ligands in IUPHAR-DB.

Useful links:

HUGO Gene Nomenclature committee	Pharmacological reviews
BJP Guide to Receptors and Channels A FREE ONLINE laboratory handbook containing concise summaries, with key references, of the molecular, pharmacological and signal transduction properties of receptors, ion channels & transporters	IUPHAR Career Centre

We welcome all questions, comments and suggestions - Email us: curators@iuphar-db.org

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Page last updated 21st September 2011