VOLTAGE-GATED ION CHANNEL SUBUNITS

Ligand-gated ion channel subunits

Download a list of all targets, including voltage- and ligand-gated and other ion channels, in the IUPHAR/BPS Guide to PHARMACOLOGY as a CSV file

Calcium-activated potassium channels
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Calcium-activated potassium channels K+ KCa1.1 KCNMA1
Kcnma1
Kcnma1
Calcium-activated potassium channels K+ KCa2.1 KCNN1
Kcnn1
Kcnn1
Calcium-activated potassium channels K+ KCa2.2 KCNN2
Kcnn2
Kcnn2
Calcium-activated potassium channels K+ KCa2.3 KCNN3
Kcnn3
Kcnn3
Calcium-activated potassium channels K+ KCa3.1 KCNN4
Kcnn4
Kcnn4
Calcium-activated potassium channels K+ KCa4.1 KCNT1
Kcnt1
Kcnt1
Calcium-activated potassium channels K+ KCa4.2 KCNT2
Kcnt2
Kcnt2
Calcium-activated potassium channels K+ KCa5.1 KCNU1
Kcnu1
Kcnu1
CatSper and Two-Pore channels
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
CatSper and Two-Pore channels Ca2+ CatSper1 CATSPER1
Catsper1
Catsper1
CatSper and Two-Pore channels Ca2+ CatSper2 CATSPER2
Catsper2
Catsper2
CatSper and Two-Pore channels Ca2+ CatSper3 CATSPER3
Catsper3
Catsper3
CatSper and Two-Pore channels Ca2+ CatSper4 CATSPER4
Catsper4
Catsper4
CatSper and Two-Pore channels Ca2+ TPC1 TPCN1
Tpcn1
Tpcn1
CatSper and Two-Pore channels Ca2+ TPC2 TPCN2
Tpcn2
Tpcn2
Cyclic nucleotide-regulated channels
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Cyclic nucleotide-regulated channels See comments below CNGA1 CNGA1
Cnga1
Cnga1
Cyclic nucleotide-regulated channels See comments below CNGA2 CNGA2
Cnga2
Cnga2
Cyclic nucleotide-regulated channels See comments below CNGA3 CNGA3
Cnga3
Cnga3
Cyclic nucleotide-regulated channels See comments below CNGA4 CNGA4
Cnga4
Cnga4
Cyclic nucleotide-regulated channels See comments below CNGB1 CNGB1
Cngb1
Cngb1
Cyclic nucleotide-regulated channels See comments below CNGB3 CNGB3
Cngb3
Cngb3
Cyclic nucleotide-regulated channels See comments below HCN1 HCN1
Hcn1
Hcn1
Cyclic nucleotide-regulated channels See comments below HCN2 HCN2
Hcn2
Hcn2
Cyclic nucleotide-regulated channels See comments below HCN3 HCN3
Hcn3
Hcn3
Cyclic nucleotide-regulated channels See comments below HCN4 HCN4
Hcn4
Hcn4
Comments: Most of these channels are permeable to sodium, potassium and calcium ions, however the main physiological ion has yet to be definitively established.
Inwardly rectifying potassium channels
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Inwardly rectifying potassium channels K+ Kir1.1 KCNJ1
Kcnj1
Kcnj1
Inwardly rectifying potassium channels K+ Kir2.1 KCNJ2
Kcnj2
Kcnj2
Inwardly rectifying potassium channels K+ Kir2.2 KCNJ12
Kcnj12
Kcnj12
Inwardly rectifying potassium channels K+ Kir2.3 KCNJ4
Kcnj4
Kcnj4
Inwardly rectifying potassium channels K+ Kir2.4 KCNJ14
Kcnj14
Kcnj14
Inwardly rectifying potassium channels K+ Kir3.1 KCNJ3
Kcnj3
Kcnj3
Inwardly rectifying potassium channels K+ Kir3.2 KCNJ6
Kcnj6
Kcnj6
Inwardly rectifying potassium channels K+ Kir3.3 KCNJ9
Kcnj9
Kcnj9
Inwardly rectifying potassium channels K+ Kir3.4 KCNJ5
Kcnj5
Kcnj5
Inwardly rectifying potassium channels K+ Kir4.1 KCNJ10
Kcnj10
Kcnj10
Inwardly rectifying potassium channels K+ Kir4.2 KCNJ15
Kcnj15
Kcnj15
Inwardly rectifying potassium channels K+ Kir5.1 KCNJ16
Kcnj16
Kcnj16
Inwardly rectifying potassium channels K+ Kir6.1 KCNJ8
Kcnj8
Kcnj8
Inwardly rectifying potassium channels K+ Kir6.2 KCNJ11
Kcnj11
Kcnj11
Inwardly rectifying potassium channels K+ Kir7.1 KCNJ13
Kcnj13
Kcnj13
Transient Receptor Potential channels
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Transient Receptor Potential channels See comments below TRPA1 TRPA1
Trpa1
Trpa1
Transient Receptor Potential channels See comments below TRPC1 TRPC1
Trpc1
Trpc1
Transient Receptor Potential channels See comments below TRPC2 TRPC2
Trpc2
Trpc2
Transient Receptor Potential channels See comments below TRPC3 TRPC3
Trpc3
Trpc3
Transient Receptor Potential channels See comments below TRPC4 TRPC4
Trpc4
Trpc4
Transient Receptor Potential channels See comments below TRPC5 TRPC5
Trpc5
Trpc5
Transient Receptor Potential channels See comments below TRPC6 TRPC6
Trpc6
Trpc6
Transient Receptor Potential channels See comments below TRPC7 TRPC7
Trpc7
Trpc7
Transient Receptor Potential channels See comments below TRPM1 TRPM1
Trpm1
Trpm1
Transient Receptor Potential channels See comments below TRPM2 TRPM2
Trpm2
Trpm2
Transient Receptor Potential channels See comments below TRPM3 TRPM3
Trpm3
Trpm3
Transient Receptor Potential channels See comments below TRPM4 TRPM4
Trpm4
Trpm4
Transient Receptor Potential channels See comments below TRPM5 TRPM5
Trpm5
Trpm5
Transient Receptor Potential channels See comments below TRPM6 TRPM6
Trpm6
Trpm6
Transient Receptor Potential channels See comments below TRPM7 TRPM7
Trpm7
Trpm7
Transient Receptor Potential channels See comments below TRPM8 TRPM8
Trpm8
Trpm8
Transient Receptor Potential channels See comments below TRPML1 MCOLN1
Mcoln1
Mcoln1
Transient Receptor Potential channels See comments below TRPML2 MCOLN2
Mcoln2
Mcoln2
Transient Receptor Potential channels See comments below TRPML3 MCOLN3
Mcoln3
Mcoln3
Transient Receptor Potential channels See comments below TRPP1 PKD2
Pkd2
Pkd2
Transient Receptor Potential channels See comments below TRPP2 PKD2L1
Pkd2l1
Pkd2l1
Transient Receptor Potential channels See comments below TRPP3 PKD2L2
Pkd2l2
Pkd2l2
Transient Receptor Potential channels See comments below TRPV1 TRPV1
Trpv1
Trpv1
Transient Receptor Potential channels See comments below TRPV2 TRPV2
Trpv2
Trpv2
Transient Receptor Potential channels See comments below TRPV3 TRPV3
Trpv3
Trpv3
Transient Receptor Potential channels See comments below TRPV4 TRPV4
Trpv4
Trpv4
Transient Receptor Potential channels See comments below TRPV5 TRPV5
Trpv5
Trpv5
Transient Receptor Potential channels See comments below TRPV6 TRPV6
Trpv6
Trpv6
Comments: Most of these channels are permeable to sodium, potassium and calcium ions, however the main physiological ion has yet to be definitively established.
Two-P potassium channels
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Two-P potassium channels K+ K2P1.1 KCNK1
Kcnk1
Kcnk1
Two-P potassium channels K+ K2P2.1 KCNK2
Kcnk2
Kcnk2
Two-P potassium channels K+ K2P3.1 KCNK3
Kcnk3
Kcnk3
Two-P potassium channels K+ K2P4.1 KCNK4
Kcnk4
Kcnk4
Two-P potassium channels K+ K2P5.1 KCNK5
Kcnk5
Kcnk5
Two-P potassium channels K+ K2P6.1 KCNK6
Kcnk6
Kcnk6
Two-P potassium channels K+ K2P7.1 KCNK7
Kcnk7
Kcnk7
Two-P potassium channels K+ K2P9.1 KCNK9
Kcnk9
Kcnk9
Two-P potassium channels K+ K2P10.1 KCNK10
Kcnk10
Kcnk10
Two-P potassium channels K+ K2P12.1 KCNK12
Kcnk12
Kcnk12
Two-P potassium channels K+ K2P13.1 KCNK13
Kcnk13
Kcnk13
Two-P potassium channels K+ K2P15.1 KCNK15
Kcnk15
Kcnk15
Two-P potassium channels K+ K2P16.1 KCNK16
Kcnk16
Kcnk16
Two-P potassium channels K+ K2P17.1 KCNK17
Two-P potassium channels K+ K2P18.1 KCNK18
Kcnk18
Kcnk18
Voltage-gated calcium channels
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Voltage-gated calcium channels Ca2+ Cav1.1 CACNA1S
Cacna1s
Cacna1s
Voltage-gated calcium channels Ca2+ Cav1.2 CACNA1C
Cacna1c
Cacna1c
Voltage-gated calcium channels Ca2+ Cav1.3 CACNA1D
Cacna1d
Cacna1d
Voltage-gated calcium channels Ca2+ Cav1.4 CACNA1F
Cacna1f
Cacna1f
Voltage-gated calcium channels Ca2+ Cav2.1 CACNA1A
Cacna1a
Cacna1a
Voltage-gated calcium channels Ca2+ Cav2.2 CACNA1B
Cacna1b
Cacna1b
Voltage-gated calcium channels Ca2+ Cav2.3 CACNA1E
Cacna1e
Cacna1e
Voltage-gated calcium channels Ca2+ Cav3.1 CACNA1G
Cacna1g
Cacna1g
Voltage-gated calcium channels Ca2+ Cav3.2 CACNA1H
Cacna1h
Cacna1h
Voltage-gated calcium channels Ca2+ Cav3.3 CACNA1I
Cacna1i
Cacna1i
Voltage-gated potassium channels
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Voltage-gated potassium channels K+ Kv1.1 KCNA1
Kcna1
Kcna1
Voltage-gated potassium channels K+ Kv1.2 KCNA2
Kcna2
Kcna2
Voltage-gated potassium channels K+ Kv1.3 KCNA3
Kcna3
Kcna3
Voltage-gated potassium channels K+ Kv1.4 KCNA4
Kcna4
Kcna4
Voltage-gated potassium channels K+ Kv1.5 KCNA5
Kcna5
Kcna5
Voltage-gated potassium channels K+ Kv1.6 KCNA6
Kcna6
Kcna6
Voltage-gated potassium channels K+ Kv1.7 KCNA7
Kcna7
Kcna7
Voltage-gated potassium channels K+ Kv1.8 KCNA10
Kcna10
Kcna10
Voltage-gated potassium channels K+ Kv2.1 KCNB1
Kcnb1
Kcnb1
Voltage-gated potassium channels K+ Kv2.2 KCNB2
Kcnb2
Kcnb2
Voltage-gated potassium channels K+ Kv3.1 KCNC1
Kcnc1
Kcnc1
Voltage-gated potassium channels K+ Kv3.2 KCNC2
Kcnc2
Kcnc2
Voltage-gated potassium channels K+ Kv3.3 KCNC3
Kcnc3
Kcnc3
Voltage-gated potassium channels K+ Kv3.4 KCNC4
Kcnc4
Kcnc4
Voltage-gated potassium channels K+ Kv4.1 KCND1
Kcnd1
Kcnd1
Voltage-gated potassium channels K+ Kv4.2 KCND2
Kcnd2
Kcnd2
Voltage-gated potassium channels K+ Kv4.3 KCND3
Kcnd3
Kcnd3
Voltage-gated potassium channels K+ Kv5.1 KCNF1
Kcnf1
Kcnf1
Voltage-gated potassium channels K+ Kv6.1 KCNG1
Kcng1
Kcng1
Voltage-gated potassium channels K+ Kv6.2 KCNG2
Kcng2
Kcng2
Voltage-gated potassium channels K+ Kv6.3 KCNG3
Kcng3
Kcng3
Voltage-gated potassium channels K+ Kv6.4 KCNG4
Kcng4
Kcng4
Voltage-gated potassium channels K+ Kv7.1 KCNQ1
Kcnq1
Kcnq1
Voltage-gated potassium channels K+ Kv7.2 KCNQ2
Kcnq2
Kcnq2
Voltage-gated potassium channels K+ Kv7.3 KCNQ3
Kcnq3
Kcnq3
Voltage-gated potassium channels K+ Kv7.4 KCNQ4
Kcnq4
Kcnq4
Voltage-gated potassium channels K+ Kv7.5 KCNQ5
Kcnq5
Kcnq5
Voltage-gated potassium channels K+ Kv8.1 KCNV1
Kcnv1
Kcnv1
Voltage-gated potassium channels K+ Kv8.2 KCNV2
Kcnv2
Kcnv2
Voltage-gated potassium channels K+ Kv9.1 KCNS1
Kcns1
Kcns1
Voltage-gated potassium channels K+ Kv9.2 KCNS2
Kcns2
Kcns2
Voltage-gated potassium channels K+ Kv9.3 KCNS3
Kcns3
Kcns3
Voltage-gated potassium channels K+ Kv10.1 KCNH1
Kcnh1
Kcnh1
Voltage-gated potassium channels K+ Kv10.2 KCNH5
Kcnh5
Kcnh5
Voltage-gated potassium channels K+ Kv11.1 KCNH2
Kcnh2
Kcnh2
Voltage-gated potassium channels K+ Kv11.2 KCNH6
Kcnh6
Kcnh6
Voltage-gated potassium channels K+ Kv11.3 KCNH7
Kcnh7
Kcnh7
Voltage-gated potassium channels K+ Kv12.1 KCNH8
Kcnh8
Kcnh8
Voltage-gated potassium channels K+ Kv12.2 KCNH3
Kcnh3
Kcnh3
Voltage-gated potassium channels K+ Kv12.3 KCNH4
Kcnh4
Kcnh4
Voltage-gated sodium channels
Family name Physiological ion Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Voltage-gated sodium channels Na+ Nav1.1 SCN1A
Scn1a
Scn1a
Voltage-gated sodium channels Na+ Nav1.2 SCN2A
Scn2a1
Scn2a1
Voltage-gated sodium channels Na+ Nav1.3 SCN3A
Scn3a
Scn3a
Voltage-gated sodium channels Na+ Nav1.4 SCN4A
Scn4a
Scn4a
Voltage-gated sodium channels Na+ Nav1.5 SCN5A
Scn5a
Scn5a
Voltage-gated sodium channels Na+ Nav1.6 SCN8A
Scn8a
Scn8a
Voltage-gated sodium channels Na+ Nav1.7 SCN9A
Scn9a
Scn9a
Voltage-gated sodium channels Na+ Nav1.8 SCN10A
Scn10a
Scn10a
Voltage-gated sodium channels Na+ Nav1.9 SCN11A
Scn11a
Scn11a

Contact us | Print | Back to top | Help