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VOLTAGE-GATED ION CHANNEL SUBUNITS

Ligand-gated ion channel subunits  |  Download ion channel data as an Excel file

Calcium-Activated Potassium Channels
Family name	Physiological ion	Official IUPHAR receptor name	Human gene name	Rat gene name	Mouse gene name	Comment
Calcium-Activated Potassium Channels	K+	KCa1.1	KCNMA1	Kcnma1	Kcnma1
Calcium-Activated Potassium Channels	K+	KCa2.1	KCNN1	Kcnn1	Kcnn1
Calcium-Activated Potassium Channels	K+	KCa2.2	KCNN2	Kcnn2	Kcnn2
Calcium-Activated Potassium Channels	K+	KCa2.3	KCNN3	Kcnn3	Kcnn3
Calcium-Activated Potassium Channels	K+	KCa3.1	KCNN4	Kcnn4	Kcnn4
Calcium-Activated Potassium Channels	K+	KCa4.1	KCNT1	Kcnt1	Kcnt1
Calcium-Activated Potassium Channels	K+	KCa4.2	KCNT2	Kcnt2	Kcnt2
Calcium-Activated Potassium Channels	K+	KCa5.1	KCNU1	Kcnu1	Kcnu1
CatSper and Two-Pore Channels
Family name	Physiological ion	Official IUPHAR receptor name	Human gene name	Rat gene name	Mouse gene name	Comment
CatSper and Two-Pore Channels	Ca2+	CatSper1	CATSPER1	Catsper1	Catsper1
CatSper and Two-Pore Channels	Ca2+	CatSper2	CATSPER2	Catsper2	Catsper2
CatSper and Two-Pore Channels	Ca2+	CatSper3	CATSPER3	Catsper3	Catsper3
CatSper and Two-Pore Channels	Ca2+	CatSper4	CATSPER4		Catsper4
CatSper and Two-Pore Channels	Ca2+	TPC1	TPCN1	Tpcn1	Tpcn1
CatSper and Two-Pore Channels	Ca2+	TPC2	TPCN2	Tpcn2	Tpcn2
Cyclic Nucleotide-Regulated Channels
Family name	Physiological ion	Official IUPHAR receptor name	Human gene name	Rat gene name	Mouse gene name	Comment
Cyclic Nucleotide-Regulated Channels	See comments below	CNGA1	CNGA1	Cnga1	Cnga1
Cyclic Nucleotide-Regulated Channels	See comments below	CNGA2	CNGA2	Cnga2	Cnga2
Cyclic Nucleotide-Regulated Channels	See comments below	CNGA3	CNGA3	Cnga3	Cnga3
Cyclic Nucleotide-Regulated Channels	See comments below	CNGA4	CNGA4	Cnga4	Cnga4
Cyclic Nucleotide-Regulated Channels	See comments below	CNGB1	CNGB1	Cngb1	Cngb1
Cyclic Nucleotide-Regulated Channels	See comments below	CNGB3	CNGB3		Cngb3
Cyclic Nucleotide-Regulated Channels	See comments below	HCN1	HCN1	Hcn1	Hcn1
Cyclic Nucleotide-Regulated Channels	See comments below	HCN2	HCN2	Hcn2	Hcn2
Cyclic Nucleotide-Regulated Channels	See comments below	HCN3	HCN3	Hcn3	Hcn3
Cyclic Nucleotide-Regulated Channels	See comments below	HCN4	HCN4	Hcn4	Hcn4
Comments: Most of these channels are permeable to sodium, potassium and calcium ions, however the main physiological ion has yet to be definitively established.
Inwardly Rectifying Potassium Channels
Family name	Physiological ion	Official IUPHAR receptor name	Human gene name	Rat gene name	Mouse gene name	Comment
Inwardly Rectifying Potassium Channels	K+	Kir1.1	KCNJ1	Kcnj1	Kcnj1
Inwardly Rectifying Potassium Channels	K+	Kir2.1	KCNJ2	Kcnj2	Kcnj2
Inwardly Rectifying Potassium Channels	K+	Kir2.2	KCNJ12	Kcnj12	Kcnj12
Inwardly Rectifying Potassium Channels	K+	Kir2.3	KCNJ4	Kcnj4	Kcnj4
Inwardly Rectifying Potassium Channels	K+	Kir2.4	KCNJ14	Kcnj14	Kcnj14
Inwardly Rectifying Potassium Channels	K+	Kir3.1	KCNJ3	Kcnj3	Kcnj3
Inwardly Rectifying Potassium Channels	K+	Kir3.2	KCNJ6	Kcnj6	Kcnj6
Inwardly Rectifying Potassium Channels	K+	Kir3.3	KCNJ9	Kcnj9	Kcnj9
Inwardly Rectifying Potassium Channels	K+	Kir3.4	KCNJ5	Kcnj5	Kcnj5
Inwardly Rectifying Potassium Channels	K+	Kir4.1	KCNJ10	Kcnj10	Kcnj10
Inwardly Rectifying Potassium Channels	K+	Kir4.2	KCNJ15	Kcnj15	Kcnj15
Inwardly Rectifying Potassium Channels	K+	Kir5.1	KCNJ16	Kcnj16	Kcnj16
Inwardly Rectifying Potassium Channels	K+	Kir6.1	KCNJ8	Kcnj8	Kcnj8
Inwardly Rectifying Potassium Channels	K+	Kir6.2	KCNJ11	Kcnj11	Kcnj11
Inwardly Rectifying Potassium Channels	K+	Kir7.1	KCNJ13	Kcnj13
Transient Receptor Potential Channels
Family name	Physiological ion	Official IUPHAR receptor name	Human gene name	Rat gene name	Mouse gene name	Comment
Transient Receptor Potential Channels	See comments below	TRPA1	TRPA1	Trpa1	Trpa1
Transient Receptor Potential Channels	See comments below	TRPC1	TRPC1	Trpc1	Trpc1
Transient Receptor Potential Channels	See comments below	TRPC2	TRPC2	Trpc2	Trpc2
Transient Receptor Potential Channels	See comments below	TRPC3	TRPC3	Trpc3	Trpc3
Transient Receptor Potential Channels	See comments below	TRPC4	TRPC4	Trpc4	Trpc4
Transient Receptor Potential Channels	See comments below	TRPC5	TRPC5	Trpc5	Trpc5
Transient Receptor Potential Channels	See comments below	TRPC6	TRPC6	Trpc6	Trpc6
Transient Receptor Potential Channels	See comments below	TRPC7	TRPC7	Trpc7	Trpc7
Transient Receptor Potential Channels	See comments below	TRPM1	TRPM1	Trpm1	Trpm1
Transient Receptor Potential Channels	See comments below	TRPM2	TRPM2	Trpm2	Trpm2
Transient Receptor Potential Channels	See comments below	TRPM3	TRPM3	Trpm3	Trpm3
Transient Receptor Potential Channels	See comments below	TRPM4	TRPM4	Trpm4	Trpm4
Transient Receptor Potential Channels	See comments below	TRPM5	TRPM5	Trpm5	Trpm5
Transient Receptor Potential Channels	See comments below	TRPM6	TRPM6	Trpm6	Trpm6
Transient Receptor Potential Channels	See comments below	TRPM7	TRPM7	Trpm7	Trpm7
Transient Receptor Potential Channels	See comments below	TRPM8	TRPM8	Trpm8	Trpm8
Transient Receptor Potential Channels	See comments below	TRPML1	MCOLN1	Mcoln1	Mcoln1
Transient Receptor Potential Channels	See comments below	TRPML2	MCOLN2	Mcoln2	Mcoln2
Transient Receptor Potential Channels	See comments below	TRPML3	MCOLN3	Mcoln3	Mcoln3
Transient Receptor Potential Channels	See comments below	TRPP1	PKD2	Pkd2	Pkd2
Transient Receptor Potential Channels	See comments below	TRPP2	PKD2L1	Pkd2l1	Pkd2l1
Transient Receptor Potential Channels	See comments below	TRPP3	PKD2L2	Pkd2l2	Pkd2l2
Transient Receptor Potential Channels	See comments below	TRPV1	TRPV1	Trpv1	Trpv1
Transient Receptor Potential Channels	See comments below	TRPV2	TRPV2	Trpv2	Trpv2
Transient Receptor Potential Channels	See comments below	TRPV3	TRPV3	Trpv3	Trpv3
Transient Receptor Potential Channels	See comments below	TRPV4	TRPV4	Trpv4	Trpv4
Transient Receptor Potential Channels	See comments below	TRPV5	TRPV5	Trpv5	Trpv5
Transient Receptor Potential Channels	See comments below	TRPV6	TRPV6	Trpv6	Trpv6
Comments: Most of these channels are permeable to sodium, potassium and calcium ions, however the main physiological ion has yet to be definitively established.
Two-P Potassium Channels
Family name	Physiological ion	Official IUPHAR receptor name	Human gene name	Rat gene name	Mouse gene name	Comment
Two-P Potassium Channels	K+	K2P1.1	KCNK1	Kcnk1	Kcnk1
Two-P Potassium Channels	K+	K2P2.1	KCNK2	Kcnk2	Kcnk2
Two-P Potassium Channels	K+	K2P3.1	KCNK3	Kcnk3	Kcnk3
Two-P Potassium Channels	K+	K2P4.1	KCNK4	Kcnk4	Kcnk4
Two-P Potassium Channels	K+	K2P5.1	KCNK5	Kcnk5	Kcnk5
Two-P Potassium Channels	K+	K2P6.1	KCNK6	Kcnk6	Kcnk6
Two-P Potassium Channels	K+	K2P7.1	KCNK7	RGD1565025	Kcnk7
Two-P Potassium Channels	K+	K2P9.1	KCNK9	Kcnk9	Kcnk9
Two-P Potassium Channels	K+	K2P10.1	KCNK10	Kcnk10	Kcnk10
Two-P Potassium Channels	K+	K2P12.1	KCNK12	Kcnk12	Kcnk12
Two-P Potassium Channels	K+	K2P13.1	KCNK13	Kcnk13	Kcnk13
Two-P Potassium Channels	K+	K2P15.1	KCNK15	Kcnk15	Kcnk15
Two-P Potassium Channels	K+	K2P16.1	KCNK16	Kcnk16	Kcnk16
Two-P Potassium Channels	K+	K2P17.1	KCNK17
Two-P Potassium Channels	K+	K2P18.1	KCNK18	Kcnk18	Kcnk18
Voltage-Gated Calcium Channels
Family name	Physiological ion	Official IUPHAR receptor name	Human gene name	Rat gene name	Mouse gene name	Comment
Voltage-Gated Calcium Channels	Ca2+	Cav1.1	CACNA1S	Cacna1s	Cacna1s
Voltage-Gated Calcium Channels	Ca2+	Cav1.2	CACNA1C	Cacna1c	Cacna1c
Voltage-Gated Calcium Channels	Ca2+	Cav1.3	CACNA1D	Cacna1d	Cacna1d
Voltage-Gated Calcium Channels	Ca2+	Cav1.4	CACNA1F	Cacna1f	Cacna1f
Voltage-Gated Calcium Channels	Ca2+	Cav2.1	CACNA1A	Cacna1a	Cacna1a
Voltage-Gated Calcium Channels	Ca2+	Cav2.2	CACNA1B	Cacna1b	Cacna1b
Voltage-Gated Calcium Channels	Ca2+	Cav2.3	CACNA1E	Cacna1e	Cacna1e
Voltage-Gated Calcium Channels	Ca2+	Cav3.1	CACNA1G	Cacna1g	Cacna1g
Voltage-Gated Calcium Channels	Ca2+	Cav3.2	CACNA1H	Cacna1h	Cacna1h
Voltage-Gated Calcium Channels	Ca2+	Cav3.3	CACNA1I	Cacna1i	Cacna1i
Voltage-Gated Potassium Channels
Family name	Physiological ion	Official IUPHAR receptor name	Human gene name	Rat gene name	Mouse gene name	Comment
Voltage-Gated Potassium Channels	K+	Kv1.1	KCNA1	Kcna1	Kcna1
Voltage-Gated Potassium Channels	K+	Kv1.2	KCNA2	Kcna2	Kcna2
Voltage-Gated Potassium Channels	K+	Kv1.3	KCNA3	Kcna3	Kcna3
Voltage-Gated Potassium Channels	K+	Kv1.4	KCNA4	Kcna4	Kcna4
Voltage-Gated Potassium Channels	K+	Kv1.5	KCNA5	Kcna5	Kcna5
Voltage-Gated Potassium Channels	K+	Kv1.6	KCNA6	Kcna6	Kcna6
Voltage-Gated Potassium Channels	K+	Kv1.7	KCNA7	Kcna7	Kcna7
Voltage-Gated Potassium Channels	K+	Kv1.8	KCNA10	Kcna10	Kcna10
Voltage-Gated Potassium Channels	K+	Kv2.1	KCNB1	Kcnb1	Kcnb1
Voltage-Gated Potassium Channels	K+	Kv2.2	KCNB2	Kcnb2	Kcnb2
Voltage-Gated Potassium Channels	K+	Kv3.1	KCNC1	Kcnc1	Kcnc1
Voltage-Gated Potassium Channels	K+	Kv3.2	KCNC2	Kcnc2	Kcnc2
Voltage-Gated Potassium Channels	K+	Kv3.3	KCNC3	Kcnc3	Kcnc3
Voltage-Gated Potassium Channels	K+	Kv3.4	KCNC4	Kcnc4	Kcnc4
Voltage-Gated Potassium Channels	K+	Kv4.1	KCND1	Kcnd1	Kcnd1
Voltage-Gated Potassium Channels	K+	Kv4.2	KCND2	Kcnd2	Kcnd2
Voltage-Gated Potassium Channels	K+	Kv4.3	KCND3	Kcnd3	Kcnd3
Voltage-Gated Potassium Channels	K+	Kv5.1	KCNF1	Kcnf1	Kcnf1
Voltage-Gated Potassium Channels	K+	Kv6.1	KCNG1	Kcng1	Kcng1
Voltage-Gated Potassium Channels	K+	Kv6.2	KCNG2	Kcng2	Kcng2
Voltage-Gated Potassium Channels	K+	Kv6.3	KCNG3	Kcng3	Kcng3
Voltage-Gated Potassium Channels	K+	Kv6.4	KCNG4	Kcng4	Kcng4
Voltage-Gated Potassium Channels	K+	Kv7.1	KCNQ1	Kcnq1	Kcnq1
Voltage-Gated Potassium Channels	K+	Kv7.2	KCNQ2	Kcnq2	Kcnq2
Voltage-Gated Potassium Channels	K+	Kv7.3	KCNQ3	Kcnq3	Kcnq3
Voltage-Gated Potassium Channels	K+	Kv7.4	KCNQ4	Kcnq4	Kcnq4
Voltage-Gated Potassium Channels	K+	Kv7.5	KCNQ5	Kcnq5l	Kcnq5
Voltage-Gated Potassium Channels	K+	Kv8.1	KCNV1	Kcnv1	Kcnv1
Voltage-Gated Potassium Channels	K+	Kv8.2	KCNV2	Kcnv2	Kcnv2
Voltage-Gated Potassium Channels	K+	Kv9.1	KCNS1	Kcns1	Kcns1
Voltage-Gated Potassium Channels	K+	Kv9.2	KCNS2	Kcns2	Kcns2
Voltage-Gated Potassium Channels	K+	Kv9.3	KCNS3	Kcns3	Kcns3
Voltage-Gated Potassium Channels	K+	Kv10.1	KCNH1	Kcnh1	Kcnh1
Voltage-Gated Potassium Channels	K+	Kv10.2	KCNH5	Kcnh5	Kcnh5
Voltage-Gated Potassium Channels	K+	Kv11.1	KCNH2	Kcnh2	Kcnh2
Voltage-Gated Potassium Channels	K+	Kv11.2	KCNH6	Kcnh6	Kcnh6
Voltage-Gated Potassium Channels	K+	Kv11.3	KCNH7	Kcnh7	Kcnh7
Voltage-Gated Potassium Channels	K+	Kv12.1	KCNH8	Kcnh8	Kcnh8
Voltage-Gated Potassium Channels	K+	Kv12.2	KCNH3	Kcnh3	Kcnh3
Voltage-Gated Potassium Channels	K+	Kv12.3	KCNH4	Kcnh4	Kcnh4
Voltage-Gated Sodium Channels
Family name	Physiological ion	Official IUPHAR receptor name	Human gene name	Rat gene name	Mouse gene name	Comment
Voltage-Gated Sodium Channels	Na+	Nav1.1	SCN1A	Scn1a	Scn1a
Voltage-Gated Sodium Channels	Na+	Nav1.2	SCN2A	Scn2a1	Scn2a1
Voltage-Gated Sodium Channels	Na+	Nav1.3	SCN3A	Scn3a	Scn3a
Voltage-Gated Sodium Channels	Na+	Nav1.4	SCN4A	Scn4a	Scn4a
Voltage-Gated Sodium Channels	Na+	Nav1.5	SCN5A	Scn5a	Scn5a
Voltage-Gated Sodium Channels	Na+	Nav1.6	SCN8A	Scn8a	Scn8a
Voltage-Gated Sodium Channels	Na+	Nav1.7	SCN9A	Scn9a	Scn9a
Voltage-Gated Sodium Channels	Na+	Nav1.8	SCN10A	Scn10a	Scn10a
Voltage-Gated Sodium Channels	Na+	Nav1.9	SCN11A	Scn11a	Scn11a

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