Nomenclature: GPR26

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 337 10q26.2-q26.3 GPR26 G protein-coupled receptor 26 4-5
Mouse 7 337 7 F3 Gpr26 G protein-coupled receptor 26
Rat 7 317 1q41 Gpr26 G protein-coupled receptor 26 4
Previous and Unofficial Names
GPR26
G-protein coupled receptor 26
G protein-coupled receptor 26
probable G-protein coupled receptor 26
9630036A11Rik
Database Links
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Primary Transduction Mechanisms
Transducer Effector/Response
Gs family Adenylate cyclase stimulation
References:  3
Tissue Distribution
Brain, thalamus, hippocampus, amygdala, caudate, cerebellum, testis
Species:  Mouse
Technique:  RT-PCR
References:  3
Amygdala regions (basolateral, central and medial) cortex, hippocampus, Purkinje cells in cerebellum
Species:  Mouse
Technique:  Immunohistochemistry
References:  6
Entire neocortex including limbic, motor and sensory cortical areas, anterior olfactory nucleus, septum, vertical and horizontal limbs of the diagonal band of Broca, hippocampal CA1, CA2, CA3, subiculum, presubiculum, entorhinal cortex and fasciola cinereum, amygdala region including lateral, basolateral and medial nuclei, cortical and hippocampal transition areas, striatal region including caudate putamen, olfactory tubercule, islands of Calleja and nucleus accumbens, thalamus region including medial habenula, paraventricular nucleus, geniculate nuclei, hypothalamus region including ventromedial nucleus, midbrain region such as substantia nigta pars compacta. ventral tegmental area and inferior colliculus, brainstem nuclei including ventral tegmental, lateral parabrachial, dorsal cochlear and spinal trigeminal nuclei.
Species:  Mouse
Technique:  in situ hybridisation
References:  3
Brain regions such as striatum, pons, cerebellum and cortex, testis
Species:  Rat
Technique:  Northern blot
References:  4
Anterior cingulate, posterior cingulate, frontopariental cortex, somatosensory cortex, piriform cortex, olfactory tubercle, islands of Calleja, ventromedial and posterior nuclei of the hypothalamus, medial septal nucleus, nucleus of diagonal band, ventral tegmental area, CA2 and CA3 regions of Ammon's horn, dendrate gyrus, caudate putamen, inferior olivary nucleus
Species:  Rat
Technique:  in situ hybridisation
References:  4
Tissue Distribution Comments
RT-PCR carried by Zhang et al did not detect GPR26 in testis [6].
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Physiological Consequences of Altering Gene Expression
Mice with Gpr26 knockout show increased levels of anxiety-like behaviors and depression-like behaviors.
Species:  Mouse
Tissue: 
Technique: 
References:  6
Gene Expression and Pathophysiology Comments
Epigenetic silencing of GPR26 is associated with human glioblastoma [1-2].
Available Assays
DiscoveRx PathHunter® CHO-K1 GPR26 β-Arrestin Orphan GPCR Cell Line (Cat no. 93-0392C2A)
PathHunter® eXpress GPR26 CHO-K1 β-Arrestin Orphan GPCR Assay (Cat no. 93-0392E2ACP1M)
more info

REFERENCES

1. Boulay JL, Ionescu MC, Sivasankaran B, Labuhn M, Dolder-Schlienger B, Taylor E, Morin P, Hemmings BA, Lino MM, Jones G, Maier D, Merlo A. (2009) The 10q25.3-26.1 G protein-coupled receptor gene GPR26 is epigenetically silenced in human gliomas. Int. J. Oncol.35 (5): 1123-31. [PMID:19787267]

2. Carter AN, Cole CL, Playle AG, Ramsay EJ, Shervington AA. (2008) GPR26: a marker for primary glioblastoma?. Mol. Cell. Probes22 (2): 133-7. [PMID:18037267]

3. Jones PG, Nawoschik SP, Sreekumar K, Uveges AJ, Tseng E, Zhang L, Johnson J, He L, Paulsen JE, Bates B, Pausch MH. (2007) Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78. Biochim. Biophys. Acta1770 (6): 890-901. [PMID:17363172]

4. Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, Liu Y, Liu IS, Heng HH, Seeman P, George SR, O'Dowd BF, Marchese A. (2000) Cloning and characterization of additional members of the G protein-coupled receptor family. Biochim. Biophys. Acta1490 (3): 311-23. [PMID:10684976]

5. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF. (2001) Discovery and mapping of ten novel G protein-coupled receptor genes. Gene275: 83-91. [PMID:11574155]

6. Zhang LL, Wang JJ, Liu Y, Lu XB, Kuang Y, Wan YH, Chen Y, Yan HM, Fei J, Wang ZG. (2011) GPR26-deficient mice display increased anxiety- and depression-like behaviors accompanied by reduced phosphorylated cyclic AMP responsive element-binding protein level in central amygdala. Neuroscience196: 203-14. [PMID:21924326]

To cite this database page, please use the following:

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: GPR26. Last modified on 24/07/2013. Accessed on 31/10/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=96.

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