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GPR26

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Transduction Mechanisms
Tissue Distribution
Expression Datasets
Physiological Consequences of Altering Gene Expression
Gene Expression and Pathophysiology
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 337 10q26.2-q26.3 GPR26 G protein-coupled receptor 26 4-5
Mouse 7 337 7 F3 Gpr26 G protein-coupled receptor 26
Rat 7 317 1q41 Gpr26 G protein-coupled receptor 26 5
Previous and Unofficial Names
GPR26
G-protein coupled receptor 26
G protein-coupled receptor 26
probable G-protein coupled receptor 26
9630036A11Rik
Database Links
Ensembl ENSG00000154478 (Hs), ENSMUSG00000040125 (Mm)
Entrez Gene 2849 (Hs), 233919 (Mm), 192153 (Rn)
GeneCards GPR26 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr26 (Mm)
HomoloGene 17764 (Hs)
Human Protein Reference Database 07275 (Hs)
InterPro Q8NDV2 (Hs), Q8BZA7 (Mm), Q9QXI3 (Rn)
KEGG Gene hsa:2849 (Hs), mmu:233919 (Mm), rno:192153 (Rn)
OMIM 604847 (Hs)
PharmGKB Gene PA28869 (Hs)
Protein Ontology (PRO) PRO:000001641 (Hs)
RefSeq Nucleotide NM_153442 (Hs), NM_173410 (Mm), NM_138841 (Rn)
RefSeq Protein NP_703143 (Hs), NP_775586 (Mm), NP_620196 (Rn)
TreeFam ENSG00000154478 (Hs), ENSMUSG00000040125 (Mm)
UniGene Hs. 12751 (Hs)
UniProt Q8NDV2 (Hs), Q8BZA7 (Mm), Q9QXI3 (Rn)
Wikipedia GPR26
Orphan and other 7TM receptors
Primary Transduction Mechanisms
Transducer Effector/Response
Gs family Adenylate cyclase stimulation
References:  3
Tissue Distribution
Brain, thalamus, hippocampus, amygdala, caudate, cerebellum, testis
Species:  Mouse
Technique:  RT-PCR
References:  3
Entire neocortex including limbic, motor and sensory cortical areas, anterior olfactory nucleus, medical and laterial nuclei, vertical and horizontal limbs of the diagonal band of Broca, hippocampal CA1, CA2, CA3, subiculum, presubiculum, entorhinal cortex and fasciola cinereum, amygdala region including lateral, basolateral and medial nuclei, cortical and hippocampal transition areas, striatal region including caudate putamen, olfactory tubercule, islands of Calleja and nucleus accumbens, thalamus region including medial habenula, paraventricular nucleus, geniculate nuclei, hypothalamus region including ventromedial nucleus, midbrain region such as substantia nigta pars compacta. ventral tegmental area and inferior colliculus, brainstem nuclei including ventral tegmental, lateral parabrachial, dorsal cochlear, spinal trigeminal nuclei.
Species:  Mouse
Technique:  in situ hybridisation
References:  3
Amygadala regions (BLA, CeA and MeA), cortex, hippocampus (CA2 and CA3 regions), Purkinje cells in cerebellum
Species:  Mouse
Technique:  immunohistochemistry
References: 
Brain regions such as striatum, pons, cerebellum and cortex, testis
Species:  Rat
Technique:  Northern blot
References:  5
Anterior cingulate, posterior cingulate, frontopariental cortex, somatosensory cortex, piriform cortex, olfactory tubercle, islands of Calleja, ventromedial and posterior nuclei of the hypothalamus, medial septal nucleus, nucleus of diagonal band, ventral tegmental area, CA2 and CA3 regions of Ammon's horn, dendate gyrus, caudate putamen, inferior olivary nucleus
Species:  Rat
Technique:  in situ hybridisation
References:  5
Tissue Distribution Comments
RT-PCR carried by Zhang et al did not detect GPR26 in testis [6].
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Consequences of Altering Gene Expression
Mice with Gpr26 knockout show increased levels of anxiety-like behaviors and depression-like behaviors.
Species:  Mouse
Tissue:  Amygadala regions (BLA, CeA and MeA), cortex, hippocampus (CA2 and CA3 regions), Purkinje cells in cerebellum
Technique:  Gene knockout in the mouse by gene targeting in ES cells.
References:  6
Gene Expression and Pathophysiology Comments
Epigenetic silencing of GPR26 is associated with human glioblastoma [1-2].
Available Assays
DiscoveRx PathHunter® CHO-K1 GPR26 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0392C2A
DiscoveRx PathHunter® eXpress GPR26 CHO-K1 β-Arrestin (Orphan) GPCR Assay Human Cat No. 93-0392E2ACP1

REFERENCES

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1. Boulay, JL; Ionescu, MC; Sivasankaran, B; Labuhn, M; Dolder-Schlienger, B; Taylor, E; Morin, P; Hemmings, BA; Lino, MM; Jones, G; Maier, D; Merlo, A. (2009) The 10q25.3-26.1 G protein-coupled receptor gene GPR26 is epigenetically silenced in human gliomas. Int. J. Oncol., 35 (5): 1123-31. [PMID:19787267]

2. Carter, AN; Cole, CL; Playle, AG; Ramsay, EJ; Shervington, AA. (2008) GPR26: a marker for primary glioblastoma?. Mol. Cell. Probes, 22 (2): 133-7. [PMID:18037267]

3. Jones, PG; Nawoschik, SP; Sreekumar, K; Uveges, AJ; Tseng, E; Zhang, L; Johnson, J; He, L; Paulsen, JE; Bates, B; Pausch, MH. (2007) Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78. Biochim. Biophys. Acta, 1770 (6): 890-901. [PMID:17363172]

4. Lee, D. K., Nguyen, T., Lynch, K. R., Cheng, R., Vanti, W. B., Arkhitko, O., Lewis, T., Evans, J. F., George, S. R. and O'Dowd, B. F. (2001) Discovery and mapping of ten novel G protein-coupled receptor genes. Gene, 275: 83-91. [PMID:11574155]

5. Lee, DK; Lynch, KR; Nguyen, T; Im, DS; Cheng, R; Saldivia, VR; Liu, Y; Liu, IS; Heng, HH; Seeman, P; George, SR; O'Dowd, BF; Marchese, A. (2000) Cloning and characterization of additional members of the G protein-coupled receptor family. Biochim. Biophys. Acta, 1490 (3): 311-23. [PMID:10684976]

6. Zhang, LL; Wang, JJ; Liu, Y; Lu, XB; Kuang, Y; Wan, YH; Chen, Y; Yan, HM; Fei, J; Wang, ZG. (2011) GPR26-deficient mice display increased anxiety- and depression-like behaviors accompanied by reduced phosphorylated cyclic AMP responsive element-binding protein level in central amygdala. Neuroscience, 196: 203-14. [PMID:21924326]

To cite this database page, please use the following:

Wen Chiy Liew.
Class A Orphans: GPR26. Last modified on 26/07/2012. Accessed on 19/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=96.


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