Nomenclature: CXCR4

Family: Chemokine receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 352 2q21 CXCR4 chemokine (C-X-C motif) receptor 4 10,29
Mouse 7 359 1 E3 Cxcr4 chemokine (C-X-C motif) receptor 4 15,33
Rat 7 349 13q12 Cxcr4 chemokine (C-X-C motif) receptor 4 23,42
Previous and Unofficial Names
Names References
fusin 6,10,15
LCR1 42
LESTR 29,33
HUMSTSR
HM89
NPY3R
NPYY3R
D2S201E
HSY3RR
NPYR
CD184
chemokine (C-X-C motif), receptor 4 (fusin)
Cmkar4
Sdf1r
MGC108696
C-X-C chemokine receptor type 4
CXC chemokine receptor
CXC-R4
CXCR-4
Chemokine receptor (LCR1)
SDF-1 receptor
leukocyte-derived seven transmembrane domain receptor
stromal cell-derived factor 1 receptor
PB-CKR
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
Orphanet Gene
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  CXCR4 chemokine receptor in complex with small molecule antagonist
PDB Id:  3ODU
Ligand:  isothiourea-1t
Resolution:  2.5Å
Species:  Human
References:  43
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the CXCR4 chemokine receptor in complex with a cyclic peptide antagonist CVX15
PDB Id:  3OE0
Resolution:  2.9Å
Species:  Human
References:  43
Natural/Endogenous Ligands
SDF-1α {Sp: Human}
SDF-1β {Sp: Human}
Comments: SDF1α and SDF1β are the active isomers of CXCL12
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[125I]SDF-1α (human) Hs Full agonist 8.1 – 8.4 pKd 9,18
pKd 8.1 – 8.4 (Kd 3.98x10-9 – 7.94x10-9 M) [9,18]
SDF-1α {Sp: Human} Hs Full agonist 7.7 – 8.2 pKd 18,30
pKd 7.7 – 8.2 [18,30]
[125I]SDF-1β (human) Hs Full agonist 7.9 pKd 18
pKd 7.9 [18]
SDF-1β {Sp: Human} Hs Full agonist 7.86 pKd 18
pKd 7.86 (Kd 1.37x10-8 M) [18]
CXCL12-(1-17) Hs Full agonist 6.1 pKi 30
pKi 6.1 [30]
CXCL12-(1-9) dimer Hs Full agonist 6.1 pKi 30
pKi 6.1 [30]
CXCL12-(1-9) Hs Full agonist 4.9 pKi 30
pKi 4.9 [30]
isothiourea-1t Hs Agonist 9.0 pEC50 41
pEC50 9.0 [41]
isothiourea-1a Hs Agonist 7.96 pEC50 41
pEC50 7.96 [41]
isothiourea-1t Hs Agonist 8.1 pIC50 41
pIC50 8.1 [41]
isothiourea-1t Rn Agonist 7.96 pIC50 41
pIC50 7.96 [41]
isothiourea-1a Hs Agonist 7.32 pIC50 41
pIC50 7.32 [41]
isothiourea-1a Rn Agonist 7.26 pIC50 41
pIC50 7.26 [41]
ALX40-4C Hs Partial agonist 6.1 pIC50 45
pIC50 6.1 [45]
View species-specific agonist tables
Agonist Comments
SDF-1α and SDF-1β are both referred to as CXCL12 and they have equivalent binding affinity and potency [18].
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
plerixafor Hs Antagonist 7.0 pKi 45
pKi 7.0 [45]
SDF-1, 1-9[P2G] dimer Hs Antagonist 5.6 pKi 30
pKi 5.6 [30]
T134 Hs Antagonist 8.4 pIC50 40
pIC50 8.4 [40]
T140 Hs Inverse agonist 7.8 – 8.6 pIC50 40,45
pIC50 7.8 – 8.6 [40,45]
vMIP-II Hs Antagonist 8.2 pIC50 26
pIC50 8.2 [26]
T22 Hs Antagonist 7.3 pIC50 40
pIC50 7.3 [40]
Antagonist Comments
AMD3100 is in clinical trials for hematopoietic progenitor cell mobilisation [28].
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family Calcium channel
References:  33,35
Tissue Distribution
Natural killer (NK) cells.
Species:  Human
Technique:  Flow cytometric and RNase protection assay.
References:  22
Colon.
Species:  Human
Technique:  RT-PCR and Immunohistochemistry.
References:  24
Precursor and mature megakaryocyte cells, and platelets.
Species:  Human
Technique:  RT-PCR and flow cytometry.
References:  27
CD34+ hematopoietic progenitor cells.
Species:  Human
Technique:  RT-PCR and Southern blotting.
References:  7
Fetal thymocytes.
Species:  Human
Technique:  Flow cytometry.
References:  25
Developing CNS: retina, olfactory epithelium, olfactory bulb, hippocampus, cerebellum, spinal cord.
Species:  Human
Technique:  in situ hybridisation.
References:  46
Basophils.
Species:  Human
Technique:  RT-PCR and flow cytometry.
References:  21
Blood dendritic cells.
Species:  Human
Technique:  RT-PCR.
References:  3
CD4 lymphocytes in normal intestinal mucosa.
Species:  Human
Technique:  Flow cytometry.
References:  2
CNS: Frontal lobe, temporal lobe, spinal cord.
Species:  Human
Technique:  Northern blotting.
References:  37
Glomerular podocytes.
Species:  Human
Technique:  RT-PCR.
References:  20
Bone marrow stromal cells (BMSCs).
Species:  Human
Technique:  Flow cytometry and RT-PCR.
References:  19
Testes.
Species:  Human
Technique:  RT-PCR.
References:  14
Microglia.
Species:  Human
Technique:  Flow cytometry.
References:  1,11
Developing neocortex and hippocampus.
Species:  Mouse
Technique:  in situ hybridisation.
References:  31
Primordial germ cells.
Species:  Mouse
Technique:  RT-PCR
References:  34
Thymus > spleen.
Species:  Mouse
Technique:  Northern blotting.
References:  15
Testicular macrophages.
Species:  Rat
Technique:  Northern blotting.
References:  14
Brain: choroid plexus > olfactory nucleus, cortex, pituitary.
Species:  Rat
Technique:  Radioligand binding.
References:  4
Hippocampal neurons.
Species:  Rat
Technique:  RT-PCR.
References:  32
Primary cultures of rat astrocytes and microglia.
Species:  Rat
Technique:  Northern blotting.
References:  23
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Functional Assays
Measurement of chemotaxis of thymocyte cells endogenously expressing the CXCR4 receptor.
Species:  Human
Tissue:  Thymocytes.
Response measured:  Chemotaxis.
References:  44
Measurement of Ca2+ levels in thymocytes endogenously expressing the CXCR4 receptor.
Species:  Human
Tissue:  Thymocytes.
Response measured:  Stimulation of Ca2+ influx.
References:  44
Detection of HIV-1 entry into human U87MG cells transfected with human HA-tagged CXCR4 receptors and human CD4.
Species:  Human
Tissue:  Human astroglioma cell line U87MG.
Response measured:  HIV-1 entry.
References:  6
Measurement of Ca2+ levels in the human colonic epithelial cell line HT-29 endogenously expressing the CXCR4 receptor.
Species:  Human
Tissue:  HT-29 cells.
Response measured:  Increase in intracellular Ca2+ concentration.
References:  24
Detection of neutrophil morphological change (activation) by light microscopy.
Species:  Human
Tissue:  Neutrophils.
Response measured:  Activation.
References:  12
Measurement of ERK and p38 MAPK activity in HEK 293 cells transfected with the human CXCR4 receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Activation of ERK and p38 MAPK via β-arrestin2
References:  39
Measurement of chemotaxis of HEK 293 cells transfected with the human CXCR4 receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Chemotaxis involving β-arrstin2 and p38 MAPK activation.
References:  39
Measurement of Ca2+ currents in HEK 293 cells stably expressing N-type calcium channels and the rat CXCR4 receptor, using Ba2+ as the charge carrier (IBa).
Species:  Rat
Tissue:  HEK 293 cells.
Response measured:  IBa inhibition.
References:  35
Physiological Functions
HIV coreceptor.
Species:  Human
Tissue:  Intestinal cell line HT-29.
References:  8
Chemotaxis.
Species:  Human
Tissue:  Neutrophils.
References:  12
Lymphopoiesis.
Species:  Human
Tissue:  Thymocytes.
References:  25
Haematopoiesis.
Species:  Mouse
Tissue:  In vivo.
References:  46
Cell migration and survival.
Species:  Mouse
Tissue:  Primordial germ cells.
References:  34
Interneuron migration.
Species:  Mouse
Tissue:  Neocortex.
References:  38
Neovascularisation (angiogenesis).
Species:  Rat
Tissue:  Aorta.
References:  36
Physiological Consequences of Altering Gene Expression
CXCR4 receptor knockout mice exhibit defective haematopoiesis and cardiac development.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  46
CXCR4 receptor knockout mice exhibit small and malformed dorsal root ganglia as well as delayed migration of sensory neuron progenitors to the dorsal root ganglion.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  5
CXCR4 receptor knockout mice embryos exhibit defects in primordial germ cell migration and survival.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  34
CXCR4 receptor knockout mice exhibit fewer interneurons in the superficial layers of the neocortex, these interneurons instead being located in the deep layers of the neocortex.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  38
CXCR4 receptor knockout mice exhibit abnormal development of the dorsal root ganglia with major defects in cell migration in the developing cerebellar cortex.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  31
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Cxcr4tm1Tng Cxcr4tm1Tng/Cxcr4tm1Tng
involves: 129P2/OlaHsd
MGI:109563  MP:0000260 abnormal angiogenesis PMID: 9634237 
Cxcr4tm1Tng Cxcr4tm1Tng/Cxcr4tm1Tng
involves: 129P2/OlaHsd
MGI:109563  MP:0002144 abnormal B cell differentiation PMID: 9634237 
Cd19+|Cd19tm1(cre)Cgn|Cxcr4tm2Yzo Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
involves: 129P2/OlaHsd
MGI:109563  MGI:88319  MP:0002144 abnormal B cell differentiation PMID: 15520246 
Cxcr4tm1Yzo Cxcr4tm1Yzo/Cxcr4tm1Yzo
Not Specified
MGI:109563  MP:0000872 abnormal cerebellum external granule cell layer morphology PMID: 9634238 
Cxcr4tm1Qma Cxcr4tm1Qma/Cxcr4tm1Qma
involves: 129X1/SvJ
MGI:109563  MP:0000849 abnormal cerebellum morphology PMID: 9689100 
Cxcr4tm1Yzo Cxcr4tm1Yzo/Cxcr4tm1Yzo
Not Specified
MGI:109563  MP:0000849 abnormal cerebellum morphology PMID: 9634238 
Cxcr4tm1Yzo Cxcr4tm1Yzo/Cxcr4tm1Yzo
Not Specified
MGI:109563  MP:0000788 abnormal cerebral cortex morphology PMID: 11983855 
Cxcr4tm1Yzo Cxcr4tm1Yzo/Cxcr4tm1Yzo
Not Specified
MGI:109563  MP:0000812 abnormal dentate gyrus morphology PMID: 11983855  12183377 
Cxcr4tm1Yzo Cxcr4tm1Yzo/Cxcr4tm1Yzo
Not Specified
MGI:109563  MP:0000281 abnormal interventricular septum morphology PMID: 9634238 
Cxcr4tm1Yiw|Tg(Lck-cre)1Jtak Cxcr4tm1Yiw/Cxcr4tm1Yiw,Tg(Lck-cre)1Jtak/0
Not Specified
MGI:109563  MGI:3655253  MP:0003156 abnormal leukocyte migration PMID: 20939892 
Cxcr4tm1Yzo Cxcr4tm1Yzo/Cxcr4tm1Yzo
Not Specified
MGI:109563  MP:0005460 abnormal leukopoiesis PMID: 9634238 
Cxcr4tm1Yzo Cxcr4tm1Yzo/Cxcr4tm1Yzo
Not Specified
MGI:109563  MP:0002401 abnormal lymphopoiesis PMID: 9634238 
Cxcr4tm1Qma Cxcr4tm1Qma/Cxcr4tm1Qma
B6.129X-Cxcr4/J
MGI:109563  MP:0003090 abnormal muscle progenitor cell migration PMID: 16166380 
Cxcr4tm1Qma|Gab1tm1Wbm Cxcr4tm1Qma/Cxcr4tm1Qma,Gab1tm1Wbm/Gab1tm1Wbm
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MGI:108088  MGI:109563  MP:0003090 abnormal muscle progenitor cell migration PMID: 16166380 
Cxcr4tm1Qma Cxcr4tm1Qma/Cxcr4tm1Qma
B6.129X-Cxcr4/J
MGI:109563  MP:0000729 abnormal myogenesis PMID: 16166380 
Cxcr4tm1Qma|Gab1tm1Wbm Cxcr4tm1Qma/Cxcr4tm1Qma,Gab1tm1Wbm/Gab1tm1Wbm
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MGI:108088  MGI:109563  MP:0000729 abnormal myogenesis PMID: 16166380 
Cd19+|Cd19tm1(cre)Cgn|Cxcr4tm2Yzo Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
involves: 129P2/OlaHsd
MGI:109563  MGI:88319  MP:0002389 abnormal Peyer's patch follicle morphology PMID: 15520246 
Cxcr4tm1Yzo Cxcr4tm1Yzo/Cxcr4tm1Yzo
Not Specified
MGI:109563  MP:0002982 abnormal primordial germ cell migration PMID: 12900445 
Cxcr4tm1Tng Cxcr4tm1Tng/Cxcr4tm1Tng
B6.Cg-Cxcr4
MGI:109563  MP:0002982 abnormal primordial germ cell migration PMID: 12684531 
Cxcr4tm1Tng Cxcr4tm1Tng/Cxcr4tm1Tng
B6.Cg-Cxcr4
MGI:109563  MP:0002145 abnormal T cell differentiation PMID: 12707343 
Cxcr4tm1Qma Cxcr4tm1Qma/Cxcr4tm1Qma
involves: 129X1/SvJ
MGI:109563  MP:0000853 absent cerebellar foliation PMID: 9689100 
Cxcr4tm1Qma Cxcr4tm1Qma/Cxcr4tm1Qma
involves: 129X1/SvJ
MGI:109563  MP:0001177 atelectasis PMID: 9689100 
Cd19+|Cd19tm1(cre)Cgn|Cxcr4tm2Yzo Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
involves: 129P2/OlaHsd
MGI:109563  MGI:88319  MP:0004978 decreased B-1 B cell number PMID: 15520246 
Cd19+|Cd19tm1(cre)Cgn|Cxcr4tm2Yzo Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
involves: 129P2/OlaHsd
MGI:109563  MGI:88319  MP:0008207 decreased B-2 B cell number PMID: 15520246 
Cxcr4tm1Qma Cxcr4tm1Qma/Cxcr4tm1Qma
involves: 129X1/SvJ
MGI:109563  MP:0001265 decreased body size PMID: 9689100 
Cxcr4tm1Qma Cxcr4tm1Qma/Cxcr4tm1Qma
involves: 129X1/SvJ
MGI:109563  MP:0000333 decreased bone marrow cell number PMID: 9689100 
Cxcr4tm1Tng Cxcr4tm1Tng/Cxcr4tm1Tng
B6.Cg-Cxcr4
MGI:109563  MP:0005092 decreased double-positive T cell number PMID: 12707343 
Cxcr4tm1Yzo Cxcr4tm1Yzo/Cxcr4tm1Yzo
Not Specified
MGI:109563  MP:0004200 decreased fetal size PMID: 9634238 
Cd19+|Cd19tm1(cre)Cgn|Cxcr4tm2Yzo Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
involves: 129P2/OlaHsd
MGI:109563  MGI:88319  MP:0002460 decreased immunoglobulin level PMID: 15520246 
Cd19+|Cd19tm1(cre)Cgn|Cxcr4tm2Yzo Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
involves: 129P2/OlaHsd
MGI:109563  MGI:88319  MP:0008211 decreased mature B cell number PMID: 15520246 
Cd19+|Cd19tm1(cre)Cgn|Cxcr4tm2Yzo Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
involves: 129P2/OlaHsd
MGI:109563  MGI:88319  MP:0008098 decreased plasma cell number PMID: 15520246 
Cd19+|Cd19tm1(cre)Cgn|Cxcr4tm1Tng|Cxcr4tm2Tng Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm1Tng/Cxcr4tm2Tng
involves: 129P2/OlaHsd * C57BL/6
MGI:109563  MGI:88319  MP:0008098 decreased plasma cell number PMID: 15189736 
Cxcr4tm1Yzo Cxcr4tm1Yzo/Cxcr4tm1Yzo
Not Specified
MGI:109563  MP:0008392 decreased primordial germ cell number PMID: 12900445 
Cxcr4tm1Qma Cxcr4tm1Qma/Cxcr4tm1Qma
involves: 129X1/SvJ
MGI:109563  MP:0008208 decreased pro-B cell number PMID: 9689100 
Cxcr4tm1Yiw|Tg(Lck-cre)1Jtak Cxcr4tm1Yiw/Cxcr4tm1Yiw,Tg(Lck-cre)1Jtak/0
Not Specified
MGI:109563  MGI:3655253  MP:0003436 decreased susceptibility to induced arthritis PMID: 20939892 
Cxcr4tm1Yiw|Tg(Lck-cre)1Jtak Cxcr4tm1Yiw/Cxcr4tm1Yiw,Tg(Lck-cre)1Jtak/0
Not Specified
MGI:109563  MGI:3655253  MP:0000715 decreased thymocyte number PMID: 20939892 
Cxcr4tm1Qma|Gab1tm1Wbm Cxcr4tm1Qma/Cxcr4tm1Qma,Gab1tm1Wbm/Gab1tm1Wbm
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MGI:108088  MGI:109563  MP:0009907 decreased tongue size PMID: 16166380 
Cxcr4tm1Qma Cxcr4tm1Qma/Cxcr4tm1Qma
involves: 129X1/SvJ
MGI:109563  MP:0000885 ectopic Purkinje cell PMID: 9689100 
Cxcr4tm1Tng Cxcr4tm1Tng/Cxcr4tm1Tng
involves: 129P2/OlaHsd
MGI:109563  MP:0001603 failure of myelopoiesis PMID: 9634237 
Cxcr4tm1Tng Cxcr4tm1Tng/Cxcr4tm1Tng
involves: 129P2/OlaHsd
MGI:109563  MP:0000465 gastrointestinal hemorrhage PMID: 9634237 
Cxcr4tm1Yzo Cxcr4tm1Yzo/Cxcr4tm1Yzo
Not Specified
MGI:109563  MP:0002192 hydrops fetalis PMID: 9634238 
Cxcr4tm1Qma|Gab1tm1Wbm Cxcr4tm1Qma/Cxcr4tm1Qma,Gab1tm1Wbm/Gab1tm1Wbm
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
MGI:108088  MGI:109563  MP:0003359 hypaxial muscle hypoplasia PMID: 16166380 
Cxcr4tm1Qma Cxcr4tm1Qma/Cxcr4tm1Qma
involves: 129X1/SvJ
MGI:109563  MP:0001602 impaired myelopoiesis PMID: 9689100 
Cxcr4tm1Yzo Cxcr4tm1Yzo/Cxcr4tm1Yzo
Not Specified
MGI:109563  MP:0001602 impaired myelopoiesis PMID: 9634238 
Cxcr4tm1Qma Cxcr4tm1Qma/Cxcr4tm1Qma
involves: 129X1/SvJ
MGI:109563  MP:0000533 kidney hemorrhage PMID: 9689100 
Cxcr4tm1Qma Cxcr4tm1Qma/Cxcr4tm1Qma
involves: 129X1/SvJ
MGI:109563  MP:0000532 kidney vascular congestion PMID: 9689100 
Cxcr4tm1Yzo Cxcr4tm1Yzo/Cxcr4tm1Yzo
Not Specified
MGI:109563  MP:0006208 lethality throughout fetal growth and development PMID: 9634238 
Cxcr4tm1Tng Cxcr4tm1Tng/Cxcr4tm1Tng
involves: 129P2/OlaHsd
MGI:109563  MP:0002058 neonatal lethality PMID: 9634237 
Cxcr4tm1Tng Cxcr4tm1Tng/Cxcr4tm1Tng
involves: 129P2/OlaHsd
MGI:109563  MP:0010418 perimembraneous ventricular septal defect PMID: 9634237 
Cxcr4tm1Qma Cxcr4tm1Qma/Cxcr4tm1Qma
involves: 129X1/SvJ
MGI:109563  MP:0002081 perinatal lethality PMID: 9689100 
Cxcr4tm1Tng Cxcr4tm1Tng/Cxcr4tm1Tng
involves: 129P2/OlaHsd
MGI:109563  MP:0002081 perinatal lethality PMID: 9634237 
Cxcr4tm1Qma Cxcr4tm1Qma/Cxcr4tm1Qma
involves: 129X1/SvJ
MGI:109563  MP:0000873 thin external granule cell layer PMID: 9689100 
Clinically-Relevant Mutations and Pathophysiology
Disease:  WHIM syndrome
OMIM:  193670
Orphanet:  51636
Comments: 
References:  17
Mutations not determined
Biologically Significant Variants
Type:  Splice variant.
Species:  Human
Description:  An unspliced version of the human CXCR4 receptor, called CXCR4-Lo, has been found, with a 9 amino acid extension at the N-terminus. This receptor may be a functional backup to CXCR4 during embryogenesis.
References:  13
Type:  Splice variant.
Species:  Mouse
Description:  A fully functioning splice variant of the mouse CXCR4 receptor, CXCR4-B, has been found with a different expression pattern from CXCR4.
References:  16,33
Available Assays
DiscoveRx PathHunter® C2C12 CXCR4 β-Arrestin Cell Line (Cat no. 93-0203C7) more info

REFERENCES

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2. Anton PA, Elliott J, Poles MA, McGowan IM, Matud J, Hultin LE, Grovit-Ferbas K, Mackay CR, Chen ISY, Giorgi JV. (2000) Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue. AIDS14: 1761-1765. [PMID:10985313]

3. Ayehunie S, Garcia-Zepeda EA, Hoxie JA, Horuk R, Kupper TS, Luster AD, Ruprecht RM. (1997) Human immunodeficiency virus-1 entry into purified blood dendritic cells through CC and CXC chemokine coreceptors. Blood90: 1379-1386. [PMID:9269754]

4. Banisadr G, Dicou E, Berbar T, Rostene W, Lombet A, Haour F. (2000) Characterization and visualization of [125I] stromal cell-derived factor-1alpha binding to CXCR4 receptors in rat brain and human neuroblastoma cells. J Neuroimmunol110: 151-160. [PMID:11024545]

5. Belmadani A, Tran PB, Ren D, Assimacopoulos S, Grove EA, Miller RJ. (2005) The chemokine stromal cell-derived factor-1 regulates the migration of sensory neuron progenitors. J Neurosci25: 3995-4003. [PMID:15843601]

6. Berson JF, Long D, Doranz BJ, Rucker J, Jirik FR, Doms RW. (1996) A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains. J Virol70: 6288-6295. [PMID:8709256]

7. Deichmann M, Kronenwett R, Haas R. (1997) Expression of the human immunodeficiency virus type-1 coreceptors CXCR-4 (fusin, LESTR) and CKR-5 in CD34+ hematopoietic progenitor cells. Blood89: 3522-3528. [PMID:9160656]

8. Delézay O, Koch N, Yahi N, Hammache D, Tourres C, Tamalet C, Fantini J. (1997) Co-expression of CXCR4/fusin and galactosylceramide in the human intestinal epithelial cell line HT-29. AIDS11: 1311-1318. [PMID:9302439]

9. Di Salvo J, Koch GE, Johnson KE, Blake AD, Daugherty BL, DeMartino JA, Sirotina-Meisher A, Liu Y, Springer MS, Cascieri MA, Sullivan KA. (2000) The CXCR4 agonist ligand stromal derived factor-1 maintains high affinity for receptors in both Galpha(i)-coupled and uncoupled states. Eur J Pharmacol409: 143-154. [PMID:11104827]

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To cite this database page, please use the following:

Israel F. Charo, Rebecca Hills, Richard Horuk, Kouji Matsushima, Philip M. Murphy, Joost J. Oppenheim.
Chemokine receptors: CXCR4. Last modified on 06/03/2014. Accessed on 01/10/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=71.

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