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CCR8

Previous and Unofficial Names
Names References
GPR-CY6
CKR-L1 186
ChemR1 213
TER1 214,217
Structural Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Name Reference
Human 7 355 3p22 CCR8 186,212-215
Rat 7 - 8q32 Ccr8
Mouse 7 353 9 F4 Ccr8 216
Contents:
Previous and Unofficial Names
Structural Information
Database Links
Agonists
Antagonists
Transduction Mechanisms
Tissue Distribution
Functional Assays
Physiological Functions
Physiological Consequences of Altering Gene Expression
Database Links
Ensembl ENSG00000179934 (Hs), ENSMUSG00000042262 (Mm), ENSRNOG00000026759 (Rn)
Entrez Gene 1237 (Hs), 12776 (Mm), 301066 (Rn)
GeneCards CCR8 (Hs)
HomoloGene 21080 (Hs)
OMIM 601834 (Hs)
PharmGKB Gene PA26173 (Hs)
Protein Ontology (PRO) PRO:000001204 (Hs)
RefSeq Nucleotide NM_005201 (Hs), NM_007720 (Mm), XM_236704 (Rn)
RefSeq Protein NP_005192 (Hs), NP_031746 (Mm), XP_236704 (Rn)
UniGene Hs. 113222 (Hs)
UniProt Q9BYX5 (Hs), P56484 (Mm)
Wikipedia CCR8
Search for 3D structures on the PDB
Search using keywords: Chemokine receptors CCR8 Search using accession numbers: Q9BYX5 || P56484
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[125I]CCL1 Hs Full agonist 8.9 – 9.7 pKd 210,215
[125I]CCL1 Mm Full agonist 8.7 pKd 216
vMIP-I Hs Full agonist 8.9 – 9.9 pIC50 210,225
CCL1 Hs Full agonist 8.5 – 9.8 pIC50 210,220,225
ZK 756326 Hs Full agonist 5.7 pIC50 220
View species-specific agonist tables
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
vMCC-I Hs Antagonist 9.4 pIC50 225
vMIP-II Hs Antagonist 8.1 pIC50 225

N.B. We are currently working to provide sequence information about endogenous peptide ligands using the chemokine receptors as a pilot. Comments are welcome.

Explore drug-target interactions for this set of compounds using iPHACE

Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family Calcium channel
References:  212
Tissue Distribution
Glomerular podocytes.
Species:  Human
Technique:  RT-PCR.
References:  135
Monocytes.
Species:  Mouse
Technique:  RT-PCR.
References:  207
Functional Assays
Measurement of Ca2+ levels in the murine pre-B cell line, 300-19, transfected with the human CCR8 receptor.
Species:  Human
Tissue:  murine 300-19 cells.
Response measured:  Ca2+ mobilisation.
References:  215
Measurement of chemotaxis of the murine pre-B cell line, 300-19, transfected with the human CCR8 receptor.
Species:  Human
Tissue:  murine 300-19 cells.
Response measured:  Chemotaxis.
References:  215
Detection of HIV-1 infection of NP-2 cells expressing CD4 and transfected with the human CCR8 receptor.
Species:  Human
Tissue:  NP-2/CD4 cells.
Response measured:  HIV-1 infection.
References:  217
Measurement of Ca2+ levels in HEK 293 cells transfected with the mouse CCR8 receptor.
Species:  Mouse
Tissue:  HEK 293 cells.
Response measured:  Ca2+ mobilisation.
References:  220
Measurement of chemotaxis of Jurkat cells transfected with the human CCR8 receptor.
Species:  Human
Tissue:  Jurkat cells.
Response measured:  Chemotaxis.
References:  221
Differentiation of human umbilical vein endothelial cells (HUVECs) into capillary-like structures.
Species:  Human
Tissue:  HUVECs
Response measured:  Angiogenesis.
References:  222
Measurement of MAP kinase cascade activity in murine BW5147 cells endogenously expressing the CCR8 receptor.
Species:  Mouse
Tissue:  BW5147 cells.
Response measured:  ERK2 activation.
References:  223
Physiological Functions
Eosinophil recruitment to the lung.
Species:  Mouse
Tissue:  In vivo.
References:  224
Migration of dendritic cells from the skin to the lymph nodes.
Species:  Mouse
Tissue:  In vivo.
References:  207
Antiapoptotic signalling.
Species:  Mouse
Tissue:  Thymocytes.
References:  223
Physiological Consequences of Altering Gene Expression
CCR8 receptor knockout mice infected with Schistosoma mansoni soluble egg antigen, ovalbumin or cockroach antigen exhibit impaired Th2 cytokine production.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  218
CCR8 receptor knockout mice exhibit challenged with Schistosoma mansoni egg exhibit impaired Il-10 production and defective recruitment of granuloma eosinophils.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  219
CCR8 receptor knockout mice have reduced monocyte migration to the lymph nodes.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  207

To cite this receptor data page, please use the following:

Israel F. Charo, Rebecca Hills, Richard Horuk, Kouji Matsushima, Philip M. Murphy, Joost J. Oppenheim.
Chemokine receptors: CCR8. Last modified on 2010-06-29. Accessed on 2010-09-09. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=65.


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