Nomenclature: GPR176

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 


Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 515 15q14-q15.1 GPR176 G protein-coupled receptor 176 1
Mouse 7 515 2 Gpr176 G protein-coupled receptor 176
Rat 7 513 3 Gpr176 G protein-coupled receptor 176
Previous and Unofficial Names
G-protein coupled receptor 176
probable G-protein coupled receptor 176
G-protein coupled receptor AGR9
gene model 1012, (NCBI)
putative G protein coupled receptor
Database Links
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Reference Database
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
UniGene Hs.
Tissue Distribution
Brain, spleen, lung, kidney, intestine, cultured rat aortic smooth muscle
Species:  Rat
Technique:  Northern blot
References:  1-2
Tissue Distribution Comments
Highest levels of expression are seen in human ovary, embryonic and nerve tissues (based on Unigene EST profile).
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Type:  SNP
Species:  Human
Change:  K77R
Global MAF (%):  1
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 14|6|17|3
Minor allele count:  C=0.099/216
SNP accession: 
Validation:  1000 Genomes, Frequency
Biologically Significant Variant Comments
The RefSeq gene (Gene ID:11245) has 3 coding exons, first contains most of TM 1, second contains most of TMs 2 and 3. There are a number of cDNAs which insert an extra 58 base exon between exons 1 and 2 and then use a compensating shorter (by 61 bases at acceptor end) version of exon 2. These alternate splice variants seem to be associated with one allele of the SNP rs66490630 which is the last base of the extra exon.
Available Assays
DiscoveRx PathHunter® CHO-K1 GPR176 β-Arrestin Orphan GPCR Cell Line (Cat no. 93-0382C2A)
PathHunter® eXpress GPR176 CHO-K1 β-Arrestin Orphan GPCR Assay (Cat no. 93-0382E2ACP1M)
more info


1. Hata S, Emi Y, Iyanagi T, Osumi T. (1995) cDNA cloning of a putative G protein-coupled receptor from brain. Biochim. Biophys. Acta1261 (1): 121-5. [PMID:7893747]

2. Ishizaka N, Okazaki H, Kurokawa K, Kumada M, Takuwa Y. (1994) Molecular cloning of a novel putative G protein-coupled receptor from rat aortic smooth muscle. Downregulation of the mRNA level by the cyclic AMP messenger pathway. Biochim. Biophys. Acta1218 (2): 173-80. [PMID:8018717]

To cite this database page, please use the following:

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: GPR176. Last modified on 24/07/2013. Accessed on 01/11/2014. IUPHAR database (IUPHAR-DB),

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