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GPR176

Family: Class A Orphans

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Tissue Distribution
Expression Datasets
Biologically Significant Variants
References
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 515 15q14-q15.1 GPR176 G protein-coupled receptor 176 1
Mouse 7 515 2 Gpr176 G protein-coupled receptor 176
Rat 7 513 3 Gpr176 G protein-coupled receptor 176
Previous and Unofficial Names
AGR9
Gm1012
HB954
GPR176
G-protein coupled receptor 176
HB-954
probable G-protein coupled receptor 176
Gpr
RBU-15
G-protein coupled receptor AGR9
gene model 1012, (NCBI)
putative G protein coupled receptor
LOC381413
Database Links
Ensembl ENSG00000166073 (Hs), ENSMUSG00000040133 (Mm), ENSRNOG00000005971 (Rn)
Entrez Gene 11245 (Hs), 381413 (Mm), 117257 (Rn)
GeneCards GPR176 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gpr176 (Mm)
HomoloGene 5226
Human Protein Reference Database 13597 (Hs)
InterPro Q14439 (Hs), Q80WT4 (Mm), Q64017 (Rn)
KEGG Gene hsa:11245 (Hs), mmu:381413 (Mm), rno:117257 (Rn)
OMIM 612183
PhosphoSitePlus Q14439 (Hs), Q80WT4 (Mm), Q64017 (Rn)
Protein Ontology (PRO) PRO:PR:000001519 (Hs)
RefSeq Nucleotide NM_007223 (Hs), NM_201367 (Mm), XM_001080723 (Rn)
RefSeq Protein NP_009154 (Hs), NP_958755 (Mm), XP_001080723 (Rn)
TreeFam ENSG00000166073 (Hs), ENSMUSG00000040133 (Mm), ENSRNOG00000005971 (Rn)
UniGene Hs. 37196 (Hs)
UniProt Q14439 (Hs), Q80WT4 (Mm), Q64017 (Rn)
Wikipedia GPR176
Orphan and other 7TM receptors
Tissue Distribution
Brain, spleen, lung, kidney, intestine, cultured rat aortic smooth muscle
Species:  Rat
Technique:  Northern blot
References:  1-2
Tissue Distribution Comments
Highest levels of expression are seen in human ovary, embryonic and nerve tissues (based on Unigene EST profile).
Expression Datasets

Click here to show/hide data

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variant Comments
The RefSeq gene (Gene ID:11245) has 3 coding exons, first contains most of TM 1, second contains most of TMs 2 and 3. There are a number of cDNA which insert an extra 58 base exon between exons 1 and 2 and then use a compensating shorter (by 61 bases at acceptor end) version of exon 2. These alternate splice variants seem to be associated with one allele of the SNP rs66490630 which is the last base of the extra exon.
Available Assays
DiscoveRx PathHunter® CHO-K1 GPR176 (Orphan) High Expression β-Arrestin Cell Line Human Cat No. 93-0382C2A
DiscoveRx PathHunter® eXpress GPR176 CHO-K1 β-Arrestin (Orphan) GPCR Assay Human Cat No. 93-0382E2ACP1

REFERENCES

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1. Hata, S; Emi, Y; Iyanagi, T; Osumi, T. (1995) cDNA cloning of a putative G protein-coupled receptor from brain. Biochim. Biophys. Acta, 1261 (1): 121-5. [PMID:7893747]

2. Ishizaka, N; Okazaki, H; Kurokawa, K; Kumada, M; Takuwa, Y. (1994) Molecular cloning of a novel putative G protein-coupled receptor from rat aortic smooth muscle. Downregulation of the mRNA level by the cyclic AMP messenger pathway. Biochim. Biophys. Acta, 1218 (2): 173-80. [PMID:8018717]

To cite this database page, please use the following:

Amy E. Monaghan.
Class A Orphans: GPR176. Last modified on 03/09/2012. Accessed on 20/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=637.


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