Nomenclature: Nuclear receptor related 1

Systematic Nomenclature: NR4A2

Family: 4A. Nerve growth factor IB-like receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
Species AA Chromosomal Location Gene Symbol Gene Name Reference
Human 598 2q22-q23 NR4A2 nuclear receptor subfamily 4, group A, member 2 15
Mouse 598 3 34.5cM Nr4a2 nuclear receptor subfamily 4, group A, member 2 9
Rat 598 3q12 Nr4a2 nuclear receptor subfamily 4, group A, member 2 20
Previous and Unofficial Names
NOT
RNR1
HZF-3
NURR1
Immediate early response protein NOT
transcriptionally inducible nuclear receptor
TINUR
RNR-1
NUR-related factor 1
SL-322
nuclear orphan receptor HZF-3
nuclear receptor subfamily 4 group A member 2
nuclear receptor subfamily 4 group A member 2 variant TINUR
nuclear receptor subfamily 4 group A member 2 variant NURR1a
nuclear receptor subfamily 4 group A member 2 variant NURR1b
nuclear receptor subfamily 4 group A member 2 variant NURR1c
nuclear receptor subfamily 4 group A member 2 variant NURR2c
nuclear receptor subfamily 4 group A member 2 variant TINUR
nuclear receptor subfamily 4, group A, member 2
nur related protein 1
orphan nuclear receptor NURR1
regenerating liver nuclear receptor 1
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
NURSA Receptor
OMIM
Orphanet Gene
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  NR4A2 Ligand Binding Domain - apo-structure
PDB Id:  1OVL
Resolution:  2.2Å
Species:  Human
References:  22
Natural/Endogenous Ligands
Comments: Orphan
Agonist Comments
NR4A2 (NURR) is the first nuclear receptor described that lacks a bona fide ligand binding pocket in its LBD. It is therefore the first unambiguously orphan receptor [22].
DNA Binding
Structure:  Monomer, Homodimer, Heterodimer, RXR partner
HRE core sequence:  AAAGGTCA
Response element:  Other - see comments
DNA Binding Comments
NR4A2 is able to interact with DNA in various manner. As monomers, NR4A2 as other N4R4A subfamily members interact with the so-called NBRE sequence (AAAGGTCA). NR4A2 also interacts with DNA as an heterodimer with RXR and bind NBRE as well as DR5 response elements (AGGTCA nnnAA AGGTCA). NR4A2 is also able to homodimerize and to heterodimerize with other NR4A family members and bind the so-called NuRE sequence which has the structure of an ER10 (two AGGTCA elements as everted repeats spaced by 10 bp, the two immediate 5’ bases of each element being As).
Co-binding Partners
Name Interaction Effect Reference
Nerve Growth factor IB Physical, Functional DNA binding 12
Neuron-derived orphan receptor 1 Physical, Functional DNA binding 12
Retinoid X receptor-α Physical, Functional DNA binding 16,24
CDKN1C (p57KIP2) Physical, Functional specify NR4A3/p57kip2 interaction seems to inhibit NR4A2 transcriptional activity 7
PIASγ Physical, Functional represses Nurr1 transcriptional activity 3
Main Target Genes
Name Species Effect Technique Comments References
Spp1 Mouse Activated Transient transfection, EMSA, Other The activation of the OPN promoter is mediated by the monomeric form of Nurr1, required direct binding of Nurr1 to the OPN promoter, and is dependent on the amino-terminal transactivation function-1. The OPN promoter is also regulated by vitamin D receptor and estrogen-related receptors. Nurr1 and vitamin D activate the OPN promoter in a synergistic fashion, whereas Nurr1-mediated transactivation of the OPN promoter is repressed by estrogen-related receptors. 8
Bglap Rat Activated ChIP, Transient transfection, EMSA NR4A2 positively regulate the osteocalcin promoter as a monomer. 17
Th Mouse Activated ChIP, Transient transfection, EMSA, Footprint NR4A2 stimulates TH promoter activity in mouse and rat but not in human 18
Nrp1 Mouse Activated ChIP, Transient transfection 5
Tissue Distribution
CNS (specifically in mesencephalic dopaminergic neurones of the ventral tegmental area and of the substantia nigra), liver, pituitary, thymus, osteoblasts
Species:  Human
Technique:  Northern, Q-PCR, In situ, Western, Immunohistology, Other
References:  1,9,11,20,24-25
Tissue Distribution Comments
The NR4A2 is expressed as a 3.5 kb transcript and exhibit a strong inducibility, for example by membrane depolarisation in PC12 cells.The three NR4A subfamily members are expressed in a complex pattern in the nervous system where they are induced as part of the immediate early response to stimuli such as growth factors, membrane depolarisation and seizure. Their expression pattern outside the nervous system is quite large. NR4A2 is expressed more specifically in mesencephalic dopaminergic neurones of the ventral tegmental area and of the substantia nigra. Outside of the CNS, NR4A2 is expressed in the adult liver as well as in pituitary, thymus and osteoblasts. It is important to notice that NR4A2 is constitutively expressed in various region of the CNS and quickly induced as an immediate early gene in numerous peripheric tissus and in the CNS in response to various stimuli. (NB: similar patterns are seen in rodents).
Physiological Consequences of Altering Gene Expression
NR4A2 null mice: Three independent knock out mice strain were generated by different groups. Homozygous mice from all strains exhibit a complete loss of ventral mesencephalic dopaminergic neurons and die at birth. In addition to the deficiency of dopaminergic neurons, these mice exhibit respiratory dysfunction and altered gene expression in the dorsal motor nucleus of the brain stem.
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  2,13,19,21,23
Phenotypes, Alleles and Disease Models Mouse data from MGI

Show »

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Nr4a2+|Nr4a2tm1Tpe Nr4a2tm1Tpe/Nr4a2+
B6.129P2-Nr4a2
MGI:1352456  MP:0001905 abnormal dopamine level PMID: 17457314 
Nr4a2tm2.1Tpe|Slc6a3tm1(cre)Lrsn Nr4a2tm2.1Tpe/Nr4a2tm2.1Tpe,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
involves: 129S1/Sv * 129X1/SvJ
MGI:1352456  MGI:94862  MP:0003243 abnormal dopaminergic neuron morphology PMID: 20016108 
Nr4a2tm2.1Tpe Nr4a2tm2.1Tpe/Nr4a2tm2.1Tpe
Not Specified
MGI:1352456  MP:0003243 abnormal dopaminergic neuron morphology PMID: 20016108 
Nr4a2+|Nr4a2tm1Omc Nr4a2tm1Omc/Nr4a2+
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352456  MP:0003313 abnormal locomotor activation PMID: 15589522 
Nr4a2tm1Omc Nr4a2tm1Omc/Nr4a2tm1Omc
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352456  MP:0003864 abnormal midbrain development PMID: 9520484 
Nr4a2+|Nr4a2tm1Omc Nr4a2tm1Omc/Nr4a2+
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352456  MP:0003864 abnormal midbrain development PMID: 10506516 
Nr4a2tm1Tpe Nr4a2tm1Tpe/Nr4a2tm1Tpe
involves: 129P2/OlaHsd
MGI:1352456  MP:0002066 abnormal motor capabilities/coordination/movement PMID: 9092472 
Nr4a2tm1Tpe Nr4a2tm1Tpe/Nr4a2tm1Tpe
involves: 129P2/OlaHsd
MGI:1352456  MP:0003861 abnormal nervous system development PMID: 9092472 
Nr4a2tm1Omc Nr4a2tm1Omc/Nr4a2tm1Omc
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352456  MP:0002204 abnormal neurotransmitter level PMID: 10506516 
Nr4a2+|Nr4a2tm1Tpe Nr4a2tm1Tpe/Nr4a2+
B6.129P2-Nr4a2
MGI:1352456  MP:0003964 abnormal noradrenaline level PMID: 17457314 
Nr4a2tm2.1Tpe|Slc6a3tm1(cre)Lrsn Nr4a2tm2.1Tpe/Nr4a2tm2.1Tpe,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
involves: 129S1/Sv * 129X1/SvJ
MGI:1352456  MGI:94862  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 20016108 
Nr4a2+|Nr4a2tm1Tpe Nr4a2tm1Tpe/Nr4a2+
B6.129P2-Nr4a2
MGI:1352456  MP:0005322 abnormal serotonin concentration PMID: 17457314 
Nr4a2tm2.1Tpe|Slc6a3tm1(cre)Lrsn Nr4a2tm2.1Tpe/Nr4a2tm2.1Tpe,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
involves: 129S1/Sv * 129X1/SvJ
MGI:1352456  MGI:94862  MP:0005322 abnormal serotonin concentration PMID: 20016108 
Nr4a2tm1Omc Nr4a2tm1Omc/Nr4a2tm1Omc
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352456  MP:0000836 abnormal substantia nigra morphology PMID: 9520484 
Nr4a2tm1Omc Nr4a2tm1Omc/Nr4a2tm1Omc
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352456  MP:0001436 abnormal suckling behavior PMID: 10506516 
Nr4a2tm1Tpe Nr4a2tm1Tpe/Nr4a2tm1Tpe
involves: 129P2/OlaHsd
MGI:1352456  MP:0001436 abnormal suckling behavior PMID: 9092472 
Nr4a2tm1Omc Nr4a2tm1Omc/Nr4a2tm1Omc
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352456  MP:0006100 abnormal tegmentum morphology PMID: 9520484 
Nr4a2tm2.1Tpe Nr4a2tm2.1Tpe/Nr4a2tm2.1Tpe
Not Specified
MGI:1352456  MP:0002690 akinesia PMID: 20016108 
Nr4a2+|Nr4a2tm1Tpe Nr4a2tm1Tpe/Nr4a2+
B6.129P2-Nr4a2
MGI:1352456  MP:0002573 behavioral despair PMID: 17457314 
Nr4a2tm2.1Tpe|Slc6a3tm1(cre)Lrsn Nr4a2tm2.1Tpe/Nr4a2tm2.1Tpe,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
involves: 129S1/Sv * 129X1/SvJ
MGI:1352456  MGI:94862  MP:0001265 decreased body size PMID: 20016108 
Nr4a2tm1Omc Nr4a2tm1Omc/Nr4a2tm1Omc
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352456  MP:0005643 decreased dopamine level PMID: 9520484 
Nr4a2+|Nr4a2tm1Omc Nr4a2tm1Omc/Nr4a2+
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352456  MP:0005643 decreased dopamine level PMID: 15589522 
Nr4a2tm1Tpe Nr4a2tm1Tpe/Nr4a2tm1Tpe
involves: 129P2/OlaHsd
MGI:1352456  MP:0005643 decreased dopamine level PMID: 9092472 
Nr4a2+|Nr4a2tm1Tpe Nr4a2tm1Tpe/Nr4a2+
involves: 129P2/OlaHsd
MGI:1352456  MP:0005643 decreased dopamine level PMID: 9092472 
Nr4a2tm1Niko Nr4a2tm1Niko/Nr4a2tm1Niko
involves: 129S4/SvJae
MGI:1352456  MP:0005643 decreased dopamine level PMID: 9608532 
Nr4a2tm2.1Tpe|Slc6a3tm1(cre)Lrsn Nr4a2tm2.1Tpe/Nr4a2tm2.1Tpe,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
involves: 129S1/Sv * 129X1/SvJ
MGI:1352456  MGI:94862  MP:0005643 decreased dopamine level PMID: 20016108 
Nr4a2tm2.1Tpe Nr4a2tm2.1Tpe/Nr4a2tm2.1Tpe
Not Specified
MGI:1352456  MP:0005643 decreased dopamine level PMID: 20016108 
Nr4a2tm2.1Tpe|Slc6a3tm1(cre)Lrsn Nr4a2tm2.1Tpe/Nr4a2tm2.1Tpe,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
involves: 129S1/Sv * 129X1/SvJ
MGI:1352456  MGI:94862  MP:0002757 decreased vertical activity PMID: 20016108 
Nr4a2tm1Niko Nr4a2tm1Niko/Nr4a2tm1Niko
involves: 129S4/SvJae
MGI:1352456  MP:0001429 dehydration PMID: 9608532 
Nr4a2+|Nr4a2tm1Tpe Nr4a2tm1Tpe/Nr4a2+
B6.129P2-Nr4a2
MGI:1352456  MP:0009749 enhanced behavioral response to addictive substance PMID: 17457314 
Nr4a2+|Nr4a2tm1Tpe Nr4a2tm1Tpe/Nr4a2+
B6.129P2-Nr4a2
MGI:1352456  MP:0009746 enhanced behavioral response to xenobiotic PMID: 17457314 
Nr4a2+|Nr4a2tm1Tpe Nr4a2tm1Tpe/Nr4a2+
B6.129P2-Nr4a2
MGI:1352456  MP:0001399 hyperactivity PMID: 17457314 
Nr4a2tm2.1Tpe|Slc6a3tm1(cre)Lrsn Nr4a2tm2.1Tpe/Nr4a2tm2.1Tpe,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
involves: 129S1/Sv * 129X1/SvJ
MGI:1352456  MGI:94862  MP:0001399 hyperactivity PMID: 20016108 
Nr4a2tm1Omc Nr4a2tm1Omc/Nr4a2tm1Omc
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352456  MP:0001402 hypoactivity PMID: 10506516 
Nr4a2tm1Tpe Nr4a2tm1Tpe/Nr4a2tm1Tpe
involves: 129P2/OlaHsd
MGI:1352456  MP:0001402 hypoactivity PMID: 9092472 
Nr4a2tm2.1Tpe|Slc6a3tm1(cre)Lrsn Nr4a2tm2.1Tpe/Nr4a2tm2.1Tpe,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
involves: 129S1/Sv * 129X1/SvJ
MGI:1352456  MGI:94862  MP:0001402 hypoactivity PMID: 20016108 
Nr4a2+|Nr4a2tm1Omc Nr4a2tm1Omc/Nr4a2+
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352456  MP:0001405 impaired coordination PMID: 15589522 
Nr4a2+|Nr4a2tm1Tpe Nr4a2tm1Tpe/Nr4a2+
B6.129P2-Nr4a2
MGI:1352456  MP:0004000 impaired passive avoidance behavior PMID: 17457314 
Nr4a2tm1Tpe Nr4a2tm1Tpe/Nr4a2tm1Tpe
involves: 129P2/OlaHsd
MGI:1352456  MP:0001523 impaired righting response PMID: 9092472 
Nr4a2tm2.1Tpe|Slc6a3tm1(cre)Lrsn Nr4a2tm2.1Tpe/Nr4a2tm2.1Tpe,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
involves: 129S1/Sv * 129X1/SvJ
MGI:1352456  MGI:94862  MP:0001409 increased stereotypic behavior PMID: 20016108 
Nr4a2+|Nr4a2tm1Tpe|Nr4a3tm1Dgen Nr4a2tm1Tpe/Nr4a2+,Nr4a3tm1Dgen/Nr4a3tm1Dgen
involves: 129P2/OlaHsd
MGI:1352456  MGI:1352457  MP:0008235 increased susceptibility to neuronal excitotoxicity PMID: 20566846 
Nr4a2tm1Tpe Nr4a2tm1Tpe/Nr4a2tm1Tpe
involves: 129P2/OlaHsd
MGI:1352456  MP:0003244 loss of dopaminergic neurons PMID: 9092472 
Nr4a2tm1Niko Nr4a2tm1Niko/Nr4a2tm1Niko
involves: 129S4/SvJae
MGI:1352456  MP:0003244 loss of dopaminergic neurons PMID: 9608532 
Nr4a2tm1Omc Nr4a2tm1Omc/Nr4a2tm1Omc
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352456  MP:0002058 neonatal lethality PMID: 10506516  9520484 
Nr4a2tm1Niko Nr4a2tm1Niko/Nr4a2tm1Niko
involves: 129S4/SvJae
MGI:1352456  MP:0002058 neonatal lethality PMID: 9608532 
Nr4a2tm2.1Tpe|Slc6a3tm1(cre)Lrsn Nr4a2tm2.1Tpe/Nr4a2tm2.1Tpe,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
involves: 129S1/Sv * 129X1/SvJ
MGI:1352456  MGI:94862  MP:0003224 neuron degeneration PMID: 20016108 
Nr4a2+|Nr4a2tm1Tpe|Nr4a3tm1Dgen Nr4a2tm1Tpe/Nr4a2+,Nr4a3tm1Dgen/Nr4a3tm1Dgen
involves: 129P2/OlaHsd
MGI:1352456  MGI:1352457  MP:0003674 oxidative stress PMID: 20566846 
Nr4a2tm1Tpe Nr4a2tm1Tpe/Nr4a2tm1Tpe
involves: 129P2/OlaHsd
MGI:1352456  MP:0002082 postnatal lethality PMID: 9092472 
Nr4a2tm2.1Tpe|Slc6a3tm1(cre)Lrsn Nr4a2tm2.1Tpe/Nr4a2tm2.1Tpe,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
involves: 129S1/Sv * 129X1/SvJ
MGI:1352456  MGI:94862  MP:0002082 postnatal lethality PMID: 20016108 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Parkinson disease
OMIM:  168600
Comments: 
References:  4,6,10
Mutations not determined
Disease:  Young adult-onset Parkinsonism
Orphanet:  2828
References: 
Mutations not determined
Biologically Significant Variants
Type:  Splice variant
Species:  Human
Description:  Nurr2: Has a novel cryptic exon located upstream in the Nurr1 promoter region, and was generated by alternative splicing at exons 1, 2 and 6. The C-terminal region was encoded by frame-shifted exon 6, and so Nurr2 lacked the C-terminal sequences corresponding to the putative ligand binding domain or dimerization domain. Functional analysis using a reporter gene, containing NBRE response elements, indicated that while the isoform was inactive by itself, it could inhibit transactivation by the members of the NGFI-B family
References:  14

REFERENCES

1. Bandoh S, Tsukada T, Maruyama K, Ohkura N, Yamaguchi K. (1997) Differential expression of NGFI-B and RNR-1 genes in various tissues and developing brain of the rat: comparative study by quantitative reverse transcription-polymerase chain reaction. J. Neuroendocrinol.9 (1): 3-8. [PMID:9023733]

2. Castillo SO, Baffi JS, Palkovits M, Goldstein DS, Kopin IJ, Witta J, Magnuson MA, Nikodem VM. (1998) Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene. Mol. Cell. Neurosci.11 (1-2): 36-46. [PMID:9608532]

3. Galleguillos D, Vecchiola A, Fuentealba JA, Ojeda V, Alvarez K, Gómez A, Andrés ME. (2004) PIASgamma represses the transcriptional activation induced by the nuclear receptor Nurr1. J. Biol. Chem.279 (3): 2005-11. [PMID:14559918]

4. Hering R, Petrovic S, Mietz EM, Holzmann C, Berg D, Bauer P, Woitalla D, Müller T, Berger K, Krüger R, Riess O. (2004) Extended mutation analysis and association studies of Nurr1 (NR4A2) in Parkinson disease. Neurology62 (7): 1231-2. [PMID:15079038]

5. Hermanson E, Borgius L, Bergsland M, Joodmardi E, Perlmann T. (2006) Neuropilin1 is a direct downstream target of Nurr1 in the developing brain stem. J. Neurochem.97 (5): 1403-11. [PMID:16638018]

6. Ibáñez P, Lohmann E, Pollak P, Durif F, Tranchant C, Agid Y, Dürr A, Brice A, French Parkinson's Disease Genetics Study Group. (2004) Absence of NR4A2 exon 1 mutations in 108 families with autosomal dominant Parkinson disease. Neurology62 (11): 2133-4. [PMID:15184637]

7. Joseph B, Wallén-Mackenzie A, Benoit G, Murata T, Joodmardi E, Okret S, Perlmann T. (2003) p57(Kip2) cooperates with Nurr1 in developing dopamine cells. Proc. Natl. Acad. Sci. U.S.A.100 (26): 15619-24. [PMID:14671317]

8. Lammi J, Huppunen J, Aarnisalo P. (2004) Regulation of the osteopontin gene by the orphan nuclear receptor NURR1 in osteoblasts. Mol. Endocrinol.18 (6): 1546-57. [PMID:14988426]

9. Law SW, Conneely OM, DeMayo FJ, O'Malley BW. (1992) Identification of a new brain-specific transcription factor, NURR1. Mol. Endocrinol.6 (12): 2129-35. [PMID:1491694]

10. Le WD, Xu P, Jankovic J, Jiang H, Appel SH, Smith RG, Vassilatis DK. (2003) Mutations in NR4A2 associated with familial Parkinson disease. Nat. Genet.33 (1): 85-9. [PMID:12496759]

11. Mages HW, Rilke O, Bravo R, Senger G, Kroczek RA. (1994) NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3. Mol. Endocrinol.8 (11): 1583-91. [PMID:7877627]

12. Maira M, Martens C, Philips A, Drouin J. (1999) Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation. Mol. Cell. Biol.19 (11): 7549-57. [PMID:10523643]

13. Nsegbe E, Wallén-Mackenzie A, Dauger S, Roux JC, Shvarev Y, Lagercrantz H, Perlmann T, Herlenius E. (2004) Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice. J. Physiol. (Lond.)556 (Pt 1): 43-59. [PMID:14742729]

14. Ohkura N, Hosono T, Maruyama K, Tsukada T, Yamaguchi K. (1999) An isoform of Nurr1 functions as a negative inhibitor of the NGFI-B family signaling. Biochim. Biophys. Acta1444 (1): 69-79. [PMID:9931442]

15. Okabe T, Takayanagi R, Imasaki K, Haji M, Nawata H, Watanabe T. (1995) cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line. J. Immunol.154 (8): 3871-9. [PMID:7706727]

16. Perlmann T, Jansson L. (1995) A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes Dev.9 (7): 769-82. [PMID:7705655]

17. Pirih FQ, Tang A, Ozkurt IC, Nervina JM, Tetradis S. (2004) Nuclear orphan receptor Nurr1 directly transactivates the osteocalcin gene in osteoblasts. J. Biol. Chem.279 (51): 53167-74. [PMID:15485875]

18. Sakurada K, Ohshima-Sakurada M, Palmer TD, Gage FH. (1999) Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. Development126 (18): 4017-26. [PMID:10457011]

19. Saucedo-Cardenas O, Quintana-Hau JD, Le WD, Smidt MP, Cox JJ, De Mayo F, Burbach JP, Conneely OM. (1998) Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc. Natl. Acad. Sci. U.S.A.95 (7): 4013-8. [PMID:9520484]

20. Scearce LM, Laz TM, Hazel TG, Lau LF, Taub R. (1993) RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver. J. Biol. Chem.268 (12): 8855-61. [PMID:8473329]

21. Wallén A A, Castro DS, Zetterström RH, Karlén M, Olson L, Ericson J, Perlmann T. (2001) Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem. Mol. Cell. Neurosci.18 (6): 649-63. [PMID:11749040]

22. Wang Z, Benoit G, Liu J, Prasad S, Aarnisalo P, Liu X, Xu H, Walker NP, Perlmann T. (2003) Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature423 (6939): 555-60. [PMID:12774125]

23. Zetterström RH, Solomin L, Jansson L, Hoffer BJ, Olson L, Perlmann T. (1997) Dopamine neuron agenesis in Nurr1-deficient mice. Science276 (5310): 248-50. [PMID:9092472]

24. Zetterström RH, Solomin L, Mitsiadis T, Olson L, Perlmann T. (1996) Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1. Mol. Endocrinol.10 (12): 1656-66. [PMID:8961274]

25. Zetterström RH, Williams R, Perlmann T, Olson L. (1996) Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system. Brain Res. Mol. Brain Res.41 (1-2): 111-20. [PMID:8883941]

To cite this database page, please use the following:

4A. Nerve growth factor IB-like receptors: Nuclear receptor related 1. Last modified on 13/12/2013. Accessed on 01/08/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=630.

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