Nomenclature: COUP-TF2

Systematic Nomenclature: NR2F2

Family: 2F. COUP-TF-like receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
Species AA Chromosomal Location Gene Symbol Gene Name Reference
Human 414 15q26 NR2F2 nuclear receptor subfamily 2, group F, member 2 13
Mouse 414 7 33.0 cM Nr2f2 nuclear receptor subfamily 2, group F, member 2 20
Rat 414 1q31 Nr2f2 nuclear receptor subfamily 2, group F, member 2 18
Previous and Unofficial Names
COUPTFB
COUP-TFII
COUPβ
ARP1
SVP40
TFCOUP2
NF-E3
ARP-1
COUP transcription factor 2
COUP transcription factor II
COUP-TF II
COUPb
apolipoprotein A-I regulatory protein 1
apolipoprotein AI regulatory protein 1
nuclear receptor subfamily 2, group F, member 2
ovalbumin upstream promoter beta nuclear receptor
Aporp1
Tcfcoup2
EAR3
9430015G03Rik
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
NURSA Receptor
OMIM
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  COUP-TF2 - ligand binding domain (apo-structure)
PDB Id:  3CJW
Resolution:  1.48Å
Species:  Human
References:  10
Natural/Endogenous Ligands
Comments: Orphan
DNA Binding
Structure:  Homodimer, Heterodimer
HRE core sequence:  A/GGGTCA n AGGGTCA
Response element:  DR1, DR3, DR4, DR5, Palindrome, Other - see comments
DNA Binding Comments
Heterodimerization with RXR in solution is still a controversial issue. However, COUP-TFs readily form DNA-binding heterodimers with RXR. COUP-TFI is able to heterodimerize with COUP-TFII. Systematic comparison of the relative affinities of COUP-TFs for the various elements reveal that DR1 is the preferred element and then DR6, DR4, DR8, DR0 and DR11. Palindromic and inverted repeats are also recognised but with a lower affinity. In contrast, monomeric elements are not efficiently recognised by COUP-TFs. It has been demonstrated that COUP-TFs repress the hormonal induction of target genes by PPAR, VDR, TR, and RAR in transient transfection assays through direct competition with VDR, TR, and RAR for the available binding sites.
Co-binding Partners
Name Interaction Effect Reference
Retinoid X receptor-α Physical COUP-TFs are able to sequester the common heterodimerization partner RXR and reduce the available concentrations of RXR. The loss of RXR indirectly decreases the DNA-binding affinity of TR, VDR, RAR, and PPAR and thereby interferes with the potential of this subgroup of receptors to transactivate their target genes. 4,9,29
Hepatocyte nuclear factor-4-α Physical, Functional COUP-TF interact both functionally and physically with the NRs HNF4. COUP-TFs have been shown to inhibit the transactivation of HNF4 due to mutually exclusive binding to the promoter of many genes. In addition, COUP-TF activates transcription through protein-protein interaction with DNA-bound factor, such as with HNF-4 in the HNF-1a gene promoter. Similar mechanism are observed for other transcription factor (Sp1). 11,21,26
V-erbA-related gene Physical 2
Retinoic acid receptor-α 15
Thyroid hormone receptor-α 15
Main Co-regulators
Name Activity Specific Ligand dependent AF-2 dependent Comments References
NCOR1 Co-repressor No No No 22
NCOR2 Co-repressor No No No 22
BCL11A Co-repressor No No No 1
BCL11B Co-activator No No Yes 1
SQSTM1 Co-activator Yes No Yes 18
Main Target Genes
Name Species Effect Technique Comments References
APOA1 Human Activated Transient transfection, Other COUP-TFs repressed the apolipoprotein A1 gene expression by interacting with RXR and HNF4. (shown in other species) 7,13,30
MHC Class I Mouse Repressed Transient transfection, EMSA COUP-TFs directly inhibits MHC Class I expression via interaction with the R2 promoter element and recruitment of the NCoR and HDACs. 12,23,33
CYP7A1 Human Activated Transient transfection, EMSA, Other COUP-TFII stimulates the transcriptional activity of the rat cholesterol 7a-hydroxylase (CYP7A) promoter by binding to the nucleotide sequence located between 74 and 54 (relative to the transcription start site), which contains a direct repeat of two hormone response element half-sites separated by 4 nucleotides. COUP-TFII also exerts a regulatory role of the CYP7A gene expression via its interaction with GR, HNF4 and RXR. 3,5-6,8,24-25
Arrestin Human Activated Transient transfection, EMSA In the arrestin gene promoter, a DR-7 element mediates the positive transcriptional effect of COUP-TF (seen in all species) 16
Tissue Distribution Comments
In the mouse COUP-TFII gene generate a transcript of 4.5 kb found in all tissues examined. COUP-TFII expression is similar to the one of COUP-TFI in the sense that it exhibit a complex expression pattern in the CNS and a broad expression in other tissues. The beginning of the expression at 7.5 dpc is identical to the one of COUP-TFI. A segmented expression in the diencephalic neuromeres was also found but the specific set of neuromeres in which COUP-TFII are different, although overlapping with COUP-TFI. In the hindbrain, the specific rhombomeres in which the genes are expressed are also distinct. In the neural tube the expression is restricted to the motorneurons.The levels of COUP-TFII expression are in general higher than the one of COUP-TFI especially in salivary gland, lung, oesophagus, stomach, pancreas, kidney, prostate. It is also found at lower levels in testes, ovary, retina, skin, inner ear or limb bud. The expression in the mesenchymal portion of places were mesenchyme-epithelial interactions occurs was also found. In the adult the expression is also higher to the one of COUP-TFI in supraoptic nucleus. COUP-TFII was shown to be regulated by all-trans retinoic acid in the neural tube. In addition a regulation of COUP-TFII by Sonic hedgehog has been found by Tsai group [13,17].
Physiological Consequences of Altering Gene Expression
COUP-TFII knock-out animal exhibit a lethal phenotype.
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  14,19,27-28,32
Physiological Consequences of Altering Gene Expression Comments
Homozygous mutants die around embryonic day 10 whereas two-third of heterozygous animals die during the first weeks of life. Examination of the homozygous embryos show that they are growth retarded with severe haemorrhage and oedema just before death. Histological analysis revealed enlarged blood vessels, lack of normal heart development and malformed cardinal veins. The vascular system exhibit a decrease in the complexity of the microvasculature in the head and spine regions suggesting that vasculogenesis (i.e. de novo formation of blood vessels from mesodermal precursor cells) and vascular remodelling (conversion of the primary capillaries of the plexus into large and small vessels of the mature vasculature) are defective in COUP-TFII mutants. These defects are consistent with a need of COUP-TFII function in the mesenchymal compartments of the head, spine and heart. Molecular analysis revealed that the Angiopoietine 1 gene which is important for the development of both the vascular system and the heart is down regulated in mutant animals. All these data suggest that COUP-TF is required for the signalling between the endothelial and mesenchymal compartments. Heterozygous mice have growth and reproductive defects. Reproductive defect is due to reduced expression of enzymes important for progesterone synthesis in the ovary and defective decidual response in the uterus. In addition, COUP-TFII conditional mutants have defect in migration of myoblast precursor cells to the limb resulting in hypoplastic muscle in the limbs. Furthermore, conditional mutants have defect in stomach development resulting in both anterior-posterior and radial axis defect. Using the same conditional mutants, it was found that COUP-TFII is important for diaphragm development. Thus animals develop a hole in the left side of diaphragm resulting in the protrusion of stomach content to the thorasic chamber. Finally, deletion of COUP-TFII in the endothelial cells resulting in the vein to acquire artery characteristics. Conversely, over expression of COUP-TFII in endothelial cells resulting in the fusion of vein and artery into a vein like vessel. Therefore, COUP-TFII is important in determine the vein vs. artery identity.
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2tm1Tsa
either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR)
MGI:1352452  MP:0004784 abnormal anterior cardinal vein morphology PMID: 10215630 
Nr2f2tm2.1Tsa Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352452  MP:0001614 abnormal blood vessel morphology PMID: 15875024 
Nkx3-2+|Nkx3-2tm1(cre)Tsa|Nr2f2tm2.1Tsa Nkx3-2tm1(cre)Tsa/Nkx3-2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd * C57BL/6
MGI:108015  MGI:1352452  MP:0003119 abnormal digestive system development PMID: 15829524 
Nkx3-2+|Nkx3-2tm1(cre)Tsa|Nr2f2tm2.1Tsa Nkx3-2tm1(cre)Tsa/Nkx3-2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd * C57BL/6
MGI:108015  MGI:1352452  MP:0001046 abnormal enteric neuron morphology PMID: 15829524 
Nr2f2+|Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2+
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352452  MP:0001927 abnormal estrous cycle PMID: 15890675 
Nr2f1tm2.1Mjts|Nr2f2tm2.1Tsa|Tg(rx3-cre)1Mjam Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(rx3-cre)1Mjam/0
involves: 129S7/SvEvBrd
MGI:1352451  MGI:1352452  MGI:3665327  MP:0001286 abnormal eye development PMID: 20147377 
Nkx3-2+|Nkx3-2tm1(cre)Tsa|Nr2f2tm2.1Tsa Nkx3-2tm1(cre)Tsa/Nkx3-2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd * C57BL/6
MGI:108015  MGI:1352452  MP:0004139 abnormal gastric parietal cell morphology PMID: 15829524 
Nr2f2+|Nr2f2tm1Vco|Tg(Ins2-cre)25Mgn Nr2f2tm1Vco/Nr2f2+,Tg(Ins2-cre)25Mgn/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA
MGI:1352452  MGI:2176225  MP:0002078 abnormal glucose homeostasis PMID: 15855320 
Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2tm1Tsa
either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR)
MGI:1352452  MP:0000270 abnormal heart tube morphology PMID: 10215630 
Nr2f2+|Nr2f2tm1Vco|Tg(Ins2-cre)25Mgn Nr2f2tm1Vco/Nr2f2+,Tg(Ins2-cre)25Mgn/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA
MGI:1352452  MGI:2176225  MP:0001547 abnormal lipid level PMID: 15855320 
Gt(ROSA)26Sor+|Gt(ROSA)26Sortm1Sor|Nr2f2tm2.1Tsa|Prox1+|Prox1tm3(cre/ERT2)Gco Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Prox1tm3(cre/ERT2)Gco/Prox1+
involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6
MGI:104735  MGI:1352452  MGI:97772  MP:0001879 abnormal lymphatic vessel morphology PMID: 20360386 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0004256 abnormal maternal decidual layer morphology PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0008256 abnormal myometrium morphology PMID: 17404209 
Nr2f1tm2.1Mjts|Nr2f2tm2.1Tsa|Tg(rx3-cre)1Mjam Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(rx3-cre)1Mjam/0
involves: 129S7/SvEvBrd
MGI:1352451  MGI:1352452  MGI:3665327  MP:0008259 abnormal optic disc morphology PMID: 20147377 
Nr2f1tm2.1Mjts|Nr2f2tm2.1Tsa|Tg(rx3-cre)1Mjam Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(rx3-cre)1Mjam/0
involves: 129S7/SvEvBrd
MGI:1352451  MGI:1352452  MGI:3665327  MP:0004268 abnormal optic stalk morphology PMID: 20147377 
Nr2f2+|Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2+
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352452  MP:0001126 abnormal ovary morphology PMID: 15890675 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0001712 abnormal placenta development PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0008803 abnormal placental labyrinth vasculature morphology PMID: 17404209 
Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2tm1Tsa
either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR)
MGI:1352452  MP:0004785 abnormal posterior cardinal vein morphology PMID: 10215630 
Nr2f1tm2.1Mjts|Nr2f2tm2.1Tsa|Tg(rx3-cre)1Mjam Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(rx3-cre)1Mjam/0
involves: 129S7/SvEvBrd
MGI:1352451  MGI:1352452  MGI:3665327  MP:0005201 abnormal retinal pigment epithelium morphology PMID: 20147377 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0008959 abnormal spongiotrophoblast cell morphology PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0004244 abnormal spontaneous abortion rate PMID: 17404209 
Nkx3-2+|Nkx3-2tm1(cre)Tsa|Nr2f2tm2.1Tsa Nkx3-2tm1(cre)Tsa/Nkx3-2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd * C57BL/6
MGI:108015  MGI:1352452  MP:0000471 abnormal stomach epithelium morphology PMID: 15829524 
Nkx3-2+|Nkx3-2tm1(cre)Tsa|Nr2f2tm2.1Tsa Nkx3-2tm1(cre)Tsa/Nkx3-2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd * C57BL/6
MGI:108015  MGI:1352452  MP:0000473 abnormal stomach glandular epithelium morphology PMID: 15829524 
Nkx3-2+|Nkx3-2tm1(cre)Tsa|Nr2f2tm2.1Tsa Nkx3-2tm1(cre)Tsa/Nkx3-2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd * C57BL/6
MGI:108015  MGI:1352452  MP:0000470 abnormal stomach morphology PMID: 15829524 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0004014 abnormal uterine environment PMID: 17404209 
Nr2f2+|Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2+
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352452  MP:0009085 abnormal uterine horn morphology PMID: 15890675 
Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2tm1Tsa
either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR)
MGI:1352452  MP:0002725 abnormal vein morphology PMID: 10215630 
Nr2f2tm2.1Tsa Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352452  MP:0002725 abnormal vein morphology PMID: 15875024 
Nr2f2+|Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2+
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352452  MP:0009021 absent estrus PMID: 15890675 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0003403 absent placental labyrinth PMID: 17404209 
Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2tm1Tsa
either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR)
MGI:1352452  MP:0000296 absent trabeculae carneae PMID: 10215630 
Nr2f1tm2.1Mjts|Nr2f2tm2.1Tsa|Tg(rx3-cre)1Mjam Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(rx3-cre)1Mjam/0
involves: 129S7/SvEvBrd
MGI:1352451  MGI:1352452  MGI:3665327  MP:0005262 coloboma PMID: 20147377 
Nr2f1+|Nr2f1tm2.1Mjts|Nr2f2tm2.1Tsa|Tg(rx3-cre)1Mjam Nr2f1tm2.1Mjts/Nr2f1+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(rx3-cre)1Mjam/0
involves: 129S7/SvEvBrd
MGI:1352451  MGI:1352452  MGI:3665327  MP:0005262 coloboma PMID: 20147377 
Nr2f1tm2.1Mjts|Nr2f2+|Nr2f2tm2.1Tsa|Tg(rx3-cre)1Mjam Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2+,Tg(rx3-cre)1Mjam/0
involves: 129S7/SvEvBrd
MGI:1352451  MGI:1352452  MGI:3665327  MP:0005262 coloboma PMID: 20147377 
Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2tm1Tsa
either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR)
MGI:1352452  MP:0005602 decreased angiogenesis PMID: 10215630 
Nr2f2+|Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2+
either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR)
MGI:1352452  MP:0001265 decreased body size PMID: 10215630 
Nr2f2+|Nr2f2tm1Vco|Tg(Ins2-cre)25Mgn Nr2f2tm1Vco/Nr2f2+,Tg(Ins2-cre)25Mgn/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA
MGI:1352452  MGI:2176225  MP:0005560 decreased circulating glucose level PMID: 15855320 
Nr2f2+|Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2+
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352452  MP:0005185 decreased circulating progesterone level PMID: 15890675 
Nr2f2+|Nr2f2tm1Vco|Tg(Ins2-cre)25Mgn Nr2f2tm1Vco/Nr2f2+,Tg(Ins2-cre)25Mgn/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA
MGI:1352452  MGI:2176225  MP:0005282 decreased fatty acid level PMID: 15855320 
Nr2f2+|Nr2f2tm1Vco|Tg(Ins2-cre)25Mgn Nr2f2tm1Vco/Nr2f2+,Tg(Ins2-cre)25Mgn/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA
MGI:1352452  MGI:2176225  MP:0003059 decreased insulin secretion PMID: 15855320 
Nr2f2+|Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2+
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352452  MP:0001935 decreased litter size PMID: 15890675 
Nr2f2tm2.1Tsa|Rbpjtm1Hon|Tg(Tek-cre)1Ywa Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Rbpjtm1Hon/Rbpjtm1Hon,Tg(Tek-cre)1Ywa/0
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL
MGI:1352452  MGI:2450309  MGI:96522  MP:0010198 decreased lymphatic vessel endothelial cell number PMID: 20360386 
Nr2f2tm2.1Tsa|Tg(Tek-cre)1Ywa Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL
MGI:1352452  MGI:2450309  MP:0010198 decreased lymphatic vessel endothelial cell number PMID: 20360386 
Nr2f2+|Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2+
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352452  MP:0002636 delayed vaginal opening PMID: 15890675 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0001785 edema PMID: 17404209 
Gt(ROSA)26Sor+|Gt(ROSA)26Sortm1Sor|Nr2f2tm2.1Tsa|Prox1+|Prox1tm3(cre/ERT2)Gco Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Prox1tm3(cre/ERT2)Gco/Prox1+
involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6
MGI:104735  MGI:1352452  MGI:97772  MP:0001785 edema PMID: 20360386 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0008762 embryonic lethality PMID: 17404209 
Nr2f2tm2.1Tsa|Rbpjtm1Hon|Tg(Tek-cre)1Ywa Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Rbpjtm1Hon/Rbpjtm1Hon,Tg(Tek-cre)1Ywa/0
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL
MGI:1352452  MGI:2450309  MGI:96522  MP:0008762 embryonic lethality PMID: 20360386 
Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2tm1Tsa
either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR)
MGI:1352452  MP:0006207 embryonic lethality during organogenesis PMID: 10215630 
Nr2f2tm2.1Tsa Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352452  MP:0006207 embryonic lethality during organogenesis PMID: 15875024 
Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2tm1Tsa
either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR)
MGI:1352452  MP:0001914 hemorrhage PMID: 10215630 
Nr2f2+|Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2+
either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR)
MGI:1352452  MP:0001914 hemorrhage PMID: 10215630 
Nr2f2tm2.1Tsa Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352452  MP:0001914 hemorrhage PMID: 15875024 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0001914 hemorrhage PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0001729 impaired embryo implantation PMID: 17404209 
Nr2f2+|Nr2f2tm1Vco|Tg(Ins2-cre)25Mgn Nr2f2tm1Vco/Nr2f2+,Tg(Ins2-cre)25Mgn/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA
MGI:1352452  MGI:2176225  MP:0005293 impaired glucose tolerance PMID: 15855320 
Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2tm1Tsa
either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR)
MGI:1352452  MP:0001689 incomplete somite formation PMID: 10215630 
Nr2f2+|Nr2f2tm1Vco|Tg(Ins2-cre)25Mgn Nr2f2tm1Vco/Nr2f2+,Tg(Ins2-cre)25Mgn/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA
MGI:1352452  MGI:2176225  MP:0002079 increased circulating insulin level PMID: 15855320 
Nr2f2+|Nr2f2tm1Vco|Tg(Ins2-cre)25Mgn Nr2f2tm1Vco/Nr2f2+,Tg(Ins2-cre)25Mgn/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA
MGI:1352452  MGI:2176225  MP:0001552 increased circulating triglyceride level PMID: 15855320 
Nr2f2+|Nr2f2tm1Vco|Tg(Ins2-cre)25Mgn Nr2f2tm1Vco/Nr2f2+,Tg(Ins2-cre)25Mgn/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA
MGI:1352452  MGI:2176225  MP:0003058 increased insulin secretion PMID: 15855320 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0009397 increased trophoblast giant cell number PMID: 17404209 
Nr2f2+|Nr2f2tm1Vco|Tg(Ins2-cre)25Mgn Nr2f2tm1Vco/Nr2f2+,Tg(Ins2-cre)25Mgn/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA
MGI:1352452  MGI:2176225  MP:0005331 insulin resistance PMID: 15855320 
Nr2f1tm2.1Mjts|Nr2f2tm2.1Tsa|Tg(rx3-cre)1Mjam Nr2f1tm2.1Mjts/Nr2f1tm2.1Mjts,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(rx3-cre)1Mjam/0
involves: 129S7/SvEvBrd
MGI:1352451  MGI:1352452  MGI:3665327  MP:0001297 microphthalmia PMID: 20147377 
Nr2f2tm1Vco Nr2f2tm1Vco/Nr2f2tm1Vco
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
MGI:1352452  MP:0002081 perinatal lethality PMID: 15855320 
Nr2f2+|Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2+
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352452  MP:0001732 postnatal growth retardation PMID: 15890675 
Nr2f2+|Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2+
either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR)
MGI:1352452  MP:0002082 postnatal lethality PMID: 10215630 
Nr2f2tm1Vco|Tg(Ins2-cre)25Mgn Nr2f2tm1Vco/Nr2f2tm1Vco,Tg(Ins2-cre)25Mgn/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA
MGI:1352452  MGI:2176225  MP:0002080 prenatal lethality PMID: 15855320 
Nr2f2+|Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2+
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352452  MP:0009011 prolonged diestrus PMID: 15890675 
Nr2f2+|Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2+
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352452  MP:0009020 prolonged metestrus PMID: 15890675 
Nr2f2+|Nr2f2tm1Tsa Nr2f2tm1Tsa/Nr2f2+
involves: 129S7/SvEvBrd * C57BL/6
MGI:1352452  MP:0001923 reduced female fertility PMID: 15890675 
Nr2f2tm2.1Tsa Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:1352452  MP:0001923 reduced female fertility PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0001923 reduced female fertility PMID: 17404209 
Amhr2+|Amhr2tm3(cre)Bhr|Nr2f2tm2.1Tsa Amhr2tm3(cre)Bhr/Amhr2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd
MGI:105062  MGI:1352452  MP:0009089 short uterine horn PMID: 17404209 
Nkx3-2+|Nkx3-2tm1(cre)Tsa|Nr2f2tm2.1Tsa Nkx3-2tm1(cre)Tsa/Nkx3-2+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd * C57BL/6
MGI:108015  MGI:1352452  MP:0002691 small stomach PMID: 15829524 
Clinically-Relevant Mutations and Pathophysiology Comments
Some CDH patients were shown to have COUP-TFII deletion and conditional mouse mutants has CDH [31].

REFERENCES

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26. Sugiyama T, Wang JC, Scott DK, Granner DK. (2000) Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene. J. Biol. Chem.275 (5): 3446-54. [PMID:10652338]

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32. You LR, Takamoto N, Yu CT, Tanaka T, Kodama T, Demayo FJ, Tsai SY, Tsai MJ. (2005) Mouse lacking COUP-TFII as an animal model of Bochdalek-type congenital diaphragmatic hernia. Proc. Natl. Acad. Sci. U.S.A.102 (45): 16351-6. [PMID:16251273]

33. Zhao B, Hou S, Ricciardi RP. (2003) Chromatin repression by COUP-TFII and HDAC dominates activation by NF-kappaB in regulating major histocompatibility complex class I transcription in adenovirus tumorigenic cells. Virology306 (1): 68-76. [PMID:12620799]

To cite this database page, please use the following:

2F. COUP-TF-like receptors: COUP-TF2. Last modified on 13/12/2013. Accessed on 02/09/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=618.

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