Nomenclature: Farnesoid X receptor-β

Systematic Nomenclature: NR1H5

Family: 1H. Liver X receptor-like receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
Species AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1p13.2 NR1H5P nuclear receptor subfamily 1, group H, member 5, pseudogene
Mouse 505 3 F2.2 Nr1h5 nuclear receptor subfamily 1, group H, member 5 1
Rat - 2q34 Nr1h5 nuclear receptor subfamily 1, group H, member 5
Gene and Protein Information Comments
FXRb is a pseudogene in human[1]
Previous and Unofficial Names
FXR-β
Fxrb
FXRβ
Lanosterol receptor
NR1H5
nuclear receptor subfamily 1, group H, member 5 pseudogene
LOC690430
Nr1h5p
nuclear receptor subfamily 1, group H, member 5
similar to nuclear receptor subfamily 1, group H, member 5 isoform 2
Database Links
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
KEGG Gene
NURSA Receptor
OMIM
RefSeq Nucleotide
RefSeq Protein
TreeFam
Natural/Endogenous Ligands
Comments: A series of oxysterols and bile acids are natural ligands
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
lanosterol Mm Agonist 6.0 pEC50 1
pEC50 6.0 [1]
vitamin D3 Mm Agonist 5.0 pEC50 1
pEC50 5.0 [1]
cholesten Mm Agonist 5.0 pEC50 1
pEC50 5.0 [1]
desmosterol Mm Agonist 5.0 pEC50 1
pEC50 5.0 [1]
DNA Binding
Structure:  Heterodimer
HRE core sequence:  AGTTCA N TGAACT
Response element: 
DNA Binding Comments
Also binds as RXR heterodimer to an everted repeat with a spacer of 2 (ER2).
Main Co-regulators
Name Activity Specific Ligand dependent AF-2 dependent Comments References
NCOA1 Co-activator No Yes No 1
Tissue Distribution
Ubiquitous
Species:  Mouse
Technique:  RT-PCR
References:  1
Biologically Significant Variants
Type:  Splice variant
Species:  Mouse
Description:  nuclear receptor subfamily 1, group H, member 5 isoform 1
Amino acids:  505
Protein accession: 
References:  1
Type:  Splice variant
Species:  Mouse
Description:  nuclear receptor subfamily 1, group H, member 5 isoform 2
Amino acids:  497
Protein accession: 
References:  1
Type:  Splice variant
Species:  Mouse
Description:  nuclear receptor subfamily 1, group H, member 5 isoform 5
Amino acids:  447
Protein accession: 
References:  1

REFERENCES

1. Otte K, Kranz H, Kober I, Thompson P, Hoefer M, Haubold B, Remmel B, Voss H, Kaiser C, Albers M, Cheruvallath Z, Jackson D, Casari G, Koegl M, Pääbo S, Mous J, Kremoser C, Deuschle U. (2003) Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. Mol. Cell. Biol.23 (3): 864-72. [PMID:12529392]

To cite this database page, please use the following:

1H. Liver X receptor-like receptors: Farnesoid X receptor-β. Last modified on 27/11/2013. Accessed on 19/09/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=604.

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