IUPHAR DATABASE | 1H. Liver X receptor-like receptors

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Farnesoid X receptor-β

Systematic Nomenclature: NR1H5

Family: 1H. Liver X receptor-like receptors

Contents:

Gene and Protein Information

Previous and Unofficial Names

Biologically Significant Variants

References

Gene and Protein Information
Species	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1p13.2	NR1H5P	nuclear receptor subfamily 1, group H, member 5, pseudogene
Mouse	505	3 F2.2	Nr1h5	nuclear receptor subfamily 1, group H, member 5	1
Rat	-	2q34	Nr1h5	nuclear receptor subfamily 1, group H, member 5
Structural Information Comments
FXRb is a pseudogene in human[1]

Previous and Unofficial Names
FXR-β
Fxrb
FXRβ
Lanosterol receptor
NR1H5
nuclear receptor subfamily 1, group H, member 5 pseudogene
LOC690430
Nr1h5p
nuclear receptor subfamily 1, group H, member 5
similar to nuclear receptor subfamily 1, group H, member 5 isoform 2

Previous and Unofficial Names

FXR-β

Fxrb

FXRβ

Lanosterol receptor

NR1H5

nuclear receptor subfamily 1, group H, member 5 pseudogene

LOC690430

Nr1h5p

nuclear receptor subfamily 1, group H, member 5

similar to nuclear receptor subfamily 1, group H, member 5 isoform 2

Database Links
Ensembl	ENSG00000227970 (Hs), ENSMUSG00000048938 (Mm), ENSRNOG00000023073 (Rn)
Entrez Gene	643609 (Hs), 381463 (Mm), 690430 (Rn)
GeneCards	NR1H5P (Hs)
GenitoUrinary Development Molecular Anatomy Project	Nr1h5 (Mm)
HomoloGene	19748 (Hs)
KEGG Gene	hsa:643609 (Hs), mmu:381463 (Mm), rno:690430 (Rn)
NURSA Receptor	1H5
OMIM	3026618 (Hs)
RefSeq Nucleotide	NM_198658 (Mm), NM_201619 (Mm), NM_201622 (Mm)
RefSeq Protein	NP_963913 (Mm), NP_941060 (Mm), NP_963916 (Mm), XP_001072587 (Rn)
TreeFam	ENSG00000227970 (Hs), ENSMUSG00000048938 (Mm), ENSRNOG00000023073 (Rn)
	1H. Liver X receptor-like receptors

Search for 3D structures on the PDB
Search by keyword: Farnesoid X receptor-β

Natural/Endogenous Ligand(s)
Comments: A series of oxysterols and bile acids are natural ligands

Agonists

Key to terms and symbols

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Ligand	Sp.	Action	Affinity	Units	Reference
lanosterol	Mm	Agonist	6.0	pEC₅₀	1
cholesten	Mm	Agonist	5.0	pEC₅₀	1
desmosterol	Mm	Agonist	5.0	pEC₅₀	1
vitamin D3	Mm	Agonist	5.0	pEC₅₀	1

DNA Binding

Structure:	Heterodimer
HRE core sequence:	AGTTCA N TGAACT
Response element:

DNA Binding Comments

Also binds as RXR heterodimer to an everted repeat with a spacer of 2 (ER2)

Main Co-regulators
Name	Activity	Specific	Ligand dependent	AF-2 dependent	Comments	References
NCOA1	Co-activator	No	Yes	No		1

Tissue Distribution

ubiquitous

Species:	Mouse
Technique:	RT-PCR
References:	1

Biologically Significant Variants

nuclear receptor subfamily 1, group H, member 5 isoform 1

Protein accession:	NP_941060
Amino acids:	505
Type:	Splice variant
Species:	Mouse
References:	1

nuclear receptor subfamily 1, group H, member 5 isoform 2

Protein accession:	NP_963913
Amino acids:	497
Type:	Splice variant
Species:	Mouse
References:	1

nuclear receptor subfamily 1, group H, member 5 isoform 5

Protein accession:	NP_963916
Amino acids:	447
Type:	Splice variant
Species:	Mouse
References:	1

REFERENCES

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1. Otte, K; Kranz, H; Kober, I; Thompson, P; Hoefer, M; Haubold, B; Remmel, B; Voss, H; Kaiser, C; Albers, M; Cheruvallath, Z; Jackson, D; Casari, G; Koegl, M; Pääbo, S; Mous, J; Kremoser, C; Deuschle, U. (2003) Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. Mol. Cell. Biol., 23 (3): 864-72. [PMID:12529392]

To cite this database page, please use the following:

1H. Liver X receptor-like receptors: Farnesoid X receptor-β. Last modified on 15/11/2012. Accessed on 20/06/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=604.