Nomenclature: Liver X receptor-α

Systematic Nomenclature: NR1H3

Family: 1H. Liver X receptor-like receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
Species AA Chromosomal Location Gene Symbol Gene Name Reference
Human 447 11p11.2 NR1H3 nuclear receptor subfamily 1, group H, member 3 39
Mouse 445 2 40.4 cM Nr1h3 nuclear receptor subfamily 1, group H, member 3 1
Rat 445 3q24 Nr1h3 nuclear receptor subfamily 1, group H, member 3 2
Previous and Unofficial Names
LXR-a
RLD-1
LXRα
Oxysterols receptor α
liver X receptor-alpha
LXRalpha
liver X receptor alpha
nuclear orphan receptor LXR-alpha
nuclear receptor subfamily 1, group H, member 3
oxysterols receptor LXR-alpha
LXR alpha
Unr1
AU018371
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
NURSA Receptor
OMIM
Orphanet Gene
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Heteromeric complex of the ligand binding domain of hLXR-alpha receptor and hRXR-alpha
PDB Id:  1UHL
Ligand:  T0901317
Resolution:  2.9Å
Species:  Human
References:  35
Natural/Endogenous Ligand(s)
Comments: A series of oxysterols are natural ligands
Potency order (Human)
20S-hydroxycholesterol, 22R-hydroxycholesterol, 24(S)-hydroxycholesterol > 25-hydroxycholesterol, 27-hydroxycholesterol  [21]
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
L-783483 Hs Agonist 7.9 pKd 26
pKd 7.9 [26]
acetyl-podocarpic dimer Hs Agonist 9.0 pEC50 34
pEC50 9.0 [34]
T0901317 Hs Agonist 7.3 pEC50 31
pEC50 7.3 [31]
27-hydroxycholesterol Hs Agonist 7.1 pEC50 9
pEC50 7.1 [9]
GW3965 Hs Agonist 6.7 pEC50 6
pEC50 6.7 [6]
24(S), 25-epoxycholesterol Hs Agonist 5.4 pEC50 13,21
pEC50 5.4 [13,21]
paxilline Hs Agonist 5.4 pEC50 3
pEC50 5.4 [3]
24(S)-hydroxycholesterol Hs Agonist 5.4 pEC50 21
pEC50 5.4 [21]
22R-hydroxycholesterol Hs Agonist 5.3 pEC50 14
pEC50 5.3 [14]
Agonist Comments
Other oxysterols were also identified as endogenous ligands by Janowski et al. [14]. Activity of endogenous LXR agonists is compared in Janowski et al.[13]. Efficacy value for ligand 27-hydroxycholesterol was determined in vitro.
DNA Binding
Structure:  RXR partner
HRE core sequence:  AGGTCANNNNAGGTCA
Response element:  DR4, Other - see comments
DNA Binding Comments
RXR binds the 5’ half-site while LXR binds the 3’ half-site of DR4 HREs.
Co-binding Partners
Name Interaction Effect Reference
Retinoid X receptor-α Physical, Functional Required for transactivation 39
SHP Physical, Functional Represses transactivation 4
LRH-1 Functional Competence factor 25
Main Co-regulators
Name Activity Specific Ligand dependent AF-2 dependent Comments References
EP300 Co-activator No Yes No Overexpression increased transactivation of the ABCA1 promoter 12
NCOA1 Co-activator No Yes No p160 family: Overexpression increased transactivation of the ABCA1 promoter 12
TRRAP Co-activator No Yes No Overexpression increased transactivation of LXRE, RNAi decreased expression of LXR regulated genes 36
NCOA2 Co-activator No Yes No Interaction determined by affinity pull-down 33
PPARGC1A Co-activator No Yes No Overexpression increased transactivation of the CETP promoter 27
PPARGC1B Co-activator No Yes No Overexpression increased transactivation of LXRE Viral transduction increased expression of LXR genes 22
NCOR1 Co-repressor No Yes No Interaction determined in mammalian two-hybrid LXR alpha>beta. Overexpression decreased transactivation of LXRE 10
NCOR2 Co-repressor No Yes No Interaction determined in mammalian two-hybrid LXR alpha>beta 10
Main Target Genes
Name Species Effect Technique Comments References
Vegfa Mouse Activated 38
ABCA1 Human Activated Transient transfection, EMSA 7,29
ABCG1 Human Activated Transient transfection, EMSA 17,37
SREBF1 Human Activated Transient transfection, EMSA 29
APOE Human Activated Transient transfection, EMSA 20
APOD Human Activated Transient transfection, EMSA 11
CETP Human Activated Transient transfection, EMSA 24
LPL Human Activated Transient transfection, EMSA 40
PLTP Human Activated Transient transfection, EMSA 5,18
NR1H3 Human Activated Transient transfection, EMSA 19
FAS Human Activated Transient transfection, EMSA 15
SLC2A4 Human Activated Transient transfection, EMSA 8
ApoCI/IV/II Human Activated Transient transfection 25
Cyp7a1 Mouse Activated Transient transfection, EMSA 21
Tissue Distribution
Liver, small intestine, kidney, adipose, macrophages, spleen, adrenal
Expression level:  High
Species:  Rat
Technique:  Northern blot
References:  39
Tissue Distribution Comments
Mouse expression determined by Northern in [23].
Physiological Consequences of Altering Gene Expression
Knockout mice are resistant to obesity when challenged with a diet containing high fat and cholesterol.
Species:  Mouse
Tissue: 
Technique:  Knockout
References:  16
Knockout mice display an inability to tolerate dietary cholesterol; accumulation of hepatic cholesteryl esters resulting in hepatomegaly; accumulation of macrophage cholesterol; increased serum LDL; decreased serum HDL, VLDL, and triglycerides.
Species:  Mouse
Tissue: 
Technique:  Knockout
References:  28,30-32
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0002182 abnormal astrocyte morphology PMID: 12368482 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0005365 abnormal bile salt homeostasis PMID: 9630215 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0009278 abnormal bone marrow cell physiology PMID: 12193651 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0010152 abnormal brain ependyma morphology PMID: 12368482 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0004950 abnormal brain vasculature morphology PMID: 12368482 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0000822 abnormal brain ventricle morphology PMID: 12368482 
Nr1h3tm1.1Gstr Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MP:0003191 abnormal cellular cholesterol metabolism PMID: 11238557 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0005537 abnormal cerebral aqueduct morphology PMID: 12368482 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0005278 abnormal cholesterol homeostasis PMID: 12368482 
Nr1h3tm1Dgen Nr1h3tm1Dgen/Nr1h3tm1Dgen
Not Specified
MGI:1352462  MP:0005278 abnormal cholesterol homeostasis PMID: 16614371 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0000820 abnormal choroid plexus morphology PMID: 12368482 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0002679 abnormal corpus luteum PMID: 19325005 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0001119 abnormal female reproductive system morphology PMID: 17166844 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0003699 abnormal female reproductive system physiology PMID: 17166844 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0000828 abnormal fourth ventricle morphology PMID: 12368482 
Nr1h3tm1Dgen Nr1h3tm1Dgen/Nr1h3tm1Dgen
Not Specified
MGI:1352462  MP:0002139 abnormal hepatobiliary system physiology PMID: 16614371 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0000823 abnormal lateral ventricle morphology PMID: 12368482 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0002786 abnormal Leydig cell morphology PMID: 17341595 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0002118 abnormal lipid homeostasis PMID: 12368482 
Nr1h3tm1Dgen Nr1h3tm1Dgen/Nr1h3tm1Dgen
Not Specified
MGI:1352462  MP:0002118 abnormal lipid homeostasis PMID: 16614371 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0002446 abnormal macrophage morphology PMID: 12193651 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0001145 abnormal male reproductive system morphology PMID: 17166844 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0003698 abnormal male reproductive system physiology PMID: 17166844 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0009229 abnormal median eminence morphology PMID: 12368482 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0000920 abnormal myelination PMID: 12368482 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0003871 abnormal myelin sheath morphology PMID: 12368482 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0008256 abnormal myometrium morphology PMID: 17166844 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0003507 abnormal ovary physiology PMID: 19325005 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0002907 abnormal parturition PMID: 17166844 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0002216 abnormal seminiferous tubule morphology PMID: 17341595 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0002784 abnormal Sertoli cell morphology PMID: 17341595 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0002685 abnormal spermatogonia proliferation PMID: 17341595 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0009688 abnormal spinal cord central canal morphology PMID: 12368482 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0000836 abnormal substantia nigra morphology PMID: 12368482 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0009648 abnormal superovulation PMID: 19325005 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0000826 abnormal third ventricle morphology PMID: 12368482 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0009671 abnormal uterus physiology PMID: 17166844 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0008934 absent choroid plexus PMID: 12368482 
Nr1h3tm1Djm|Tg(APPswe,PSEN1dE9)85Dbo Nr1h3tm1Djm/Nr1h3tm1Djm,Tg(APPswe,PSEN1dE9)85Dbo/0
involves: 129S6/SvEvTac * C3H * C57BL/6
MGI:1352462  MGI:3525178  MP:0003329 amyloid beta deposits PMID: 17563384 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0003354 astrocytosis PMID: 12368482 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0002773 decreased circulating luteinizing hormone level PMID: 17341595 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0002773 decreased circulating luteinizing hormone level PMID: 17341595 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0002780 decreased circulating testosterone level PMID: 17341595 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0002780 decreased circulating testosterone level PMID: 17341595 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0008948 decreased neuron number PMID: 12368482 
Nr1h3tm1Wexi Nr1h3tm1Wexi/Nr1h3tm1Wexi
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MGI:1352462  MP:0008734 decreased susceptibility to endotoxin shock PMID: 19717840 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0004852 decreased testis weight PMID: 17341595 
Nr1h3tm1.1Gstr Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MP:0000599 enlarged liver PMID: 11238557 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0004832 enlarged ovary PMID: 19325005 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0002628 hepatic steatosis PMID: 9630215 
Nr1h3tm1Wexi Nr1h3tm1Wexi/Nr1h3tm1Wexi
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MGI:1352462  MP:0002628 hepatic steatosis PMID: 19717840 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0000755 hindlimb paralysis PMID: 17166844 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0000740 impaired smooth muscle contractility PMID: 17166844 
Nr1h3tm1.1Gstr Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MP:0002941 increased circulating alanine transaminase level PMID: 11238557 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0002941 increased circulating alanine transaminase level PMID: 9630215 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0005343 increased circulating aspartate transaminase level PMID: 9630215 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0005178 increased circulating cholesterol level PMID: 9630215 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0005182 increased circulating estradiol level PMID: 19325005 
Nr1h3tm1.1Gstr Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MP:0000182 increased circulating LDL cholesterol level PMID: 11238557 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0000182 increased circulating LDL cholesterol level PMID: 9630215 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0001846 increased inflammatory response PMID: 19325005 
Nr1h3tm1.1Gstr Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MP:0010027 increased liver cholesterol level PMID: 11238557 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0010027 increased liver cholesterol level PMID: 9630215 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac
MGI:1352462  MGI:1352463  MP:0010027 increased liver cholesterol level PMID: 10968783 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0002981 increased liver weight PMID: 9630215 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0004778 increased macrophage derived foam cell number PMID: 12368482 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0009763 increased sensitivity to induced morbidity/mortality PMID: 12524534 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0009763 increased sensitivity to induced morbidity/mortality PMID: 12524534 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0002412 increased susceptibility to bacterial infection PMID: 12524534 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0002412 increased susceptibility to bacterial infection PMID: 12524534 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0003070 increased vascular permeability PMID: 19325005 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0001915 intracranial hemorrhage PMID: 12368482 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0003103 liver degeneration PMID: 9630215 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0008280 male germ cell apoptosis PMID: 17341595 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0008280 male germ cell apoptosis PMID: 17341595 
Nr1h2tm1.1Gstr|Nr1h3tm1.1Gstr Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr,Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MGI:1352463  MP:0003224 neuron degeneration PMID: 12368482 
Nr1h3tm1Gstr Nr1h3tm1Gstr/Nr1h3tm1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MP:0002169 no abnormal phenotype detected PMID: 11238557 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0002016 ovary cysts PMID: 19325005 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0004834 ovary hemorrhage PMID: 19325005 
Nr1h3tm1.1Gstr Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1352462  MP:0000603 pale liver PMID: 11238557 
Nr1h3tm1Djm Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MP:0000603 pale liver PMID: 9630215 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0008028 pregnancy-related premature death PMID: 17166844 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0001922 reduced male fertility PMID: 17341595 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0001154 seminiferous tubule degeneration PMID: 17341595 
Nr1h2tm1Djm|Nr1h3tm1Djm Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
MGI:1352462  MGI:1352463  MP:0003205 testicular atrophy PMID: 17341595 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Amyotrophic lateral sclerosis
Orphanet:  803
References: 
Mutations not determined

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1H. Liver X receptor-like receptors: Liver X receptor-α. Last modified on 13/12/2013. Accessed on 21/04/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=602.

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