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Peroxisome proliferator-activated receptor-γ

Systematic Nomenclature: NR1C3

Family: 1C. Peroxisome proliferator-activated receptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Selected 3D Structures
Agonists
DNA Binding
Co-binding Partners
Main Co-regulators
Main Target Genes
Tissue Distribution
Functional Assays
Phenotypes, Alleles and Disease Models
Clinically-Relevant Mutations and Pathophysiology
Gene Expression and Pathophysiology
Biologically Significant Variants
References
Gene and Protein Information
Species AA Chromosomal Location Gene Symbol Gene Name Reference
Human 477 3p25 PPARG peroxisome proliferator-activated receptor gamma 2,36,92
Mouse 475 6 25.7 cM Pparg peroxisome proliferator activated receptor gamma 123
Rat 505 4q42 Pparg peroxisome proliferator-activated receptor gamma 38
Previous and Unofficial Names
PPARγ
PPARG1
PPARG2
NR1C3
PPARgamma
peroxisome proliferative activated receptor, gamma
PPAR-gamma
nuclear receptor subfamily 1 group C member 3
peroxisome proliferator activated receptor gamma
peroxisome proliferator activated receptor, gamma
peroxisome proliferator activator receptor gamma
peroxisome proliferator activator receptor, gamma
peroxisome proliferator-activated receptor gamma
Ppar-gamma2
PPARgamma2
Database Links
ChEMBL Target
DrugBank Target
Ensembl
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
NURSA Receptor
OMIM
Orphanet Gene
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniProt
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Peroxisome proliferator-activated receptor-γ (ligand binding domain)
PDB Id:  1NYX
Ligand:  ragaglitazar
Resolution:  2.65Å
Species:  Human
References:  26
Search for other structures on the PDB
Search by keyword: Peroxisome proliferator-activated receptor-γ
Natural/Endogenous Ligand(s)
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
COOH ? Full agonist - - 12,62
diclofenac ? Partial agonist - - 59
DRF 2519 ? Full agonist - - 16
ibuprofen ? Full agonist - - 50,59
LG100754 Hs Full agonist - - 14,32
farglitazar Hs Partial agonist 7.47 pKd 43,118
indomethacin Hs Partial agonist 7.38 pKd 31,65
rosiglitazone Hs Full agonist 7.37 pKd 43,65,117
[125I]SB-236636 Hs Full agonist 7.1 pKd 117
GW2331 ? Full agonist 6.52 pKd 55
[3H]GW2331 ? Full agonist 6.52 pKd 55
MK-0767 Hs Full agonist 6.49 pKd 74-75
PAT5A Hs Partial agonist 6.35 pKd 70,108
netoglitazone Hs Full agonist 6.3 pKd 87
linoleic acid Hs Full agonist 5.3 pKd 31,118
BADGE Hs Full agonist 4.0 pKd 8,112
GW1929 Hs Full agonist 8.84 pKi 10
L-796449 Hs Full agonist 8.7 pKi 6
GW7845 Hs Full agonist 8.43 pKi 19,43
CDDO Hs Partial agonist 8.0 pKi 110
L-783483 Hs Full agonist 7.85 pKi 6
L-165461 Hs Full agonist 7.8 pKi 6
AD5075 Hs Full agonist 7.66 pKi 6-7
[3H]AD5075 Hs Full agonist 7.66 pKi 5
FMOC-L-Leucine Hs Partial agonist 6.0 pKi 89
troglitazone Hs Full agonist 5.8 pKi 5
GW409544 Hs Full agonist 9.55 pEC50 42,113
reglitazar Hs Full agonist 7.1 pEC50 101
MK-0767 Hs Full agonist 7.0 pEC50 25
GW9578 Hs Full agonist 6.0 pEC50 11
ciglitazone Hs Full agonist 4.64 pEC50 43
SB-219994 Hs Full agonist 8.68 pIC50 117
LY-510929 Hs Full agonist 8.0 pIC50 1,114
AD-5061 Hs Full agonist 7.7 pIC50 93-94
TZD18 Hs Full agonist 7.24 pIC50 39
L-764406 Hs Partial agonist 7.15 pIC50 28
ragaglitazar Hs Full agonist 7.03 pIC50 17,26,82
thiazolidinone Hs Partial agonist 7.0 pIC50 80
nTzDpa Hs Partial agonist 6.5 pIC50 7
15-deoxy-δ 12 14-prostaglandin J2 Hs Full agonist 6.3 pIC50 54-55,76,79,102
troglitazone Hs Full agonist 6.27 pIC50 43,117
LY-465608 Hs Full agonist 6.26 pIC50 9
pioglitazone Hs Full agonist 6.23 pIC50 43,94,117
SB-219993 Hs Full agonist 5.5 pIC50 117
mesalazine ? Full agonist 1.82 pIC50 91
View species-specific agonist tables
Agonist Comments
Various endogenous fatty acid agonists , with pIC50 values of approximately 6, have been reported [113].
DNA Binding
Structure:  Heterodimer, RXR partner
HRE core sequence:  5'-AACTAGGNCA A AGGTCA-3'
Response element:  DR1
Co-binding Partners
Name Interaction Effect Reference
RXR Physical, Functional DNA binding 56
Main Co-regulators
Name Activity Specific Ligand dependent AF-2 dependent Comments References
SCAND1 Co-activator Yes Yes Yes 13
NCOA4 Co-activator Yes No No 41
PPARGC1A Co-activator No Yes Yes 46-47,57,81,83
PPARGC1B Co-activator No Yes Yes 37,51,57,81,83
CREBBP Co-activator No Yes Yes 71,122
EP300 Co-activator No Yes Yes 35
CITED2 Co-activator No Yes Yes 103
NCOR2 Co-repressor Yes No No 49,119
NCOA7 Co-activator No No No 100
MED1 Co-activator No Yes Yes 58,116,126
NCOA6 Co-activator No Yes Yes 85,124
PRMT2 Co-activator No Yes No 84
TGS1 Co-activator No Yes No 125
NCOA1 Co-activator No No No 86,122,125
NCOA2 Co-activator No Yes Yes 64
NCOA3 Co-activator No No Yes 72
NRIP1 Co-repressor No Yes Yes 106
SMARCA1 Co-activator No No No 21,67
SAFB Co-repressor Yes No No 20
TAZ Co-repressor No Yes No 45
NCOR1 Co-repressor No No No 24,119,121
Main Target Genes
Name Species Effect Technique Comments References
Fabp4: fatty acid binding protein 4 Mouse Activated ChIP 104
Apoa2: apolipoprotein A-II Mouse Activated EMSA, ChIP 109
Pck1: phosphoenolpyruvate carboxykinase 1 Mouse Activated Transient transfection, EMSA 105
Ucp1: uncoupling protein 1 Mouse Activated Transient transfection 99,115
Acsf2: acyl CoA-synthetase Mouse Activated EMSA, Other 69,98
Lpl: lipoprotein lipase Mouse Activated EMSA 97
Slc27a: solute carrier family 27 member 1 Mouse Activated Transient transfection, EMSA 34
Tissue Distribution
Adipose tissues, lymphoid tissues, colon, liver and heart
Species:  Human
Technique:  Northern Blot, Western Blot, Immunohistochemistry
References:  24
Tissue Distribution Comments
Expression of Ppar-γ in mice and rats has been detected in adipose, lymphoid tissues and the colon.
Functional Assays
BADGE: adipogenesis assay
Species:  Mouse
Tissue:  3T3-L1, 3T3-F442A cells
Response measured:  staining of lipids with oil Red O, adipocyte-specific markers
References:  112
Induction of apoptotic cell death
Species:  Rat
Tissue:  C6 glioma cells
Response measured:  lipogenesis by TUNEL staining
References:  37
Adipocyte differentiation assay
Species:  Human
Tissue:  C3H10T1/2 cells
Response measured:  triglyceride accumulation in adipocytes by adding lipoprotein lipase and glycerol phosphatase oxidase
References:  10,66
Phenotypes, Alleles and Disease Models Mouse data from MGI

Click here to show/hide data

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Ppargtm1.1Auw Ppargtm1.1Auw/Ppargtm1.1Auw
B6.Cg-Pparg
MGI:97747  MP:0004185 abnormal adipocyte glucose uptake PMID: 19117549 
Pparg+|Ppargtm1Mae Ppargtm1Mae/Pparg+
involves: 129S6/SvEvTac * C57BL/6
MGI:97747  MP:0000013 abnormal adipose tissue distribution PMID: 15254591 
Pparg+|Ppargtm1Avp Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:97747  MP:0000013 abnormal adipose tissue distribution PMID: 17003330 
Ppargtm2Avp Ppargtm2Avp/Ppargtm2Avp
Not Specified
MGI:97747  MP:0000013 abnormal adipose tissue distribution PMID: 15919792 
Pparg+|Ppargtm1Lja Ppargtm1Lja/Pparg+
involves: 129S1/Sv * 129X1/SvJ
MGI:97747  MP:0000003 abnormal adipose tissue morphology PMID: 15716267 
Ppargtm1.2Mtz|Tg(Fabp4-cre/ERT2)1Ipc Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(Fabp4-cre/ERT2)1Ipc/0
involves: C57BL/6
MGI:2450254  MGI:97747  MP:0005666 abnormal adipose tissue physiology PMID: 15070754 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA * ICR
MGI:97747  MP:0002459 abnormal B cell physiology PMID: 10549291 
Atp2b2m1Mae|Ppargtm2Mae Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0001993 abnormal blinking PMID: 16845470 
Ppargtm1Auw Ppargtm1Auw/Ppargtm1Auw
either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
MGI:97747  MP:0001777 abnormal body temperature regulation PMID: 14603033 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0000168 abnormal bone marrow development PMID: 15067317 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0002397 abnormal bone marrow morphology PMID: 15067317 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0008271 abnormal bone ossification PMID: 15067317 
Ppargtm1.1Auw Ppargtm1.1Auw/Ppargtm1.1Auw
B6.Cg-Pparg
MGI:97747  MP:0003795 abnormal bone structure PMID: 19117549 
Ppargtm2Rev|Tg(Fabp4-cre)1Rev Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
involves: 129S4/SvJae * C57BL/6
MGI:2450253  MGI:97747  MP:0002971 abnormal brown adipose tissue morphology PMID: 14660788 
Ppargtm1Yec Ppargtm1Yec/Ppargtm1Yec
involves: 129S4/SvJae * C57BL/6
MGI:97747  MP:0002971 abnormal brown adipose tissue morphology PMID: 15249658 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0002971 abnormal brown adipose tissue morphology PMID: 17921248 
Pparg+|Ppargtm3Yba Ppargtm3Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0002971 abnormal brown adipose tissue morphology PMID: 17921248 
Ppargtm1.2Mtz|Tg(Fabp4-cre/ERT2)1Ipc Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(Fabp4-cre/ERT2)1Ipc/0
involves: C57BL/6
MGI:2450254  MGI:97747  MP:0009116 abnormal brown fat cell morphology PMID: 15070754 
Pparg+|Ppargtm1Lja Ppargtm1Lja/Pparg+
involves: 129S1/Sv * 129X1/SvJ
MGI:97747  MP:0009116 abnormal brown fat cell morphology PMID: 15716267 
Pparg+|Ppargtm3Yba Ppargtm3Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0009116 abnormal brown fat cell morphology PMID: 17921248 
Ppargtm2Rev|Tg(Fabp4-cre)1Rev Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
involves: 129S4/SvJae * C57BL/6
MGI:2450253  MGI:97747  MP:0009135 abnormal brown fat cell size PMID: 14660788 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0000130 abnormal cancellous bone morphology PMID: 15067317 
Ppargtm1Tka Ppargtm1Tka/Ppargtm1Tka
involves: C57BL/6 * CBA
MGI:97747  MP:0005076 abnormal cell differentiation PMID: 10549291  15067317 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0005076 abnormal cell differentiation PMID: 10549291 
Ppargtm1.1Auw Ppargtm1.1Auw/Ppargtm1.1Auw
B6.Cg-Pparg
MGI:97747  MP:0005076 abnormal cell differentiation PMID: 19117549 
Ppargtm1Rev Ppargtm1Rev/Ppargtm1Rev
involves: 129S4/SvJae
MGI:97747  MP:0004560 abnormal chorionic plate morphology PMID: 10549290 
Ppargtm1Auw Ppargtm1Auw/Ppargtm1Auw
either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
MGI:97747  MP:0001573 abnormal circulating alanine transaminase level PMID: 14603033 
Pparg+|Ppargtm1Mae Ppargtm1Mae/Pparg+
involves: 129S6/SvEvTac * C57BL/6
MGI:97747  MP:0009165 abnormal endocrine pancreas morphology PMID: 15254591 
Pparg+|Ppargtm1Mae Ppargtm1Mae/Pparg+
involves: 129S6/SvEvTac * C57BL/6
MGI:97747  MP:0009115 abnormal fat cell morphology PMID: 15254591 
Pparg+|Ppargtm1Avp Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:97747  MP:0009115 abnormal fat cell morphology PMID: 17003330 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0009115 abnormal fat cell morphology PMID: 17465682 
Ppargtm1Laz Ppargtm1Laz/Ppargtm1Laz
involves: 129S6/SvEvTac * C57BL/6
MGI:97747  MP:0009115 abnormal fat cell morphology PMID: 14536066 
Dok1tm1Yyam|Ppargtm1Laz Dok1tm1Yyam/Dok1tm1Yyam,Ppargtm1Laz/Ppargtm1Laz
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MGI:893587  MGI:97747  MP:0009115 abnormal fat cell morphology PMID: 18204460 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0009115 abnormal fat cell morphology PMID: 10549291  15067317 
Ppargtm1Rev Ppargtm1Rev/Ppargtm1Rev
involves: 129S4/SvJae
MGI:97747  MP:0008788 abnormal fetal cardiomyocyte morphology PMID: 10549290 
Atp2b2m1Mae|Ppargtm2Mae Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0001406 abnormal gait PMID: 16845470 
Pparg+|Ppargtm1Rev Ppargtm1Rev/Pparg+
involves: 129S4/SvJae * C57BL/6J
MGI:97747  MP:0002078 abnormal glucose homeostasis PMID: 10675354 
Ppargtm1Auw Ppargtm1Auw/Ppargtm1Auw
either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
MGI:97747  MP:0002078 abnormal glucose homeostasis PMID: 14603033 
Lepob|Pparg+|Ppargtm1Avp Lepob/Lepob,Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:104663  MGI:97747  MP:0002078 abnormal glucose homeostasis PMID: 17003330 
Ppargtm2Avp Ppargtm2Avp/Ppargtm2Avp
Not Specified
MGI:97747  MP:0002078 abnormal glucose homeostasis PMID: 15919792 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0002078 abnormal glucose homeostasis PMID: 17465682 
Ppargtm1Laz Ppargtm1Laz/Ppargtm1Laz
involves: 129S6/SvEvTac * C57BL/6
MGI:97747  MP:0002078 abnormal glucose homeostasis PMID: 14536066 
Pparg+|Ppargtm1Mae Ppargtm1Mae/Pparg+
involves: 129S6/SvEvTac * C57BL/6
MGI:97747  MP:0005335 abnormal gonadal fat pad morphology PMID: 15254591 
Lepob|Pparg+|Ppargtm1Avp Lepob/Lepob,Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:104663  MGI:97747  MP:0005335 abnormal gonadal fat pad morphology PMID: 17003330 
Ppargtm1Tka Ppargtm1Tka/Ppargtm1Tka
involves: C57BL/6 * CBA
MGI:97747  MP:0000267 abnormal heart development PMID: 10549291 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0000607 abnormal hepatocyte morphology PMID: 17921248 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA * ICR
MGI:97747  MP:0001800 abnormal humoral immune response PMID: 10549291 
Pparg+|Ppargtm1Mae Ppargtm1Mae/Pparg+
involves: 129S6/SvEvTac * C57BL/6
MGI:97747  MP:0005336 abnormal inguinal fat pad morphology PMID: 15254591 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0003564 abnormal insulin secretion PMID: 17465682 
Ppargtm1.2Mtz|Tg(Krt1-10-cre)1Pcn Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(Krt1-10-cre)1Pcn/0
involves: C57BL/6 * SJL
MGI:3629071  MGI:97747  MP:0002655 abnormal keratinocyte morphology PMID: 16751185 
Pparg+|Ppargtm1Avp Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:97747  MP:0002118 abnormal lipid homeostasis PMID: 17003330 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0002118 abnormal lipid homeostasis PMID: 17465682 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0000598 abnormal liver morphology PMID: 17465682 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0001392 abnormal locomotor activity PMID: 17465682 
Ppargtm1.1Gonz|Tg(Mx1-cre)1Cgn Ppargtm1.1Gonz/Ppargtm1.1Gonz,Tg(Mx1-cre)1Cgn/?
involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N
MGI:2176072  MGI:97747  MP:0002451 abnormal macrophage physiology PMID: 11909955 
Ppargtm1Gonz|Tg(MMTV-cre)1Mam Ppargtm1Gonz/Ppargtm1Gonz,Tg(MMTV-cre)1Mam/?
involves: 129X1/SvJ * FVB
MGI:2176162  MGI:97747  MP:0006269 abnormal mammary gland growth during pregnancy PMID: 11884400 
Atp2b2m1Mae|Ppargtm2Mae Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0001516 abnormal motor coordination/ balance PMID: 16845470 
Pparg+|Ppargtm1Lja Ppargtm1Lja/Pparg+
involves: 129S1/Sv * 129X1/SvJ
MGI:97747  MP:0004130 abnormal muscle cell glucose uptake PMID: 15716267 
Ppargtm1Rev Ppargtm1Rev/Ppargtm1Rev
involves: 129S4/SvJae
MGI:97747  MP:0000278 abnormal myocardial fiber morphology PMID: 10549290 
Ppargtm1Rev Ppargtm1Rev/Ppargtm1Rev
involves: 129S4/SvJae
MGI:97747  MP:0002189 abnormal myocardial trabeculae morphology PMID: 10549290 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0008395 abnormal osteoblast differentiation PMID: 15067317 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0005215 abnormal pancreatic islet morphology PMID: 17465682 
Ppargtm2Avp Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:97747  MP:0005215 abnormal pancreatic islet morphology PMID: 17465682 
Ppargtm1.1Mtz Ppargtm1.1Mtz/Ppargtm1.1Mtz
involves: C57BL/6
MGI:97747  MP:0001712 abnormal placenta development PMID: 15070754 
Ppargtm1Rev Ppargtm1Rev/Ppargtm1Rev
involves: 129S4/SvJae
MGI:97747  MP:0001716 abnormal placenta labyrinth morphology PMID: 10549290 
Ppargtm1Tka Ppargtm1Tka/Ppargtm1Tka
involves: C57BL/6 * CBA
MGI:97747  MP:0001716 abnormal placenta labyrinth morphology PMID: 10549291 
Ppargtm1Rev Ppargtm1Rev/Ppargtm1Rev
involves: 129S4/SvJae
MGI:97747  MP:0008803 abnormal placental labyrinth vasculature morphology PMID: 10549290 
Ppargtm1Tka Ppargtm1Tka/Ppargtm1Tka
involves: C57BL/6 * CBA
MGI:97747  MP:0008803 abnormal placental labyrinth vasculature morphology PMID: 10549291 
Ppargtm1Rev Ppargtm1Rev/Ppargtm1Rev
involves: 129S4/SvJae
MGI:97747  MP:0001711 abnormal placenta morphology PMID: 10549290 
Atp2b2m1Mae|Ppargtm2Mae Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0003088 abnormal prepulse inhibition PMID: 16845470 
Atp2b2+|Atp2b2m1Mae|Pparg+|Ppargtm2Mae Atp2b2m1Mae/Atp2b2+,Ppargtm2Mae/Pparg+
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0003088 abnormal prepulse inhibition PMID: 16845470 
Atp2b2m1Mae|Ppargtm2Mae Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0001961 abnormal reflex PMID: 16845470 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0005164 abnormal response to injury PMID: 11889020 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA * ICR
MGI:97747  MP:0005164 abnormal response to injury PMID: 11159886 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0002792 abnormal retinal vasculature morphology PMID: 17003451 
Lepob|Pparg+|Ppargtm1Avp Lepob/Lepob,Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:104663  MGI:97747  MP:0000759 abnormal skeletal muscle morphology PMID: 17003330 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0000759 abnormal skeletal muscle morphology PMID: 17465682 
Ppargtm1.2Mtz|Tg(Krt1-10-cre)1Pcn Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(Krt1-10-cre)1Pcn/0
involves: C57BL/6 * SJL
MGI:3629071  MGI:97747  MP:0002060 abnormal skin morphology PMID: 16751185 
Pparg+|Ppargtm1Avp Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:97747  MP:0000187 abnormal triglyceride level PMID: 17003330 
Ppargtm1Rev Ppargtm1Rev/Ppargtm1Rev
involves: 129S4/SvJae
MGI:97747  MP:0005033 abnormal trophoblast giant cells PMID: 10549290 
Ppargtm1Rev Ppargtm1Rev/Ppargtm1Rev
involves: 129S4/SvJae
MGI:97747  MP:0005031 abnormal trophoblast layer morphology PMID: 10549290 
Atp2b2m1Mae|Ppargtm2Mae Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0001490 abnormal vibrissae reflex PMID: 16845470 
Atp2b2m1Mae|Ppargtm2Mae Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0003491 abnormal voluntary movement PMID: 16845470 
Ppargtm2Rev|Tg(Fabp4-cre)1Rev Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
involves: 129S4/SvJae * C57BL/6
MGI:2450253  MGI:97747  MP:0001781 abnormal white adipose tissue amount PMID: 14660788 
Lepob|Pparg+|Ppargtm1Avp Lepob/Lepob,Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:104663  MGI:97747  MP:0001781 abnormal white adipose tissue amount PMID: 17003330 
Ppargtm1Yec Ppargtm1Yec/Ppargtm1Yec
involves: 129S4/SvJae * C57BL/6
MGI:97747  MP:0002970 abnormal white adipose tissue morphology PMID: 15249658 
Pparg+|Ppargtm1Lja Ppargtm1Lja/Pparg+
involves: 129S1/Sv * 129X1/SvJ
MGI:97747  MP:0002970 abnormal white adipose tissue morphology PMID: 15716267 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0002970 abnormal white adipose tissue morphology PMID: 17921248 
Ppargtm1Yec Ppargtm1Yec/Ppargtm1Yec
involves: 129S4/SvJae * C57BL/6
MGI:97747  MP:0005670 abnormal white adipose tissue physiology PMID: 15249658 
Ppargtm2Avp Ppargtm2Avp/Ppargtm2Avp
Not Specified
MGI:97747  MP:0005670 abnormal white adipose tissue physiology PMID: 15919792 
Ppargtm1.2Mtz|Tg(Fabp4-cre/ERT2)1Ipc Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(Fabp4-cre/ERT2)1Ipc/0
involves: C57BL/6
MGI:2450254  MGI:97747  MP:0009117 abnormal white fat cell morphology PMID: 15070754 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0009117 abnormal white fat cell morphology PMID: 17921248 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0009132 abnormal white fat cell size PMID: 17921248 
Atp2b2m1Mae|Ppargtm2Mae Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0006358 absent pinna reflex PMID: 16845470 
Atp2b2m1Mae|Ppargtm2Mae Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0006359 absent startle reflex PMID: 16845470 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0008843 absent subcutaneous adipose tissue PMID: 17921248 
Atp2b2m1Mae|Ppargtm2Mae Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0001393 ataxia PMID: 16845470 
Ppargtm1.1Gonz|Tg(Myhca-cre)1Abel Ppargtm1.1Gonz/Ppargtm1.1Gonz,Tg(Myhca-cre)1Abel/0
involves: 129X1/SvJ * FVB
MGI:2182090  MGI:97747  MP:0001625 cardiac hypertrophy PMID: 16051889 
Ppargtm1Yec Ppargtm1Yec/Ppargtm1Yec
involves: 129S4/SvJae * C57BL/6
MGI:97747  MP:0004893 decreased adiponectin level PMID: 15249658 
Pparg+|Ppargtm1Lja Ppargtm1Lja/Pparg+
involves: 129S1/Sv * 129X1/SvJ
MGI:97747  MP:0004893 decreased adiponectin level PMID: 15716267 
Pparg+|Ppargtm1Avp Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:97747  MP:0004893 decreased adiponectin level PMID: 17003330 
Lepob|Pparg+|Ppargtm1Avp Lepob/Lepob,Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:104663  MGI:97747  MP:0004893 decreased adiponectin level PMID: 17003330 
Ppargtm2Avp Ppargtm2Avp/Ppargtm2Avp
Not Specified
MGI:97747  MP:0004893 decreased adiponectin level PMID: 15919792 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0004893 decreased adiponectin level PMID: 17465682 
Ppargtm2Avp Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:97747  MP:0004893 decreased adiponectin level PMID: 17465682 
Ppargtm1.1Auw Ppargtm1.1Auw/Ppargtm1.1Auw
B6.Cg-Pparg
MGI:97747  MP:0006086 decreased body mass index PMID: 19117549 
Atp2b2m1Mae|Ppargtm2Mae Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0001265 decreased body size PMID: 16845470 
Ppargtm1Auw Ppargtm1Auw/Ppargtm1Auw
either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
MGI:97747  MP:0001262 decreased body weight PMID: 14603033 
Ppargtm1Yec Ppargtm1Yec/Ppargtm1Yec
involves: 129S4/SvJae * C57BL/6
MGI:97747  MP:0001262 decreased body weight PMID: 15249658 
Pparg+|Ppargtm1Lja Ppargtm1Lja/Pparg+
involves: 129S1/Sv * 129X1/SvJ
MGI:97747  MP:0001262 decreased body weight PMID: 15716267 
Lepob|Pparg+|Ppargtm1Avp Lepob/Lepob,Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:104663  MGI:97747  MP:0001262 decreased body weight PMID: 17003330 
Ppargtm1.1Auw Ppargtm1.1Auw/Ppargtm1.1Auw
B6.Cg-Pparg
MGI:97747  MP:0001262 decreased body weight PMID: 19117549 
Ppargtm1Auw Ppargtm1Auw/Ppargtm1Auw
either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
MGI:97747  MP:0001780 decreased brown adipose tissue amount PMID: 14603033 
Ppargtm2Rev|Tg(Fabp4-cre)1Rev Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
involves: 129S4/SvJae * C57BL/6
MGI:2450253  MGI:97747  MP:0001780 decreased brown adipose tissue amount PMID: 14660788 
Ppargtm1.2Mtz|Tg(Fabp4-cre/ERT2)1Ipc Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(Fabp4-cre/ERT2)1Ipc/0
involves: C57BL/6
MGI:2450254  MGI:97747  MP:0001780 decreased brown adipose tissue amount PMID: 15070754 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0001780 decreased brown adipose tissue amount PMID: 10549291 
Ppargtm1Yec Ppargtm1Yec/Ppargtm1Yec
involves: 129S4/SvJae * C57BL/6
MGI:97747  MP:0009125 decreased brown fat cell lipid droplet size PMID: 15249658 
Ppargtm2Rev|Tg(Fabp4-cre)1Rev Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
involves: 129S4/SvJae * C57BL/6
MGI:2450253  MGI:97747  MP:0009128 decreased brown fat cell number PMID: 14660788 
Ppargtm1Yec Ppargtm1Yec/Ppargtm1Yec
involves: 129S4/SvJae * C57BL/6
MGI:97747  MP:0009137 decreased brown fat lipid droplet number PMID: 15249658 
Ppargtm1.1Auw Ppargtm1.1Auw/Ppargtm1.1Auw
B6.Cg-Pparg
MGI:97747  MP:0005179 decreased circulating cholesterol level PMID: 19117549 
Ppargtm1Laz Ppargtm1Laz/Ppargtm1Laz
involves: 129S6/SvEvTac * C57BL/6
MGI:97747  MP:0002702 decreased circulating free fatty acid level PMID: 14536066 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0002727 decreased circulating insulin level PMID: 17465682 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0002727 decreased circulating insulin level PMID: 10549291 
Ppargtm1Yec Ppargtm1Yec/Ppargtm1Yec
involves: 129S4/SvJae * C57BL/6
MGI:97747  MP:0005668 decreased circulating leptin level PMID: 15249658 
Ppargtm1Laz Ppargtm1Laz/Ppargtm1Laz
involves: 129S6/SvEvTac * C57BL/6
MGI:97747  MP:0005668 decreased circulating leptin level PMID: 14536066 
Ppargtm1Laz Ppargtm1Laz/Ppargtm1Laz
involves: 129S6/SvEvTac * C57BL/6
MGI:97747  MP:0002644 decreased circulating triglyceride level PMID: 14536066 
Ppargtm1.1Auw Ppargtm1.1Auw/Ppargtm1.1Auw
B6.Cg-Pparg
MGI:97747  MP:0002644 decreased circulating triglyceride level PMID: 19117549 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0003910 decreased eating behavior PMID: 10549291 
Ppargtm1Lja Ppargtm1Lja/Ppargtm1Lja
involves: 129S1/Sv * 129X1/SvJ
MGI:97747  MP:0001698 decreased embryo size PMID: 15716267 
Ppargtm1.2Mtz|Tg(Fabp4-cre/ERT2)1Ipc Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(Fabp4-cre/ERT2)1Ipc/0
involves: C57BL/6
MGI:2450254  MGI:97747  MP:0009289 decreased epididymal fat pad weight PMID: 15070754 
Lepob|Pparg+|Ppargtm1Avp Lepob/Lepob,Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:104663  MGI:97747  MP:0009269 decreased fat cell size PMID: 17003330 
Ppargtm1Yec Ppargtm1Yec/Ppargtm1Yec
involves: 129S4/SvJae * C57BL/6
MGI:97747  MP:0009283 decreased gonadal fat pad weight PMID: 15249658 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0009283 decreased gonadal fat pad weight PMID: 17921248 
Pparg+|Ppargtm3Yba Ppargtm3Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0009283 decreased gonadal fat pad weight PMID: 17921248 
Atp2b2m1Mae|Ppargtm2Mae Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0010053 decreased grip strength PMID: 16845470 
Ppargtm1.1Gonz|Tg(Myhca-cre)1Abel Ppargtm1.1Gonz/Ppargtm1.1Gonz,Tg(Myhca-cre)1Abel/0
involves: 129X1/SvJ * FVB
MGI:2182090  MGI:97747  MP:0005333 decreased heart rate PMID: 16051889 
Ppargtm1Yec Ppargtm1Yec/Ppargtm1Yec
involves: 129S4/SvJae * C57BL/6
MGI:97747  MP:0009293 decreased inguinal fat pad weight PMID: 15249658 
Ppargtm2Rev|Tg(Fabp4-cre)1Rev Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
involves: 129S4/SvJae * C57BL/6
MGI:2450253  MGI:97747  MP:0009295 decreased interscapular fat pad weight PMID: 14660788 
Ppargtm1Gonz|Tg(MMTV-cre)1Mam Ppargtm1Gonz/Ppargtm1Gonz,Tg(MMTV-cre)1Mam/?
involves: 129X1/SvJ * FVB
MGI:2176162  MGI:97747  MP:0001935 decreased litter size PMID: 11884400 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0009356 decreased liver triglyceride level PMID: 17465682 
Ppargtm1.2Mtz|Tg(Fabp4-cre/ERT2)1Ipc Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(Fabp4-cre/ERT2)1Ipc/0
involves: C57BL/6
MGI:2450254  MGI:97747  MP:0005459 decreased percent body fat PMID: 15070754 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0010379 decreased respiratory quotient PMID: 17465682 
Ppargtm1Yec Ppargtm1Yec/Ppargtm1Yec
involves: 129S4/SvJae * C57BL/6
MGI:97747  MP:0009305 decreased retroperitoneal fat pad weight PMID: 15249658 
Atp2b2+|Atp2b2m1Mae|Pparg+|Ppargtm2Mae Atp2b2m1Mae/Atp2b2+,Ppargtm2Mae/Pparg+
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0001489 decreased startle reflex PMID: 16845470 
Pparg+|Ppargtm3Yba Ppargtm3Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0008844 decreased subcutaneous adipose tissue amount PMID: 17921248 
Ppargtm1.1Unc Ppargtm1.1Unc/Ppargtm1.1Unc
involves: 129S6/SvEvTac * C57BL/6J
MGI:97747  MP:0002843 decreased systemic arterial blood pressure PMID: 19884495 
Pparg+|Ppargtm1.1Unc Ppargtm1.1Unc/Pparg+
involves: 129S6/SvEvTac * C57BL/6J
MGI:97747  MP:0002843 decreased systemic arterial blood pressure PMID: 19884495 
Pparg+|Ppargtm1Uls Ppargtm1Uls/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:97747  MP:0010025 decreased total body fat amount PMID: 15231871 
Pparg+|Ppargtm1Lja Ppargtm1Lja/Pparg+
involves: 129S1/Sv * 129X1/SvJ
MGI:97747  MP:0010025 decreased total body fat amount PMID: 15716267 
Lepob|Pparg+|Ppargtm1Avp Lepob/Lepob,Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:104663  MGI:97747  MP:0010025 decreased total body fat amount PMID: 17003330 
Ppargtm2Avp Ppargtm2Avp/Ppargtm2Avp
Not Specified
MGI:97747  MP:0010025 decreased total body fat amount PMID: 15919792 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0010025 decreased total body fat amount PMID: 10549291 
Ppargtm1.1Auw Ppargtm1.1Auw/Ppargtm1.1Auw
B6.Cg-Pparg
MGI:97747  MP:0008907 decreased total fat pad weight PMID: 19117549 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0005318 decreased triglyceride level PMID: 17465682 
Ppargtm1Auw Ppargtm1Auw/Ppargtm1Auw
either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
MGI:97747  MP:0001783 decreased white adipose tissue amount PMID: 14603033 
Ppargtm1Yec Ppargtm1Yec/Ppargtm1Yec
involves: 129S4/SvJae * C57BL/6
MGI:97747  MP:0001783 decreased white adipose tissue amount PMID: 15249658 
Pparg+|Ppargtm1Lja Ppargtm1Lja/Pparg+
involves: 129S1/Sv * 129X1/SvJ
MGI:97747  MP:0001783 decreased white adipose tissue amount PMID: 15716267 
Ppargtm1Yec Ppargtm1Yec/Ppargtm1Yec
involves: 129S4/SvJae * C57BL/6
MGI:97747  MP:0009131 decreased white fat cell number PMID: 15249658 
Ppargtm1Yec Ppargtm1Yec/Ppargtm1Yec
involves: 129S4/SvJae * C57BL/6
MGI:97747  MP:0009133 decreased white fat cell size PMID: 15249658 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0009254 disorganized pancreatic islets PMID: 17465682 
Ppargtm1Tka Ppargtm1Tka/Ppargtm1Tka
involves: C57BL/6 * CBA
MGI:97747  MP:0003984 embryonic growth retardation PMID: 10549291 
Ppargtm1Rev Ppargtm1Rev/Ppargtm1Rev
involves: 129S4/SvJae
MGI:97747  MP:0006207 embryonic lethality during organogenesis PMID: 10549290 
Ppargtm1Lja Ppargtm1Lja/Ppargtm1Lja
involves: 129S1/Sv * 129X1/SvJ
MGI:97747  MP:0006207 embryonic lethality during organogenesis PMID: 15716267 
Ppargtm1.1Mtz Ppargtm1.1Mtz/Ppargtm1.1Mtz
involves: C57BL/6
MGI:97747  MP:0006207 embryonic lethality during organogenesis PMID: 15070754 
Ppargtm1Tka Ppargtm1Tka/Ppargtm1Tka
involves: C57BL/6 * CBA
MGI:97747  MP:0006207 embryonic lethality during organogenesis PMID: 10549291 
Ppargtm1Auw Ppargtm1Auw/Ppargtm1Auw
either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
MGI:97747  MP:0000599 enlarged liver PMID: 14603033 
Ppargtm2Rev|Tg(Fabp4-cre)1Rev Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
involves: 129S4/SvJae * C57BL/6
MGI:2450253  MGI:97747  MP:0000599 enlarged liver PMID: 14660788 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0000599 enlarged liver PMID: 17921248 
Pparg+|Ppargtm3Yba Ppargtm3Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0000599 enlarged liver PMID: 17921248 
Ppargtm1.1Gonz|Tg(Myhca-cre)1Abel Ppargtm1.1Gonz/Ppargtm1.1Gonz,Tg(Myhca-cre)1Abel/0
involves: 129X1/SvJ * FVB
MGI:2182090  MGI:97747  MP:0004564 enlarged myocardial fiber PMID: 16051889 
Ppargtm1.1Auw Ppargtm1.1Auw/Ppargtm1.1Auw
B6.Cg-Pparg
MGI:97747  MP:0001661 extended life span PMID: 19117549 
Ppargtm1Gonz|Tg(MMTV-cre)1Mam Ppargtm1Gonz/Ppargtm1Gonz,Tg(MMTV-cre)1Mam/?
involves: 129X1/SvJ * FVB
MGI:2176162  MGI:97747  MP:0001926 female infertility PMID: 11884400 
Atp2b2m1Mae|Ppargtm2Mae Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0001410 head bobbing PMID: 16845470 
Ppargtm1Auw Ppargtm1Auw/Ppargtm1Auw
either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
MGI:97747  MP:0002628 hepatic steatosis PMID: 14603033 
Ppargtm2Rev|Tg(Fabp4-cre)1Rev Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
involves: 129S4/SvJae * C57BL/6
MGI:2450253  MGI:97747  MP:0002628 hepatic steatosis PMID: 14660788 
Pparg+|Ppargtm1Lja Ppargtm1Lja/Pparg+
involves: 129S1/Sv * 129X1/SvJ
MGI:97747  MP:0002628 hepatic steatosis PMID: 15716267 
Pparg+|Ppargtm1Avp Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:97747  MP:0002628 hepatic steatosis PMID: 17003330 
Lepob|Pparg+|Ppargtm1Avp Lepob/Lepob,Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:104663  MGI:97747  MP:0002628 hepatic steatosis PMID: 17003330 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0002628 hepatic steatosis PMID: 17465682 
Ppargtm1.1Auw Ppargtm1.1Auw/Ppargtm1.1Auw
B6.Cg-Pparg
MGI:97747  MP:0001399 hyperactivity PMID: 19117549 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0001559 hyperglycemia PMID: 17465682 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0001559 hyperglycemia PMID: 17921248 
Ppargtm1Auw Ppargtm1Auw/Ppargtm1Auw
either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
MGI:97747  MP:0001548 hyperlipidemia PMID: 14603033 
Pparg+|Ppargtm1Mae Ppargtm1Mae/Pparg+
involves: 129S6/SvEvTac * C57BL/6
MGI:97747  MP:0000231 hypertension PMID: 15254591 
Pparg+|Ppargtm1Lja Ppargtm1Lja/Pparg+
involves: 129S1/Sv * 129X1/SvJ
MGI:97747  MP:0000231 hypertension PMID: 15716267 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0001402 hypoactivity PMID: 17465682 
Atp2b2m1Mae|Ppargtm2Mae Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0001525 impaired balance PMID: 16845470 
Ppargtm1Auw Ppargtm1Auw/Ppargtm1Auw
either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
MGI:97747  MP:0005293 impaired glucose tolerance PMID: 14603033 
Ppargtm2Avp Ppargtm2Avp/Ppargtm2Avp
Not Specified
MGI:97747  MP:0005293 impaired glucose tolerance PMID: 15919792 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0005293 impaired glucose tolerance PMID: 17921248 
Ppargtm1.1Unc Ppargtm1.1Unc/Ppargtm1.1Unc
involves: 129S6/SvEvTac * C57BL/6J
MGI:97747  MP:0005293 impaired glucose tolerance PMID: 19884495 
Atp2b2m1Mae|Ppargtm2Mae Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0006325 impaired hearing PMID: 16845470 
Atp2b2+|Atp2b2m1Mae|Pparg+|Ppargtm2Mae Atp2b2m1Mae/Atp2b2+,Ppargtm2Mae/Pparg+
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0006325 impaired hearing PMID: 16845470 
Atp2b2m1Mae|Ppargtm2Mae Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0001523 impaired righting response PMID: 16845470 
Pparg+|Ppargtm1Mae Ppargtm1Mae/Pparg+
involves: 129S6/SvEvTac * C57BL/6
MGI:97747  MP:0005292 improved glucose tolerance PMID: 15254591 
Ppargtm1Laz Ppargtm1Laz/Ppargtm1Laz
involves: 129S6/SvEvTac * C57BL/6
MGI:97747  MP:0005292 improved glucose tolerance PMID: 14536066 
Ppargtm1.1Auw Ppargtm1.1Auw/Ppargtm1.1Auw
B6.Cg-Pparg
MGI:97747  MP:0005292 improved glucose tolerance PMID: 19117549 
Ppargtm1Laz Ppargtm1Laz/Ppargtm1Laz
involves: 129S6/SvEvTac * C57BL/6
MGI:97747  MP:0004892 increased adiponectin level PMID: 14536066 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA * ICR
MGI:97747  MP:0005154 increased B cell proliferation PMID: 10549291 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0005533 increased body temperature PMID: 10549291 
Ppargtm1.1Auw Ppargtm1.1Auw/Ppargtm1.1Auw
B6.Cg-Pparg
MGI:97747  MP:0005533 increased body temperature PMID: 19117549 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0005605 increased bone mass PMID: 15067317 
Ppargtm1.2Mtz|Tg(Fabp4-cre/ERT2)1Ipc Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(Fabp4-cre/ERT2)1Ipc/0
involves: C57BL/6
MGI:2450254  MGI:97747  MP:0009124 increased brown fat cell lipid droplet size PMID: 15070754 
Ppargtm2Rev|Tg(Fabp4-cre)1Rev Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
involves: 129S4/SvJae * C57BL/6
MGI:2450253  MGI:97747  MP:0009119 increased brown fat cell size PMID: 14660788 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0009119 increased brown fat cell size PMID: 17921248 
Pparg+|Ppargtm3Yba Ppargtm3Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0009119 increased brown fat cell size PMID: 17921248 
Ppargtm1Auw Ppargtm1Auw/Ppargtm1Auw
either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
MGI:97747  MP:0005343 increased circulating aspartate transaminase level PMID: 14603033 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0005178 increased circulating cholesterol level PMID: 17921248 
Ppargtm1Auw Ppargtm1Auw/Ppargtm1Auw
either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
MGI:97747  MP:0001554 increased circulating free fatty acid level PMID: 14603033 
Pparg+|Ppargtm1Lja Ppargtm1Lja/Pparg+
involves: 129S1/Sv * 129X1/SvJ
MGI:97747  MP:0001554 increased circulating free fatty acid level PMID: 15716267 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0001554 increased circulating free fatty acid level PMID: 17465682 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0001554 increased circulating free fatty acid level PMID: 17921248 
Lepob|Pparg+|Ppargtm1Avp Lepob/Lepob,Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:104663  MGI:97747  MP:0005559 increased circulating glucose level PMID: 17003330 
Ppargtm2Avp Ppargtm2Avp/Ppargtm2Avp
Not Specified
MGI:97747  MP:0005559 increased circulating glucose level PMID: 15919792 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0005559 increased circulating glucose level PMID: 17465682 
Ppargtm2Rev|Tg(Fabp4-cre)1Rev Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
involves: 129S4/SvJae * C57BL/6
MGI:2450253  MGI:97747  MP:0002079 increased circulating insulin level PMID: 14660788 
Pparg+|Ppargtm1Lja Ppargtm1Lja/Pparg+
involves: 129S1/Sv * 129X1/SvJ
MGI:97747  MP:0002079 increased circulating insulin level PMID: 15716267 
Lepob|Pparg+|Ppargtm1Avp Lepob/Lepob,Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:104663  MGI:97747  MP:0002079 increased circulating insulin level PMID: 17003330 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0002079 increased circulating insulin level PMID: 17465682 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0002079 increased circulating insulin level PMID: 17921248 
Pparg+|Ppargtm3Yba Ppargtm3Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0002079 increased circulating insulin level PMID: 17921248 
Ppargtm2Avp Ppargtm2Avp/Ppargtm2Avp
Not Specified
MGI:97747  MP:0005669 increased circulating leptin level PMID: 15919792 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0005669 increased circulating leptin level PMID: 10549291 
Ppargtm1Auw Ppargtm1Auw/Ppargtm1Auw
either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
MGI:97747  MP:0001552 increased circulating triglyceride level PMID: 14603033 
Pparg+|Ppargtm1Avp Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:97747  MP:0001552 increased circulating triglyceride level PMID: 17003330 
Lepob|Pparg+|Ppargtm1Avp Lepob/Lepob,Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:104663  MGI:97747  MP:0001552 increased circulating triglyceride level PMID: 17003330 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0001552 increased circulating triglyceride level PMID: 17465682 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0001552 increased circulating triglyceride level PMID: 17921248 
Pparg+|Ppargtm3Yba Ppargtm3Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0001552 increased circulating triglyceride level PMID: 17921248 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0003911 increased drinking behavior PMID: 17465682 
Ppargtm1.1Auw Ppargtm1.1Auw/Ppargtm1.1Auw
B6.Cg-Pparg
MGI:97747  MP:0003911 increased drinking behavior PMID: 19117549 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA * ICR
MGI:97747  MP:0002493 increased IgG level PMID: 10549291 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA * ICR
MGI:97747  MP:0002494 increased IgM level PMID: 10549291 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0004499 increased incidence of chemically-induced tumors PMID: 15930296 
Pparg+|Ppargtm1Rev Ppargtm1Rev/Pparg+
involves: 129S4/SvJae * C57BL/6J
MGI:97747  MP:0002891 increased insulin sensitivity PMID: 10675354 
Ppargtm1Laz Ppargtm1Laz/Ppargtm1Laz
involves: 129S6/SvEvTac * C57BL/6
MGI:97747  MP:0002891 increased insulin sensitivity PMID: 14536066 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0002891 increased insulin sensitivity PMID: 10549291 
Ppargtm1.1Auw Ppargtm1.1Auw/Ppargtm1.1Auw
B6.Cg-Pparg
MGI:97747  MP:0002891 increased insulin sensitivity PMID: 19117549 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA * ICR
MGI:97747  MP:0008566 increased interferon-gamma secretion PMID: 10549291 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA * ICR
MGI:97747  MP:0008687 increased interleukin-2 secretion PMID: 10549291 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0009294 increased interscapular fat pad weight PMID: 17921248 
Ppargtm1Auw Ppargtm1Auw/Ppargtm1Auw
either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
MGI:97747  MP:0009355 increased liver triglyceride level PMID: 14603033 
Pparg+|Ppargtm1Lja Ppargtm1Lja/Pparg+
involves: 129S1/Sv * 129X1/SvJ
MGI:97747  MP:0009355 increased liver triglyceride level PMID: 15716267 
Pparg+|Ppargtm1Avp Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:97747  MP:0002981 increased liver weight PMID: 17003330 
Lepob|Pparg+|Ppargtm1Avp Lepob/Lepob,Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:104663  MGI:97747  MP:0002981 increased liver weight PMID: 17003330 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0004988 increased osteoblast cell number PMID: 15067317 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0005458 increased percent body fat PMID: 17465682 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0005659 increased resistance to diet-induced obesity PMID: 10549291 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0002310 increased resistance to hepatic steatosis PMID: 10549291 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality PMID: 15930296 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA * ICR
MGI:97747  MP:0003724 increased susceptibility to induced arthritis PMID: 10549291 
Ppargtm1Rev|Ppargtm2Mae Ppargtm1Rev/Ppargtm2Mae
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J
MGI:97747  MP:0002842 increased systemic arterial blood pressure PMID: 19884495 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0001759 increased urine glucose level PMID: 17465682 
Ppargtm2Avp Ppargtm2Avp/Ppargtm2Avp
Not Specified
MGI:97747  MP:0000008 increased white adipose tissue amount PMID: 15919792 
Ppargtm2Rev|Tg(Fabp4-cre)1Rev Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
involves: 129S4/SvJae * C57BL/6
MGI:2450253  MGI:97747  MP:0009118 increased white fat cell size PMID: 14660788 
Ppargtm1Auw Ppargtm1Auw/Ppargtm1Auw
either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
MGI:97747  MP:0005331 insulin resistance PMID: 14603033 
Ppargtm2Rev|Tg(Fabp4-cre)1Rev Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
involves: 129S4/SvJae * C57BL/6
MGI:2450253  MGI:97747  MP:0005331 insulin resistance PMID: 14660788 
Ppargtm1Yec Ppargtm1Yec/Ppargtm1Yec
involves: 129S4/SvJae * C57BL/6
MGI:97747  MP:0005331 insulin resistance PMID: 15249658 
Pparg+|Ppargtm1Lja Ppargtm1Lja/Pparg+
involves: 129S1/Sv * 129X1/SvJ
MGI:97747  MP:0005331 insulin resistance PMID: 15716267 
Lepob|Pparg+|Ppargtm1Avp Lepob/Lepob,Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:104663  MGI:97747  MP:0005331 insulin resistance PMID: 17003330 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0005331 insulin resistance PMID: 17465682 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0005331 insulin resistance PMID: 17921248 
Pparg+|Ppargtm1Tka Ppargtm1Tka/Pparg+
involves: C57BL/6 * CBA
MGI:97747  MP:0008541 leukostasis PMID: 17003451 
Ppargtm1.1Mgn Ppargtm1.1Mgn/Ppargtm1.1Mgn
involves: 129S6/SvEvTac * C57BL/6J
MGI:97747  MP:0002169 no abnormal phenotype detected PMID: 11857800 
Ppargtm1.2Mtz|Tg(KRT14-cre)1Ipc Ppargtm1.2Mtz/Ppargtm1.2Mtz,Tg(KRT14-cre)1Ipc/0
involves: C57BL/6 * SJL
MGI:2177412  MGI:97747  MP:0002169 no abnormal phenotype detected PMID: 16751185 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0003674 oxidative stress PMID: 17465682 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0009110 pancreas hyperplasia PMID: 17921248 
Ppargtm1.1Gonz|Tg(Ins2-cre)25Mgn Ppargtm1.1Gonz/Ppargtm1.1Gonz,Tg(Ins2-cre)25Mgn/0
involves: 129 * C57 * FVB
MGI:2176225  MGI:97747  MP:0005491 pancreatic islet hyperplasia PMID: 14517292 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0005491 pancreatic islet hyperplasia PMID: 17921248 
Ppargtm1Tka Ppargtm1Tka/Ppargtm1Tka
involves: C57BL/6 * CBA
MGI:97747  MP:0001715 placental labyrinth hypoplasia PMID: 10549291 
Lepob|Pparg+|Ppargtm1Avp Lepob/Lepob,Ppargtm1Avp/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:104663  MGI:97747  MP:0001433 polyphagia PMID: 17003330 
Lepob|Ppargtm2Avp Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
involves: 129/Sv * C57BL/6
MGI:104663  MGI:97747  MP:0001433 polyphagia PMID: 17465682 
Ppargtm1Auw Ppargtm1Auw/Ppargtm1Auw
either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
MGI:97747  MP:0001732 postnatal growth retardation PMID: 14603033 
Pparg+|Ppargtm1Uls Ppargtm1Uls/Pparg+
involves: 129S2/SvPas * C57BL/6
MGI:97747  MP:0001732 postnatal growth retardation PMID: 15231871 
Atp2b2m1Mae|Ppargtm2Mae Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0001732 postnatal growth retardation PMID: 16845470 
Ppargtm1Auw Ppargtm1Auw/Ppargtm1Auw
either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
MGI:97747  MP:0002082 postnatal lethality PMID: 14603033 
Ppargtm2Rev|Tg(Fabp4-cre)1Rev Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
involves: 129S4/SvJae * C57BL/6
MGI:2450253  MGI:97747  MP:0008489 postnatal slow weight gain PMID: 14660788 
Ppargtm1.2Auw Ppargtm1.2Auw/Ppargtm1.2Auw
B6.Cg-Pparg
MGI:97747  MP:0002083 premature death PMID: 19997628 
Ppargtm1.2Mgn Ppargtm1.2Mgn/Ppargtm1.2Mgn
involves: 129S6/SvEvTac * C57BL/6J
MGI:97747  MP:0002080 prenatal lethality PMID: 11857800 
Ppargtm1Mae Ppargtm1Mae/Ppargtm1Mae
involves: 129S6/SvEvTac * C57BL/6
MGI:97747  MP:0002080 prenatal lethality PMID: 15254591 
Ppargtm1Uls Ppargtm1Uls/Ppargtm1Uls
involves: 129S2/SvPas * C57BL/6
MGI:97747  MP:0002080 prenatal lethality PMID: 15231871 
Ppargtm1Wwah Ppargtm1Wwah/Ppargtm1Wwah
Not Specified
MGI:97747  MP:0002080 prenatal lethality PMID: 11514592 
Ppargtm1Avp Ppargtm1Avp/Ppargtm1Avp
involves: 129S2/SvPas * C57BL/6
MGI:97747  MP:0002080 prenatal lethality PMID: 17003330 
Ppargtm1Gonz|Tg(MMTV-cre)1Mam Ppargtm1Gonz/Ppargtm1Gonz,Tg(MMTV-cre)1Mam/?
involves: 129X1/SvJ * FVB
MGI:2176162  MGI:97747  MP:0001923 reduced female fertility PMID: 11884400 
Pparg+|Ppargtm2Yba Ppargtm2Yba/Pparg+
involves: 129S1/SvImJ * C57BL/6
MGI:97747  MP:0001921 reduced fertility PMID: 17921248 
Ppargtm1Rev Ppargtm1Rev/Ppargtm1Rev
involves: 129S4/SvJae
MGI:97747  MP:0010725 thin interventricular septum PMID: 10549290 
Ppargtm1Rev Ppargtm1Rev/Ppargtm1Rev
involves: 129S4/SvJae
MGI:97747  MP:0002652 thin myocardium PMID: 10549290 
Ppargtm1Tka Ppargtm1Tka/Ppargtm1Tka
involves: C57BL/6 * CBA
MGI:97747  MP:0002652 thin myocardium PMID: 10549291 
Ppargtm1Rev Ppargtm1Rev/Ppargtm1Rev
involves: 129S4/SvJae
MGI:97747  MP:0010556 thin ventricle myocardium compact layer PMID: 10549290 
Ppargtm1Rev Ppargtm1Rev/Ppargtm1Rev
involves: 129S4/SvJae
MGI:97747  MP:0000280 thin ventricular wall PMID: 10549290 
Atp2b2m1Mae|Ppargtm2Mae Atp2b2m1Mae/Atp2b2m1Mae,Ppargtm2Mae/Ppargtm2Mae
involves: 129S6/SvEvTac * C57BL/6J
MGI:105368  MGI:97747  MP:0000745 tremors PMID: 16845470 
Clinically-Relevant Mutations and Pathophysiology
Disease:  artherosclerosis
Comments: 
References:  52,88
Mutations not determined
Disease:  thyroid tumors
Comments: 
References:  18,68,77
Mutations not determined
Disease:  obesity (and insulin resistance)
Comments: 
References:  4,22,27,52,107
Mutations not determined
Disease:  Syndrome X (metabolic syndrome)
Comments: 
References:  23,33,63
Mutations not determined
Disease:  Type II diabetes mellitus ( and Insulin resistance)
Comments: 
References:  3,22-23,42,52
Mutations not determined
Disease:  colon cancer
Comments: 
References:  15,53,95-96
Mutations not determined
Disease:  prostate cancer
Comments: 
References:  73
Mutations not determined
Disease:  Familial partial lipodystrophy
OMIM: 
Orphanet: 
References: 
Mutations not determined
Disease:  Glioblastoma
OMIM: 
Orphanet: 
References: 
Mutations not determined
Gene Expression and Pathophysiology
disrupted expression in macrophages
Tissue or cell type:  macrophage
Pathophysiology: 
Species:  Mouse
Technique:  Transgenesis
References:  111
PPAR gamma L466A dominant negative knock-in mutant
Tissue or cell type: 
Pathophysiology: 
Species:  Mouse
Technique:  knock-in
References:  33
Forced expression in hepatocytes induced the classical pattern of PPAR gamma-mediated gene activation and resulted in steatosis
Tissue or cell type:  hepatocytes
Pathophysiology:  steatosis
Species:  Mouse
Technique:  retroviral mediated gene transfer
References:  120
PPAR gamma KO : not viable (defects in placenta formation)
Tissue or cell type: 
Pathophysiology: 
Species:  Mouse
Technique:  Knockout
References:  2
PPAR gamma conditional KO in adipocytes: lipodystrophy (hypocellularity and hypertrophy),elevated plasma FFAs and TGs, decreased plasma leptin and adiponectin, insuline resistance in fat and liver
Tissue or cell type:  Adipose tissue
Pathophysiology:  lipodystrophy
Species:  Mouse
Technique:  Cre-loxP system
References:  48
PPAR gamma conditional KO in adipocytes: white and brown adipocytes are replaced by newly formed PPAR gamma positive adipocytes
Tissue or cell type:  Adipose tissue
Pathophysiology: 
Species:  Mouse
Technique:  tamoxifen-dependent Cre-ERT2 recombination
References:  40
PPAR gamma conditional KO in white adipocytes
Tissue or cell type: 
Pathophysiology:  Retarded growth, severe lipodystrophy (hypocellularity and hypertrophy) and hyperlipidemia
Species:  Mouse
Technique:  Cre-loxP system
References:  60
PPAR gamma conditional KO in muscle
Tissue or cell type:  Adipose tissue
Pathophysiology:  progressive insulin resistance combined with increased adipose tissue mass
Species:  Mouse
Technique:  Cre-loxP system
References:  44,78
PPAR gamma conditional KO in pancreatic beta cells:
Tissue or cell type:  pancreatic beta cells
Pathophysiology:  Significant islet hyperplasia on chow diet, blunted expansion of beta-cell mass
Species:  Mouse
Technique:  Cre-loxP system
References:  90
PPAR gamma heterozygous mice
Tissue or cell type: 
Pathophysiology:  reduced body size and weight, reduced insulin resistance, smaller adipocytes and fat depots
Species:  Mouse
Technique:  ablation of one allele
References:  61
Biologically Significant Variants
PPAR-gamma2;N-terminus carries 30 additional amino acids encoded by exon B PPAR-gamma2-specific, encoded by 7 exons
Protein accession:  NP_056953 
Amino acids:  505
Type:  Splice variant
Species:  Human
References:  29,36
PPAR-gamma3; gives rise to a protein indistinguishable from PPAR-gamma1 from a distinct promotor. Restricted expression, like PPAR-gamma2, to colon and adipose tissue in human
Protein accession:  NP_619725 
Amino acids:  505
Type:  Alternative promoters.
Species:  Human
References:  30
PPAR-gamma Isoform1; encoded by 8 exons (2 of them PPAR-gamma1-specific)
Protein accession:  NP_619725 
Amino acids:  477
Type:  Splice variant
Species:  Human
References:  29,36,127
gammaORF4: readthrough in intron 4, encoded protein lacks the LBD, dominant negative versus PPAR-gamma, expressed in tumor cell lines and tissues
Type:  Splice variant
Species:  Human
References:  92

REFERENCES

To cite this database page, please use the following:

1C. Peroxisome proliferator-activated receptors: Peroxisome proliferator-activated receptor-γ. Last modified on 15/11/2012. Accessed on 21/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=595.


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