Nomenclature: Retinoic acid receptor-α

Systematic Nomenclature: NR1B1

Family: 1B. Retinoic acid receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
Species AA Chromosomal Location Gene Symbol Gene Name Reference
Human 462 17q21.1 RARA retinoic acid receptor, alpha 49,55
Mouse 462 11D Rara retinoic acid receptor, alpha 40-41,49,70
Rat 459 10 Rara retinoic acid receptor, alpha 1,49
Previous and Unofficial Names
RAR
RARα
NR1B1
retinoic acid receptor alpha
retinoic acid receptor, alpha
RAR alpha 1
RARalpha1
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
NURSA Receptor
OMIM
Orphanet Gene
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  RAR-α ligand binding domain in complex with a corepressor - cocrystallised with inverse agonist
PDB Id:  3KMZ
Ligand:  BMS493
Resolution:  2.1Å
Species:  Human
References:  39
Image of receptor 3D structure from RCSB PDB
Description:  RAR-α complexed to a coactivate fragment-cocrystallised with RARα agonist
PDB Id:  3KMR
Ligand:  Ro 40-6055
Resolution:  1.8Å
Species:  Human
References:  39
Image of receptor 3D structure from RCSB PDB
Description:  Hetermeric complex (RAR-α and RXR-α Ligand-Binding Domains)-cocrystallised with RARα antagonist
PDB Id:  1DKF
Ligand:  BMS614
Resolution:  2.5Å
Species:  Human
References:  8
Natural/Endogenous Ligands
tretinoin
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
alitretinoin Hs Agonist 9.5 pKd 31,51
pKd 9.5 [31,51]
tretinoin Hs Agonist 9.4 pKd 2,32-33,51,65
pKd 9.4 [2,32-33,51,65]
AGN193836 Hs Agonist 8.4 pKd 5
pKd 8.4 [5]
Ro 40-6055 Hs Agonist 8.22 pKd 20
pKd 8.22 (Kd 6x10-9 M) [20]
CD666 Hs Agonist 5.65 pKd 6
pKd 5.65 [6]
BMS753 Hs Agonist 8.7 pKi 29
pKi 8.7 [29]
adapalene Hs Agonist 5.96 pKi 10
pKi 5.96 (Ki 1.1x10-6 M) [10]
Description: Binding affinity to RARα using [3H]CD 367 as radioligand.
tretinoin Hs Agonist 7.77 pEC50 11
pEC50 7.77 (EC50 1.7x10-8 M) [11]
tazarotene Hs Agonist 7.2 pEC50 11
pEC50 7.2 (EC50 6.3x10-8 M) [11]
TTNPB Hs Agonist 7.44 pIC50 32-33,51,65
pIC50 7.44 [32-33,51,65]
tamibarotene Hs Agonist 6.9 pIC50 31,51,65
pIC50 6.9 [31,51,65]
Agonist Comments
All-trans-retinoic acid is the most potent endogenous retinoid. The existence of 9-cis retinoic acid as natural bioactive retinoid remains to be established. Synthetic compounds (reported above) are not metabolized by CYP26. No significant species variation has been reported. The possibility of establishing a hydrogen bond between an amino group present in the linker of the identified RARα-selective agonists and the RARα-specific Ser232 is predicted to favour RARα selectivity.
Adapalene is selective for the β and γ RARs over the α isoform [10].
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
AGN193109 Hs Inverse agonist 8.7 pIC50 34-35,65
pIC50 8.7 [34-35,65]
BMS614 Hs Antagonist 8.7 pIC50 8,26,29
pIC50 8.7 [8,26,29]
BMS493 Hs Inverse agonist 8.4 pIC50 26
pIC50 8.4 [26]
Ro 41-5253 Hs Antagonist 6.34 – 7.22 pIC50 4,32
pIC50 6.34 – 7.22 [4,32]
Antagonist Comments
No significant species variation has been reported.
DNA Binding
Structure:  Heterodimer, RXR partner
HRE core sequence:  5’-PuG(G/T)TCA-3’
Response element:  DR1, DR2, DR5
DNA Binding Comments
The classical sequence is a 5-pb-spaced direct repeat (DR5). In DR5 and DR2 RXR occupies the 5' element, whereas RARa occupies the 3' one (5'-RXR-RARa-3'). In DR1 elements, the polarity of these elements is inverted (5'-RARa-RXR-3').
Co-binding Partners
Name Interaction Effect Reference
cyclin H/cdk7/TFIIH Physical, Functional TFIIH phosphorylates RARa1 in its A/B region (ser 77) by cdk7 subunit. 7,56-57
AP-1 Physical, Functional RAR inhibits AP-1 driven transactivation and AP-1 represses RAR-mediated transcription 13,36,52,62,71
CRABPII Physical, Functional Indispensable to RARα-mediated transcription from the RARα2 21
PARP-1 Physical, Functional Indispensable to RARα-mediated transcription from the RARα2 54
Main Co-regulators
Name Activity Specific Ligand dependent AF-2 dependent Comments References
NCOA1 Co-activator No Yes Yes A member of the p160 family 53,68
NCOR1 Co-repressor No No No Binding of an agonist to RARa causes NCoR dissociation 30,50
EP300 Co-activator No Yes Yes A common cointegrator 28
CREBBP Co-activator No Yes Yes A common cointegrator 28
MED1 Co-activator No Yes Yes A member of the DRIP/TRAP/SMCC complex 28,37,47
NCOA3 Co-activator No Yes Yes A member of the p160 family 12
NCOA2 Co-activator No Yes Yes A member of the p160 family 67
NCOR2 Co-repressor No No No Binding of an agonist to RARa causes SMRT dissociation 13,61,69
Main Target Genes
Name Species Effect Technique Comments References
RARB Human Activated Footprint, Transient transfection,ChIP,EMSA Activation is seen across all species including mouse and rat. Note: promoter harbors a DR5 element. 14,16,18,26
CYP26 Human Activated Footprint, Transient transfection,ChIP,EMSA CYP26 is also activated by RARa in mouse and rat. Note: promoter harbors a DR5 element. 45
Crabp2 Mouse Activated Transient transfection, EMSA Promoter harbors a DR2 element. 16,25
Hoxa1 Mouse Activated Promoter harbors a DR5 element. 16,24,38
Rbp1 Mouse Activated Transient transfection Promoter harbors a DR2 element. 16,63
Tissue Distribution
ubiquitous
Species:  Human
Technique:  in situ hybridisation, Northern Blot, Western blotting
References:  22-23,27,38,58-60,70
Tissue Distribution Comments
Ubiquitous distribution pattern of the Rarα1 is also reported in both the mouse and rat.
Functional Assays
Cellular proliferation assay
Species:  Human
Tissue:  MCF-7 breast cancer cell line
Response measured:  Inihibition of cell proliferation
References:  17
Induction of maturation of acute myeloid leukemia cell lines.
Species:  Human
Tissue:  Leukemia cell lines (NB4 , PLB985, U937, HL60)
Response measured:  Histological NBT reaction, and analysis of CD11c integrin expression by direct immunofluorescence.
References:  3,15,37,51
Cellular differentiation assay
Species:  Mouse
Tissue:  F9 murine embryonal carcinoma cell line.
Response measured:  Parietal endodermal differentiation in the presence of cAMP
References:  64
Physiological Consequences of Altering Gene Expression
RARα null mutant : - abnormalities (growth retardation; male sterility; impaired alveolar formation). - congenital defects (webbed digits; homeotic transformations and malformations of cervical vertebrae; pterygoquadrate cartilage; malformation of the squamosal bone).
Species:  Mouse
Tissue:  Various
Technique:  Knock-out by homologous recombination in embryonic stem cells
References:  43,46-48
Physiological Consequences of Altering Gene Expression Comments
Note that both the specific RARα1 null and RARα2 null mutants are apparently normal.
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas
MGI:97856  MP:0003235 abnormal alisphenoid bone morphology PMID: 9376317 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0003235 abnormal alisphenoid bone morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003235 abnormal alisphenoid bone morphology PMID: 9376317 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002747 abnormal aortic valve morphology PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002747 abnormal aortic valve morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002747 abnormal aortic valve morphology PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002257 abnormal arytenoid cartilage morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002257 abnormal arytenoid cartilage morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0002257 abnormal arytenoid cartilage morphology PMID: 9240560 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0002114 abnormal axial skeleton morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002114 abnormal axial skeleton morphology PMID: 9376317 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000079 abnormal basioccipital bone morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002672 abnormal branchial arch artery morphology PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002672 abnormal branchial arch artery morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002672 abnormal branchial arch artery morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002884 abnormal branchial arch morphology PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002264 abnormal bronchus morphology PMID: 7607068 
Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002264 abnormal bronchus morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002264 abnormal bronchus morphology PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002127 abnormal cardiovascular system morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002127 abnormal cardiovascular system morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002127 abnormal cardiovascular system morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000163 abnormal cartilage morphology PMID: 9240560 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0003048 abnormal cervical vertebrae morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003048 abnormal cervical vertebrae morphology PMID: 9376317 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010584 abnormal conotruncus septation PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002258 abnormal cricoid cartilage morphology PMID: 7607068 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas
MGI:97856  MP:0002258 abnormal cricoid cartilage morphology PMID: 9376317 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002258 abnormal cricoid cartilage morphology PMID: 7607068 
Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 7607068 
Rara+|Raratm1Ipc Raratm1Ipc/Rara+
involves: 129S2/SvPas
MGI:97856  MP:0002258 abnormal cricoid cartilage morphology PMID: 9376317 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002258 abnormal cricoid cartilage morphology PMID: 9376317 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0002258 abnormal cricoid cartilage morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002085 abnormal embryonic tissue morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000468 abnormal esophageal epithelium morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0001119 abnormal female reproductive system morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0001119 abnormal female reproductive system morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0008380 abnormal gonial bone morphology PMID: 9240560 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0005248 abnormal Harderian gland morphology PMID: 9376317 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas
MGI:97856  MP:0003056 abnormal hyoid bone morphology PMID: 9376317 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0003056 abnormal hyoid bone morphology PMID: 9376317 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0001076 abnormal hypoglossal nerve morphology PMID: 9240560 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas
MGI:97856  MP:0005106 abnormal incus morphology PMID: 9376317 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0005106 abnormal incus morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0005106 abnormal incus morphology PMID: 9376317 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0005106 abnormal incus morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0005106 abnormal incus morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0006063 abnormal inferior vena cava morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0008823 abnormal interventricular septum membranous part morphology PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0008823 abnormal interventricular septum membranous part morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0008823 abnormal interventricular septum membranous part morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000521 abnormal kidney cortex PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000521 abnormal kidney cortex PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000521 abnormal kidney cortex PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0000527 abnormal kidney development PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002265 abnormal left major bronchus morphology PMID: 7607068 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0003049 abnormal lumbar vertebrae morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003049 abnormal lumbar vertebrae morphology PMID: 9376317 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0001175 abnormal lung morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000678 abnormal parathyroid gland morphology PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0000678 abnormal parathyroid gland morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000678 abnormal parathyroid gland morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0000678 abnormal parathyroid gland morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000484 abnormal pulmonary artery morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000484 abnormal pulmonary artery morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0005325 abnormal renal glomerulus morphology PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0005325 abnormal renal glomerulus morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0005325 abnormal renal glomerulus morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002703 abnormal renal tubule morphology PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002703 abnormal renal tubule morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002703 abnormal renal tubule morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002132 abnormal respiratory system morphology PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002132 abnormal respiratory system morphology PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002132 abnormal respiratory system morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002132 abnormal respiratory system morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002132 abnormal respiratory system morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002266 abnormal right major bronchus morphology PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0005508 abnormal skeleton morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0005508 abnormal skeleton morphology PMID: 7607068 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97856  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Rara+|Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Rara+,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0005508 abnormal skeleton morphology PMID: 9240560 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97856  MP:0006380 abnormal spermatid morphology PMID: 15901285 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas
MGI:97856  MP:0001156 abnormal spermatogenesis PMID: 8394014 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97856  MP:0001932 abnormal spermiogenesis PMID: 15901285 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0004423 abnormal squamosal bone morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0004423 abnormal squamosal bone morphology PMID: 9376317 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97856  MP:0004423 abnormal squamosal bone morphology PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004423 abnormal squamosal bone morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004423 abnormal squamosal bone morphology PMID: 9240560 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0004665 abnormal stapedial artery morphology PMID: 9376317 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0005107 abnormal stapes morphology PMID: 9240560 
Rara+|Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Rara+,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000157 abnormal sternum morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000471 abnormal stomach epithelium morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0009527 abnormal sublingual duct morphology PMID: 9240560 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas
MGI:97856  MP:0001146 abnormal testis morphology PMID: 8394014 
Raratm3.1Ipc Raratm3.1Ipc/Raratm3.1Ipc
involves: 129/Sv * C57BL/6 * SJL
MGI:97856  MP:0001146 abnormal testis morphology PMID: 11857786 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0003047 abnormal thoracic vertebrae morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003047 abnormal thoracic vertebrae morphology PMID: 9376317 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000703 abnormal thymus morphology PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0000703 abnormal thymus morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000703 abnormal thymus morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002260 abnormal thyroid cartilage morphology PMID: 7607068 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas
MGI:97856  MP:0002260 abnormal thyroid cartilage morphology PMID: 9376317 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002260 abnormal thyroid cartilage morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002260 abnormal thyroid cartilage morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002260 abnormal thyroid cartilage morphology PMID: 7607068 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0002260 abnormal thyroid cartilage morphology PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002260 abnormal thyroid cartilage morphology PMID: 9376317 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97856  MP:0002260 abnormal thyroid cartilage morphology PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0002260 abnormal thyroid cartilage morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0002260 abnormal thyroid cartilage morphology PMID: 9240560 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0000681 abnormal thyroid gland morphology PMID: 7607068 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97856  MP:0003120 abnormal tracheal cartilage morphology PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003120 abnormal tracheal cartilage morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003120 abnormal tracheal cartilage morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003117 abnormal tracheal-esophageal septation PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002282 abnormal trachea morphology PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002282 abnormal trachea morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002282 abnormal trachea morphology PMID: 7607068 
Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002282 abnormal trachea morphology PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002282 abnormal trachea morphology PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0006032 abnormal ureteric bud morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000534 abnormal ureter morphology PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000534 abnormal ureter morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000534 abnormal ureter morphology PMID: 9240560 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0000516 abnormal urinary system morphology PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0001120 abnormal uterus morphology PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0001139 abnormal vagina morphology PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000137 abnormal vertebrae morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000137 abnormal vertebrae morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004599 abnormal vertebral arch morphology PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000159 abnormal xiphoid process PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0009054 absent anal canal PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0009054 absent anal canal PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0009072 absent cranial vagina PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0009072 absent cranial vagina PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0009072 absent cranial vagina PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010565 absent fetal ductus arteriosus PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0010565 absent fetal ductus arteriosus PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010565 absent fetal ductus arteriosus PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0000520 absent kidney PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0001181 absent lungs PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0006425 absent Mullerian ducts PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0006425 absent Mullerian ducts PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0003575 absent oviduct PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003575 absent oviduct PMID: 9240560 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003642 absent seminal vesicle PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004666 absent stapedial artery PMID: 9240560 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003722 absent ureter PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0003558 absent uterus PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003558 absent uterus PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0003558 absent uterus PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003558 absent uterus PMID: 9240560 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003557 absent vas deferens PMID: 7607068 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0004620 cervical vertebral fusion PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0004620 cervical vertebral fusion PMID: 9376317 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97856  MP:0004615 cervical vertebral transformation PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004615 cervical vertebral transformation PMID: 9240560 
Rara+|Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Rara+,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004615 cervical vertebral transformation PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004615 cervical vertebral transformation PMID: 9240560 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0000284 double outlet heart right ventricle PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002185 ectopia PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002185 ectopia PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002185 ectopia PMID: 7607068 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003007 ectopic thymus PMID: 9376317 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010728 fusion of atlas and occipital bones PMID: 9240560 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97856  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Rara+|Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Rara+,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010701 fusion of atlas and odontoid process PMID: 9240560 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97856  MP:0004613 fusion of vertebral arches PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004613 fusion of vertebral arches PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004613 fusion of vertebral arches PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003924 herniated diaphragm PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000519 hydronephrosis PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000519 hydronephrosis PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0000519 hydronephrosis PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000536 hydroureter PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0000536 hydroureter PMID: 7607068 
Rara+|Raratm3.1Ipc|Trim24tm1.1Los Raratm3.1Ipc/Rara+,Trim24tm1.1Los/Trim24tm1.1Los
involves: 129/Sv * C57BL/6 * SJL
MGI:109275  MGI:97856  MP:0003893 increased hepatocyte proliferation PMID: 18026104 
Raratm3Ipc|Tg(Alb-cre)21Mgn|Trim24tm1Los Raratm3Ipc/Raratm3Ipc,Tg(Alb-cre)21Mgn/?,Trim24tm1Los/Trim24tm1Los
involves: 129/Sv * C57BL/6 * DBA * SJL
MGI:109275  MGI:2176226  MGI:97856  MP:0003893 increased hepatocyte proliferation PMID: 18026104 
Rara+|Raratm3Ipc|Tg(Alb-cre)21Mgn|Trim24tm1Los Raratm3Ipc/Rara+,Tg(Alb-cre)21Mgn/?,Trim24tm1Los/Trim24tm1Los
involves: 129/Sv * C57BL/6 * DBA * SJL
MGI:109275  MGI:2176226  MGI:97856  MP:0003893 increased hepatocyte proliferation PMID: 18026104 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas
MGI:97856  MP:0000571 interdigital webbing PMID: 8394014 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97856  MP:0004616 lumbar vertebral transformation PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004616 lumbar vertebral transformation PMID: 9240560 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97856  MP:0008280 male germ cell apoptosis PMID: 15901285 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas
MGI:97856  MP:0001925 male infertility PMID: 8394014 
Raratm3.1Ipc Raratm3.1Ipc/Raratm3.1Ipc
involves: 129/Sv * C57BL/6 * SJL
MGI:97856  MP:0001925 male infertility PMID: 11857786 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97856  MP:0001925 male infertility PMID: 15901285 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97856  MP:0005287 narrow eye opening PMID: 9240560 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas
MGI:97856  MP:0002058 neonatal lethality PMID: 8394014 
Raratm2Ipc Raratm2Ipc/Raratm2Ipc
involves: 129S2/SvPas
MGI:97856  MP:0002169 no abnormal phenotype detected PMID: 8394014 
Raratm1Rev Raratm1Rev/Raratm1Rev
involves: 129S4/SvJae
MGI:97856  MP:0002169 no abnormal phenotype detected PMID: 7679509 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas
MGI:97856  MP:0002687 oligozoospermia PMID: 8394014 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97856  MP:0002687 oligozoospermia PMID: 15901285 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010418 perimembraneous ventricular septal defect PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010418 perimembraneous ventricular septal defect PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002081 perinatal lethality PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002081 perinatal lethality PMID: 7607068 
Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002081 perinatal lethality PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002081 perinatal lethality PMID: 7607068 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0002081 perinatal lethality PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002081 perinatal lethality PMID: 9376317 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0002081 perinatal lethality PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010711 persistent hyperplastic primary vitreous PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010572 persistent right dorsal aorta PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010572 persistent right dorsal aorta PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0010572 persistent right dorsal aorta PMID: 7607068 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002633 persistent truncus arteriosis PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002633 persistent truncus arteriosis PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0002633 persistent truncus arteriosis PMID: 7607068 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0002633 persistent truncus arteriosis PMID: 9376317 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0002633 persistent truncus arteriosis PMID: 9240560 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas
MGI:97856  MP:0001732 postnatal growth retardation PMID: 8394014 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas
MGI:97856  MP:0002083 premature death PMID: 8394014 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0002080 prenatal lethality PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0001178 pulmonary hypoplasia PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0001178 pulmonary hypoplasia PMID: 9240560 
Raratm1Ipc|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0003446 renal hypoplasia PMID: 7607068 
Raratm1Ipc|Rarb+|Rarbtm1Ipc Raratm1Ipc/Raratm1Ipc,Rarbtm1Ipc/Rarb+
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0003446 renal hypoplasia PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0003446 renal hypoplasia PMID: 7607068 
Rara+|Raratm1Ipc|Raratm2Ipc|Rargtm1Ipc Raratm2Ipc/Raratm2Ipc,Raratm1Ipc/Rara+,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003446 renal hypoplasia PMID: 7607068 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0003446 renal hypoplasia PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0003446 renal hypoplasia PMID: 9376317 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003446 renal hypoplasia PMID: 9240560 
Raratm1Ipc|Rargtm4Ipc Raratm1Ipc/Raratm1Ipc,Rargtm4Ipc/Rargtm4Ipc
involves: 129/Sv * 129S2/SvPas
MGI:97856  MGI:97858  MP:0004158 right aortic arch PMID: 9376317 
Raratm1Ipc|Rargtm2Ipc Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0004158 right aortic arch PMID: 9376317 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004158 right aortic arch PMID: 9240560 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0009076 rudimentary Mullerian ducts PMID: 7607068 
Raratm2Ipc|Rarbtm1Ipc Raratm2Ipc/Raratm2Ipc,Rarbtm1Ipc/Rarbtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97857  MP:0009076 rudimentary Mullerian ducts PMID: 7607068 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0009075 rudimentary Wolffian ducts PMID: 7607068 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas
MGI:97856  MP:0001154 seminiferous tubule degeneration PMID: 8394014 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010702 split cervical atlas PMID: 9240560 
Rara+|Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Rara+,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010703 split cervical axis PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010703 split cervical axis PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004687 split vertebrae PMID: 9240560 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97856  MP:0005578 teratozoospermia PMID: 15901285 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97856  MP:0004618 thoracic vertebral transformation PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0004618 thoracic vertebral transformation PMID: 9240560 
Raratm1Ipc|Rargtm1Ipc Raratm1Ipc/Raratm1Ipc,Rargtm1Ipc/Rargtm1Ipc
involves: 129S2/SvPas
MGI:97856  MGI:97858  MP:0010502 ventricle myocardium hypoplasia PMID: 7607068 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0010402 ventricular septal defect PMID: 9240560 
Raratm1Ipc Raratm1Ipc/Raratm1Ipc
involves: 129S2/SvPas * C57BL/6
MGI:97856  MP:0003036 vertebral transformation PMID: 9240560 
Raratm1Ipc|Rarb+|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarb+
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003036 vertebral transformation PMID: 9240560 
Raratm1Ipc|Rarbtm1Mma Raratm1Ipc/Raratm1Ipc,Rarbtm1Mma/Rarbtm1Mma
involves: 129S2/SvPas * C57BL/6
MGI:97856  MGI:97857  MP:0003036 vertebral transformation PMID: 9240560 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Acute promyelocytic leukemia (APL)
OMIM:  612376
Orphanet:  520
Role: 
Comments: 
References:  18-19,44
Mutations not determined
Biologically Significant Variants
Type:  Splice variant
Species:  Human
Description:  RARa1: retinoic acid receptor, alpha isoform 1:- The a1 isoform is transcribed from the promoter P1 and differs from a2 in the A domain. These two isforms exhibit distinct expression patterns. RARa1 is phosphorylated by cdk7/TFIIH (ser 77).
Amino acids:  462
Protein accession: 
References:  9,41,66
Type:  Splice variant
Species:  Human
Description:  RARa2: retinoic acid receptor, α isoform 2: - In contrast to the a1 isoform, a2 is transcribed from promoter (the downstream one, P2) that contains a DR5 and which is inducible by retinoid. The a2 isoform differs from a1 in the A domain.
Amino acids:  457
Protein accession: 
References:  41-42

REFERENCES

1. Akmal KM, Dufour JM, Kim KH. (1996) Region-specific localization of retinoic acid receptor-alpha expression in the rat epididymis. Biol. Reprod.54 (5): 1111-9. [PMID:8722633]

2. Allenby G, Bocquel MT, Saunders M, Kazmer S, Speck J, Rosenberger M, Lovey A, Kastner P, Grippo JF, Chambon P. (1993) Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc. Natl. Acad. Sci. U.S.A.90 (1): 30-4. [PMID:8380496]

3. Altucci L, Rossin A, Raffelsberger W, Reitmair A, Chomienne C, Gronemeyer H. (2001) Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL. Nat. Med.7 (6): 680-6. [PMID:11385504]

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