Nomenclature: Thyroid hormone receptor-β

Systematic Nomenclature: NR1A2

Family: 1A. Thyroid Hormone Receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
Species AA Chromosomal Location Gene Symbol Gene Name Reference
Human 461 3p24.1-p22 THRB thyroid hormone receptor, beta 27
Mouse 461 14 A3 Thrb thyroid hormone receptor beta 30
Rat 461 15p16 Thrb thyroid hormone receptor beta 26
Previous and Unofficial Names
THRB1
THRB2
THR1
ERBA-β
GRTH
TRβ
THRB
erbAβ
erbA2
PRTH
NR1A2
ERBA-BETA
thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2)
pituitary resistance to thyroid hormone
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2
oncogene ERBA2
generalized resistance to thyroid hormone
thyroid hormone receptor beta 1
C-erba-beta
RATT3REC
T3rec
TRbeta
TRbeta2Delta
Thyroid hormone receptor beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2)
c-erbA-2
nuclear receptor subfamily 1 group A member 2
thyroid hormone receptor beta
thyroid hormone receptor beta 3
thyroid hormone receptor beta2delta
T3R[b]
T3Rbeta
TR beta
c-erbAbeta
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
NURSA Receptor
OMIM
Orphanet Gene
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Thyroid hormone receptor-β (Ligand Binding Domain) - cocrystallised with agonist
PDB Id:  3JZC
Ligand:  tiratricol
Resolution:  2.5Å
Species:  Human
References:  17
Image of receptor 3D structure from RCSB PDB
Description:  Thyroid receptor beta - in complex with inhibitor of cofactor recruitment
PDB Id:  2PIN
Resolution:  2.3Å
Species:  Human
References:  6
Natural/Endogenous Ligands
T3
T4
Comments: T3 is the more potent endogenous ligand
Rank order of potency (Human)
T3 > T4
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
tiratricol Hs Agonist 10.7 pKd 21
pKd 10.7 [21]
GC-1 Hs Agonist 10.17 pKd 4,23
pKd 10.17 [4,23]
T3 Hs Agonist 10.1 pKd 20
pKd 10.1 [20]
rT3 Hs Agonist 7.34 pKd 21
pKd 7.34 [21]
KB-141 Hs Agonist 8.96 pIC50 10
pIC50 8.96 [10]
T4 Hs Agonist 8.52 pIC50 21
pIC50 8.52 [21]
dextrothyroxine Hs Agonist - - 2
[2]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
NH-3 Hs Antagonist 7.03 pKd 20
pKd 7.03 [20]
Antagonist Comments
NH-3 is relatively selective for TRa1 [20].
DNA Binding
Structure:  Homodimer, Heterodimer, RXR partner
HRE core sequence:  AGGTCA
Response element:  DR4, Palindrome
References:  5
DNA Binding Comments
Unlike TRα1, TRβ1 is unable to bind as monomer and can form more stable homodimers. For both receptors, RXR heterodimerization seems to be the favoured configuration, at least on DR4 [5]. The size of rat TRβ1 protein appears to be false when calculated from several genebank references.
Co-binding Partners
Name Interaction Effect Reference
RXR Physical, Functional DNA binding 5
Main Co-regulators
Name Activity Specific Ligand dependent AF-2 dependent Comments References
NCOA1 Co-activator No Yes Yes 18
NCOR1 Co-repressor No No No 12
NCOA3 Co-activator Yes Yes Yes 3
NCOA2 Co-activator No Yes Yes 16
Main Target Genes
Name Species Effect Technique Comments References
TshΒ Mouse Repressed Directed mutation studies THRB is expressed at higher level than THRA in TSH cells. 24
Dio1 Mouse Activated 31
Tissue Distribution
Brain, Heart, Liver
Species:  Human
Technique:  Northern blot, Q-PCR.
References:  13
Tissue Distribution Comments
Similar patterns of expression are seen in mice and rats [13].
Functional Assays
Liver response
Species:  Mouse
Tissue:  Liver
Response measured:  Type 1 deiodinase expression
References:  31
Xenopus tadpole metamorphosis
Species:  None
Tissue:  Intestine, brain, muscle, skin
Response measured:  Metamorphosis: body shape change, tail loss
References:  25
Physiological Consequences of Altering Gene Expression
Deafness, impaired colour perception and elevated T3 levels
Species:  None
Tissue:  Various
Technique:  Knockout
References:  1,7-9,19
Deafness, elevated T3 level, cerebellum development
Species:  None
Tissue:  Brain
Technique:  knock-in mutations
References:  11,14,24
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0002896 abnormal bone mineralization PMID: 12677005 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0002896 abnormal bone mineralization PMID: 17327419 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0003795 abnormal bone structure PMID: 17327419 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0000130 abnormal cancellous bone morphology PMID: 17327419 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac
MGI:98743  MP:0004039 abnormal cardiac cell glucose uptake PMID: 15304375 
Thrbtm2Few Thrbtm2Few/Thrbtm2Few
involves: 129X1/SvJ * C57BL/6
MGI:98743  MP:0000875 abnormal cerebellar Purkinje cell layer PMID: 11274423 
Thrb+|Thrbtm2Few Thrbtm2Few/Thrb+
involves: 129X1/SvJ * C57BL/6
MGI:98743  MP:0000875 abnormal cerebellar Purkinje cell layer PMID: 11274423 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0009780 abnormal chondrocyte physiology PMID: 17065405 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0005418 abnormal circulating hormone level PMID: 11069286 
Thrbtm3Few Thrbtm3Few/Thrbtm3Few
involves: 129 * C57BL/6
MGI:98743  MP:0000031 abnormal cochlea morphology PMID: 12925699 
Thrbtm4Few Thrbtm4Few/Thrbtm4Few
involves: 129 * C57BL/6
MGI:98743  MP:0000031 abnormal cochlea morphology PMID: 12925699 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98743  MP:0000031 abnormal cochlea morphology PMID: 12382103 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0004433 abnormal cochlear inner hair cell physiology PMID: 11739587  9861043 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0004433 abnormal cochlear inner hair cell physiology PMID: 11739587 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
B6.129S1-Thrb
MGI:98743  MP:0004433 abnormal cochlear inner hair cell physiology PMID: 11726557 
Tg(Pres-cre)1Jnz|Thrbtm1Df|Thrbtm1Mkni Thrbtm1Df/Thrbtm1Mkni,Tg(Pres-cre)1Jnz/0
involves: 129S1/Sv * C57BL/6J * FVB/NJ
MGI:3052547  MGI:98743  MP:0004433 abnormal cochlear inner hair cell physiology PMID: 19244534 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J * FVB/NJ
MGI:98743  MP:0004415 abnormal cochlear nerve compound action potential PMID: 19244534 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0004434 abnormal cochlear outer hair cell physiology PMID: 11739587 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0004434 abnormal cochlear outer hair cell physiology PMID: 11739587 
Thrbtm2Df Thrbtm2Df/Thrbtm2Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0004022 abnormal cone electrophysiology PMID: 11138006 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0000438 abnormal cranium morphology PMID: 12677005 
Thrbtm3Few Thrbtm3Few/Thrbtm3Few
involves: 129 * C57BL/6
MGI:98743  MP:0004736 abnormal distortion product otoacoustic emission PMID: 12925699 
Thrbtm4Few Thrbtm4Few/Thrbtm4Few
involves: 129 * C57BL/6
MGI:98743  MP:0004736 abnormal distortion product otoacoustic emission PMID: 12925699 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J * FVB/NJ
MGI:98743  MP:0004736 abnormal distortion product otoacoustic emission PMID: 19244534 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0006395 abnormal epiphyseal plate morphology PMID: 12677005 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0004197 abnormal fetal growth/weight/body size PMID: 12677005 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0000084 abnormal fontanelle morphology PMID: 12677005 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0000084 abnormal fontanelle morphology PMID: 17327419 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0002109 abnormal limb morphology PMID: 12677005 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0003055 abnormal long bone epiphyseal plate morphology PMID: 17327419 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0003055 abnormal long bone epiphyseal plate morphology PMID: 9927422 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0003662 abnormal long bone epiphyseal plate proliferative zone PMID: 12677005 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0000165 abnormal long bone hypertrophic chondrocyte zone PMID: 12677005 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0000042 abnormal organ of Corti PMID: 11739587 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0000042 abnormal organ of Corti PMID: 11739587 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98743  MP:0000042 abnormal organ of Corti PMID: 12382103 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0001541 abnormal osteoclast physiology PMID: 17327419 
Thrbtm3Few Thrbtm3Few/Thrbtm3Few
involves: 129 * C57BL/6
MGI:98743  MP:0003825 abnormal pillar cell morphology PMID: 12925699 
Thrbtm4Few Thrbtm4Few/Thrbtm4Few
involves: 129 * C57BL/6
MGI:98743  MP:0003825 abnormal pillar cell morphology PMID: 12925699 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0003825 abnormal pillar cell morphology PMID: 11739587 
Thrbtm3Few Thrbtm3Few/Thrbtm3Few
involves: 129 * C57BL/6
MGI:98743  MP:0005646 abnormal pituitary gland physiology PMID: 12925699 
Thrbtm4Few Thrbtm4Few/Thrbtm4Few
involves: 129 * C57BL/6
MGI:98743  MP:0005646 abnormal pituitary gland physiology PMID: 12925699 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0005646 abnormal pituitary gland physiology PMID: 11069286 
Thrb+|Thrbtm1.1Syc Thrbtm1.1Syc/Thrb+
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0005646 abnormal pituitary gland physiology PMID: 11069286 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0003965 abnormal pituitary hormone level PMID: 17210747 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MGI:98743  MP:0003965 abnormal pituitary hormone level PMID: 15601836 
Thra+|Thratm3Ven|Thrb+|Thrbtm1Df Thratm3Ven/Thra+,Thrbtm1Df/Thrb+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl
MGI:98742  MGI:98743  MP:0001731 abnormal postnatal growth PMID: 12356724 
Thrbtm2Few Thrbtm2Few/Thrbtm2Few
involves: 129X1/SvJ * C57BL/6
MGI:98743  MP:0000877 abnormal Purkinje cell morphology PMID: 11274423 
Thrb+|Thrbtm2Few Thrbtm2Few/Thrb+
involves: 129X1/SvJ * C57BL/6
MGI:98743  MP:0000877 abnormal Purkinje cell morphology PMID: 11274423 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 12576486  17327419 
Ncoa1tm1Bwo|Thrbtm1Olc Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thrbtm1Olc/Thrbtm1Olc
B6.129-Ncoa1 Thrb
MGI:1276523  MGI:98743  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 12576486 
Thrbtm2Df Thrbtm2Df/Thrbtm2Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0001006 abnormal retinal cone cell morphology PMID: 11138006 
Thrbtm3Few Thrbtm3Few/Thrbtm3Few
involves: 129 * C57BL/6
MGI:98743  MP:0001006 abnormal retinal cone cell morphology PMID: 12925699 
Thrbtm4Few Thrbtm4Few/Thrbtm4Few
involves: 129 * C57BL/6
MGI:98743  MP:0001006 abnormal retinal cone cell morphology PMID: 12925699 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0002113 abnormal skeleton development PMID: 12677005 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0002113 abnormal skeleton development PMID: 9927422 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0000496 abnormal small intestine morphology PMID: 9927422 
Thrbtm2Few Thrbtm2Few/Thrbtm2Few
involves: 129X1/SvJ * C57BL/6
MGI:98743  MP:0001463 abnormal spatial learning PMID: 11274423 
Thrb+|Thrbtm2Few Thrbtm2Few/Thrb+
involves: 129X1/SvJ * C57BL/6
MGI:98743  MP:0001463 abnormal spatial learning PMID: 11274423 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0002674 abnormal sperm motility PMID: 17210747 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0003149 abnormal tectorial membrane morphology PMID: 11739587 
Thrbtm4Few Thrbtm4Few/Thrbtm4Few
involves: 129 * C57BL/6
MGI:98743  MP:0003149 abnormal tectorial membrane morphology PMID: 12925699 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0003149 abnormal tectorial membrane morphology PMID: 11739587 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98743  MP:0003149 abnormal tectorial membrane morphology PMID: 12382103 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0004696 abnormal thyroid follicle morphology PMID: 8670802 
Thratm2Ven|Thrbtm1Df Thratm2Ven/Thratm2Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0004696 abnormal thyroid follicle morphology PMID: 11726557 
Thrb+|Thrbtm1.1Syc Thrbtm1.1Syc/Thrb+
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0004696 abnormal thyroid follicle morphology PMID: 11069286 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0004696 abnormal thyroid follicle morphology PMID: 9927422 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0004696 abnormal thyroid follicle morphology PMID: 9927422 
Thratm2Ven|Thrbtm1Df Thratm2Ven/Thratm2Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0005468 abnormal thyroid hormone level PMID: 11726557 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MGI:98743  MP:0005468 abnormal thyroid hormone level PMID: 15601836 
Thrbtm1Few Thrbtm1Few/Thrbtm1Few
involves: 129S4/SvJae
MGI:98743  MP:0002876 abnormal thyroid physiology PMID: 10430610 
Thrbtm4Few Thrbtm4Few/Thrbtm4Few
involves: 129 * C57BL/6
MGI:98743  MP:0004737 absent distortion product otoacoustic emissions PMID: 12925699 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
either: B6.129S1-Thrb or (involves: 129S1/Sv * C57BL/6J)
MGI:98743  MP:0001496 audiogenic seizures PMID: 11496110 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98743  MP:0004362 cochlear hair cell degeneration PMID: 12382103 
Thrbtm3Few Thrbtm3Few/Thrbtm3Few
involves: 129 * C57BL/6
MGI:98743  MP:0004404 cochlear outer hair cell degeneration PMID: 12925699 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0001967 deafness PMID: 8673137 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
either: B6.129S1-Thrb or (involves: 129S1/Sv * C57BL/6J)
MGI:98743  MP:0001967 deafness PMID: 11496110 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0001258 decreased body length PMID: 12677005 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0001265 decreased body size PMID: 11739587 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0001265 decreased body size PMID: 11069286  12677005 
Thra+|Thratm3Ven|Thrb+|Thrbtm1Df Thratm3Ven/Thra+,Thrbtm1Df/Thrb+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl
MGI:98742  MGI:98743  MP:0001262 decreased body weight PMID: 12356724 
Thra+|Thratm3Ven|Thrbtm1Df Thratm3Ven/Thra+,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl
MGI:98742  MGI:98743  MP:0001262 decreased body weight PMID: 12356724 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0001262 decreased body weight PMID: 17210747 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0001262 decreased body weight PMID: 17327419 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0001262 decreased body weight PMID: 9927422 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0004765 decreased brainstem auditory evoked potential PMID: 8673137  9861043 
Thrbtm3Few Thrbtm3Few/Thrbtm3Few
involves: 129 * C57BL/6
MGI:98743  MP:0004765 decreased brainstem auditory evoked potential PMID: 12925699 
Thrbtm4Few Thrbtm4Few/Thrbtm4Few
involves: 129 * C57BL/6
MGI:98743  MP:0004765 decreased brainstem auditory evoked potential PMID: 12925699 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0004765 decreased brainstem auditory evoked potential PMID: 11739587 
Thra+|Thratm1Ven|Thrbtm1Df Thratm1Ven/Thra+,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0004765 decreased brainstem auditory evoked potential PMID: 11739587 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
either: B6.129S1-Thrb or (involves: 129S1/Sv * C57BL/6J)
MGI:98743  MP:0004765 decreased brainstem auditory evoked potential PMID: 11496110 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
B6.129S1-Thrb
MGI:98743  MP:0004765 decreased brainstem auditory evoked potential PMID: 11726557 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98743  MP:0004765 decreased brainstem auditory evoked potential PMID: 12382103 
Tg(Pres-cre)1Jnz|Thrbtm1Df|Thrbtm1Mkni Thrbtm1Df/Thrbtm1Mkni,Tg(Pres-cre)1Jnz/0
involves: 129S1/Sv * C57BL/6J * FVB/NJ
MGI:3052547  MGI:98743  MP:0004765 decreased brainstem auditory evoked potential PMID: 19244534 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J * FVB/NJ
MGI:98743  MP:0004765 decreased brainstem auditory evoked potential PMID: 19244534 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0009346 decreased cancellous bone thickness PMID: 17327419 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0004701 decreased circulating insulin-like growth factor I level PMID: 17327419 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0005478 decreased circulating thyroxine level PMID: 8670802 
Thratm2Ven|Thrbtm1Df Thratm2Ven/Thratm2Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0005478 decreased circulating thyroxine level PMID: 11726557 
Thratm2Ven|Thrbtm1Df Thratm2Ven/Thratm2Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0005479 decreased circulating triiodothyronine level PMID: 11726557 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J * FVB/NJ
MGI:98743  MP:0004414 decreased cochlear microphonics PMID: 19244534 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0004437 decreased cochlear outer hair cell electromotility PMID: 11739587  9861043 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0004437 decreased cochlear outer hair cell electromotility PMID: 11739587 
Thrbtm4Few Thrbtm4Few/Thrbtm4Few
involves: 129 * C57BL/6
MGI:98743  MP:0004402 decreased cochlear outer hair cell number PMID: 12925699 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0000135 decreased cortical bone thickness PMID: 17327419 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0004411 decreased endocochlear potential PMID: 11739587 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0005130 decreased follicle stimulating hormone level PMID: 17210747 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0005136 decreased growth hormone level PMID: 17210747 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0006396 decreased long bone epiphyseal plate size PMID: 17327419 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0005132 decreased luteinizing hormone level PMID: 17210747 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0005138 decreased prolactin level PMID: 17210747 
Thrbtm2Few Thrbtm2Few/Thrbtm2Few
involves: 129X1/SvJ * C57BL/6
MGI:98743  MP:0000880 decreased Purkinje cell number PMID: 11274423 
Thrb+|Thrbtm2Few Thrbtm2Few/Thrb+
involves: 129X1/SvJ * C57BL/6
MGI:98743  MP:0000880 decreased Purkinje cell number PMID: 11274423 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0008142 decreased small intestinal villus size PMID: 9927422 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0004852 decreased testis weight PMID: 17210747 
Thrbtm4Few Thrbtm4Few/Thrbtm4Few
involves: 129 * C57BL/6
MGI:98743  MP:0004465 degeneration of organ of Corti supporting cells PMID: 12925699 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0004664 delayed inner ear development PMID: 11739587  8673137 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0004664 delayed inner ear development PMID: 11739587 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0000478 delayed intestine development PMID: 9927422 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98743  MP:0003150 detached tectorial membrane PMID: 12382103 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MGI:98743  MP:0000636 enlarged pituitary gland PMID: 15601836 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0004591 enlarged tectorial membrane PMID: 11739587 
Thrbtm3Few Thrbtm3Few/Thrbtm3Few
involves: 129 * C57BL/6
MGI:98743  MP:0004591 enlarged tectorial membrane PMID: 12925699 
Thrbtm4Few Thrbtm4Few/Thrbtm4Few
involves: 129 * C57BL/6
MGI:98743  MP:0004591 enlarged tectorial membrane PMID: 12925699 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0004591 enlarged tectorial membrane PMID: 11739587 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98743  MP:0004591 enlarged tectorial membrane PMID: 12382103 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J * FVB/NJ
MGI:98743  MP:0004591 enlarged tectorial membrane PMID: 19244534 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0005355 enlarged thyroid gland PMID: 8670802 
Thrbtm3Few Thrbtm3Few/Thrbtm3Few
involves: 129 * C57BL/6
MGI:98743  MP:0005355 enlarged thyroid gland PMID: 12925699 
Thrbtm4Few Thrbtm4Few/Thrbtm4Few
involves: 129 * C57BL/6
MGI:98743  MP:0005355 enlarged thyroid gland PMID: 12925699 
Thrbtm5Few Thrbtm5Few/Thrbtm5Few
involves: 129 * C57BL/6
MGI:98743  MP:0005355 enlarged thyroid gland PMID: 16100573 
Thrb+|Thrbtm5Few Thrbtm5Few/Thrb+
involves: 129 * C57BL/6
MGI:98743  MP:0005355 enlarged thyroid gland PMID: 16100573 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0005355 enlarged thyroid gland PMID: 11069286 
Thrb+|Thrbtm1.1Syc Thrbtm1.1Syc/Thrb+
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0005355 enlarged thyroid gland PMID: 11069286 
Thrbtm1.1Syc|Thrbtm1Df Thrbtm1Df/Thrbtm1.1Syc
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J
MGI:98743  MP:0005355 enlarged thyroid gland PMID: 15231697 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J
MGI:98743  MP:0005355 enlarged thyroid gland PMID: 15231697 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0001926 female infertility PMID: 11739587 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0001926 female infertility PMID: 11739587 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98743  MP:0006325 impaired hearing PMID: 12382103 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0003502 increased activity of thyroid PMID: 8670802 
Thrbtm3Few Thrbtm3Few/Thrbtm3Few
involves: 129 * C57BL/6
MGI:98743  MP:0003502 increased activity of thyroid PMID: 12925699 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0003502 increased activity of thyroid PMID: 17327419 
Thrbtm2Df Thrbtm2Df/Thrbtm2Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 11138006 
Thrbtm3Few Thrbtm3Few/Thrbtm3Few
involves: 129 * C57BL/6
MGI:98743  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 12925699 
Thrbtm4Few Thrbtm4Few/Thrbtm4Few
involves: 129 * C57BL/6
MGI:98743  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 12925699 
Thrbtm1Few Thrbtm1Few/Thrbtm1Few
involves: 129S4/SvJae
MGI:98743  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 10430610 
Thrbtm2Few Thrbtm2Few/Thrbtm2Few
involves: 129X1/SvJ * C57BL/6
MGI:98743  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 11274423 
Thrb+|Thrbtm2Few Thrbtm2Few/Thrb+
involves: 129X1/SvJ * C57BL/6
MGI:98743  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 11274423 
Thrbtm5Few Thrbtm5Few/Thrbtm5Few
involves: 129 * C57BL/6
MGI:98743  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 16100573 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 11069286 
Thrb+|Thrbtm1.1Syc Thrbtm1.1Syc/Thrb+
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 11069286 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MGI:98743  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 15601836 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:98742  MGI:98743  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 15601836 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 12576486  17327419  9927422 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 9927422 
Ncoa1tm1Bwo|Thrbtm1Olc Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thrbtm1Olc/Thrbtm1Olc
B6.129-Ncoa1 Thrb
MGI:1276523  MGI:98743  MP:0005122 increased circulating thyroid-stimulating hormone level PMID: 12576486 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0005477 increased circulating thyroxine level PMID: 8670802 
Thrbtm3Few Thrbtm3Few/Thrbtm3Few
involves: 129 * C57BL/6
MGI:98743  MP:0005477 increased circulating thyroxine level PMID: 12925699 
Thrbtm5Few Thrbtm5Few/Thrbtm5Few
involves: 129 * C57BL/6
MGI:98743  MP:0005477 increased circulating thyroxine level PMID: 16100573 
Thrb+|Thrbtm5Few Thrbtm5Few/Thrb+
involves: 129 * C57BL/6
MGI:98743  MP:0005477 increased circulating thyroxine level PMID: 16100573 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
either: B6.129S1-Thrb or (involves: 129S1/Sv * C57BL/6J)
MGI:98743  MP:0005477 increased circulating thyroxine level PMID: 11496110 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0005477 increased circulating thyroxine level PMID: 11069286  12677005 
Thrb+|Thrbtm1.1Syc Thrbtm1.1Syc/Thrb+
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0005477 increased circulating thyroxine level PMID: 11069286 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MGI:98743  MP:0005477 increased circulating thyroxine level PMID: 15601836 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:98742  MGI:98743  MP:0005477 increased circulating thyroxine level PMID: 15601836 
Thrbtm6.1Few Thrbtm6.1Few/Thrbtm6.1Few
involves: 129 * C57BL/6
MGI:98743  MP:0005477 increased circulating thyroxine level PMID: 19439650 
Thrb+|Thrbtm6.1Few Thrbtm6.1Few/Thrb+
involves: 129 * C57BL/6
MGI:98743  MP:0005477 increased circulating thyroxine level PMID: 19439650 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0005477 increased circulating thyroxine level PMID: 11159823  12576486  17327419  9927422 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0005477 increased circulating thyroxine level PMID: 9927422 
Ncoa1tm1Bwo|Thrbtm1Olc Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thrbtm1Olc/Thrbtm1Olc
B6.129-Ncoa1 Thrb
MGI:1276523  MGI:98743  MP:0005477 increased circulating thyroxine level PMID: 12576486 
Thrbtm2Df Thrbtm2Df/Thrbtm2Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0005480 increased circulating triiodothyronine level PMID: 11138006 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0005480 increased circulating triiodothyronine level PMID: 8670802 
Thrbtm3Few Thrbtm3Few/Thrbtm3Few
involves: 129 * C57BL/6
MGI:98743  MP:0005480 increased circulating triiodothyronine level PMID: 12925699 
Thrbtm5Few Thrbtm5Few/Thrbtm5Few
involves: 129 * C57BL/6
MGI:98743  MP:0005480 increased circulating triiodothyronine level PMID: 16100573 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
either: B6.129S1-Thrb or (involves: 129S1/Sv * C57BL/6J)
MGI:98743  MP:0005480 increased circulating triiodothyronine level PMID: 11496110 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0005480 increased circulating triiodothyronine level PMID: 11069286 
Thrb+|Thrbtm1.1Syc Thrbtm1.1Syc/Thrb+
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0005480 increased circulating triiodothyronine level PMID: 11069286 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MGI:98743  MP:0005480 increased circulating triiodothyronine level PMID: 15601836 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:98742  MGI:98743  MP:0005480 increased circulating triiodothyronine level PMID: 15601836 
Thrbtm6.1Few Thrbtm6.1Few/Thrbtm6.1Few
involves: 129 * C57BL/6
MGI:98743  MP:0005480 increased circulating triiodothyronine level PMID: 19439650 
Thrb+|Thrbtm6.1Few Thrbtm6.1Few/Thrb+
involves: 129 * C57BL/6
MGI:98743  MP:0005480 increased circulating triiodothyronine level PMID: 19439650 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0005480 increased circulating triiodothyronine level PMID: 12576486  9927422 
Ncoa1tm1Bwo|Thrbtm1Olc Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thrbtm1Olc/Thrbtm1Olc
B6.129-Ncoa1 Thrb
MGI:1276523  MGI:98743  MP:0005480 increased circulating triiodothyronine level PMID: 12576486 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0004148 increased cortical bone thickness PMID: 17327419 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0002626 increased heart rate PMID: 11159823 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0004984 increased osteoclast cell number PMID: 17327419 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MGI:98743  MP:0002041 increased pituitary adenoma incidence PMID: 15601836 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality PMID: 11739587 
Thrbtm1.1Syc|Thrbtm1Df Thrbtm1Df/Thrbtm1.1Syc
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J
MGI:98743  MP:0010346 increased thyroid carcinioma incidence PMID: 15231697 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J
MGI:98743  MP:0010346 increased thyroid carcinioma incidence PMID: 15231697 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0005135 increased thyroid-stimulating hormone level PMID: 8670802 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
B6.129-Thra Thrb
MGI:98742  MGI:98743  MP:0005135 increased thyroid-stimulating hormone level PMID: 17210747 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
either: B6.129S1-Thrb or (involves: 129S1/Sv * C57BL/6J)
MGI:98743  MP:0005135 increased thyroid-stimulating hormone level PMID: 11496110 
Thrbtm3Few Thrbtm3Few/Thrbtm3Few
involves: 129 * C57BL/6
MGI:98743  MP:0008337 increased thyrotroph cell number PMID: 12925699 
Thrbtm4Few Thrbtm4Few/Thrbtm4Few
involves: 129 * C57BL/6
MGI:98743  MP:0008337 increased thyrotroph cell number PMID: 12925699 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0008337 increased thyrotroph cell number PMID: 11069286 
Thrbtm1Few Thrbtm1Few/Thrbtm1Few
involves: 129S4/SvJae
MGI:98743  MP:0005470 increased thyroxine level PMID: 10430610 
Thrbtm2Few Thrbtm2Few/Thrbtm2Few
involves: 129X1/SvJ * C57BL/6
MGI:98743  MP:0005470 increased thyroxine level PMID: 11274423 
Thrb+|Thrbtm2Few Thrbtm2Few/Thrb+
involves: 129X1/SvJ * C57BL/6
MGI:98743  MP:0005470 increased thyroxine level PMID: 11274423 
Thrbtm1Few Thrbtm1Few/Thrbtm1Few
involves: 129S4/SvJae
MGI:98743  MP:0005474 increased triiodothyronine level PMID: 10430610 
Thrbtm2Few Thrbtm2Few/Thrbtm2Few
involves: 129X1/SvJ * C57BL/6
MGI:98743  MP:0005474 increased triiodothyronine level PMID: 11274423 
Thrb+|Thrbtm2Few Thrbtm2Few/Thrb+
involves: 129X1/SvJ * C57BL/6
MGI:98743  MP:0005474 increased triiodothyronine level PMID: 11274423 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0005474 increased triiodothyronine level PMID: 9927422 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98743  MP:0000043 organ of Corti degeneration PMID: 12382103 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0000066 osteoporosis PMID: 17327419 
Thratm2Ven|Thrbtm1Df Thratm2Ven/Thratm2Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0001732 postnatal growth retardation PMID: 11726557 
Thra+|Thratm2Ven|Thrbtm1Df Thratm2Ven/Thra+,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * BALB/c * C57BL/6J
MGI:98742  MGI:98743  MP:0001732 postnatal growth retardation PMID: 11726557 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0001732 postnatal growth retardation PMID: 11069286  12677005 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0001732 postnatal growth retardation PMID: 9927422 
Thra+|Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thra+,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0001732 postnatal growth retardation PMID: 9927422 
Thratm3Ven|Thrbtm1Df Thratm3Ven/Thratm3Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl
MGI:98742  MGI:98743  MP:0002082 postnatal lethality PMID: 12356724 
Thrbtm1.1Syc|Thrbtm1Df Thrbtm1Df/Thrbtm1.1Syc
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J
MGI:98743  MP:0002083 premature death PMID: 15231697 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J
MGI:98743  MP:0002083 premature death PMID: 15231697 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0002083 premature death PMID: 9927422 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0003417 premature endochondral bone ossification PMID: 12677005 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98743  MP:0003417 premature endochondral bone ossification PMID: 16051666 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0003417 premature endochondral bone ossification PMID: 17327419 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0003418 premature intramembranous bone ossification PMID: 12677005 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98743  MP:0003418 premature intramembranous bone ossification PMID: 16051666 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0000081 premature suture closure PMID: 12677005 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98743  MP:0000081 premature suture closure PMID: 16051666 
Thrbtm1.1Syc|Thrbtm1Df Thrbtm1Df/Thrbtm1.1Syc
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J
MGI:98743  MP:0001954 respiratory distress PMID: 15231697 
Thrbtm3Few Thrbtm3Few/Thrbtm3Few
involves: 129 * C57BL/6
MGI:98743  MP:0004740 sensorineural hearing loss PMID: 12925699 
Thrbtm4Few Thrbtm4Few/Thrbtm4Few
involves: 129 * C57BL/6
MGI:98743  MP:0004740 sensorineural hearing loss PMID: 12925699 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0004466 short cochlear outer hair cells PMID: 9861043 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0003109 short femur PMID: 11069286 
Thrb+|Thrbtm1.1Syc Thrbtm1.1Syc/Thrb+
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0003109 short femur PMID: 11069286 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0000547 short limbs PMID: 17327419 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0000592 short tail PMID: 17327419 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0002764 short tibia PMID: 11069286 
Thrb+|Thrbtm1.1Syc Thrbtm1.1Syc/Thrb+
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0002764 short tibia PMID: 11069286 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MGI:98743  MP:0002764 short tibia PMID: 16051666 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0002764 short tibia PMID: 17327419 
Thrbtm2Few Thrbtm2Few/Thrbtm2Few
involves: 129X1/SvJ * C57BL/6
MGI:98743  MP:0000852 small cerebellum PMID: 11274423 
Thrb+|Thrbtm2Few Thrbtm2Few/Thrb+
involves: 129X1/SvJ * C57BL/6
MGI:98743  MP:0000852 small cerebellum PMID: 11274423 
Thratm1Ven|Thrbtm1Df Thratm1Ven/Thratm1Ven,Thrbtm1Df/Thrbtm1Df
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:98742  MGI:98743  MP:0005361 small pituitary gland PMID: 15601836 
Thrbtm4Few Thrbtm4Few/Thrbtm4Few
involves: 129 * C57BL/6
MGI:98743  MP:0004864 spiral ligament degeneration PMID: 12925699 
Thrbtm2Few Thrbtm2Few/Thrbtm2Few
involves: 129X1/SvJ * C57BL/6
MGI:98743  MP:0000890 thin cerebellar molecular layer PMID: 11274423 
Thrb+|Thrbtm2Few Thrbtm2Few/Thrb+
involves: 129X1/SvJ * C57BL/6
MGI:98743  MP:0000890 thin cerebellar molecular layer PMID: 11274423 
Thrbtm1Df Thrbtm1Df/Thrbtm1Df
involves: 129S1/Sv * C57BL/6J
MGI:98743  MP:0003498 thyroid gland hyperplasia PMID: 8670802 
Thrbtm1.1Syc Thrbtm1.1Syc/Thrbtm1.1Syc
involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MGI:98743  MP:0003498 thyroid gland hyperplasia PMID: 11069286 
Thrbtm1Olc Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv
MGI:98743  MP:0003498 thyroid gland hyperplasia PMID: 9927422 
Thratm1Jas|Thrbtm1Olc Thratm1Jas/Thratm1Jas,Thrbtm1Olc/Thrbtm1Olc
involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MGI:98742  MGI:98743  MP:0003498 thyroid gland hyperplasia PMID: 9927422 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Resistance to thyroid hormone (RTH)
OMIM:  188570, 274300
Orphanet:  3221
Comments: 
References:  28
Mutations not determined
Disease:  Selective pituitary resistance to thyroid hormone
OMIM:  145650
Orphanet:  165994
References: 
Mutations not determined
Disease:  Peripheral resistance to thyroid hormones
Orphanet:  97927
References: 
Mutations not determined
Biologically Significant Variants
Type:  Splice variant
Species:  Rat
Description:  TRβ3: Alternative promoter usage and slicing
References:  29
Type:  Splice variant
Species:  Rat
Description:  TRδβ3: Alternative promoter usage and splicing.
References:  29
Type:  Splice variant
Species:  Human
Description:  TRβ2: Alternative promoter usage. Nterminal variant
Amino acids:  461
Protein accession: 
References:  15
Biologically Significant Variant Comments
The TRβ2 variant has also been observed in mouse and rat [22]

REFERENCES

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17. Martínez L, Nascimento AS, Nunes FM, Phillips K, Aparicio R, Dias SM, Figueira AC, Lin JH, Nguyen P, Apriletti JW, Neves FA, Baxter JD, Webb P, Skaf MS, Polikarpov I. (2009) Gaining ligand selectivity in thyroid hormone receptors via entropy. Proc. Natl. Acad. Sci. U.S.A., . [PMID:19926848]

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To cite this database page, please use the following:

1A. Thyroid Hormone Receptors: Thyroid hormone receptor-β. Last modified on 13/12/2013. Accessed on 30/08/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=589.

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