Nomenclature: Nav1.7

Family: Voltage-gated sodium channels

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing. 

Contents

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 24 1 1977 2q24 SCN9A sodium channel, voltage-gated, type IX, alpha subunit 43
Mouse 24 1 1975 2 C1.3 Scn9a sodium channel, voltage-gated, type IX, alpha 2,44
Rat 24 1 1984 3q21 Scn9a sodium channel, voltage-gated, type IX, alpha 54,60
Previous and Unofficial Names
PN1
hNE-Na
Nas
Nav1.7
NaS
NE-NA
NENA
ETHA
sodium channel, voltage-gated, type IX, alpha polypeptide
Scn2a
peripheral sodium channel 1
sodium channel protein type 9 subunit alpha
sodium channel protein type IX subunit alpha
sodium channel type IX alpha polypeptide
sodium channel voltage-gated type IX alpha polypeptide
sodium channel, voltage-gated, type 9, alpha polypeptide
sodium channel, voltage-gated, type IX, alpha
voltage-gated sodium channel subunit alpha Nav1.7
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
Orphanet Gene
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Associated Proteins
Heteromeric Pore-forming Subunits
Name References
Not determined
Auxiliary Subunits
Name References
β2 26,40
β1 28,39,48
Other Associated Proteins
Name References
Not determined
Functional Characteristics
Fast inactivation (0.5 ms)
Ion Selectivity and Conductance
Species:  Rat
Rank order:  Na+ [- pS]
References:  53
Species:  Rat
Single channel conductance (pS):  19.5
References:  53
Voltage Dependence
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -24.6 - 17 HEK 293 cells. Human
Inactivation  -73.6 1.0 17
Comments  This is a human channel with a TTX resistant mutation (Y362S).
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -27.3 0.1 9 Nav1.8 null mouse DRG neurons. Human
Inactivation  -71.3 1.0 9
Comments  Human channel with a TTX resistant mutation (Y362S), kinetics measured at 10mV.
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -25.6 – -27.9 (median: -26.0) - 9,61 Xenopus laevis oocyte Rat
Inactivation  -61.9 – -68.4 (median: -67.0) 1.0 – 429.0 9,61
Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
batrachotoxin Hs - - - - -
veratridine Hs - - - - -
Gating inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
N-Me-aminopyrimidinone 9 Hs Inhibition 7.1 pIC50 - - 51
pIC50 7.1 (IC50 8x10-8 M) [51]
Description: Electrophysiology
Gating Inhibitor Comments
Scorpion toxins are known inhibitors of Nav1.7 for example the α-scorpion toxins (Odonthobuthus doriae) [47] and other scopion toxins (Lqh-2 and Lqh-3) [5].
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
tetrodotoxin Hs - - - 4x10-9 -
Conc range: 4x10-9 M
XEN907 Hs Inhibition 8.52 pIC50 - - 14
pIC50 8.52 (IC50 3x10-9 M) [14]
Description: [14C]guanidinium influx
tetrodotoxin Rn Antagonist 8.4 pIC50 - -100.0 54
pIC50 8.4 [54]
Holding voltage: -100.0 mV
tetrodotoxin Hs Antagonist 7.6 pIC50 - -100.0 43
pIC50 7.6 [43]
Holding voltage: -100.0 mV
pyrrolopyrimidine 48 Hs Inhibition 6.96 pIC50 - - 4
pIC50 6.96 (IC50 1.1x10-7 M) [4]
Description: Electrophysiology
lacosamide Hs Antagonist 3.74 pIC50 - - 55
pIC50 3.74 (IC50 1.82x10-4 M) [55]
lidocaine Rn Antagonist 3.3 pIC50 - -100.0 9
pIC50 3.3 [9]
Holding voltage: -100.0 mV
Cd2+ Hs Antagonist 3.0 pIC50 - -100.0 43
pIC50 3.0 [43]
Holding voltage: -100.0 mV
saxitoxin Hs - - - - -
View species-specific channel blocker tables
Tissue Distribution
All types of DRG neurons, sympathetic neurons, Schwann cells and neuroendocrine cells.
Species:  Rat
Technique:  In situ hybridisation
References:  29
All types of DRG neurons, sympathetic neurons, Schwann cells and neuroendorcrine cells.
Species:  Rat
Technique:  Northern Blot
References:  43
All types of DRG neurons, sympathetic neurons, Schwann cells and neuroendocrine cells.
Species:  Rat
Technique:  RT-PCR
References:  54
Physiological Consequences of Altering Gene Expression
Epilepsy
Species:  Mouse
Tissue: 
Technique:  Knock-in of N641Y
References:  57
Minett et al. suggest that NaV1.7 in sympathetic ganglion neurons is essential for neuropathic pain
Species:  Mouse
Tissue:  DRG-neuron, sympathetic ganglion neurons
Technique:  Cell type-specific knockout
References:  50
NaV1.7 is essential for heat pain after burning injuries
Species:  Mouse
Tissue:  DRG neurons
Technique:  Knockout
References:  56
Phenotypes, Alleles and Disease Models Mouse data from MGI

Show »

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Scn9atm1.1Naas Scn9atm1.1Naas/Scn9atm1.1Naas
B6.129-Scn9a
MGI:107636  MP:0001499 abnormal kindling response PMID: 19763161 
Scn10a+|Scn10atm2(cre)Jnw|Scn9atm1Jnw Scn10atm2(cre)Jnw/Scn10a+,Scn9atm1Jnw/Scn9atm1Jnw
involves: 129
MGI:107636  MGI:108029  MP:0002736 abnormal nociception after inflammation PMID: 15314237 
Scn10a+|Scn10atm2(cre)Jnw|Scn9atm1Jnw Scn10atm2(cre)Jnw/Scn10a+,Scn9atm1Jnw/Scn9atm1Jnw
involves: 129
MGI:107636  MGI:108029  MP:0001970 abnormal pain threshold PMID: 15314237 
Scn9atm1.1Naas Scn9atm1.1Naas/Scn9atm1.1Naas
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MGI:107636  MP:0001650 abnormal seizure response to electrical stimulation PMID: 19763161 
Scn9a+|Scn9atm1Dgen Scn9atm1Dgen/Scn9a+
involves: 129P2/OlaHsd * C57BL/6
MGI:107636  MP:0009141 increased prepulse inhibition
Scn10a+|Scn10atm2(cre)Jnw|Scn9atm1Jnw Scn10atm2(cre)Jnw/Scn10a+,Scn9atm1Jnw/Scn9atm1Jnw
involves: 129
MGI:107636  MGI:108029  MP:0001973 increased thermal nociceptive threshold PMID: 15314237 
Scn9atm1.1Naas Scn9atm1.1Naas/Scn9atm1.1Naas
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MGI:107636  MP:0002193 minimal clonic seizures PMID: 19763161 
Scn9atm1.1Jnw Scn9atm1.1Jnw/Scn9atm1.1Jnw
involves: 129
MGI:107636  MP:0002058 neonatal lethality PMID: 15314237 
Scn9atm1Dgen Scn9atm1Dgen/Scn9atm1Dgen
involves: 129P2/OlaHsd * C57BL/6
MGI:107636  MP:0002081 perinatal lethality
Clinically-Relevant Mutations and Pathophysiology
Disease:  Erythermalgia
OMIM:  133020
Orphanet:  90026, 1956, 306577
Role: 
References:  12,15,18,20,49,62-63
Click column headers to sort
Type Species Molecular location Description Reference
Missense Human F1449V 20
Missense Human A863P 37
Missense Human L858F 21,36
Missense Human P610T 21
Missense Human N395K 21
Missense Human F216S 12,21
Missense Human S241T 46,49
Missense Human I848T 17,21
Missense Human G823R 45
Missense Human Del-955 6
Missense Human L858H 17
Missense Human A1632E 23
Missense Human M1136V 7
Missense Human Q10R 33
Missense Human V400M 31
Missense Human V872G 13
Missense Human G616R 11
Missense Human P1308L 8
Missense Human S241P 22
Missense Human I234T 1
Disease:  Congenital inability to experience pain
OMIM:  243000
Orphanet:  88642
Role: 
References:  16,32
Click column headers to sort
Type Species Molecular location Description Reference
Compound mutation Human C1719R & IVS17+3delA 58
Truncation Human W897X 16
Truncation Human K767X 16
Truncation Human S459X 16
Truncation Human Y328X 32
Truncation Human R277X 32
Disease:  Paroxysmal Extreme Pain Disorder (PEPD)
OMIM:  167400
Orphanet:  46348
Role: 
References:  3,10,30
Click column headers to sort
Type Species Molecular location Description Reference
Missense Human T1464I 30
Missense Human F1462V 30
Missense Human V1298D 30
Missense Human R996C 30
Missense Human M1627K 19,30
Missense Human I1461T 30,41-42
Missense Human V1299F 30,59
Missense Human V1298F 8,30
Missense Human G1607R 10
Disease:  Epilepsy, generalized, with febrile seizures plus, type 7; GEFSP7
OMIM:  613863
Orphanet:  36387
References: 
Mutations not determined
Disease:  Febrile seizures
OMIM:  613863
References: 
Click column headers to sort
Type Species Molecular location Description Reference
Missense Human N461Y 57
Disease:  Small-Fiber Peripheral Neuropathy
OMIM:  133020
Orphanet:  118525
References: 
Click column headers to sort
Type Species Molecular location Description Reference
Missense Human D623N 27
Missense Human I720K 27
Missense Human M932L/V991L 27
Missense Human M1532I 27
Missense Human I739V 34
Missense Human I228M 24
Missense Human R185H 35
Disease:  Acromesomelia (small hands and feet) and painful neuropathy
References: 
Click column headers to sort
Type Species Molecular location Description Reference
Missense Human G856D 38
Disease:  Human SNP that increases sensitivity to pain
References: 
Click column headers to sort
Type Species Molecular location Description Reference
Missense Human R1150W 25,52
Disease:  Dravet syndrome
OMIM:  607208
Orphanet:  33069
References: 
Mutations not determined
Disease:  Hereditary sensory and autonomic neuropathy type 2
Orphanet:  970
References:  64
Mutations not determined

REFERENCES

1. Ahn HS, Dib-Hajj SD, Cox JJ, Tyrrell L, Elmslie FV, Clarke AA, Drenth JP, Woods CG, Waxman SG. (2010) A new Nav1.7 sodium channel mutation I234T in a child with severe pain. Eur J Pain14 (9): 944-50. [PMID:20385509]

2. Beckers MC, Ernst E, Belcher S, Howe J, Levenson R, Gros P. (1996) A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2. Genomics36 (1): 202-5. [PMID:8812438]

3. Catterall WA, Yu FH. (2006) Painful channels. Neuron52 (5): 743-4. [PMID:17145494]

4. Chakka N, Bregman H, Du B, Nguyen HN, Buchanan JL, Feric E, Ligutti J, Liu D, McDermott JS, Zou A et al.. (2012) Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Na(v)1.7 antagonists. Bioorg. Med. Chem. Lett.22 (5): 2052-62. [PMID:22318156]

5. Chen H, Lu S, Leipold E, Gordon D, Hansel A, Heinemann SH. (2002) Differential sensitivity of sodium channels from the central and peripheral nervous system to the scorpion toxins Lqh-2 and Lqh-3. Eur. J. Neurosci.16 (4): 767-70. [PMID:12270053]

6. Cheng X, Dib-Hajj SD, Tyrrell L, Te Morsche RH, Drenth JP, Waxman SG. (2011) Deletion mutation of sodium channel Na(V)1.7 in inherited erythromelalgia: enhanced slow inactivation modulates dorsal root ganglion neuron hyperexcitability. Brain134 (Pt 7): 1972-86. [PMID:21705421]

7. Cheng X, Dib-Hajj SD, Tyrrell L, Waxman SG. (2008) Mutation I136V alters electrophysiological properties of the Na(v)1.7 channel in a family with onset of erythromelalgia in the second decade. Mol Pain4: 1. [PMID:18171466]

8. Cheng X, Dib-Hajj SD, Tyrrell L, Wright DA, Fischer TZ, Waxman SG. (2010) Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel Na V 1.7 produce distinct pain disorders. Mol Pain6: 24. [PMID:20429905]

9. Chevrier P, Vijayaragavan K, Chahine M. (2004) Differential modulation of Nav1.7 and Nav1.8 peripheral nerve sodium channels by the local anesthetic lidocaine. Br. J. Pharmacol.142 (3): 576-84. [PMID:15148257]

10. Choi JS, Boralevi F, Brissaud O, Sánchez-Martín J, Te Morsche RH, Dib-Hajj SD, Drenth JP, Waxman SG. (2011) Paroxysmal extreme pain disorder: a molecular lesion of peripheral neurons. Nat Rev Neurol7 (1): 51-5. [PMID:21079636]

11. Choi JS, Cheng X, Foster E, Leffler A, Tyrrell L, Te Morsche RH, Eastman EM, Jansen HJ, Huehne K, Nau C et al.. (2010) Alternative splicing may contribute to time-dependent manifestation of inherited erythromelalgia. Brain133 (Pt 6): 1823-35. [PMID:20478850]

12. Choi JS, Dib-Hajj SD, Waxman SG. (2006) Inherited erythermalgia: limb pain from an S4 charge-neutral Na channelopathy. Neurology67 (9): 1563-7. [PMID:16988069]

13. Choi JS, Zhang L, Dib-Hajj SD, Han C, Tyrrell L, Lin Z, Wang X, Yang Y, Waxman SG. (2009) Mexiletine-responsive erythromelalgia due to a new Na(v)1.7 mutation showing use-dependent current fall-off. Exp. Neurol.216 (2): 383-9. [PMID:19162012]

14. Chowdhury S, Chafeev M, Liu S, Sun J, Raina V, Chui R, Young W, Kwan R, Fu J, Cadieux JA. (2011) Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain. Bioorg. Med. Chem. Lett.21 (12): 3676-81. [PMID:21570288]

15. Coulter DA, Rafiq A, Shumate M, Gong QZ, DeLorenzo RJ, Lyeth BG. (1996) Brain injury-induced enhanced limbic epileptogenesis: anatomical and physiological parallels to an animal model of temporal lobe epilepsy. Epilepsy Res.26 (1): 81-91. [PMID:8985690]

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17. Cummins TR, Dib-Hajj SD, Waxman SG. (2004) Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy. J. Neurosci.24 (38): 8232-6. [PMID:15385606]

18. Dib-Hajj SD, Cummins TR, Black JA, Waxman SG. (2010) Sodium channels in normal and pathological pain. Annu. Rev. Neurosci.33: 325-47. [PMID:20367448]

19. Dib-Hajj SD, Estacion M, Jarecki BW, Tyrrell L, Fischer TZ, Lawden M, Cummins TR, Waxman SG. (2008) Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable. Mol Pain4: 37. [PMID:18803825]

20. Dib-Hajj SD, Rush AM, Cummins TR, Hisama FM, Novella S, Tyrrell L, Marshall L, Waxman SG. (2005) Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons. Brain128 (Pt 8): 1847-54. [PMID:15958509]

21. Drenth JP, te Morsche RH, Guillet G, Taieb A, Kirby RL, Jansen JB. (2005) SCN9A mutations define primary erythermalgia as a neuropathic disorder of voltage gated sodium channels. J. Invest. Dermatol.124 (6): 1333-8. [PMID:15955112]

22. Estacion M, Choi JS, Eastman EM, Lin Z, Li Y, Tyrrell L, Yang Y, Dib-Hajj SD, Waxman SG. (2010) Can robots patch-clamp as well as humans? Characterization of a novel sodium channel mutation. J. Physiol. (Lond.)588 (Pt 11): 1915-27. [PMID:20123784]

23. Estacion M, Dib-Hajj SD, Benke PJ, Te Morsche RH, Eastman EM, Macala LJ, Drenth JP, Waxman SG. (2008) NaV1.7 gain-of-function mutations as a continuum: A1632E displays physiological changes associated with erythromelalgia and paroxysmal extreme pain disorder mutations and produces symptoms of both disorders. J. Neurosci.28 (43): 11079-88. [PMID:18945915]

24. Estacion M, Han C, Choi JS, Hoeijmakers JG, Lauria G, Drenth JP, Gerrits MM, Dib-Hajj SD, Faber CG, Merkies IS et al.. (2011) Intra- and interfamily phenotypic diversity in pain syndromes associated with a gain-of-function variant of NaV1.7. Mol Pain7: 92. [PMID:22136189]

25. Estacion M, Harty TP, Choi JS, Tyrrell L, Dib-Hajj SD, Waxman SG. (2009) A sodium channel gene SCN9A polymorphism that increases nociceptor excitability. Ann. Neurol.66 (6): 862-6. [PMID:20033988]

26. Eubanks J, Srinivasan J, Dinulos MB, Disteche CM, Catterall WA. (1997) Structure and chromosomal localization of the beta2 subunit of the human brain sodium channel. Neuroreport8 (12): 2775-9. [PMID:9295116]

27. Faber CG, Hoeijmakers JG, Ahn HS, Cheng X, Han C, Choi JS, Estacion M, Lauria G, Vanhoutte EK, Gerrits MM et al.. (2012) Gain of function Naν1.7 mutations in idiopathic small fiber neuropathy. Ann. Neurol.71 (1): 26-39. [PMID:21698661]

28. Farmer C, Cox JJ, Fletcher EV, Woods CG, Wood JN, Schorge S. (2012) Splice variants of Na(V)1.7 sodium channels have distinct β subunit-dependent biophysical properties. PLoS ONE7 (7): e41750. [PMID:22911851]

29. Felts PA, Yokoyama S, Dib-Hajj S, Black JA, Waxman SG. (1997) Sodium channel alpha-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system. Brain Res. Mol. Brain Res.45 (1): 71-82. [PMID:9105672]

30. Fertleman CR, Baker MD, Parker KA, Moffatt S, Elmslie FV, Abrahamsen B, Ostman J, Klugbauer N, Wood JN, Gardiner RM, Rees M. (2006) SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes. Neuron52 (5): 767-74. [PMID:17145499]

31. Fischer TZ, Gilmore ES, Estacion M, Eastman E, Taylor S, Melanson M, Dib-Hajj SD, Waxman SG. (2009) A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia. Ann. Neurol.65 (6): 733-41. [PMID:19557861]

32. Goldberg YP, MacFarlane J, MacDonald ML, Thompson J, Dube MP, Mattice M, Fraser R, Young C, Hossain S, Pape T, Payne B, Radomski C, Donaldson G, Ives E, Cox J, Younghusband HB, Green R, Duff A, Boltshauser E, Grinspan GA, Dimon JH, Sibley BG, Andria G, Toscano E, Kerdraon J, Bowsher D, Pimstone SN, Samuels ME, Sherrington R, Hayden MR. (2007) Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations. Clin. Genet.71 (4): 311-9. [PMID:17470132]

33. Han C, Dib-Hajj SD, Lin Z, Li Y, Eastman EM, Tyrrell L, Cao X, Yang Y, Waxman SG. (2009) Early- and late-onset inherited erythromelalgia: genotype-phenotype correlation. Brain132 (Pt 7): 1711-22. [PMID:19369487]

34. Han C, Hoeijmakers JG, Ahn HS, Zhao P, Shah P, Lauria G, Gerrits MM, te Morsche RH, Dib-Hajj SD, Drenth JP et al.. (2012) Nav1.7-related small fiber neuropathy: impaired slow-inactivation and DRG neuron hyperexcitability. Neurology78 (21): 1635-43. [PMID:22539570]

35. Han C, Hoeijmakers JG, Liu S, Gerrits MM, te Morsche RH, Lauria G, Dib-Hajj SD, Drenth JP, Faber CG, Merkies IS et al.. (2012) Functional profiles of SCN9A variants in dorsal root ganglion neurons and superior cervical ganglion neurons correlate with autonomic symptoms in small fibre neuropathy. Brain135 (Pt 9): 2613-28. [PMID:22826602]

36. Han C, Rush AM, Dib-Hajj SD, Li S, Xu Z, Wang Y, Tyrrell L, Wang X, Yang Y, Waxman SG. (2006) Sporadic onset of erythermalgia: a gain-of-function mutation in Nav1.7. Ann. Neurol.59 (3): 553-8. [PMID:16392115]

37. Harty TP, Dib-Hajj SD, Tyrrell L, Blackman R, Hisama FM, Rose JB, Waxman SG. (2006) Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons. J. Neurosci.26 (48): 12566-75. [PMID:17135418]

38. Hoeijmakers JG, Han C, Merkies IS, Macala LJ, Lauria G, Gerrits MM, Dib-Hajj SD, Faber CG, Waxman SG. (2012) Small nerve fibres, small hands and small feet: a new syndrome of pain, dysautonomia and acromesomelia in a kindred with a novel NaV1.7 mutation. Brain135 (Pt 2): 345-58. [PMID:22286749]

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41. Jarecki BW, Sheets PL, Jackson JO, Cummins TR. (2008) Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation. J. Physiol. (Lond.)586 (Pt 17): 4137-53. [PMID:18599537]

42. Jarecki BW, Sheets PL, Xiao Y, Jackson JO, Cummins TR. (2009) Alternative splicing of Na(V)1.7 exon 5 increases the impact of the painful PEPD mutant channel I1461T. Channels (Austin)3 (4): 259-67. [PMID:19633428]

43. Klugbauer N, Lacinova L, Flockerzi V, Hofmann F. (1995) Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells. EMBO J.14 (6): 1084-90. [PMID:7720699]

44. Kozak CA, Sangameswaran L. (1996) Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse. Mamm. Genome7 (10): 787-8. [PMID:8854872]

45. Lampert A, Dib-Hajj SD, Eastman EM, Tyrrell L, Lin Z, Yang Y, Waxman SG. (2009) Erythromelalgia mutation L823R shifts activation and inactivation of threshold sodium channel Nav1.7 to hyperpolarized potentials. Biochem. Biophys. Res. Commun.390 (2): 319-24. [PMID:19800314]

46. Lampert A, Dib-Hajj SD, Tyrrell L, Waxman SG. (2006) Size matters: Erythromelalgia mutation S241T in Nav1.7 alters channel gating. J. Biol. Chem.281 (47): 36029-35. [PMID:17008310]

47. Maertens C, Cuypers E, Amininasab M, Jalali A, Vatanpour H, Tytgat J. (2006) Potent modulation of the voltage-gated sodium channel Nav1.7 by OD1, a toxin from the scorpion Odonthobuthus doriae. Mol. Pharmacol.70 (1): 405-14. [PMID:16641312]

48. McClatchey AI, Cannon SC, Slaugenhaupt SA, Gusella JF. (1993) The cloning and expression of a sodium channel beta 1-subunit cDNA from human brain. Hum. Mol. Genet.2 (6): 745-9. [PMID:8394762]

49. Michiels JJ, te Morsche RH, Jansen JB, Drenth JP. (2005) Autosomal dominant erythermalgia associated with a novel mutation in the voltage-gated sodium channel alpha subunit Nav1.7. Arch. Neurol.62 (10): 1587-90. [PMID:16216943]

50. Minett MS, Nassar MA, Clark AK, Passmore G, Dickenson AH, Wang F, Malcangio M, Wood JN. (2012) Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons. Nat Commun3: 791. [PMID:22531176]

51. Nguyen HN, Bregman H, Buchanan JL, Du B, Feric E, Huang L, Li X, Ligutti J, Liu D, Malmberg AB et al.. (2012) Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists. Bioorg. Med. Chem. Lett.22 (2): 1055-60. [PMID:22209205]

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To cite this database page, please use the following:

William A. Catterall, Alan L. Goldin, Stephen G. Waxman.
Voltage-gated sodium channels: Nav1.7. Last modified on 27/05/2014. Accessed on 02/10/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=584.

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