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Kv8.2
Family: Voltage-gated potassium channels
| Gene and Protein Information |
| Species |
TM |
P Loops |
AA |
Chromosomal Location |
Gene Symbol |
Gene Name |
Reference |
| Human |
6 |
1 |
545 |
9p24.2 |
KCNV2
|
potassium channel, subfamily V, member 2
|
2 |
| Mouse |
6 |
1 |
562 |
19 C1 |
Kcnv2
|
potassium channel, subfamily V, member 2
|
2 |
| Rat |
6 |
1 |
561 |
1q51 |
Kcnv2
|
potassium channel, subfamily V, member 2
|
2 |
| Previous and Unofficial Names |
| kv11.1 |
| Kv8.2 |
| Kcnv2_predicted |
| LOC294065 |
| potassium channel, subfamily V, member 2 |
| potassium channel, subfamily V, member 2 (predicted) |
| potassium voltage-gated channel subfamily V member 2 |
| KV11.1 |
| Database Links |
|
Ensembl
|
ENSG00000168263 (Hs), ENSMUSG00000047298 (Mm), ENSRNOG00000012566 (Rn)
|
|
Entrez Gene
|
169522 (Hs), 240595 (Mm), 294065 (Rn)
|
|
GeneCards
|
KCNV2 (Hs)
|
|
GenitoUrinary Development Molecular Anatomy Project
|
Kcnv2 (Mm)
|
|
HomoloGene
|
26423 (Hs)
|
|
Human Protein Reference Database
|
12126 (Hs)
|
|
InterPro
|
Q8TDN2 (Hs), Q8CFS6 (Mm)
|
|
KEGG Gene
|
hsa:169522 (Hs), mmu:240595 (Mm), rno:294065 (Rn)
|
|
OMIM
|
607604 (Hs)
|
|
Orphanet Gene
|
ORPHA159360 (Hs)
|
|
PharmGKB Gene
|
PA134992655 (Hs)
|
|
PhosphoSitePlus
|
Q8TDN2 (Hs), Q8CFS6 (Mm)
|
|
Protein Ontology (PRO)
|
PRO:000000726 (Hs)
|
|
RefSeq Nucleotide
|
NM_133497 (Hs), NM_183179 (Mm), NM_001106370 (Rn)
|
|
RefSeq Protein
|
NP_598004 (Hs), NP_899002 (Mm), NP_001099840 (Rn)
|
|
TreeFam
|
ENSG00000168263 (Hs), ENSMUSG00000047298 (Mm), ENSRNOG00000012566 (Rn)
|
|
UniGene Hs.
|
660831 (Hs)
|
|
UniProt
|
Q8TDN2 (Hs), Q8CFS6 (Mm)
|
|
Wikipedia
|
Kv8.2
|
|
Potassium channels
|
| Search for 3D structures on the PDB |
|
Search by keyword:
Voltage-gated potassium channels Kv8.2
|
Search by accession number: Q8CFS6, Q8TDN2
|
| Associated Proteins |
| Heteromeric Pore-forming Subunits |
| Name |
References |
| Kv2 |
1-3 |
|
| Auxiliary Subunits |
| Name |
References |
| Not determined |
|
| Other Associated Proteins |
| Name |
References |
| Not determined |
|
| Ion Selectivity and Conductance Comments |
| Kv8.2 is not functional on its own. |
| Tissue Distribution
|
| Pancreas, testis > lung, liver, kidney, spleen, thymus, prostate, ovary |
| Species: |
Human |
| Technique: |
RT-PCR |
| References: |
2 |
|
|
| Functional Assays
|
| Molecular clone, electrophysiology, voltage clamp |
| Species: |
Human |
| Tissue: |
Xenopus laevis oocytes |
| Response measured: |
No expression of K+ currents |
| References: |
1-3 |
|
|
| Physiological Functions
|
| Regulation of membrane potential and action potential frequency by modulation of delayed rectifier potassium currents. Kv8.2 modulates the activity of Kv2.1channels by causing small changes in activationthreshold and kinetics and in C-type activation. |
| Species: |
Human |
| Tissue: |
Pulmonary artery smooth muscle cells (PASMC) |
| References: |
1 |
|
|
| Clinically-Relevant Mutations and Pathophysiology
|
| Disease: |
Retinal cone dystrophy 3B; RCD3B |
| OMIM: |
610356 |
| Orphanet: |
209932 |
| References: |
|
|
|
Mutations not determined
|
|
| Gene Expression and Pathophysiology
|
| A decrease in mRNA transcription. |
| Tissue or cell type: |
Normal pulmonary artery smooth muscle cells (PASMC) |
| Pathophysiology: |
Bone morphogenetic proteins (BMP's) significantly downregulated ( > 10-fold) KCNV2. |
| Species: |
Human |
| Technique: |
RT-PCR |
| References: |
1 |
|
|
|
General Comments
|
|
Kv8.2 has no function on its own, but it has important modulatory actions on Kv2 channels.
|
REFERENCES
Show »« Hide
1. Fantozzi, I; Platoshyn, O; Wong, AH; Zhang, S; Remillard, CV; Furtado, MR; Petrauskene, OV; Yuan, JX. (2006) Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells.
Am. J. Physiol. Lung Cell Mol. Physiol., 291 (5): L993-1004.
[PMID:16815889]
2. Ottschytsch, N; Raes, A; Van Hoorick, D; Snyders, DJ. (2002) Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome.
Proc. Natl. Acad. Sci. U.S.A., 99 (12): 7986-91.
[PMID:12060745]
3. Wu, H; Cowing, JA; Michaelides, M; Wilkie, SE; Jeffery, G; Jenkins, SA; Mester, V; Bird, AC; Robson, AG; Holder, GE; Moore, AT; Hunt, DM; Webster, AR. (2006) Mutations in the gene KCNV2 encoding a voltage-gated potassium channel subunit cause "cone dystrophy with supernormal rod electroretinogram" in humans.
Am. J. Hum. Genet., 79 (3): 574-9.
[PMID:16909397]
To cite this database page, please use the following:
K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Voltage-gated potassium channels: Kv8.2. Last modified on 23/01/2012. Accessed on 20/06/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=566.
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