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Kv6.4
Family: Voltage-gated potassium channels
| Gene and Protein Information |
| Species |
TM |
P Loops |
AA |
Chromosomal Location |
Gene Symbol |
Gene Name |
Reference |
| Human |
6 |
1 |
519 |
16q24.1 |
KCNG4
|
potassium voltage-gated channel, subfamily G, member 4
|
|
| Mouse |
6 |
1 |
506 |
8 E1 |
Kcng4
|
potassium voltage-gated channel, subfamily G, member 4
|
|
| Rat |
6 |
1 |
506 |
19q12 |
Kcng4
|
potassium voltage-gated channel, subfamily G, member 4
|
|
| Previous and Unofficial Names |
| 4921535I01Rik |
| AW049024 |
| kv6.3 |
| MGC129609 |
| MGC4558 |
| Kv6.4 |
| Kcng4_predicted |
| LOC307900 |
| potassium voltage-gated channel subfamily G member 4 |
| potassium voltage-gated channel, subfamily G, member 4 |
| potassium voltage-gated channel, subfamily G, member 4 (predicted) |
| KV6.3 |
| Database Links |
|
Ensembl
|
ENSG00000168418 (Hs), ENSMUSG00000045246 (Mm), ENSRNOG00000015746 (Rn)
|
|
Entrez Gene
|
93107 (Hs), 66733 (Mm), 307900 (Rn)
|
|
GeneCards
|
KCNG4 (Hs)
|
|
GenitoUrinary Development Molecular Anatomy Project
|
Kcng4 (Mm)
|
|
HomoloGene
|
23553 (Hs)
|
|
Human Protein Reference Database
|
16253 (Hs)
|
|
InterPro
|
Q8TDN1 (Hs), Q80XM3 (Mm)
|
|
KEGG Gene
|
hsa:93107 (Hs), mmu:66733 (Mm), rno:307900 (Rn)
|
|
OMIM
|
607603 (Hs)
|
|
PharmGKB Gene
|
PA134989953 (Hs)
|
|
PhosphoSitePlus
|
Q8TDN1 (Hs), Q80XM3 (Mm)
|
|
Protein Ontology (PRO)
|
PRO:000000789 (Hs)
|
|
RefSeq Nucleotide
|
NM_172347 (Hs), NM_025734 (Mm), NM_001107435 (Rn)
|
|
RefSeq Protein
|
NP_758857 (Hs), NP_080010 (Mm), NP_001100905 (Rn)
|
|
TreeFam
|
ENSG00000168418 (Hs), ENSMUSG00000045246 (Mm), ENSRNOG00000015746 (Rn)
|
|
UniGene Hs.
|
335877 (Hs)
|
|
UniProt
|
Q8TDN1 (Hs), Q80XM3 (Mm)
|
|
Wikipedia
|
Kv6.4
|
|
Potassium channels
|
| Search for 3D structures on the PDB |
|
Search by keyword:
Voltage-gated potassium channels Kv6.4
|
Search by accession number: Q80XM3, Q8TDN1
|
| Ion Selectivity and Conductance |
| Species: |
None |
| Macroscopic current rectification: |
Modifiers/ Silencer |
| References: |
|
|
| Tissue Distribution
|
| Brain, liver, small intestine, colon |
| Species: |
Human |
| Technique: |
RT-PCR |
| References: |
2 |
|
|
| Functional Assays
|
| Molecular clone, patch clamp, yeast two-hybrid and co-immunoprecipitation |
| Species: |
Human |
| Tissue: |
Ltk- cells (murine fibroblast cell line) |
| Response measured: |
Kv6.4 are "silent" subunits and form heterotetrameric channels with the Kv2 subfamily |
| References: |
2 |
|
|
| Physiological Functions
|
Regulation of membrane potential and action potential frequency by modulation of delayed rectifier potassium currents.
It modulates the activity of Kv2.1 channels by causing marked changes in activation threshold and kinetics, C-type inactivation, and deactivation. |
| Species: |
Human |
| Tissue: |
Ltk- cells |
| References: |
2 |
|
|
| Biologically Significant Variants
|
| Kv6.4 has no function on its own, but it has important modulatory actions on Kv2 channels |
| Nucleotide accession: |
NM_172347
|
| Protein accession: |
NP_758857
|
| Amino acids: |
519 |
| Type: |
Splice variant |
| Species: |
Human |
| References: |
1 |
|
|
| Biologically Significant Variant Comments |
| This variant has questionable validity because it originates from a cancer celline [1] :
RNA sequence: NM_133490
Protein sequence: NP_597997
Amino acids: 256
Type: Splice variant
Species: Human
|
|
General Comments
|
|
Kv6.4 has no function on its own, but has important modulatory actions on Kv2 channels.
|
REFERENCES
Show »« Hide
1. Gutman, GA; Chandy, KG; Grissmer, S; Lazdunski, M; McKinnon, D; Pardo, LA; Robertson, GA; Rudy, B; Sanguinetti, MC; Stühmer, W; Wang, X. (2005) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.
Pharmacol. Rev., 57 (4): 473-508.
[PMID:16382104]
2. Ottschytsch, N; Raes, A; Van Hoorick, D; Snyders, DJ. (2002) Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome.
Proc. Natl. Acad. Sci. U.S.A., 99 (12): 7986-91.
[PMID:12060745]
To cite this database page, please use the following:
K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Voltage-gated potassium channels: Kv6.4. Last modified on 01/07/2010. Accessed on 22/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=559.
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