Nomenclature: Kv6.4

Family: Voltage-gated potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 519 16q24.1 KCNG4 potassium voltage-gated channel, subfamily G, member 4
Mouse 6 1 506 8 E1 Kcng4 potassium voltage-gated channel, subfamily G, member 4
Rat 6 1 506 19q12 Kcng4 potassium voltage-gated channel, subfamily G, member 4
Previous and Unofficial Names
4921535I01Rik
AW049024
kv6.3
MGC129609
MGC4558
Kv6.4
Kcng4_predicted
LOC307900
potassium voltage-gated channel subfamily G member 4
potassium voltage-gated channel, subfamily G, member 4
potassium voltage-gated channel, subfamily G, member 4 (predicted)
KV6.3
Database Links
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Ion Selectivity and Conductance
Species:  None
Macroscopic current rectification:  Modifiers/ Silencer
References: 
Tissue Distribution
Brain, liver, small intestine, colon
Species:  Human
Technique:  RT-PCR
References:  2
Functional Assays
Molecular clone, patch clamp, yeast two-hybrid and co-immunoprecipitation
Species:  Human
Tissue:  Ltk- cells (murine fibroblast cell line)
Response measured:  Kv6.4 are "silent" subunits and form heterotetrameric channels with the Kv2 subfamily
References:  2
Physiological Functions
Regulation of membrane potential and action potential frequency by modulation of delayed rectifier potassium currents.
It modulates the activity of Kv2.1 channels by causing marked changes in activation threshold and kinetics, C-type inactivation, and deactivation.
Species:  Human
Tissue:  Ltk- cells
References:  2
Biologically Significant Variants
Type:  Splice variant
Species:  Human
Description:  Kv6.4 has no function on its own, but it has important modulatory actions on Kv2 channels
Amino acids:  519
Nucleotide accession: 
Protein accession: 
References:  1
Biologically Significant Variant Comments
This variant has questionable validity because it originates from a cancer celline [1] :
  • RNA sequence: NM_133490
  • Protein sequence: NP_597997
  • Amino acids: 256
  • Type: Splice variant
  • Species: Human
  • General Comments
    Kv6.4 has no function on its own, but has important modulatory actions on Kv2 channels.

    REFERENCES

    1. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X. (2005) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol. Rev.57 (4): 473-508. [PMID:16382104]

    2. Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ. (2002) Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. Proc. Natl. Acad. Sci. U.S.A.99 (12): 7986-91. [PMID:12060745]

    To cite this database page, please use the following:

    K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
    Voltage-gated potassium channels: Kv6.4. Last modified on 01/07/2010. Accessed on 24/07/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=559.

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