image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Kv3.1

Family: Voltage-gated potassium channels

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Ion Selectivity and Conductance
Voltage Dependence
Gating Inhibitors
Pore Blockers
Tissue Distribution
Functional Assays
Physiological Functions
Phenotypes, Alleles and Disease Models
Clinically-Relevant Mutations and Pathophysiology
Gene Expression and Pathophysiology
Biologically Significant Variants
General Comments
References
Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 511 11p15 KCNC1 potassium voltage-gated channel, Shaw-related subfamily, member 1
Mouse 6 1 511 7 B4 Kcnc1 potassium voltage gated channel, Shaw-related subfamily, member 1
Rat 6 1 585 1q22 Kcnc1 potassium voltage gated channel, Shaw-related subfamily, member 1 21
Previous and Unofficial Names
Kv3.1
NGK2
KV4
KShIIIB
Raw2
C230009H10Rik
Kcr2-1
Shaw
MGC129855
NGK2-KV4
potassium channel gene 1
potassium voltage gated channel, Shaw-related subfamily, member 1
potassium voltage-gated channel subfamily C member 1
voltage-gated potassium channel subunit Kv3.1
voltage-gated potassium channel subunit Kv4
Database Links
ChEMBL Target 100115 (Hs)
Ensembl ENSG00000129159 (Hs), ENSMUSG00000058975 (Mm), ENSRNOG00000011380 (Rn)
Entrez Gene 3746 (Hs), 16502 (Mm), 25327 (Rn)
GeneCards KCNC1 (Hs)
GenitoUrinary Development Molecular Anatomy Project Kcnc1 (Mm)
HomoloGene 68134 (Hs)
Human Protein Reference Database 15936 (Hs)
InterPro P48547 (Hs), P15388 (Mm), P25122 (Rn)
KEGG Gene hsa:3746 (Hs), mmu:16502 (Mm), rno:25327 (Rn)
OMIM 176258 (Hs)
PharmGKB Gene PA30026 (Hs)
PhosphoSitePlus P48547 (Hs), P15388 (Mm), P25122 (Rn)
Protein Ontology (PRO) PRO:000000781 (Hs)
RefSeq Nucleotide NM_004976 (Hs), NM_008421 (Mm), NM_001112739 (Mm), NM_012856 (Rn), NM_139217 (Rn)
RefSeq Protein NP_004967 (Hs), NP_001106210 (Mm), NP_032447 (Mm), NP_631963 (Rn), NP_036988 (Rn)
TreeFam ENSG00000129159 (Hs), ENSMUSG00000058975 (Mm), ENSRNOG00000011380 (Rn)
UniGene Hs. 552896 (Hs)
UniProt P48547 (Hs), P15388 (Mm), P25122 (Rn)
Wikipedia Kv3.1
Potassium channels
Search for 3D structures on the PDB
Search by keyword: Voltage-gated potassium channels Kv3.1 Search by accession number: P25122, P15388, P48547
Ion Selectivity and Conductance
Species:  Mouse
Rank order:  K+ [27.0 pS] > Rb+ [25.0 pS] > Cs+ [2.7 pS] = NH4+ [2.7 pS] > Na+ [0.1 pS]
References:  3-4,7,27-28
Species:  Mouse
Macroscopic current rectification:  Delayed Rectifier Current
References:  3,27
Voltage Dependence
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  16.0 - 8 L929 Mouse
Inactivation  - -
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  - - Xenopus laevis Oocytes Rat
Inactivation  - 9800.0 18
Comments  U-type inactivation also makes a major but previously unrecognised contribution to slow inactivation of Shaker [18]
Gating inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Affinity Units Concentration range (M) Holding voltage (mV) Reference
fluoxetine Rn 6.1 pIC50 - - 1
norfluoxetine Rn 4.9 pIC50 - - 1
Pore Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Affinity Units Concentration range (M) Holding voltage (mV) Reference
4-aminopyridine Mm 4.5 pIC50 - - 8
resiniferatoxin Mm 4.3 pIC50 - - 8
diltiazem Mm 4.0 pIC50 - - 8
flecainide Mm 4.0 pIC50 - - 8
nifedipine Mm 3.9 pIC50 - - 8
capsaicin Mm 3.8 pIC50 - - 8
tetraethylammonium Mm 3.7 pIC50 - - 8
cromakalim Mm 3.6 pIC50 - - 8
Tissue Distribution
SH-SY5Y cell line, human Louckes B cells
Species:  Human
Technique:  RT-PCR
References:  25
Anterior pituitary cells (AtT20)
Species:  Mouse
Technique:  In situ hybridisation, RT-PCR
References:  9,22
Brain (MNTB neurons > dorsal cochlear nucleus (DCN), ventral posterior cochlear nucleus (VCP), cerebellum, granule cells, Purkinje cells
Species:  Mouse
Technique:  In situ hybridisation
References:  31
Mouse Lung Fibroblasts (MLF)
Species:  Mouse
Technique:  Electrophysiology
References:  29
Testis, germ cell, pancreatic islets alpha cells
Species:  Mouse
Technique:  RT-PCR
References:  6
Brain (cerebellum > globus pallidus, subthalamic nucleus, substantia nigra > reticular thalamic nuclei, cortical and hippocampal interneurons > inferior colliculi, cochlear and vestibular nuclei, nucleus tractus solitarii, striatal GABA-ergic neurons)
Species:  Rat
Technique:  Immunohistochemistry
References:  2,15,19,32
Skeletal muscle
Species:  Rat
Technique:  In situ hybridisation, northern blot
References:  33
Functional Assays
Gene cloning and voltage clamp
Species:  Human
Tissue:  NIH 3T3 fibroblasts
Response measured:  Threshold of activation at approximately -10mV, showed little inactivation. It is sensitive to blockade by 4-AP and TEA, and appears to have two gating behaviours.
References:  16-17
Physiological Functions
Important for the high-firing frequency of neurons
Species:  Rat
Tissue:  Cortical neurons, globus pallidus
References:  10,22
Fast-spiking GABAergic interneurons
Species:  Mouse
Tissue:  AtT20 cells (anterior pituitary derived)
References:  9
Regulation of action potential duration in presynaptic terminals
Species:  Rat
Tissue:  Presynaptic terminals
References:  12,23,26
Kv3 potassium channels control the duration of different arousal states by distinct stochastic and clock-like mechanisms
Species:  Mouse
Tissue:  Brain
References:  13
Phenotypes, Alleles and Disease Models Mouse data from MGI

Click here to show/hide data

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Kcnc1tm1Joho|Kcnc3tm1Echa Kcnc1tm1Joho/Kcnc1tm1Joho,Kcnc3tm1Echa/Kcnc3tm1Echa
involves: 129/Sv * C57BL/6		 MGI:96667  MGI:96669  MP:0001393 ataxia PMID: 11517255 
Kcnc1tm1Joho|Kcnc3tm1Echa Kcnc1tm1Joho/Kcnc1tm1Joho,Kcnc3tm1Echa/Kcnc3tm1Echa
involves: 129/Sv * C57BL/6		 MGI:96667  MGI:96669  MP:0001265 decreased body size PMID: 11517255 
Kcnc1tm1Joho|Kcnc3tm1Echa Kcnc1tm1Joho/Kcnc1tm1Joho,Kcnc3tm1Echa/Kcnc3tm1Echa
involves: 129/Sv * C57BL/6		 MGI:96667  MGI:96669  MP:0005534 decreased body temperature PMID: 11517255 
Kcnc1tm1Joho|Kcnc3tm1Echa Kcnc1tm1Joho/Kcnc1tm1Joho,Kcnc3tm1Echa/Kcnc3tm1Echa
involves: 129/Sv * C57BL/6		 MGI:96667  MGI:96669  MP:0001262 decreased body weight PMID: 11517255 
Kcnc1+|Kcnc1tm1Joho|Kcnc3+|Kcnc3tm1Echa Kcnc1tm1Joho/Kcnc1+,Kcnc3tm1Echa/Kcnc3+
involves: 129/Sv * C57BL/6		 MGI:96667  MGI:96669  MP:0001262 decreased body weight PMID: 11517255 
Kcnc1tm1Joho|Kcnc3tm1Echa Kcnc1tm1Joho/Kcnc1tm1Joho,Kcnc3tm1Echa/Kcnc3tm1Echa
involves: 129/Sv * C57BL/6		 MGI:96667  MGI:96669  MP:0009751 enhanced behavioral response to alcohol PMID: 11517255 
Kcnc1tm1Joho|Kcnc3tm1Echa Kcnc1tm1Joho/Kcnc1tm1Joho,Kcnc3tm1Echa/Kcnc3tm1Echa
involves: 129/Sv * C57BL/6		 MGI:96667  MGI:96669  MP:0001399 hyperactivity PMID: 11517255 
Kcnc1+|Kcnc1tm1Joho|Kcnc3+|Kcnc3tm1Echa Kcnc1tm1Joho/Kcnc1+,Kcnc3tm1Echa/Kcnc3+
involves: 129/Sv * C57BL/6		 MGI:96667  MGI:96669  MP:0001399 hyperactivity PMID: 11517255 
Kcnc1tm1Joho|Kcnc3tm1Echa Kcnc1tm1Joho/Kcnc1tm1Joho,Kcnc3tm1Echa/Kcnc3tm1Echa
involves: 129/Sv * C57BL/6		 MGI:96667  MGI:96669  MP:0001525 impaired balance PMID: 11517255 
Kcnc1tm1Joho|Kcnc3tm1Echa Kcnc1tm1Joho/Kcnc1tm1Joho,Kcnc3tm1Echa/Kcnc3tm1Echa
involves: 129/Sv * C57BL/6		 MGI:96667  MGI:96669  MP:0001405 impaired coordination PMID: 11517255 
Kcnc1tm1Joho|Kcnc3tm1Echa Kcnc1tm1Joho/Kcnc1tm1Joho,Kcnc3tm1Echa/Kcnc3tm1Echa
involves: 129/Sv * C57BL/6		 MGI:96667  MGI:96669  MP:0001415 increased exploration in new environment PMID: 11517255 
Kcnc1+|Kcnc1tm1Joho|Kcnc3+|Kcnc3tm1Echa Kcnc1tm1Joho/Kcnc1+,Kcnc3tm1Echa/Kcnc3+
involves: 129/Sv * C57BL/6		 MGI:96667  MGI:96669  MP:0001415 increased exploration in new environment PMID: 11517255 
Kcnc1tm1Joho|Kcnc3tm1Echa Kcnc1tm1Joho/Kcnc1tm1Joho,Kcnc3tm1Echa/Kcnc3tm1Echa
involves: 129/Sv * C57BL/6		 MGI:96667  MGI:96669  MP:0005424 jerky movement PMID: 11517255 
Kcnc1tm1Joho|Kcnc3tm1Echa Kcnc1tm1Joho/Kcnc1tm1Joho,Kcnc3tm1Echa/Kcnc3tm1Echa
involves: 129/Sv * C57BL/6		 MGI:96667  MGI:96669  MP:0008569 lethality at weaning PMID: 11517255 
Kcnc1tm1Joho|Kcnc3tm1Echa Kcnc1tm1Joho/Kcnc1tm1Joho,Kcnc3tm1Echa/Kcnc3tm1Echa
involves: 129/Sv * C57BL/6		 MGI:96667  MGI:96669  MP:0000243 myoclonus PMID: 11517255 
Kcnc1tm1Joho|Kcnc3tm1Echa Kcnc1tm1Joho/Kcnc1tm1Joho,Kcnc3tm1Echa/Kcnc3tm1Echa
involves: 129/Sv * C57BL/6		 MGI:96667  MGI:96669  MP:0008489 postnatal slow weight gain PMID: 11517255 
Kcnc1tm1Joho|Kcnc3tm1Echa Kcnc1tm1Joho/Kcnc1tm1Joho,Kcnc3tm1Echa/Kcnc3tm1Echa
involves: 129/Sv * C57BL/6		 MGI:96667  MGI:96669  MP:0000745 tremors PMID: 11517255 
Kcnc1tm1Joho|Kcnc3tm1Echa Kcnc1tm1Joho/Kcnc1tm1Joho,Kcnc3tm1Echa/Kcnc3tm1Echa
involves: 129/Sv * C57BL/6		 MGI:96667  MGI:96669  MP:0001263 weight loss PMID: 11517255 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Severe ataxia, myoclonus and hypersensitivity to ethanol
Comments:  Kv3.1/ Kv3.3 double knock-out mice
References:  5
Click column headers to sort
Type Species Molecular location Description Reference
Deletion Mouse Kv3.1/ Kv3.3 double knock-out 5
Disease:  Constitutively increased locomotor activity and sleep loss
Comments:  Kv3.1 knock-out mice
References:  11
Click column headers to sort
Type Species Molecular location Description Reference
Deletion Mouse Kv3.1 knock-out 11
Disease:  Impaired motor skills, reduced muscle contraction force
Comments:  Kv3.1 knock-out mice
References:  14
Click column headers to sort
Type Species Molecular location Description Reference
Deletion Mouse 14
Gene Expression and Pathophysiology
mRNA expression increased in colonic carcinoma
Tissue or cell type:  Colonic cancer cells
Pathophysiology:  Colonic carcinoma
Species:  Mouse
Technique: 
References:  24
mRNA expression increased in colonic carcinoma
Tissue or cell type:  Colonic cancer cells
Pathophysiology:  Colonic carcinoma
Species:  Human
Technique: 
References:  24
Inhibition of Kv3.1 channel gene expression by chronic hypoxia
Tissue or cell type:  Distal pulmonary artery
Pathophysiology:  Chronic hypoxia
Species:  Rat
Technique: 
References:  30
Biologically Significant Variants
Kv3.1a mRNA levels may be modulated by neuronal activity.
Nucleotide accession:  NM_001112739 
Protein accession:  NP_001106210 
Amino acids:  585
Type:  Splice variant
Species:  Mouse
References:  20,34
The Kv3.1b subunit in the soma of some interneuronal populations may support their ability to fire trains of short duration action potentials at very high rate by facilitating the recovery of Na+ channel inactivation and minimizing the duration of the afterhyperpolarization.
Nucleotide accession:  NM_139217 
Protein accession:  NP_631963 
Amino acids:  638
Type:  Splice variant
Species:  Rat
References:  2
Biologically Significant Variant Comments
Kv3.1b isoform is the most abundant and thus is the most studied isoform.
General Comments
H-ras oncogene switches anterior pituitary derived cells (AtT20) to a more neuron-like phenotype in parallel with the induction of expression of Kv3.112. It is a member of the mammalian Shaw-related family.

REFERENCES

Show »

1. Choi, BH; Choi, JS; Yoon, SH; Rhie, DJ; Min, DS; Jo, YH; Kim, MS; Hahn, SJ. (2001) Effects of norfluoxetine, the major metabolite of fluoxetine, on the cloned neuronal potassium channel Kv3.1. Neuropharmacology, 41 (4): 443-53. [PMID:11543764]

2. Dallas, ML; Atkinson, L; Milligan, CJ; Morris, NP; Lewis, DI; Deuchars, SA; Deuchars, J. (2005) Localization and function of the Kv3.1b subunit in the rat medulla oblongata: focus on the nucleus tractus solitarii. J. Physiol. (Lond.), 562 (Pt 3): 655-72. [PMID:15528247]

3. De Biasi, M; Drewe, JA; Kirsch, GE; Brown, AM. (1993) Histidine substitution identifies a surface position and confers Cs+ selectivity on a K+ pore. Biophys. J., 65 (3): 1235-42. [PMID:8241404]

4. DeCoursey, TE; Chandy, KG; Gupta, S; Cahalan, MD. (1984) Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?. Nature, 307 (5950): 465-8. [PMID:6320007]

5. Espinosa, F; McMahon, A; Chan, E; Wang, S; Ho, CS; Heintz, N; Joho, RH. (2001) Alcohol hypersensitivity, increased locomotion, and spontaneous myoclonus in mice lacking the potassium channels Kv3.1 and Kv3.3. J. Neurosci., 21 (17): 6657-65. [PMID:11517255]

6. Felix, R; Serrano, CJ; Treviño, CL; Muñoz-Garay, C; Bravo, A; Navarro, A; Pacheco, J; Tsutsumi, V; Darszon, A. (2002) Identification of distinct K+ channels in mouse spermatogenic cells and sperm. Zygote, 10 (2): 183-8. [PMID:12056459]

7. Grissmer, S; Ghanshani, S; Dethlefs, B; McPherson, JD; Wasmuth, JJ; Gutman, GA; Cahalan, MD; Chandy, KG. (1992) The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells. J. Biol. Chem., 267 (29): 20971-9. [PMID:1400413]

8. Grissmer, S; Nguyen, AN; Aiyar, J; Hanson, DC; Mather, RJ; Gutman, GA; Karmilowicz, MJ; Auperin, DD; Chandy, KG. (1994) Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol. Pharmacol., 45 (6): 1227-34. [PMID:7517498]

9. Hemmick, LM; Perney, TM; Flamm, RE; Kaczmarek, LK; Birnberg, NC. (1992) Expression of the H-ras oncogene induces potassium conductance and neuron-specific potassium channel mRNAs in the AtT20 cell line. J. Neurosci., 12 (6): 2007-14. [PMID:1607925]

10. Hernández-Pineda, R; Chow, A; Amarillo, Y; Moreno, H; Saganich, M; Vega-Saenz de Miera, EC; Hernández-Cruz, A; Rudy, B. (1999) Kv3.1-Kv3.2 channels underlie a high-voltage-activating component of the delayed rectifier K+ current in projecting neurons from the globus pallidus. J. Neurophysiol., 82 (3): 1512-28. [PMID:10482766]

11. Ho, CS; Grange, RW; Joho, RH. (1997) Pleiotropic effects of a disrupted K+ channel gene: reduced body weight, impaired motor skill and muscle contraction, but no seizures. Proc. Natl. Acad. Sci. U.S.A., 94 (4): 1533-8. [PMID:9037088]

12. Ishikawa, T; Nakamura, Y; Saitoh, N; Li, WB; Iwasaki, S; Takahashi, T. (2003) Distinct roles of Kv1 and Kv3 potassium channels at the calyx of Held presynaptic terminal. J. Neurosci., 23 (32): 10445-53. [PMID:14614103]

13. Joho, RH; Marks, GA; Espinosa, F. (2006) Kv3 potassium channels control the duration of different arousal states by distinct stochastic and clock-like mechanisms. Eur. J. Neurosci., 23 (6): 1567-74. [PMID:16553620]

14. Joho, RH; Street, C; Matsushita, S; Knöpfel, T. (2006) Behavioral motor dysfunction in Kv3-type potassium channel-deficient mice. Genes Brain Behav., 5 (6): 472-82. [PMID:16923152]

15. Jung, DK; Lee, SY; Kim, D; Joo, KM; Cha, CI; Yang, HS; Lee, WB; Chung, YH. (2005) Age-related changes in the distribution of Kv1.1 and Kv3.1 in rat cochlear nuclei. Neurol. Res., 27 (4): 436-40. [PMID:15949244]

16. Kanemasa, T; Gan, L; Perney, TM; Wang, LY; Kaczmarek, LK. (1995) Electrophysiological and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblasts. J. Neurophysiol., 74 (1): 207-17. [PMID:7472324]

17. Kirsch, GE; Drewe, JA. (1993) Gating-dependent mechanism of 4-aminopyridine block in two related potassium channels. J. Gen. Physiol., 102 (5): 797-816. [PMID:8301258]

18. Klemic, KG; Kirsch, GE; Jones, SW. (2001) U-type inactivation of Kv3.1 and Shaker potassium channels. Biophys. J., 81 (2): 814-26. [PMID:11463627]

19. Lenz, S; Perney, TM; Qin, Y; Robbins, E; Chesselet, MF. (1994) GABA-ergic interneurons of the striatum express the Shaw-like potassium channel Kv3.1. Synapse, 18 (1): 55-66. [PMID:7825124]

20. Liu, SJ; Kaczmarek, LK. (1998) The expression of two splice variants of the Kv3.1 potassium channel gene is regulated by different signaling pathways. J. Neurosci., 18 (8): 2881-90. [PMID:9526005]

21. Luneau, CJ; Williams, JB; Marshall, J; Levitan, ES; Oliva, C; Smith, JS; Antanavage, J; Folander, K; Stein, RB; Swanson, R. (1991) Alternative splicing contributes to K+ channel diversity in the mammalian central nervous system. Proc. Natl. Acad. Sci. U.S.A., 88 (9): 3932-6. [PMID:2023941]

22. Massengill, JL; Smith, MA; Son, DI; O'Dowd, DK. (1997) Differential expression of K4-AP currents and Kv3.1 potassium channel transcripts in cortical neurons that develop distinct firing phenotypes. J. Neurosci., 17 (9): 3136-47. [PMID:9096148]

23. McKay, BE; Turner, RW. (2004) Kv3 K+ channels enable burst output in rat cerebellar Purkinje cells. Eur. J. Neurosci., 20 (3): 729-39. [PMID:15255983]

24. Ousingsawat, J; Spitzner, M; Puntheeranurak, S; Terracciano, L; Tornillo, L; Bubendorf, L; Kunzelmann, K; Schreiber, R. (2007) Expression of voltage-gated potassium channels in human and mouse colonic carcinoma. Clin. Cancer Res., 13 (3): 824-31. [PMID:17289873]

25. Plant, LD; Boyle, JP; Thomas, NM; Hipkins, NJ; Benedikz, E; Hooper, NM; Henderson, Z; Vaughan, PF; Peers, C; Cowburn, RF; Pearson, HA. (2002) Presenilin-1 mutations alter K+ currents in the human neuroblastoma cell line, SH-SY5Y. Neuroreport, 13 (12): 1553-6. [PMID:12218704]

26. Sacco, T; De Luca, A; Tempia, F. (2006) Properties and expression of Kv3 channels in cerebellar Purkinje cells. Mol. Cell. Neurosci., 33 (2): 170-9. [PMID:16949837]

27. Shapiro, MS; DeCoursey, TE. (1991) Permeant ion effects on the gating kinetics of the type L potassium channel in mouse lymphocytes. J. Gen. Physiol., 97 (6): 1251-78. [PMID:1875189]

28. Shapiro, MS; DeCoursey, TE. (1991) Selectivity and gating of the type L potassium channel in mouse lymphocytes. J. Gen. Physiol., 97 (6): 1227-50. [PMID:1875188]

29. Shumilina, E; Lampert, A; Lupescu, A; Myssina, S; Strutz-Seebohm, N; Henke, G; Grahammer, F; Wulff, P; Kuhl, D; Lang, F. (2005) Deranged Kv channel regulation in fibroblasts from mice lacking the serum and glucocorticoid inducible kinase SGK1. J. Cell. Physiol., 204 (1): 87-98. [PMID:15605386]

30. Wang, J; Weigand, L; Wang, W; Sylvester, JT; Shimoda, LA. (2005) Chronic hypoxia inhibits Kv channel gene expression in rat distal pulmonary artery. Am. J. Physiol. Lung Cell Mol. Physiol., 288 (6): L1049-58. [PMID:15665041]

31. Wang, LY; Gan, L; Forsythe, ID; Kaczmarek, LK. (1998) Contribution of the Kv3.1 potassium channel to high-frequency firing in mouse auditory neurones. J. Physiol. (Lond.), 509 ( Pt 1): 183-94. [PMID:9547392]

32. Weiser, M; Bueno, E; Sekirnjak, C; Martone, ME; Baker, H; Hillman, D; Chen, S; Thornhill, W; Ellisman, M; Rudy, B. (1995) The potassium channel subunit KV3.1b is localized to somatic and axonal membranes of specific populations of CNS neurons. J. Neurosci., 15 (6): 4298-314. [PMID:7790912]

33. Weiser, M; Vega-Saenz de Miera, E; Kentros, C; Moreno, H; Franzen, L; Hillman, D; Baker, H; Rudy, B. (1994) Differential expression of Shaw-related K+ channels in the rat central nervous system. J. Neurosci., 14 (3 Pt 1): 949-72. [PMID:8120636]

34. Yokoyama, S; Imoto, K; Kawamura, T; Higashida, H; Iwabe, N; Miyata, T; Numa, S. (1989) Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs. FEBS Lett., 259 (1): 37-42. [PMID:2599109]

To cite this database page, please use the following:

K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Voltage-gated potassium channels: Kv3.1. Last modified on 11/10/2012. Accessed on 25/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=548.


Contact us | Print | Back to top | Help