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Kv1.7

Family: Voltage-gated potassium channels

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Ion Selectivity and Conductance
Voltage Dependence
Pore Blockers
Tissue Distribution
Functional Assays
Physiological Functions
General Comments
References
Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 456 19q13.3 KCNA7 potassium voltage-gated channel, shaker-related subfamily, member 7 4
Mouse 6 1 532 7 B4 Kcna7 potassium voltage-gated channel, shaker-related subfamily, member 7 4
Rat 6 1 457 1q22 Kcna7 potassium voltage-gated channel, shaker-related subfamily, member 7 4
Previous and Unofficial Names
HAK6
Kcna7
KCNA7
Kv1.7
Kcna7_predicted
LOC365241
potassium voltage-gated channel subfamily A member 7
potassium voltage-gated channel, shaker-related subfamily, member 7
potassium voltage-gated channel, shaker-related subfamily, member 7 (predicted)
Database Links
ChEMBL Target 11976 (Hs)
Ensembl ENSG00000104848 (Hs), ENSMUSG00000038201 (Mm), ENSRNOG00000020779 (Rn)
Entrez Gene 3743 (Hs), 16495 (Mm), 365241 (Rn)
GeneCards KCNA7 (Hs)
GenitoUrinary Development Molecular Anatomy Project Kcna7 (Mm)
HomoloGene 7791 (Hs)
Human Protein Reference Database 01445 (Hs)
InterPro Q96RP8 (Hs), Q17ST2 (Mm)
KEGG Gene hsa:3743 (Hs), mmu:16495 (Mm), rno:365241 (Rn)
OMIM 176268 (Hs)
PharmGKB Gene PA30023 (Hs)
PhosphoSitePlus Q96RP8 (Hs), Q17ST2 (Mm)
Protein Ontology (PRO) PRO:000000814 (Hs)
RefSeq Nucleotide NM_031886 (Hs), NM_010596 (Mm), NM_001108914 (Rn)
RefSeq Protein NP_114092 (Hs), NP_034726 (Mm), NP_001102384 (Rn)
TreeFam ENSG00000104848 (Hs), ENSMUSG00000038201 (Mm), ENSRNOG00000020779 (Rn)
UniGene Hs. 306973 (Hs)
UniProt Q96RP8 (Hs), Q17ST2 (Mm)
Wikipedia Kv1.7
Potassium channels
Search for 3D structures on the PDB
Search by keyword: Voltage-gated potassium channels Kv1.7 Search by accession number: Q17ST2, Q96RP8
Ion Selectivity and Conductance
Species:  Mouse
Rank order:  K+ [21.0 pS]
References:  4
Species:  Mouse
Macroscopic current rectification:  Ik: Delayed Rectifier K+ current
References:  4
Voltage Dependence
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -8.0 - 4 RBL Cells Mouse
Inactivation  - 14.0 4
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -4.3 - 3 Xenopus laevis oocyte Mouse
Inactivation  -21.0 181.8 3
Comments  mKV1.7L isoform.
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  4.4 - 3 Xenopus laevis oocyte Mouse
Inactivation  -40.0 643.2 3
Comments  mKV1.7S isoform.
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -8.0 5.8 1 COS-7 Mouse
Inactivation  - -
Associated subunits (Human)
Kv β1 and Kv β2
Pore Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Affinity Units Concentration range (M) Holding voltage (mV) Reference
flecainide Hs 5.1 pKd - - 1
quinidine Hs 4.8 pKd - - 1
verapamil Hs 4.8 pKd - - 1
amiodarone Hs 4.5 pKd - - 1
tetraethylammonium Hs 4.1 pKd - - 1
4-aminopyridine Mm 3.8

3.6 		pKd

pIC50 		- - 3-4

3-4
ShK Toxin Mm 7.9 pIC50 - - 4
noxiustoxin Mm 7.7 pIC50 - - 4
margatoxin Mm 6.9 pIC50 - - 4
CP-339818 Mm 5.0 pIC50 - - 4
nifedipine Mm 4.9 pIC50 - - 4
resiniferatoxin Mm 4.7 pIC50 - - 4
tedisamil Mm 4.7 pIC50 - - 4
capsaicin Mm 4.6 pIC50 - - 4
diltiazem Mm 4.2 pIC50 - - 4
cromakalim Mm 3.3 pIC50 - - 4
tetraethylammonium Mm 1.1 pIC50 - - 4
View species-specific pore blocker tables
Tissue Distribution
Heart, skeletal muscle > liver, lung > placenta, brain, islets > spleen, kidney, testes.
Species:  Mouse
Technique:  RT-PCR
References:  4
Heart, lung > brain.
Species:  Rat
Technique:  RT-PCR
References:  2
Functional Assays
Voltage clamp of cloned mouse channel expressed in RBL cells reveals A-type K+ current.
Species:  Mouse
Tissue:  RBL Cells.
Response measured:  A-type potassium current.
References:  4
Voltage clamp of cloned human channel expressed in COS-7 cells reveals similarity to IKur current.
Species:  Human
Tissue:  COS-7 Cells.
Response measured:  IKur like current.
References:  1
Physiological Functions
KV1.7 plays an important role in the repolarization of cell membranes.
Species:  Human
Tissue:  Cell membrane.
References:  5
KV1.7 has properties similar to the ultra-rapidly activating IKur current in the heart.
Species:  Human
Tissue:  Heart.
References:  1
General Comments
Can co-assemble with other KV1 family members in heteromultimers, but not with members of other KV families. Unlike the other known Kv1 family members, the gene for Kv1.7 has a 1.9Kb intron in the coding region [1,4-5]

REFERENCES

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1. Bardien-Kruger, S; Wulff, H; Arieff, Z; Brink, P; Chandy, KG; Corfield, V. (2002) Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). Eur. J. Hum. Genet., 10 (1): 36-43. [PMID:11896454]

2. Davies, AR; Kozlowski, RZ. (2001) Kv channel subunit expression in rat pulmonary arteries. Lung, 179 (3): 147-61. [PMID:11891605]

3. Finol-Urdaneta, RK; Strüver, N; Terlau, H. (2006) Molecular and Functional Differences between Heart mKv1.7 Channel Isoforms. J. Gen. Physiol., 128 (1): 133-45. [PMID:16801386]

4. Kalman, K; Nguyen, A; Tseng-Crank, J; Dukes, ID; Chandy, G; Hustad, CM; Copeland, NG; Jenkins, NA; Mohrenweiser, H; Brandriff, B; Cahalan, M; Gutman, GA; Chandy, KG. (1998) Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7. J. Biol. Chem., 273 (10): 5851-7. [PMID:9488722]

5. Kashuba, VI; Kvasha, SM; Protopopov, AI; Gizatullin, RZ; Rynditch, AV; Wahlestedt, C; Wasserman, WW; Zabarovsky, ER. (2001) Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family. Gene, 268 (1-2): 115-22. [PMID:11368907]

To cite this database page, please use the following:

K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Voltage-gated potassium channels: Kv1.7. Last modified on 01/07/2010. Accessed on 20/06/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=544.


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