Nomenclature: Kv1.1

Family: Voltage-gated potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 495 12p13.32 KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 35
Mouse 6 1 495 6 F1-F3 Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1
Rat 6 1 495 4q42 Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1
Previous and Unofficial Names
HuK (I)
MBK1
MK1
RCK1
RBK1
Kcn1
HBK1
AEMK
Kv1.1
HUK1
Kcna
Kcpvd
potassium (K+) channel protein, voltage dependent
IA
Potassium voltage gated channel, shaker related subfamily, member 1
RBKI
potassium (K+) channel protein voltage dependent
potassium voltage gated channel shaker related subfamily member 1
potassium voltage-gated channel subfamily A member 1
potassium voltage-gated channel, shaker-related subfamily, member 1
voltage-gated potassium channel subunit Kv1.1
mouse brain potassium channel protein-1
Shak
Mk-1
Kca1-1
mceph
AI840627
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
Orphanet Gene
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Associated Proteins
Heteromeric Pore-forming Subunits
Name References
Kvβ1 6,10,13,23-24,27-28,34
Kvβ2 15,24
Auxiliary Subunits
Name References
Not determined
Other Associated Proteins
Name References
PSD95 7
SAP97 31
SNAP25 12
Functional Characteristics
KV
Ion Selectivity and Conductance
Species:  Mouse
Rank order:  K+ [10.0 pS]
References:  8
Species:  Rat
Rank order:  K+ [8.7 pS] > Rb+ [6.96 pS] > NH4+ [0.87 pS]
References:  29
Species:  Rat
Macroscopic current rectification:  Ik: Delayed Rectifier K+ current
References:  29
Voltage Dependence
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -29.7 15.5 29 Xenopus laevis oocyte Rat
Inactivation  -47.0 83.4 29
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -32.0 - 8 L929 Mouse
Inactivation  - 14.0 8
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -30.0 16.3 12 HIT-T15 cells Rat
Inactivation  - 4300.0 12
Associated subunits (Human)
Kv β1 and Kv β2
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
dendrotoxin-1 Mm - 7.7 pKd - - 8,26
pKd 7.7 [8,26]
kaliotoxin Mm - 7.4 pKd - - 8
pKd 7.4 [8]
resiniferatoxin Mm - 5.05 pKd - - 8
pKd 5.05 [8]
capsaicin Mm - 4.5 pKd - - 8
pKd 4.5 [8]
nifedipine Mm - 4.0 pKd - - 8
pKd 4.0 [8]
diltiazem Mm - 3.8 pKd - - 8
pKd 3.8 [8]
flecainide Mm - 3.7 pKd - - 8
pKd 3.7 [8]
tetraethylammonium Mm - 3.5 pKd - - 8
pKd 3.5 [8]
ShK Toxin Rn - 10.8 pIC50 - - 14
pIC50 10.8 [14]
hongotoxin-1 Rn - 10.5 pIC50 - - 18
pIC50 10.5 [18]
margatoxin Rn - 9.8 pIC50 - - 17
pIC50 9.8 [17]
mast cell degranulating peptide Mm - 6.3 pIC50 - - 9
pIC50 6.3 [9]
View species-specific channel blocker tables
Tissue Distribution
Brain
Species:  Mouse
Technique:  In situ hybridisation
References:  30
Retina
Species:  Mouse
Technique:  In situ hybridisation
References:  16
Skeletal and cardiac muscle
Species:  Rat
Technique:  In situ hybridisation
References:  20
Retina
Species:  Rat
Technique:  Immunocytochemistry, immunoelectron microscopy
References:  11
Brain > atrium > skeletal muscle >>> aorta
Species:  Rat
Technique:  Northern Blot
References:  25
Cerebellar cortex, deep cerebellar nuclei, Purkinje cells, granule cells, dentate gyrus, CA
Species:  Rat
Technique:  RT-PCR
References:  32
Medulla Pons, Superior Colliculus > Cerebellum, Inferior Colliculus, Midbrain devoid of the Colliculus > Cerebral cortex devoid of hippocampus and corpus striatum > Hippocampus > Olfactory bulb Corpus Striatum
Species:  Rat
Technique:  In situ hybridisation
References:  3
Brain
Species:  Rat
Technique:  Immunohistochemistry
References:  2
Brain (hippocampus)
Species:  Rat
Technique:  Radioligand Binding
References:  5,22
Most neuron containing regions
Species:  Rat
Technique:  Southern Blotting, In-situ hybridisation histochemistry
References:  21
Functional Assays
Molecular clone and voltage clamp
Species:  Mouse
Tissue:  Xenopus laevis Oocytes
Response measured:  Voltage-gated potassium currents, delayed rectifier
References:  8
Molecular clone and voltage clamp
Species:  Rat
Tissue:  Xenopus laevis Oocytes
Response measured:  Voltage-gated potassium currents, delayed rectifier
References:  12,29
Physiological Functions
Maintaining membrane potential, modulating electrical excitability
Species:  Mouse
Tissue:  brain, retina
References:  4,16
Maintaining membrane potential, modulating electrical excitability
Species:  Rat
Tissue:  brain, heart, skeletal muscle, retina
References:  3,5,11-12,22,25,32
Phenotypes, Alleles and Disease Models Mouse data from MGI

Show »

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0005402 abnormal action potential PMID: 9581771 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
C3Fe.129S7-Kcna1
MGI:96654  MP:0005402 abnormal action potential PMID: 12611922 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0002182 abnormal astrocyte morphology PMID: 8995755 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0004924 abnormal behavior PMID: 9581771 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0000913 abnormal brain development PMID: 8995755 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0002152 abnormal brain morphology PMID: 17250763  8995755 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0002152 abnormal brain morphology PMID: 17250763 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0000771 abnormal brain size PMID: 8995755 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0004994 abnormal brain wave pattern PMID: 9581771 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd
MGI:96654  MP:0001544 abnormal cardiovascular system physiology PMID: 20392939 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0000788 abnormal cerebral cortex morphology PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0002206 abnormal CNS synaptic transmission PMID: 9581771 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001406 abnormal gait PMID: 8995755 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001963 abnormal hearing physiology PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0001963 abnormal hearing physiology PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd
MGI:96654  MP:0003137 abnormal impulse conducting system conduction PMID: 20392939 
Kcna1+|Kcna1tm1Jmay Kcna1tm1Jmay/Kcna1+
B6.129S4-Kcna1
MGI:96654  MP:0002945 abnormal inhibitory postsynaptic currents PMID: 12612586 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0003492 abnormal involuntary movement PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0003492 abnormal involuntary movement PMID: 17250763 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001392 abnormal locomotor activity PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0001392 abnormal locomotor activity PMID: 17250763 
Kcna1+|Kcna1tm1Jmay Kcna1tm1Jmay/Kcna1+
B6.129S4-Kcna1
MGI:96654  MP:0001516 abnormal motor coordination/ balance PMID: 12612586 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
C3Fe.129S7-Kcna1
MGI:96654  MP:0002272 abnormal nervous system electrophysiology PMID: 12611922 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0002918 abnormal paired-pulse facilitation PMID: 9581771 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * C57BL/6
MGI:96654  MP:0002913 abnormal PNS synaptic transmission PMID: 9736643 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001504 abnormal posture PMID: 17250763  8995755 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0001504 abnormal posture PMID: 17250763 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001961 abnormal reflex PMID: 8995755 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0002566 abnormal sexual interaction PMID: 8995755 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * C57BL/6
MGI:96654  MP:0001393 ataxia PMID: 9736643 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd
MGI:96654  MP:0010519 atrioventricular block PMID: 20392939 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0000947 convulsive seizures PMID: 14686897  17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0000947 convulsive seizures PMID: 17250763 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001265 decreased body size PMID: 8995755 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
C3Fe.129S7-Kcna1
MGI:96654  MP:0001982 decreased chemically-elicited antinociception PMID: 9718989 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
C3Fe.129S7-Kcna1
MGI:96654  MP:0008532 decreased chemical nociceptive threshold PMID: 9718989 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd
MGI:96654  MP:0005333 decreased heart rate PMID: 20392939 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
C3Fe.129S7-Kcna1
MGI:96654  MP:0003483 decreased nerve fiber response threshold PMID: 12611922 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
C3Fe.129S7-Kcna1
MGI:96654  MP:0003998 decreased thermal nociceptive threshold PMID: 9718989 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001849 ear inflammation PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0001849 ear inflammation PMID: 17250763 
Kcna1tm1Jmay Kcna1tm1Jmay/Kcna1tm1Jmay
B6.129S4-Kcna1
MGI:96654  MP:0008762 embryonic lethality PMID: 12612586 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0008282 enlarged hippocampus PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0008282 enlarged hippocampus PMID: 17250763 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001349 excessive tearing PMID: 8995755 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001851 eye inflammation PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0001851 eye inflammation PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * C57BL/6
MGI:96654  MP:0001525 impaired balance PMID: 9736643 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * C57BL/6
MGI:96654  MP:0001522 impaired swimming PMID: 9736643 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0001994 increased blinking frequency PMID: 9581771 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0005238 increased brain size PMID: 14686896  8995755 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0002176 increased brain weight PMID: 8995755 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0001488 increased startle reflex PMID: 9581771 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001488 increased startle reflex PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0001488 increased startle reflex PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0002906 increased susceptibility to pharmacologically induced seizures PMID: 9581771 
Kcna1+|Kcna1tm1Tem Kcna1tm1Tem/Kcna1+
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0002906 increased susceptibility to pharmacologically induced seizures PMID: 9581771 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd
MGI:96654  MP:0000243 myoclonus PMID: 20392939 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0005654 porphyria PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0005654 porphyria PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd
MGI:96654  MP:0002082 postnatal lethality PMID: 20392939 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0002083 premature death PMID: 9581771 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0002064 seizures PMID: 9581771 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0002064 seizures PMID: 14686897 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * C57BL/6
MGI:96654  MP:0002064 seizures PMID: 9736643 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd
MGI:96654  MP:0002064 seizures PMID: 20392939 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0003997 tonic-clonic seizures PMID: 9581771 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0003997 tonic-clonic seizures PMID: 14686897 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd
MGI:96654  MP:0003997 tonic-clonic seizures PMID: 20392939 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0000745 tremors PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * C57BL/6
MGI:96654  MP:0000745 tremors PMID: 9736643 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0000745 tremors PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd
MGI:96654  MP:0009732 ventricular premature beat PMID: 20392939 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Episodic ataxia / myokymia syndrome type 1
OMIM:  160120
Orphanet:  199326, 37612, 972
References:  1,36
Click column headers to sort
Type Species Molecular location Description Reference
Missense Human F249I 36
Missense Human R239S 36
Missense Human F184C 1
Missense Human V408A 1
Gene Expression and Pathophysiology
Increase
Tissue or cell type:  Heart
Pathophysiology:  Chronic heart rate reduction
Species:  Mouse
Technique:  RT-PCR on sample derived from mouse sino-atrial node. Mice previously dosed with ivabradine and monitored.
References:  19
Decrease
Tissue or cell type:  Pulmonary artery
Pathophysiology:  Chronic pulmonary artery hypoxia
Species:  Rat
Technique:  Analysis of gene expression in intact, endothelium denuded distal pulmonary arteries from rats exposed to varying levels of chronic hypoxia.
References:  33
General Comments
Kv1.1 can coassemble with other Kv1 family members in heteromultimers but not with members of other Kv families. Unique in that it has an intronless coding region. Part of the mammalian Shaker-related family.

REFERENCES

1. Adelman JP, Bond CT, Pessia M, Maylie J. (1995) Episodic ataxia results from voltage-dependent potassium channels with altered functions. Neuron15 (6): 1449-54. [PMID:8845167]

2. Baumann A, Grupe A, Ackermann A, Pongs O. (1988) Structure of the voltage-dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous systems. EMBO J.7 (8): 2457-63. [PMID:3191911]

3. Beckh S, Pongs O. (1990) Members of the RCK potassium channel family are differentially expressed in the rat nervous system. EMBO J.9 (3): 777-82. [PMID:2311579]

4. Chandy KG, Williams CB, Spencer RH, Aguilar BA, Ghanshani S, Tempel BL, Gutman GA. (1990) A family of three mouse potassium channel genes with intronless coding regions. Science247 (4945): 973-5. [PMID:2305265]

5. Christie MJ, Adelman JP, Douglass J, North RA. (1989) Expression of a cloned rat brain potassium channel in Xenopus oocytes. Science244 (4901): 221-4. [PMID:2539643]

6. Curran ME, Landes GM, Keating MT. (1992) Molecular cloning, characterization, and genomic localization of a human potassium channel gene. Genomics12 (4): 729-37. [PMID:1349297]

7. Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R. (1996) Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell85 (7): 1067-76. [PMID:8674113]

8. Grissmer S, Nguyen AN, Aiyar J, Hanson DC, Mather RJ, Gutman GA, Karmilowicz MJ, Auperin DD, Chandy KG. (1994) Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol. Pharmacol.45 (6): 1227-34. [PMID:7517498]

9. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X. (2005) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol. Rev.57 (4): 473-508. [PMID:16382104]

10. Heinemann SH, Rettig J, Graack HR, Pongs O. (1996) Functional characterization of Kv channel beta-subunits from rat brain. J. Physiol. (Lond.)493 ( Pt 3): 625-33. [PMID:8799886]

11. Höltje M, Brunk I, Grosse J, Beyer E, Veh RW, Bergmann M, Grosse G, Ahnert-Hilger G. (2007) Differential distribution of voltage-gated potassium channels Kv 1.1-Kv1.6 in the rat retina during development. J. Neurosci. Res.85 (1): 19-33. [PMID:17075900]

12. Ji J, Tsuk S, Salapatek AM, Huang X, Chikvashvili D, Pasyk EA, Kang Y, Sheu L, Tsushima R, Diamant N, Trimble WS, Lotan I, Gaisano HY. (2002) The 25-kDa synaptosome-associated protein (SNAP-25) binds and inhibits delayed rectifier potassium channels in secretory cells. J. Biol. Chem.277 (23): 20195-204. [PMID:11925439]

13. Jing J, Peretz T, Singer-Lahat D, Chikvashvili D, Thornhill WB, Lotan I. (1997) Inactivation of a voltage-dependent K+ channel by beta subunit. Modulation by a phosphorylation-dependent interaction between the distal C terminus of alpha subunit and cytoskeleton. J. Biol. Chem.272 (22): 14021-4. [PMID:9162020]

14. Kalman K, Pennington MW, Lanigan MD, Nguyen A, Rauer H, Mahnir V, Paschetto K, Kem WR, Grissmer S, Gutman GA, Christian EP, Cahalan MD, Norton RS, Chandy KG. (1998) ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide. J. Biol. Chem.273 (49): 32697-707. [PMID:9830012]

15. Kim E, Niethammer M, Rothschild A, Jan YN, Sheng M. (1995) Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Nature378 (6552): 85-8. [PMID:7477295]

16. Klumpp DJ, Farber DB, Bowes C, Song EJ, Pinto LH. (1991) The potassium channel MBK1 (Kv1.1) is expressed in the mouse retina. Cell. Mol. Neurobiol.11 (6): 611-22. [PMID:1723658]

17. Koch RO, Wanner SG, Koschak A, Hanner M, Schwarzer C, Kaczorowski GJ, Slaughter RS, Garcia ML, Knaus HG. (1997) Complex subunit assembly of neuronal voltage-gated K+ channels. Basis for high-affinity toxin interactions and pharmacology. J. Biol. Chem.272 (44): 27577-81. [PMID:9346893]

18. Koschak A, Bugianesi RM, Mitterdorfer J, Kaczorowski GJ, Garcia ML, Knaus HG. (1998) Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venom. J. Biol. Chem.273 (5): 2639-44. [PMID:9446567]

19. Leoni AL, Marionneau C, Demolombe S, Le Bouter S, Mangoni ME, Escande D, Charpentier F. (2005) Chronic heart rate reduction remodels ion channel transcripts in the mouse sinoatrial node but not in the ventricle. Physiol. Genomics24 (1): 4-12. [PMID:16219869]

20. Matsubara H, Liman ER, Hess P, Koren G. (1991) Pretranslational mechanisms determine the type of potassium channels expressed in the rat skeletal and cardiac muscles. J. Biol. Chem.266 (20): 13324-8. [PMID:1712780]

21. McKinnon D. (1989) Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene family. J. Biol. Chem.264 (14): 8230-6. [PMID:2722779]

22. Racapé J, Lecoq A, Romi-Lebrun R, Liu J, Kohler M, Garcia ML, Ménez A, Gasparini S. (2002) Characterization of a novel radiolabeled peptide selective for a subpopulation of voltage-gated potassium channels in mammalian brain. J. Biol. Chem.277 (6): 3886-93. [PMID:11707459]

23. Rettig J, Heinemann SH, Wunder F, Lorra C, Parcej DN, Dolly JO, Pongs O. (1994) Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit. Nature369 (6478): 289-94. [PMID:8183366]

24. Rhodes KJ, Strassle BW, Monaghan MM, Bekele-Arcuri Z, Matos MF, Trimmer JS. (1997) Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes. J. Neurosci.17 (21): 8246-58. [PMID:9334400]

25. Roberds SL, Tamkun MM. (1991) Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart. Proc. Natl. Acad. Sci. U.S.A.88 (5): 1798-802. [PMID:1705709]

26. Robertson B, Owen D, Stow J, Butler C, Newland C. (1996) Novel effects of dendrotoxin homologues on subtypes of mammalian Kv1 potassium channels expressed in Xenopus oocytes. FEBS Lett.383 (1-2): 26-30. [PMID:8612784]

27. Scott VE, Rettig J, Parcej DN, Keen JN, Findlay JB, Pongs O, Dolly JO. (1994) Primary structure of a beta subunit of alpha-dendrotoxin-sensitive K+ channels from bovine brain. Proc. Natl. Acad. Sci. U.S.A.91 (5): 1637-41. [PMID:8127858]

28. Stephens GJ, Cockett MI, Nawoschik SP, Schecter LE, Owen DG. (1996) The modulation of the rate of inactivation of the mKv1.1 K+ channel by the beta subunit, Kv beta 1 and lack of effect of a Kv beta 1 N-terminal peptide. FEBS Lett.378 (3): 250-2. [PMID:8557111]

29. Stühmer W, Ruppersberg JP, Schröter KH, Sakmann B, Stocker M, Giese KP, Perschke A, Baumann A, Pongs O. (1989) Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO J.8 (11): 3235-44. [PMID:2555158]

30. Tempel BL, Jan YN, Jan LY. (1988) Cloning of a probable potassium channel gene from mouse brain. Nature332 (6167): 837-9. [PMID:2451788]

31. Tiffany AM, Manganas LN, Kim E, Hsueh YP, Sheng M, Trimmer JS. (2000) PSD-95 and SAP97 exhibit distinct mechanisms for regulating K(+) channel surface expression and clustering. J. Cell Biol.148 (1): 147-58. [PMID:10629225]

32. Tsaur ML, Sheng M, Lowenstein DH, Jan YN, Jan LY. (1992) Differential expression of K+ channel mRNAs in the rat brain and down-regulation in the hippocampus following seizures. Neuron8 (6): 1055-67. [PMID:1610565]

33. Wang J, Weigand L, Wang W, Sylvester JT, Shimoda LA. (2005) Chronic hypoxia inhibits Kv channel gene expression in rat distal pulmonary artery. Am. J. Physiol. Lung Cell Mol. Physiol.288 (6): L1049-58. [PMID:15665041]

34. Wang Z, Kiehn J, Yang Q, Brown AM, Wible BA. (1996) Comparison of binding and block produced by alternatively spliced Kvbeta1 subunits. J. Biol. Chem.271 (45): 28311-7. [PMID:8910452]

35. Wymore RS, Korenberg JR, Kinoshita KD, Aiyar J, Coyne C, Chen XN, Hustad CM, Copeland NG, Gutman GA, Jenkins NA. (1994) Genomic organization, nucleotide sequence, biophysical properties, and localization of the voltage-gated K+ channel gene KCNA4/Kv1.4 to mouse chromosome 2/human 11p14 and mapping of KCNC1/Kv3.1 to mouse 7/human 11p14.3-p15.2 and KCNA1/Kv1.1 to human 12p13. Genomics20 (2): 191-202. [PMID:8020965]

36. Zerr P, Adelman JP, Maylie J. (1998) Episodic ataxia mutations in Kv1.1 alter potassium channel function by dominant negative effects or haploinsufficiency. J. Neurosci.18 (8): 2842-8. [PMID:9526001]

To cite this database page, please use the following:

K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Voltage-gated potassium channels: Kv1.1. Last modified on 18/03/2014. Accessed on 30/10/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=538.

Contact us | Print | Back to top | Help
Copyright © 2014 IUPHAR