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K2P9.1

Family: Two-P potassium channels

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Phenotypes, Alleles and Disease Models
References
Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 0 374 8q24.3 KCNK9 potassium channel, subfamily K, member 9 1-3
Mouse 4 0 402 15 D3 Kcnk9 potassium channel, subfamily K, member 9
Rat 4 0 396 7q34 Kcnk9 potassium channel, subfamily K, member 9
Previous and Unofficial Names
KCNK9
TASK-3
K2P9.1
TASK3
TWIK-related acid-sensitive K(+) channel 3
acid-sensitive potassium channel protein TASK-3
potassium channel subfamily K member 9
potassium channel subfamily K member 9 (Task-3)
potassium channel, subfamily K, member 9 (Task-3)
two pore K(+) channel KT3.2
two pore potassium channel KT3.2
Database Links
ChEMBL Target 100113 (Rn)
Ensembl ENSG00000169427 (Hs), ENSMUSG00000036760 (Mm), ENSRNOG00000009265 (Rn)
Entrez Gene 51305 (Hs), 223604 (Mm), 84429 (Rn)
GeneCards KCNK9 (Hs)
GenitoUrinary Development Molecular Anatomy Project Kcnk9 (Mm)
HomoloGene 56758 (Hs)
Human Protein Reference Database 16167 (Hs)
InterPro Q9NPC2 (Hs), Q3LS21 (Mm), Q9ES08 (Rn)
KEGG Gene hsa:51305 (Hs), mmu:223604 (Mm), rno:84429 (Rn)
OMIM 605874 (Hs)
Orphanet Gene ORPHA166255 (Hs)
PharmGKB Gene PA30065 (Hs)
PhosphoSitePlus Q9NPC2 (Hs), Q3LS21 (Mm)
Protein Ontology (PRO) PRO:000002079 (Hs)
RefSeq Nucleotide NM_016601 (Hs), NM_001033876 (Mm), NM_053405 (Rn)
RefSeq Protein NP_057685 (Hs), NP_001029048 (Mm), NP_445857 (Rn)
TreeFam ENSG00000169427 (Hs), ENSMUSG00000036760 (Mm), ENSRNOG00000009265 (Rn)
UniGene Hs. 493037 (Hs)
UniProt Q9NPC2 (Hs), Q3LS21 (Mm), Q9ES08 (Rn)
Wikipedia K2P9.1
Potassium channels
Search for 3D structures on the PDB
Search by keyword: Two-P potassium channels K2P9.1 Search by accession number: Q3LS21, Q9NPC2, Q9ES08
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Kcnk3tm1.1Daba|Kcnk9tm1.1Daba Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:1100509  MGI:3521816  MP:0005402 abnormal action potential PMID: 18094244 
Kcnk9tm1.1Daba Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:3521816  MP:0005402 abnormal action potential PMID: 18094244 
Kcnk3tm1.1Daba|Kcnk9tm1.1Daba Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA		 MGI:1100509  MGI:3521816  MP:0002909 abnormal adrenal gland physiology PMID: 18250325 
Kcnk3tm1.1Daba|Kcnk9tm1.1Daba Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA		 MGI:1100509  MGI:3521816  MP:0003484 abnormal channel response PMID: 18250325 
Kcnk3tm1.1Daba|Kcnk9tm1.1Daba Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA		 MGI:1100509  MGI:3521816  MP:0003353 decreased circulating renin level PMID: 18250325 
Kcnk3tm1.1Daba|Kcnk9tm1.1Daba Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA		 MGI:1100509  MGI:3521816  MP:0005333 decreased heart rate PMID: 18250325 
Kcnk3tm1.1Daba|Kcnk9tm1.1Daba Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA		 MGI:1100509  MGI:3521816  MP:0000231 hypertension PMID: 18250325 
Kcnk3tm1.1Daba|Kcnk9tm1.1Daba Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA		 MGI:1100509  MGI:3521816  MP:0004119 hypokalemia PMID: 18250325 
Kcnk3tm1.1Daba|Kcnk9tm1.1Daba Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA		 MGI:1100509  MGI:3521816  MP:0002666 increased circulating aldosterone level PMID: 18250325 
Kcnk9tm1Sgb Kcnk9tm1Sgb/Kcnk9tm1Sgb
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:3521816  MP:0002169 no abnormal phenotype detected PMID: 17728447 

REFERENCES

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1. Chapman, CG; Meadows, HJ; Godden, RJ; Campbell, DA; Duckworth, M; Kelsell, RE; Murdock, PR; Randall, AD; Rennie, GI; Gloger, IS. (2000) Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel. Brain Res. Mol. Brain Res., 82 (1-2): 74-83. [PMID:11042359]

2. Kim, Y; Bang, H; Kim, D. (2000) TASK-3, a new member of the tandem pore K(+) channel family. J. Biol. Chem., 275 (13): 9340-7. [PMID:10734076]

3. Rajan, S; Wischmeyer, E; Xin Liu, G; Preisig-Müller, R; Daut, J; Karschin, A; Derst, C. (2000) TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histiding as pH sensor. J. Biol. Chem., 275 (22): 16650-7. [PMID:10747866]

To cite this database page, please use the following:

Leigh Daniel Plant, Douglas A. Bayliss, Donghee Kim, Florian Lesage, Steve A.N. Goldstein.
Two-P potassium channels: K2P9.1. Last modified on 01/03/2012. Accessed on 26/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=520.


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