Nomenclature: K2P9.1

Family: Two-P potassium channels

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation. 

Contents

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 0 374 8q24.3 KCNK9 potassium channel, subfamily K, member 9 1-3
Mouse 4 0 402 15 D3 Kcnk9 potassium channel, subfamily K, member 9
Rat 4 0 396 7q34 Kcnk9 potassium channel, subfamily K, member 9
Previous and Unofficial Names
KCNK9
TASK-3
K2P9.1
TASK3
TWIK-related acid-sensitive K(+) channel 3
acid-sensitive potassium channel protein TASK-3
potassium channel subfamily K member 9
potassium channel subfamily K member 9 (Task-3)
potassium channel, subfamily K, member 9 (Task-3)
two pore K(+) channel KT3.2
two pore potassium channel KT3.2
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
Orphanet Gene
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Functional Characteristics
Background current
Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
halothane Hs - - - - -
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Kcnk3tm1.1Daba|Kcnk9tm1.1Daba Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:1100509  MGI:3521816  MP:0005402 abnormal action potential PMID: 18094244 
Kcnk9tm1.1Daba Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:3521816  MP:0005402 abnormal action potential PMID: 18094244 
Kcnk3tm1.1Daba|Kcnk9tm1.1Daba Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MGI:1100509  MGI:3521816  MP:0002909 abnormal adrenal gland physiology PMID: 18250325 
Kcnk3tm1.1Daba|Kcnk9tm1.1Daba Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MGI:1100509  MGI:3521816  MP:0003484 abnormal channel response PMID: 18250325 
Kcnk3tm1.1Daba|Kcnk9tm1.1Daba Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MGI:1100509  MGI:3521816  MP:0003353 decreased circulating renin level PMID: 18250325 
Kcnk3tm1.1Daba|Kcnk9tm1.1Daba Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MGI:1100509  MGI:3521816  MP:0005333 decreased heart rate PMID: 18250325 
Kcnk3tm1.1Daba|Kcnk9tm1.1Daba Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MGI:1100509  MGI:3521816  MP:0000231 hypertension PMID: 18250325 
Kcnk3tm1.1Daba|Kcnk9tm1.1Daba Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MGI:1100509  MGI:3521816  MP:0004119 hypokalemia PMID: 18250325 
Kcnk3tm1.1Daba|Kcnk9tm1.1Daba Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MGI:1100509  MGI:3521816  MP:0002666 increased circulating aldosterone level PMID: 18250325 
Kcnk9tm1Sgb Kcnk9tm1Sgb/Kcnk9tm1Sgb
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MGI:3521816  MP:0002169 no abnormal phenotype detected PMID: 17728447 

REFERENCES

1. Chapman CG, Meadows HJ, Godden RJ, Campbell DA, Duckworth M, Kelsell RE, Murdock PR, Randall AD, Rennie GI, Gloger IS. (2000) Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel. Brain Res. Mol. Brain Res.82 (1-2): 74-83. [PMID:11042359]

2. Kim Y, Bang H, Kim D. (2000) TASK-3, a new member of the tandem pore K(+) channel family. J. Biol. Chem.275 (13): 9340-7. [PMID:10734076]

3. Rajan S, Wischmeyer E, Xin Liu G, Preisig-Müller R, Daut J, Karschin A, Derst C. (2000) TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histiding as pH sensor. J. Biol. Chem.275 (22): 16650-7. [PMID:10747866]

To cite this database page, please use the following:

Leigh Daniel Plant, Douglas A. Bayliss, Donghee Kim, Florian Lesage, Steve A.N. Goldstein.
Two-P potassium channels: K2P9.1. Last modified on 17/03/2014. Accessed on 01/11/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=520.

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