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K2P7.1

Family: Two-P potassium channels

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Phenotypes, Alleles and Disease Models
References
Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 0 307 11q13 KCNK7 potassium channel, subfamily K, member 7 2
Mouse 4 0 343 19 B2 Kcnk7 potassium channel, subfamily K, member 7 1-2
Rat 4 0 - 1q43 RGD1565025 similar to two pore domain K+ channel subunit
Previous and Unofficial Names
KCNK7
kcnk8
K2P7.1
LOC499303
RGD1565025_predicted
similar to two pore domain K+ channel subunit
similar to two pore domain K+ channel subunit (predicted)
Knot
Mlk3
2310014G03Rik
Database Links
Ensembl ENSG00000173338 (Hs), ENSMUSG00000024936 (Mm), ENSRNOG00000020784 (Rn)
Entrez Gene 10089 (Hs), 16530 (Mm), 499303 (Rn)
GeneCards KCNK7 (Hs)
GenitoUrinary Development Molecular Anatomy Project Kcnk7 (Mm)
HomoloGene 43131 (Hs)
Human Protein Reference Database 06804 (Hs)
InterPro Q9Y2U2 (Hs), Q9Z2T1 (Mm)
KEGG Gene hsa:10089 (Hs), mmu:16530 (Mm), rno:499303 (Rn)
OMIM 603940 (Hs)
PharmGKB Gene PA30064 (Hs)
Protein Ontology (PRO) PRO:000002078 (Hs)
RefSeq Nucleotide NM_033347 (Hs), NM_010609 (Mm)
RefSeq Protein NP_203133 (Hs), NP_034739 (Mm)
TreeFam ENSG00000173338 (Hs), ENSMUSG00000024936 (Mm), ENSRNOG00000020784 (Rn)
UniGene Hs. 175218 (Hs)
UniProt Q9Y2U2 (Hs), Q9Z2T1 (Mm)
Wikipedia K2P7.1
Potassium channels
Search for 3D structures on the PDB
Search by keyword: Two-P potassium channels K2P7.1 Search by accession number: Q9Z2T1, Q9Y2U2
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Kcnk7tm1Dgen Kcnk7tm1Dgen/Kcnk7tm1Dgen
involves: 129P2/OlaHsd * C57BL/6		 MGI:1341841  MP:0002169 no abnormal phenotype detected PMID: 18572259 

REFERENCES

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1. Bockenhauer, D; Nimmakayalu, MA; Ward, DC; Goldstein, SA; Gallagher, PG. (2000) Genomic organization and chromosomal localization of the murine 2 P domain potassium channel gene Kcnk8: conservation of gene structure in 2 P domain potassium channels. Gene, 261 (2): 365-72. [PMID:11167025]

2. Salinas, M; Reyes, R; Lesage, F; Fosset, M; Heurteaux, C; Romey, G; Lazdunski, M. (1999) Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. J. Biol. Chem., 274 (17): 11751-60. [PMID:10206991]

To cite this database page, please use the following:

Leigh Daniel Plant, Douglas A. Bayliss, Donghee Kim, Florian Lesage, Steve A.N. Goldstein.
Two-P potassium channels: K2P7.1. Last modified on 01/03/2012. Accessed on 21/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=519.


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