Nomenclature: K2P4.1

Family: Two-P potassium channels

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation. 

Contents

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 0 393 11q13 KCNK4 potassium channel, subfamily K, member 4 3
Mouse 4 0 394 19 A Kcnk4 potassium channel, subfamily K, member 4
Rat 4 0 397 1q43 Kcnk4 potassium channel, subfamily K, member 4
Previous and Unofficial Names
KCNK4
TRAAK
K2P4.1
KT4.1
potassium channel subfamily K member 4
potassium inwardly-rectifying channel subfamily K member 4
potassium inwardly-rectifying channel, subfamily K, member 4
TRAAKt
Database Links
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Functional Characteristics
Background current
Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
riluzole Hs Positive - - 3x10-6 - 1x10-4 - 1
Conc range: 3x10-6 - 1x10-4 M [1]
arachidonic acid Rn Positive - - 5x10-6 - 5x10-5 - 2
Conc range: 5x10-6 - 5x10-5 M [2]
View species-specific activator tables

REFERENCES

1. Duprat F, Lesage F, Patel AJ, Fink M, Romey G, Lazdunski M. (2000) The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK. Mol. Pharmacol.57 (5): 906-12. [PMID:10779373]

2. Kim D, Sladek CD, Aguado-Velasco C, Mathiasen JR. (1995) Arachidonic acid activation of a new family of K+ channels in cultured rat neuronal cells. J. Physiol. (Lond.)484 ( Pt 3): 643-60. [PMID:7623282]

3. Lesage F, Maingret F, Lazdunski M. (2000) Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel. FEBS Lett.471 (2-3): 137-40. [PMID:10767409]

To cite this database page, please use the following:

Leigh Daniel Plant, Douglas A. Bayliss, Donghee Kim, Florian Lesage, Steve A.N. Goldstein.
Two-P potassium channels: K2P4.1. Last modified on 11/02/2014. Accessed on 24/10/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=516.

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