Nomenclature: TRPV2

Family: Transient Receptor Potential channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 764 17p11.2 TRPV2 transient receptor potential cation channel, subfamily V, member 2 7
Mouse 6 1 756 11 B2 Trpv2 transient receptor potential cation channel, subfamily V, member 2 21
Rat 6 1 761 10q22 Trpv2 transient receptor potential cation channel, subfamily V, member 2 7
Previous and Unofficial Names
VRL-1
OTRPC2
GRC
MGC105451
vanilloid receptor-like protein 1
Vrl1
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Associated Proteins
Heteromeric Pore-forming Subunits
Name References
TRPV1 25,48
Auxiliary Subunits
Name References
Not determined
Other Associated Proteins
Name References
Acyl CoA binding domain protein (ACBD) 3 52
Recombinase gene activator protein (RGA) 4,53
Functional Characteristics
Conducts mono- and di-valent cations (PCa/PNa = 0.9–2.9); dual (inward and outward) rectification; current increases upon repetitive activation by heat; translocates to cell surface in response to IGF-1 to induce a constitutively active conductance, translocates to the cell surface in response to membrane stretch
Ion Selectivity and Conductance
Species:  Rat
Rank order:  Ca2+ > Mg2+ > Cs+ = K+ = Na+
References:  7
Physical activators (Human)
noxious heat (> 35°C; rodent, not human)  [42]
Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
diphenylboronic anhydride Mm Agonist - - 1x10-4 -80.0 8,19
Conc range: 1x10-4 M [8,19]
Holding voltage: -80.0 mV
lysophosphatidylcholine Mm Activation - - 1x10-6 - 31,33
Conc range: 1x10-6 M [31,33]
lysophosphatidylinositol Mm Activation - - 1x10-6 - 33
Conc range: 1x10-6 M [33]
insulin-like growth factor 1 {Sp: Mouse} Mm Agonist - - 2x10-9 -60.0 21
Conc range: 2x10-9 M [21]
Holding voltage: -60.0 mV
neuropeptide head activator Mm Agonist - - 2x10-9 -60.0 6
Conc range: 2x10-9 M [6]
Holding voltage: -60.0 mV
cannabidiol Rn Activation 5.43 pEC50 - - 47
pEC50 5.43 (EC50 3.7x10-6 M) [47]
2-APB Rn - 5.0 pEC50 - - 42,47
pEC50 5.0 (EC50 1x10-5 M) [42,47]
Δ9-tetrahydrocannabinol Rn Activation 4.85 pEC50 - - 47
pEC50 4.85 (EC50 1.4x10-5 M) [47]
cannabidiol Hs Activation 4.5 pEC50 - - 47
pEC50 4.5 (EC50 3.17x10-5 M) [47]
probenecid Rn Activation 4.5 pEC50 - - 3
pEC50 4.5 (EC50 3.19x10-5 M) [3]
cannabinol Rn Activation 4.11 pEC50 - - 47
pEC50 4.11 (EC50 7.7x10-5 M) [47]
2-APB Mm Agonist 3.8 – 3.9 pEC50 - Physiological 15,19
pEC50 3.8 – 3.9 (EC50 1.6x10-4 – 1.29x10-4 M) [15,19]
Holding voltage: Physiological
View species-specific activator tables
Activator Comments
Further evidence for the role of 2-APB as an agonist of mouse TRPV2 is provided by [30] and [31]. TRPV2 is also activated by heat and cell swelling/stretch [7,9,11,36,50].

fMetLeuPhe (Ligand ID:1022) has also been noted to activate the mouse TRPV2 [39-40].

Species differences in activation: rodent TRPV2 is activated by the nonselective agonists 2-APB, Δ9-THC, or noxious heat (∼53°C); human TRPV2 is insensitive to 2-APB and noxious heat, but is activated by Δ9-THC [19,42].
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
tetraethylammonium Mm Inhibition - - 1x10-2 - 19
Conc range: 1x10-2 M [19]
4-aminopyridine Mm Inhibition - - 5x10-3 - 19
Conc range: 5x10-3 M [19]
TRIM Mm Inhibition - - 5x10-4 - 19
Conc range: 5x10-4 M [19]
citral Rn Inhibition - - 5x10-4 - 54
Conc range: 5x10-4 M [54]
ruthenium red Hs - 6.2 pIC50 - -
pIC50 6.2 (IC50 6x10-7 M)
ruthenium red Mm Antagonist 6.2 pIC50 - -40.0 7
pIC50 6.2 [7]
Holding voltage: -40.0 mV
amiloride Hs - - - - -
La3+ Hs - - - - -
SKF96365 Hs - - - - -
View species-specific channel blocker tables
Channel Blocker Comments
Tranilast (Ligand ID: 6326) has been reported as a TRPV2 pore blocker with an ID50 of approximately 10µM [44]. Additional studies also report tranilast's inhibition of TRPV2 activity [2,13,26,31-32,43]. SKF96365 (Ligand ID: 2441) is also a TRPV2 pore blocking compound [5,19,59].
Tissue Distribution
Cancer cells: bladder cancer cell line T24, hepatocellular carcinoma, prostate cancer cell lines LNCaP, C4-2, DU145 and PC3
Species:  Human
Technique:  RT-PCR, immunohistochemistry, qPCR and western blot analysis
References:  28,33-34,57
Retinal pigment epithelium, ARPE-19 cells
Species:  Human
Technique:  Calcium imaging
References:  5,10
Skin
Species:  Human
Technique:  Immunohistochemistry, morphometry, double immunoflourescence, and qPCR
References:  55
CD34+ hematopoietic stem cells
Species:  Human
Technique:  RT-PCR
References:  45
Peripheral blood cells
Species:  Human
Technique:  qPCR, immunocytochemistry
References:  49
Glioblastoma cells
Species:  Human
Technique:  Calcium imaging
References:  38
Pancreatic β-cells
Species:  Mouse
Technique:  Immunohistochemistry, western blot analysis, calcium imaging
References:  2,13,26
Spinal motor neurons
Species:  Mouse
Technique:  Immunohistochemistry and in situ hybridization
References:  50
Mouse macrophage cells, TtT/M87, NLRP3 inflammasome, RAW264
Species:  Mouse
Technique:  Immunohistochemistry, immunoflourescence, and qPCR, western blot
References:  9,27,39,58
Inhibitory motor neurons of gastric myenteric plexus
Species:  Mouse
Technique:  RT-PCR and immunohistochemistry
References:  32
Cardiomyocytes
Species:  Mouse
Technique:  qPCR, western blot analysis
References:  22
Olfactory epithelium
Species:  Mouse
Technique:  Immunohistochemistry
References:  1
Intestinal intrinsic sensory and inhibitory motor neurons
Species:  Mouse
Technique:  RT-PCR, immunocytochemistry
References:  31
W264.7 cells (preosteoclasts)
Species:  Mouse
Technique:  Gene chip, RT-PCR, immunocytochemistry, western blot analysis
References:  20
Trigeminal ganglion (TG) neurons innervating dental pulp
Species:  Rat
Technique:  Immunohistochemistry
References:  12
RBL-2H3 mast cells
Species:  Rat
Technique:  calcium imaging response to 2-APB, western blot analysis
References:  19
Dorsal root ganglia, trigeminal ganglia, spinal cord, brain, lung, spleen, intestines.
Species:  Rat
Technique:  Immunocytochemistry, northern blot. calcium imaging, patch-clamp, in vivo pain assays
References:  3,7,24,47,51,56
Brain
Species:  Rat
Technique:  Immunohistochemistry combined with brightfield microscopy
References:  41
Retina
Species:  Rat
Technique:  qPCR; western blot analysis, immunohistochemistry
References:  23
Lung (mouse) and rat primary alveolar type II (ATII) cells
Species:  Rat
Technique:  qPCR, RT-PCR
References:  11,18
Functional Assays
Species:  Mouse
Tissue:  MIN6 β-cells
Response measured:  Response to Klotho overexpression
References:  26
Species:  Rat
Tissue:  Rat primary alveolar type II (ATII) cells
Response measured:  Response to stretch
References:  11
TRPV2 activation
Species:  Human
Tissue:  Glioblastoma cells
Response measured:  TRPV2 activation by cannabidiol
References:  37-38
Calmodulin binding assay
Species:  Human
Tissue: 
Response measured:  Binding to calmodulin
References:  14
Patch clamp (whole-cell recordings).
Species:  Mouse
Tissue:  Aortic myocytes.
Response measured:  Activation by cell swelling.
References:  36
Involved in regulation of podosome assembly
Species:  Mouse
Tissue:  TtT/M87 macrophage cell line
Response measured: 
References:  39
Caspase-1 and IL-1β measurements
Species:  Mouse
Tissue:  Macrophage NLRP3 inflammasome
Response measured:  Swelling
References:  9
Intracellular Ca2+ imaging.
Species:  Mouse
Tissue:  HEK 293 cells transfected with the TRPV2 channel.
Response measured:  Activation by diphenylboronic anhydride.
References:  8
Two-electrode voltage clamp technique.
Species:  Mouse
Tissue:  Xenopus laevis oocytes injected with TRPV2 cDNA.
Response measured:  Activation by heat and block by ruthenium red.
References:  7
Patch clamp (whole-cell recordings).
Species:  Mouse
Tissue:  CHO cells transfected with the TRPV2 channel.
Response measured:  Activation by insulin-like growth factor I
References:  21
Patch clamp (whole-cell recordings)
Species:  Human
Tissue:  Peripheral blood CD34+ hematopoietic stem cells
Response measured:  Temperature sensitivity
References:  45
Echocardiography, myocyte contractility measurement, calcium imaging, patch clamp (whole cell recordings)
Species:  Mouse
Tissue:  Heart, isolated myocytes
Response measured:  Probencid responses
References:  22
Patch clamp (whole-cell and single-channel recordings).
Species:  Mouse
Tissue:  HEK 293 cells transfected with the TRPV2 channel.
Response measured:  Activation by heat and block by ruthenium red.
References:  7
Gastric adaptive relaxation and gastric emptying
Species:  Mouse
Tissue:  Isolated mouse stomach
Response measured:  TRPV2 activation by probenecid and inhibition by tranilast
References:  32
Calcium imaging; patch clamp myenteric neurons; tension recordings; NO release measurements; gastrointestinal tract transit assay
Species:  Mouse
Tissue:  Mouse intestinal intrinsic sensory and inhibitory motor neurons
Response measured:  Activation by 2-APB, probenecid, and lysophosphatidylcholine; block by tranilast & ruthenium red
References:  31
Calcium imaging; patch clamp RAW264.7 cells (preosteoclasts), osteoclastogenesis
Species:  Mouse
Tissue:  RAW264.7 cells (preosteoclasts)
Response measured:  RANKL-pretreatment; block by ruthenium red
References:  20
Calcium imaging; patch clamp, ELISA VEGF-A measurements
Species:  Human
Tissue:  RPE; ARPE-19 cells
Response measured:  Temperature; IGF-1 responses; block by ruthenium red and lanthanium
References:  10
Patch-clamp; diC8-PIP2, PolyK recordings, calmodulin binding assay, imaging translocation of GFP-PLCδ1-PH
Species:  Rat
Tissue:  F-11, tsA201 cells
Response measured:  2-APB responses in presence and absence of diC8-PIP2, PolyK
References:  30
Calcium imaging, filter-migration assay, bead phagocytosis, membrane potential measurements
Species:  Mouse
Tissue:  Macrophage cells
Response measured:  THC response; block by ruthenium red
References:  27
Proliferation rate, cell migration, calcium imaging
Species:  Human
Tissue:  Prostate cancer cell lines: LNCaP, C4-2, DU145 and PC3
Response measured:  Proliferation rate, cell migration before and after siRNA or shRNA treatment; following LPS or LPI treatment
References:  33-34
Calcium imaging, patch clamp analysis, calcitonin gene-related peptide release assay from dorsal root ganglia cells
Species:  Rat
Tissue:  dorsal root ganglia cells, overexpression of rat & human TRPV2 in HEK293 cells
Response measured:  Response to cannabidiol, block by ruthenium and siRNA
References:  47
Crystal structure of N-terminal ankyrin repeat domain
Species:  Human
Tissue: 
Response measured: 
References:  29
Physiological Functions
Thermosensation and nociception (noxious heat).
Species:  Mouse
Tissue:  Dorsal root ganglia neurones.
References:  7
Stretch activation
Species:  Rat
Tissue:  Primary alveolar type II (ATII) cells
References:  11
Perinatal viability
Species:  Mouse
Tissue: 
References:  46
Gastric adaptive relaxation and gastric emptying
Species:  Mouse
Tissue: 
References:  32
Podosome assembly
Species:  Mouse
Tissue:  Macrophage cell line, TtT/M87
References:  39-40
Osteoclastogenesis
Species:  Mouse
Tissue:  RAW264.7 cells (preosteoclasts)
References:  20
Physiological Consequences of Altering Gene Expression
TRPV2 gene silencing in glioblastoma cells
Species:  Human
Tissue:  Glioblastoma
Technique:  siRNA
References:  35,38
Diminished response to stretch in TRPV2 gene silenced rat primary alveolar type II (ATII) cells.
Species:  Rat
Tissue:  Rat primary alveolar type II (ATII) cells
Technique:  siRNA
References:  11
TRPV2 gene silencing results in reduced e expression of phospho-Pyk2, increased number of podosomes and eliminated Cs+ currents.
Species:  Mouse
Tissue:  Macrophage cell line, TtT/M87
Technique:  siRNA
References:  39-40
TRPV2 gene silencing suppresses the accelerated exocytotic response induced by insulin; reduces insulin secretion evoked by glucose.
Species:  Mouse
Tissue:  Pancreatic β-cells
Technique:  siRNA
References:  2,13
TRPV2 gene silencing reduces the sustained phase of AngII-mediated Ca2+ transients and attenuates the heat-evoked Ca2+ response.
Species:  Human
Tissue:  Retinal pigment epithelium
Technique:  siRNA
References:  5,10
shRNA knockdown of TRPV2 results in significantly decreased frequency of Ca2+ oscillations and transient inward currents in RANKL-treated preosteoclasts; reduced RANKL-induced NAFTc1 expression, its nuclear translocation, and osteoclastogenesis .
Species:  Mouse
Tissue:  RAW264.7 cells (preosteoclasts)
Technique:  shRNA
References:  20
siRNA silencing of TRPV2 results in attenuated apoptosis due to calcium overload.
Species:  Human
Tissue:  Bladder cell line T24
Technique:  siRNA
References:  57
shRNA knockdown of TRPV2 results in inhibition of LPS-induced TNFalpha and IL-6 production as well as IκBα degradation.
Species:  Mouse
Tissue:  RAW264 macrophages
Technique:  shRNA
References:  58
Significantly promoted axon outgrowth as a result of shRNA knockdown of TRPV2.
Species:  Mouse
Tissue:  Spinal motor neurons
Technique:  shRNA
References:  58
KNockdown of TRPV2 reduces the growth and invasive properties of PC3 prostate tumors, and diminishes expression of invasive enzymes MMP2, MMP9, and cathepsin B; cell migration is decreased in PC3 cells treated with shTRPV2 I or II.
Species:  Human
Tissue:  Prostate cancer cell lines LNCaP, C4-2, DU145 and PC3
Technique:  siRNA/shRNA
References:  33-34
Transgenic or adenoviral expression of dominant-negative TRPV2 results in inhibition of Ca2+ influx via TRPV2 and ameliorates muscular dystrophy in animal models.
Species:  Mouse
Tissue:  Skeletal muscle from mdx-mice (dystrophin-deficient) and from δ-sarcoglycan (SG)-deficient BIO14.6 hamsters.
Technique:  Transgenic dominant-negative TRPV2 under the control of the α-skeletal actin promoter in skeletal muscle.
References:  17
siRNA knockdown of TRPV2 results in reduced calcitonin gene-related peptide (CGRP) release form dorsal root ganglion neurons.
Species:  Rat
Tissue:  Dorsal root ganglion neurons
Technique:  siRNA
References:  47
Zymosan-, immunoglobulin G (IgG)- and complement-mediated particle binding and phagocytosis is impaired in macrophages lacking the cation channel TRPV2. Macrophages are also defective in chemoattractant-elicited motility; accelerated mortality and greater organ bacterial load when challenged with Listeria monocytogenes. TRPV2 deficient mice show normal behavioral responses to noxious heat over a broad range of temperatures and normal responses to punctate mechanical stimuli, both in the basal state and under hyperalgesic conditions such as peripheral inflammation and L5 spinal nerve ligation. There are no thermosensory consequences of TRPV2 absence. TRPV2 is important for perinatal viability.
Species:  Mouse
Tissue:  In vivo
Technique:  Targeted gene disruption
References:  27,46
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Trpv2tm1Mijc Trpv2tm1Mijc/Trpv2tm1Mijc
involves: 129S6/SvEvTac * C57BL/6
MGI:1341836  MP:0001262 decreased body weight PMID: 20118928 
Trpv2tm1Mijc Trpv2tm1Mijc/Trpv2tm1Mijc
involves: 129S6/SvEvTac * C57BL/6
MGI:1341836  MP:0003799 impaired macrophage migration PMID: 20118928 
Trpv2tm1Mijc Trpv2tm1Mijc/Trpv2tm1Mijc
involves: 129S6/SvEvTac * C57BL/6
MGI:1341836  MP:0001798 impaired macrophage phagocytosis PMID: 20118928 
Trpv2tm1Mijc Trpv2tm1Mijc/Trpv2tm1Mijc
involves: 129S6/SvEvTac * C57BL/6
MGI:1341836  MP:0002412 increased susceptibility to bacterial infection PMID: 20118928 
Trpv2tm1Mijc Trpv2tm1Mijc/Trpv2tm1Mijc
involves: 129S6/SvEvTac * C57BL/6
MGI:1341836  MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality PMID: 20118928 
Gene Expression and Pathophysiology
Overexpression.
Tissue or cell type:  Skeletal and cardiac muscle.
Pathophysiology:  Muscular dystrophy and cardiomyopathy.
Species:  Human
Technique: 
References:  16-17,59
Upregulation
Tissue or cell type:  Prostate
Pathophysiology:  TRPV2 transcript levels were higher in patients with metastatic cancer (stage M1)
Species:  Human
Technique:  qPCR, cell migration assays
References:  34
Upregulation of TRPV2 activity negatively regulates formation of glioblastoma
Tissue or cell type:  Cancer cells
Pathophysiology:  Glioblastoma
Species:  Human
Technique: 
References:  35,37-38
Upregulation
Tissue or cell type:  Hepatocytes
Pathophysiology:  Liver cirrhosis and hepatocellular carcinoma
Species:  Human
Technique:  Immunohistochemistry, qPCR and western blot analysis
References:  28
Upregulation
Tissue or cell type:  Skin
Pathophysiology:  Rosacea
Species:  Human
Technique:  Immunohistochemistry, morphometry, double immunoflourescence and qPCR
References:  55
Upregulation
Tissue or cell type:  Dorsal doot ganglia
Pathophysiology:  Inflammation-induced hyperalgesia
Species:  Rat
Technique:  Immunocytochemistry, heat tolerance
References:  51

REFERENCES

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2. Aoyagi K, Ohara-Imaizumi M, Nishiwaki C, Nakamichi Y, Nagamatsu S. (2010) Insulin/phosphoinositide 3-kinase pathway accelerates the glucose-induced first-phase insulin secretion through TrpV2 recruitment in pancreatic β-cells. Biochem. J.432 (2): 375-86. [PMID:20854263]

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4. Barnhill JC, Stokes AJ, Koblan-Huberson M, Shimoda LM, Muraguchi A, Adra CN, Turner H. (2004) RGA protein associates with a TRPV ion channel during biosynthesis and trafficking. J. Cell. Biochem.91 (4): 808-20. [PMID:14991772]

5. Barro-Soria R, Stindl J, Müller C, Foeckler R, Todorov V, Castrop H, Strauß O. (2012) Angiotensin-2-mediated Ca2+ signaling in the retinal pigment epithelium: role of angiotensin-receptor-associated-protein and TRPV2 channel. PLoS ONE7 (11): e49624. [PMID:23185387]

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10. Cordeiro S, Seyler S, Stindl J, Milenkovic VM, Strauss O. (2010) Heat-sensitive TRPV channels in retinal pigment epithelial cells: regulation of VEGF-A secretion. Invest. Ophthalmol. Vis. Sci.51 (11): 6001-8. [PMID:20539001]

11. Fois G, Wittekindt O, Zheng X, Felder ET, Miklavc P, Frick M, Dietl P, Felder E. (2012) An ultra fast detection method reveals strain-induced Ca(2+) entry via TRPV2 in alveolar type II cells. Biomech Model Mechanobiol11 (7): 959-71. [PMID:22190268]

12. Gibbs JL, Melnyk JL, Basbaum AI. (2011) Differential TRPV1 and TRPV2 channel expression in dental pulp. J. Dent. Res.90 (6): 765-70. [PMID:21406609]

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14. Holakovska B, Grycova L, Bily J, Teisinger J. (2011) Characterization of calmodulin binding domains in TRPV2 and TRPV5 C-tails. Amino Acids40 (2): 741-8. [PMID:20686800]

15. Hu HZ, Gu Q, Wang C, Colton CK, Tang J, Kinoshita-Kawada M, Lee LY, Wood JD, Zhu MX. (2004) 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J. Biol. Chem.279 (34): 35741-8. [PMID:15194687]

16. Iwata Y, Katanosaka Y, Arai Y, Komamura K, Miyatake K, Shigekawa M. (2003) A novel mechanism of myocyte degeneration involving the Ca2+-permeable growth factor-regulated channel. J. Cell Biol.161 (5): 957-67. [PMID:12796481]

17. Iwata Y, Katanosaka Y, Arai Y, Shigekawa M, Wakabayashi S. (2009) Dominant-negative inhibition of Ca2+ influx via TRPV2 ameliorates muscular dystrophy in animal models. Hum. Mol. Genet.18 (5): 824-34. [PMID:19050039]

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20. Kajiya H, Okamoto F, Nemoto T, Kimachi K, Toh-Goto K, Nakayana S, Okabe K. (2010) RANKL-induced TRPV2 expression regulates osteoclastogenesis via calcium oscillations. Cell Calcium48 (5): 260-9. [PMID:20980052]

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22. Koch SE, Gao X, Haar L, Jiang M, Lasko VM, Robbins N, Cai W, Brokamp C, Varma P, Tranter M et al.. (2012) Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J. Mol. Cell. Cardiol.53 (1): 134-44. [PMID:22561103]

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24. Lewinter RD, Skinner K, Julius D, Basbaum AI. (2004) Immunoreactive TRPV-2 (VRL-1), a capsaicin receptor homolog, in the spinal cord of the rat. J. Comp. Neurol.470 (4): 400-8. [PMID:14961565]

25. Liapi A, Wood JN. (2005) Extensive co-localization and heteromultimer formation of the vanilloid receptor-like protein TRPV2 and the capsaicin receptor TRPV1 in the adult rat cerebral cortex. Eur. J. Neurosci.22 (4): 825-34. [PMID:16115206]

26. Lin Y, Sun Z. (2012) Antiaging gene Klotho enhances glucose-induced insulin secretion by up-regulating plasma membrane levels of TRPV2 in MIN6 β-cells. Endocrinology153 (7): 3029-39. [PMID:22597535]

27. Link TM, Park U, Vonakis BM, Raben DM, Soloski MJ, Caterina MJ. (2010) TRPV2 has a pivotal role in macrophage particle binding and phagocytosis. Nat. Immunol.11 (3): 232-9. [PMID:20118928]

28. Liu G, Xie C, Sun F, Xu X, Yang Y, Zhang T, Deng Y, Wang D, Huang Z, Yang L et al.. (2010) Clinical significance of transient receptor potential vanilloid 2 expression in human hepatocellular carcinoma. Cancer Genet. Cytogenet.197 (1): 54-9. [PMID:20113837]

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30. Mercado J, Gordon-Shaag A, Zagotta WN, Gordon SE. (2010) Ca2+-dependent desensitization of TRPV2 channels is mediated by hydrolysis of phosphatidylinositol 4,5-bisphosphate. J. Neurosci.30 (40): 13338-47. [PMID:20926660]

31. Mihara H, Boudaka A, Shibasaki K, Yamanaka A, Sugiyama T, Tominaga M. (2010) Involvement of TRPV2 activation in intestinal movement through nitric oxide production in mice. J. Neurosci.30 (49): 16536-44. [PMID:21147993]

32. Mihara H, Suzuki N, Yamawaki H, Tominaga M, Sugiyama T. (2013) TRPV2 ion channels expressed in inhibitory motor neurons of gastric myenteric plexus contribute to gastric adaptive relaxation and gastric emptying in mice. Am. J. Physiol. Gastrointest. Liver Physiol.304 (3): G235-40. [PMID:23203157]

33. Monet M, Gkika D, Lehen'kyi V, Pourtier A, Vanden Abeele F, Bidaux G, Juvin V, Rassendren F, Humez S, Prevarsakaya N. (2009) Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochim. Biophys. Acta1793 (3): 528-39. [PMID:19321128]

34. Monet M, Lehen'kyi V, Gackiere F, Firlej V, Vandenberghe M, Roudbaraki M, Gkika D, Pourtier A, Bidaux G, Slomianny C et al.. (2010) Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance. Cancer Res.70 (3): 1225-35. [PMID:20103638]

35. Morelli MB, Nabissi M, Amantini C, Farfariello V, Ricci-Vitiani L, di Martino S, Pallini R, Larocca LM, Caprodossi S, Santoni M et al.. (2012) The transient receptor potential vanilloid-2 cation channel impairs glioblastoma stem-like cell proliferation and promotes differentiation. Int. J. Cancer131 (7): E1067-77. [PMID:22492283]

36. Muraki K, Iwata Y, Katanosaka Y, Ito T, Ohya S, Shigekawa M, Imaizumi Y. (2003) TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes. Circ. Res.93 (9): 829-38. [PMID:14512441]

37. Nabissi M, Morelli MB, Amantini C, Farfariello V, Ricci-Vitiani L, Caprodossi S, Arcella A, Santoni M, Giangaspero F, De Maria R et al.. (2010) TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner. Carcinogenesis31 (5): 794-803. [PMID:20093382]

38. Nabissi M, Morelli MB, Santoni M, Santoni G. (2013) Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents. Carcinogenesis34 (1): 48-57. [PMID:23079154]

39. Nagasawa M, Kojima I. (2012) Translocation of calcium-permeable TRPV2 channel to the podosome: Its role in the regulation of podosome assembly. Cell Calcium51 (2): 186-93. [PMID:22226146]

40. Nagasawa M, Nakagawa Y, Tanaka S, Kojima I. (2007) Chemotactic peptide fMetLeuPhe induces translocation of the TRPV2 channel in macrophages. J. Cell. Physiol.210 (3): 692-702. [PMID:17154364]

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45. Park KS, Pang B, Park SJ, Lee YG, Bae JY, Park S, Kim I, Kim SJ. (2011) Identification and functional characterization of ion channels in CD34(+) hematopoietic stem cells from human peripheral blood. Mol. Cells32 (2): 181-8. [PMID:21638203]

46. Park U, Vastani N, Guan Y, Raja SN, Koltzenburg M, Caterina MJ. (2011) TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception. J. Neurosci.31 (32): 11425-36. [PMID:21832173]

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50. Shibasaki K, Murayama N, Ono K, Ishizaki Y, Tominaga M. (2010) TRPV2 enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neurons. J. Neurosci.30 (13): 4601-12. [PMID:20357111]

51. Shimosato G, Amaya F, Ueda M, Tanaka Y, Decosterd I, Tanaka M. (2005) Peripheral inflammation induces up-regulation of TRPV2 expression in rat DRG. Pain119 (1-3): 225-32. [PMID:16298071]

52. Stokes AJ, Shimoda LM, Koblan-Huberson M, Adra CN, Turner H. (2004) A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells. J. Exp. Med.200 (2): 137-47. [PMID:15249591]

53. Stokes AJ, Wakano C, Del Carmen KA, Koblan-Huberson M, Turner H. (2005) Formation of a physiological complex between TRPV2 and RGA protein promotes cell surface expression of TRPV2. J. Cell. Biochem.94 (4): 669-83. [PMID:15547947]

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55. Sulk M, Seeliger S, Aubert J, Schwab VD, Cevikbas F, Rivier M, Nowak P, Voegel JJ, Buddenkotte J, Steinhoff M. (2012) Distribution and expression of non-neuronal transient receptor potential (TRPV) ion channels in rosacea. J. Invest. Dermatol.132 (4): 1253-62. [PMID:22189789]

56. Tamura S, Morikawa Y, Senba E. (2005) TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons. Neuroscience130 (1): 223-8. [PMID:15561438]

57. Yamada T, Ueda T, Shibata Y, Ikegami Y, Saito M, Ishida Y, Ugawa S, Kohri K, Shimada S. (2010) TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer. Urology76 (2): 509.e1-7. [PMID:20546877]

58. Yamashiro K, Sasano T, Tojo K, Namekata I, Kurokawa J, Sawada N, Suganami T, Kamei Y, Tanaka H, Tajima N et al.. (2010) Role of transient receptor potential vanilloid 2 in LPS-induced cytokine production in macrophages. Biochem. Biophys. Res. Commun.398 (2): 284-9. [PMID:20599720]

59. Zanou N, Iwata Y, Schakman O, Lebacq J, Wakabayashi S, Gailly P. (2009) Essential role of TRPV2 ion channel in the sensitivity of dystrophic muscle to eccentric contractions. FEBS Lett.583 (22): 3600-4. [PMID:19840792]

To cite this database page, please use the following:

Stephanie C Stotz, David E. Clapham.
Transient Receptor Potential channels: TRPV2. Last modified on 12/02/2014. Accessed on 23/04/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=508.

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