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TRPV2

Family: Transient Receptor Potential channels

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Associated Proteins
Ion Selectivity and Conductance
Activators
Pore Blockers
Tissue Distribution
Functional Assays
Physiological Functions
Phenotypes, Alleles and Disease Models
Gene Expression and Pathophysiology
References
Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 764 17p11.2 TRPV2 transient receptor potential cation channel, subfamily V, member 2 2
Mouse 6 1 756 11 B2 Trpv2 transient receptor potential cation channel, subfamily V, member 2 6
Rat 6 1 761 10q22 Trpv2 transient receptor potential cation channel, subfamily V, member 2 2
Previous and Unofficial Names
VRL-1
OTRPC2
GRC
VRL
VRL1
MGC105451
osm-9-like TRP channel 2
stretch-activated channel 2B
transient receptor potential cation channel subfamily V member 2
transient receptor potential cation channel, subfamily V, member 2
vanilloid receptor-like protein 1
Database Links
ChEMBL Target 11847 (Hs), 101052 (Hs), 101224 (Hs), 101451 (Mm), 12018 (Rn), 12516 (Rn)
Ensembl ENSG00000187688 (Hs), ENSMUSG00000018507 (Mm), ENSRNOG00000003104 (Rn)
Entrez Gene 51393 (Hs), 22368 (Mm), 29465 (Rn)
GeneCards TRPV2 (Hs)
GenitoUrinary Development Molecular Anatomy Project Trpv2 (Mm)
HomoloGene 7993 (Hs)
Human Protein Reference Database 05980 (Hs)
InterPro Q9HBA0 (Hs), Q9Y5S1 (Hs), Q8NET8 (Hs), Q8K424 (Mm), Q9EPK8 (Mm), Q9WTR1 (Mm), Q9ERZ8 (Rn), Q9WUD2 (Rn)
KEGG Gene hsa:51393 (Hs), mmu:22368 (Mm), rno:29465 (Rn)
OMIM 606676 (Hs)
PharmGKB Gene PA38292 (Hs)
PhosphoSitePlus Q9Y5S1 (Hs), Q9WTR1 (Mm)
Protein Ontology (PRO) PRO:000001064 (Hs)
RefSeq Nucleotide NM_016113 (Hs), NM_011706 (Mm), NM_017207 (Rn)
RefSeq Protein NP_057197 (Hs), NP_035836 (Mm), NP_058903 (Rn)
TreeFam ENSG00000187688 (Hs), ENSMUSG00000018507 (Mm), ENSRNOG00000003104 (Rn)
UniGene Hs. 279746 (Hs)
UniProt Q9HBA0 (Hs), Q9Y5S1 (Hs), Q8NET8 (Hs), Q8K424 (Mm), Q9EPK8 (Mm), Q9WTR1 (Mm), Q9ERZ8 (Rn), Q9WUD2 (Rn)
Wikipedia TRPV2
Transient Receptor Potential channels
Search for 3D structures on the PDB
Search by keyword: Transient Receptor Potential channels TRPV2 Search by accession number: Q9ERZ8, Q9HBA0, Q9EPK8, Q8K424, Q8NET8, Q9Y5S1, Q9WUD2, Q9WTR1
Associated Proteins
Heteromeric Pore-forming Subunits
Name References
TRPV1 7,10
Auxiliary Subunits
Name References
Not determined
Other Associated Proteins
Name References
Not determined
Ion Selectivity and Conductance
Species:  Rat
Rank order:  Ca2+ > Mg2+ > Cs+ = K+ = Na+
References:  2
Voltage Dependence
Not Determined
Physical activators (Human)
noxious heat (> 35°C; rodent, not human)  [9]
Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Affinity Units Concentration range (M) Holding voltage (mV) Reference
diphenylboronic anhydride Mm - - 1x10-4 -80.0 3
insulin-like growth factor I {Sp: Mouse} Mm - - 2x10-9 -60.0 6
neuropeptide head activator Mm - - 2x10-9 -60.0 1
2-APB Mm 3.9 pEC50 - Physiological 4
Activator Comments
TRPV2 is also activated by heat and cell swelling [2,8].
Pore Blockers
Key to terms and symbols Click column headers to sort
Ligand Sp. Affinity Units Concentration range (M) Holding voltage (mV) Reference
ruthenium red Mm 6.2 pIC50 - -40.0 2

Explore drug-target interactions for this set of compounds using iPHACE

Tissue Distribution
Dorsal root ganglia, trigeminal ganglia, spinal cord, brain, lung, spleen, intestines.
Species:  Rat
Technique:  Immunocytochemistry, Northern Blot.
References:  2
Functional Assays
Two-electrode voltage clamp technique.
Species:  Mouse
Tissue:  Xenopus laevis oocytes injected with TRPV2 cDNA.
Response measured:  Activation by heat and block by ruthenium red.
References:  2
Patch clamp (whole-cell and single-channel recordings).
Species:  Mouse
Tissue:  HEK 293 cells transfected with the TRPV2 vector.
Response measured:  Activation by heat and block by ruthenium red.
References:  2
Patch clamp (whole-cell recordings).
Species:  Mouse
Tissue:  CHO cells transfected with the TRPV2 vector.
Response measured:  Activation by insulin-like growth factor I
References:  6
Patch clamp (whole-cell recordings).
Species:  Mouse
Tissue:  Aortic myocytes.
Response measured:  Activation by cell swelling.
References:  8
Intracellular Ca2+ imaging.
Species:  Mouse
Tissue:  HEK 293 cells transfected with the TRPV2 vector.
Response measured:  Activation by diphenylboronic anhydride.
References:  3
Physiological Functions
Thermosensation and nociception (noxious heat).
Species:  Mouse
Tissue:  Dorsal root ganglia neurones.
References:  2
Phenotypes, Alleles and Disease Models Mouse data from MGI

Click here to show/hide data

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Trpv2tm1Mijc Trpv2tm1Mijc/Trpv2tm1Mijc
involves: 129S6/SvEvTac * C57BL/6		 MGI:1341836  MP:0001262 decreased body weight PMID: 20118928 
Trpv2tm1Mijc Trpv2tm1Mijc/Trpv2tm1Mijc
involves: 129S6/SvEvTac * C57BL/6		 MGI:1341836  MP:0003799 impaired macrophage migration PMID: 20118928 
Trpv2tm1Mijc Trpv2tm1Mijc/Trpv2tm1Mijc
involves: 129S6/SvEvTac * C57BL/6		 MGI:1341836  MP:0001798 impaired macrophage phagocytosis PMID: 20118928 
Trpv2tm1Mijc Trpv2tm1Mijc/Trpv2tm1Mijc
involves: 129S6/SvEvTac * C57BL/6		 MGI:1341836  MP:0002412 increased susceptibility to bacterial infection PMID: 20118928 
Trpv2tm1Mijc Trpv2tm1Mijc/Trpv2tm1Mijc
involves: 129S6/SvEvTac * C57BL/6		 MGI:1341836  MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality PMID: 20118928 
Gene Expression and Pathophysiology
Overexpression.
Tissue or cell type:  Skeletal and cardiac muscle.
Pathophysiology:  Muscular dystrophy and cardiomyopathy.
Species:  Human
Technique: 
References:  5

REFERENCES

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1. Boels, K; Glassmeier, G; Herrmann, D; Riedel, IB; Hampe, W; Kojima, I; Schwarz, JR; Schaller, HC. (2001) The neuropeptide head activator induces activation and translocation of the growth-factor-regulated Ca(2+)-permeable channel GRC. J. Cell. Sci., 114 (Pt 20): 3599-606. [PMID:11707512]

2. Caterina, MJ; Rosen, TA; Tominaga, M; Brake, AJ; Julius, D. (1999) A capsaicin-receptor homologue with a high threshold for noxious heat. Nature, 398 (6726): 436-41. [PMID:10201375]

3. Chung, MK; Guler, AD; Caterina, MJ. (2005) Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3. J. Biol. Chem., 280 (16): 15928-41. [PMID:15722340]

4. Hu, HZ; Gu, Q; Wang, C; Colton, CK; Tang, J; Kinoshita-Kawada, M; Lee, LY; Wood, JD; Zhu, MX. (2004) 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J. Biol. Chem., 279 (34): 35741-8. [PMID:15194687]

5. Iwata, Y; Katanosaka, Y; Arai, Y; Komamura, K; Miyatake, K; Shigekawa, M. (2003) A novel mechanism of myocyte degeneration involving the Ca2+-permeable growth factor-regulated channel. J. Cell Biol., 161 (5): 957-67. [PMID:12796481]

6. Kanzaki, M; Zhang, YQ; Mashima, H; Li, L; Shibata, H; Kojima, I. (1999) Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I. Nat. Cell Biol., 1 (3): 165-70. [PMID:10559903]

7. Liapi, A; Wood, JN. (2005) Extensive co-localization and heteromultimer formation of the vanilloid receptor-like protein TRPV2 and the capsaicin receptor TRPV1 in the adult rat cerebral cortex. Eur. J. Neurosci., 22 (4): 825-34. [PMID:16115206]

8. Muraki, K; Iwata, Y; Katanosaka, Y; Ito, T; Ohya, S; Shigekawa, M; Imaizumi, Y. (2003) TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes. Circ. Res., 93 (9): 829-38. [PMID:14512441]

9. Neeper, MP; Liu, Y; Hutchinson, TL; Wang, Y; Flores, CM; Qin, N. (2007) Activation properties of heterologously expressed mammalian TRPV2: evidence for species dependence. J. Biol. Chem., 282 (21): 15894-902. [PMID:17395593]

10. Rutter, AR; Ma, QP; Leveridge, M; Bonnert, TP. (2005) Heteromerization and colocalization of TrpV1 and TrpV2 in mammalian cell lines and rat dorsal root ganglia. Neuroreport, 16 (16): 1735-9. [PMID:16237318]

To cite this database page, please use the following:

David E. Clapham, Bernd Nilius, Grzegorz Owsianik.
Transient Receptor Potential channels: TRPV2. Last modified on 30/11/2011. Accessed on 20/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=508.


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