Nomenclature: TRPV1

Family: Transient Receptor Potential channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 839 17p13.2 TRPV1 transient receptor potential cation channel, subfamily V, member 1 16
Mouse 6 1 839 11 B3 Trpv1 transient receptor potential cation channel, subfamily V, member 1 11
Rat 6 1 838 10q24 Trpv1 transient receptor potential cation channel, subfamily V, member 1 8
Previous and Unofficial Names
VR1
OTRPC1
vanilloid/capsaicin receptor
vanilloid receptor subtype 1
VR.5'sv
Vr1l1
capsaicin receptor
osm-9-like TRP channel 1
transient receptor potential cation channel subfamily V member 1
transient receptor potential cation channel, subfamily V, member 1
vanilloid receptor 1
vanilloid receptor type 1 like protein 1
vanilloid receptor type 1-like
vanilloid type 1 receptor
VR-1
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Reconstruction of TRPV1 ion channel in complex with capsaicin by single particle cryo-microscopy
PDB Id:  3J5R
Ligand:  capsaicin
Resolution:  4.2Å
Species:  Rat
References:  6
Image of receptor 3D structure from RCSB PDB
Description:  Structure of TRPV1 ion channel determined by single particle electron cryo-microscopy
PDB Id:  3J5P
Resolution:  3.275Å
Species:  Rat
References:  6
Associated Proteins
Heteromeric Pore-forming Subunits
Name References
TRPV3 34
TRPV2 21,30
Auxiliary Subunits
Name References
Not determined
Other Associated Proteins
Name References
PI3 kinase 35
calmodulin 28
A-kinase-anchoring protein (AKAP)79/150 45
Functional Characteristics
γ = 35 pS at – 60 mV; 77 pS at + 60 mV, conducts mono and di-valent cations with a selectivity for divalents (PCa/PNa = 9.6); voltage- and time- dependent outward rectification; potentiated by ethanol; activated/potentiated/upregulated by PKC stimulation; extracellular acidification facilitates activation by PKC; desensitisation inhibited by PKA; inhibited by Ca2+/ calmodulin; cooling reduces vanilloid-evoked currents; may be tonically active at body temperature
Ion Selectivity and Conductance
Species:  Rat
Rank order:  Ca2+ > Mg2+ > Cs+ [35.0 - 80.0 pS] = K+ = Na+
References:  8
Voltage Dependence
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  50.0 – 150.0 100.0 – 600.0 42 HEK 293 cells transiently transfected with hTRPV1 Human
Inactivation  - -
Comments  Activation of TRPV1 by thermal or chemical stimuli is associated with leftward shift of the voltage dependence of activation (9.1 mVºC-1). Whether voltage sensitivity underlies channel activation or represents an independent, allosterically coupled property is currently unresolved [22,24].
Other chemical activators (Human)
NO-mediated cysteine S-nitrosylation
Physical activators (Human)
depolarization (V½ ~ 0 mV at 35°C), noxious heat (> 43°C at pH 7.4)
Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
resiniferatoxin Mm Agonist 9.8 pEC50 - Physiological 11
pEC50 9.8 [11]
Holding voltage: Physiological
arvanil Mm Agonist 9.6 pEC50 - Physiological 11
pEC50 9.6 [11]
Holding voltage: Physiological
olvanil Mm Agonist 8.4 pEC50 - Physiological 11
pEC50 8.4 [11]
Holding voltage: Physiological
resiniferatoxin Hs Agonist 8.4 pEC50 - Physiological 33
pEC50 8.4 (EC50 3.98x10-9 M) [33]
Holding voltage: Physiological
olvanil Rn Agonist 8.1 pEC50 - Physiological 19
pEC50 8.1 [19]
Holding voltage: Physiological
capsaicin Mm Agonist 8.0 pEC50 - Physiological 11
pEC50 8.0 [11]
Holding voltage: Physiological
olvanil Hs Agonist 7.7 pEC50 - Physiological 33
pEC50 7.7 (EC50 1.99x10-8 M) [33]
Holding voltage: Physiological
capsaicin Hs Agonist 7.5 pEC50 - -100.0 – 160.0 42
pEC50 7.5 (EC50 3.16x10-8 M) [42]
Holding voltage: -100.0 – 160.0 mV
resiniferatoxin Rn Agonist 7.5 pEC50 - -40.0 8
pEC50 7.5 [8]
Holding voltage: -40.0 mV
DkTx Rn Activation 6.6 pEC50 - Physiological 5
pEC50 6.6 (EC50 2.3x10-10 M) [5]
Holding voltage: Physiological
vanillotoxin-3 Rn Agonist 6.35 pEC50 - -80.0 31
pEC50 6.35 (EC50 4.5x10-7 M) [31]
Holding voltage: -80.0 mV
capsaicin Rn Agonist 6.1 pEC50 - -40.0 8
pEC50 6.1 [8]
Holding voltage: -40.0 mV
anandamide Hs Agonist 5.9 pEC50 - -70.0 32
pEC50 5.9 [32]
Holding voltage: -70.0 mV
vanillotoxin-2 Rn Agonist 5.87 pEC50 - -80.0 31
pEC50 5.87 (EC50 1.35x10-6 M) [31]
Holding voltage: -80.0 mV
extracellular H+ Hs - 5.4 pEC50 - -
pEC50 5.4 (EC50 3.98x10-6 M) at 37°C
anandamide Rn Agonist 5.3 pEC50 - -40.0 46
pEC50 5.3 [46]
Holding voltage: -40.0 mV
PPAHV Rn Agonist 5.0 – 5.5 pEC50 - -60.0 25
pEC50 5.0 – 5.5 [25]
Holding voltage: -60.0 mV
12S-HPETE Rn Agonist 5.1 pEC50 - -60.0 18
pEC50 5.1 (EC50 7.94x10-6 M) [18]
Holding voltage: -60.0 mV
15S-HPETE Rn Agonist 5.1 pEC50 - -60.0 18
pEC50 5.1 (EC50 7.94x10-6 M) [18]
Holding voltage: -60.0 mV
vanillotoxin-1 Rn Agonist 5.0 pEC50 - -80.0 31
pEC50 5.0 (EC50 9.9x10-6 M) [31]
Holding voltage: -80.0 mV
5S-HPETE Rn Agonist 5.0 pEC50 - -60.0 18
pEC50 5.0 [18]
Holding voltage: -60.0 mV
LTB4 Rn Agonist 4.9 pEC50 - -60.0 18
pEC50 4.9 (EC50 1.25x10-5 M) [18]
Holding voltage: -60.0 mV
piperine Hs Agonist 4.4 pEC50 - -70.0 26
pEC50 4.4 [26]
Holding voltage: -70.0 mV
allicin Rn Agonist 3.9 – 4.6 pEC50 - Physiological 23
pEC50 3.9 – 4.6 [23]
Holding voltage: Physiological
2-APB Mm Agonist 3.7 – 3.9 pEC50 - -40.0 17
pEC50 3.7 – 3.9 [17]
Holding voltage: -40.0 mV
phenylacetylrinvanil Hs - - - - - 1
[1]
camphor Hs - - - - -
diphenylboronic anhydride Hs - - - - -
5S-HETE Hs - - - - -
[3H]resiniferatoxin Hs Activation - - - -
View species-specific activator tables
Activator Comments
TRPV1 is also activated by heat, ethanol, protons and phorbol-12-myristate-13-acetate [2,8,39].
Gating Inhibitor Comments
Phosphatidylinositol-4,5-bisphosphate is also an inhibitor of channel gating [29].
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
[3H]A778317 Hs - 8.5 pKd - - 3
pKd 8.5 (Kd 3.4x10-9 M) [3]
agatoxin 489 Rn Inhibition 6.5 pKi - -40.0 20
pKi 6.5 [20]
Holding voltage: -40.0 mV
AMG517 Hs - 9.0 pIC50 - -
pIC50 9.0 (IC50 9x10-10 M)
5'-iodoresiniferatoxin Hs - 8.4 pIC50 - -
pIC50 8.4 (IC50 3.9x10-9 M)
AMG628 Hs - 8.4 pIC50 - -
pIC50 8.4 (IC50 3.7x10-9 M)
[125I]resiniferatoxin Rn Antagonist 8.4 pIC50 - -50.0 43
pIC50 8.4 (IC50 3.98x10-9 M) [43]
Holding voltage: -50.0 mV
SB705498 Hs - 8.2 – 8.5 pIC50 - -
pIC50 8.2 – 8.5 (IC50 3x10-9 – 6x10-9 M)
A778317 Hs - 8.3 pIC50 - -
pIC50 8.3 (IC50 5x10-9 M)
A425619 Hs - 8.3 pIC50 - -
pIC50 8.3 (IC50 5x10-9 M)
JYL1421 Hs - 8.0 pIC50 - -
pIC50 8.0 (IC50 9.2x10-9 M)
6-iodo-nordihydrocapsaicin Hs - 8.0 pIC50 - -
pIC50 8.0 (IC50 1x10-8 M)
BCTC Hs Antagonist 7.5 – 8.2 pIC50 - -
pIC50 7.5 – 8.2 (IC50 6x10-9 – 3.5x10-8 M)
AMG 9810 Hs Inhibition 7.8 pIC50 - Physiological 14
pIC50 7.8 [14]
Holding voltage: Physiological
JNJ17203212 Hs Antagonist 7.8 pIC50 - Physiological 37
pIC50 7.8 (IC50 1.6x10-8 M) [37]
Holding voltage: Physiological
SB366791 Hs - 7.7 pIC50 - -
pIC50 7.7 (IC50 1.8x10-8 M)
BCTC Rn Antagonist 7.5 pIC50 - Physiological 41
pIC50 7.5 [41]
Holding voltage: Physiological
capsazepine Hs Antagonist 7.4 pIC50 - -60.0 25
pIC50 7.4 [25]
Holding voltage: -60.0 mV
ruthenium red Hs Antagonist 7.0 pIC50 - -60.0 25
pIC50 7.0 [25]
Holding voltage: -60.0 mV
ruthenium red Rn Antagonist 6.7 pIC50 - -60.0 25
pIC50 6.7 [25]
Holding voltage: -60.0 mV
capsazepine Rn Antagonist 6.7 pIC50 - -60.0 25
pIC50 6.7 [25]
Holding voltage: -60.0 mV
SB452533 Hs - - - - -
2-APB Hs - - - - -
NADA Hs - - - - -
anandamide Hs - - - - -
allicin Hs - - - - -
View species-specific channel blocker tables
Channel Blocker Comments
Of the compounds listed above, there is good evidence to denote agatoxin 489 and ruthenium red as true channel blockers. The others should be considered antagonists.
Tissue Distribution
Dorsal root ganglia, brain, kidney, pancreas, testes, uterus, spleen, stomach, small intestine, lung, liver.
Species:  Human
Technique:  RT-PCR
References:  16
Dorsal root and trigeminal ganglia, caudal hypothalamus, subset of arteriolar smooth muscle cells.
Species:  Mouse
Technique:  Transgenic reporter lines
References:  9-10,27
Bladder
Species:  Rat
Technique:  Immunocytochemistry, RT-PCR
References:  4
Dorsal root ganglia, kidney, pancreas, placenta.
Species:  Rat
Technique:  RT-PCR
References:  16
Trigeminal ganglia, dorsal root ganglia, kidney.
Species:  Rat
Technique:  In situ hybridisation, Northern Blot
References:  8
Functional Assays
Patch clamp (whole-cell recordings).
Species:  Mouse
Tissue:  Dorsal root ganglion neurones.
Response measured:  Activation by capsaicin, resiniferatoxin and heat.
References:  7
Intracellular Ca2+ imaging.
Species:  Rat
Tissue:  HEK 293 cells transfected with TRPV1.
Response measured:  Activation by capsaicin and anandamide.
References:  32
Two-electrode voltage clamp technique.
Species:  Rat
Tissue:  Xenopus laevis oocytes injected with TRPV1 cDNA.
Response measured:  Activation by capsaicin and resiniferatoxin.
References:  8
Patch clamp (whole-cell and single-channel recordings).
Species:  Rat
Tissue:  HEK cells transfected with TRPV1 vector.
Response measured:  Activation by capsaicin, resiniferatoxin and heat.
References:  8
Patch clamp (whole-cell recordings).
Species:  Human
Tissue:  HEK 293 cells transfected with TRPV1.
Response measured:  Activation by capsaicin and heat.
References:  16
Two-electrode voltage clamp technique.
Species:  Human
Tissue:  Xenopus laevis oocytes injected with TRPV1 cDNA.
Response measured:  Activation by capsaicin and pH.
References:  16
Intracellular Ca2+ imaging.
Species:  Human
Tissue:  HEK 293 cells transfected with TRPV1.
Response measured:  Activation by capsaicin, olvanil, resiniferatoxin and anandamide.
References:  33
Intracellular Ca2+ imaging.
Species:  Mouse
Tissue:  HEK 293 cells transfected with TRPV1.
Response measured:  Activation by agonists and pH.
References:  11
Physiological Functions
Thermosensation (moderate heat) and nociception.
Species:  Rat
Tissue:  Dorsal root ganlgia neurones.
References:  8
Detection an integration of noxious stimuli (actute nociceptive pain).
Species:  Rat
Tissue:  Sensory neurones.
References:  38
Physiological Consequences of Altering Gene Expression
TRPV1 null mice exhibit various phenotypes including insensitivity to capsaicin and other vanilloid irritants, diminished sensitivity to noxious heat and tissue acidosis, loss of thermal hyperalgesia.
Species:  Mouse
Tissue: 
Technique:  Gene knockout by homologous recombination.
References:  7,12,36
Phenotypes, Alleles and Disease Models Mouse data from MGI

Show »

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0005402 abnormal action potential PMID: 15509739 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1
MGI:1341787  MP:0004924 abnormal behavior PMID: 17251423 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0009745 abnormal behavioral response to xenobiotic PMID: 19705551 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
involves: 129X1/SvJ
MGI:1341787  MP:0005535 abnormal body temperature PMID: 18503767 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1
MGI:1341787  MP:0008722 abnormal chemokine secretion PMID: 19794112 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0000427 abnormal hair cycle PMID: 16645591 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0008859 abnormal hair cycle catagen phase PMID: 16645591 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0008860 abnormal hair cycle telogen phase PMID: 16645591 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1
MGI:1341787  MP:0005555 abnormal kidney excretion PMID: 19794112 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0002734 abnormal mechanical nociception PMID: 17553498 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
involves: 129X1/SvJ
MGI:1341787  MP:0002272 abnormal nervous system electrophysiology PMID: 16943565 
Trpv1tm1Jbd Trpv1tm1Jbd/Trpv1tm1Jbd
involves: 129P2/OlaHsd * C57BL/6J
MGI:1341787  MP:0002272 abnormal nervous system electrophysiology PMID: 10821274 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0002272 abnormal nervous system electrophysiology PMID: 16327782 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0004948 abnormal neuronal precursor proliferation PMID: 15266010 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
involves: 129X1/SvJ
MGI:1341787  MP:0002736 abnormal nociception after inflammation PMID: 10764638 
Trpv1tm1Jbd Trpv1tm1Jbd/Trpv1tm1Jbd
involves: 129P2/OlaHsd * C57BL/6J
MGI:1341787  MP:0002736 abnormal nociception after inflammation PMID: 10821274 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0008872 abnormal physiological response to xenobiotic PMID: 15121805  15128844  17347480  17553498  18341994 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1
MGI:1341787  MP:0002703 abnormal renal tubule morphology PMID: 19794112 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
involves: 129X1/SvJ
MGI:1341787  MP:0010055 abnormal sensory neuron physiology PMID: 10764638 
Trpv1tm1Jbd Trpv1tm1Jbd/Trpv1tm1Jbd
involves: 129P2/OlaHsd
MGI:1341787  MP:0010055 abnormal sensory neuron physiology PMID: 18499726 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0001986 abnormal taste sensitivity PMID: 19244541 
Trpv1tm1Jbd Trpv1tm1Jbd/Trpv1tm1Jbd
involves: 129P2/OlaHsd * C57BL/6J
MGI:1341787  MP:0002733 abnormal thermal nociception PMID: 10821274 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
involves: 129X1/SvJ * C57BL/6
MGI:1341787  MP:0001756 abnormal urination PMID: 12161756 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0004484 altered response of heart to induced stress PMID: 16314376 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0002862 altered righting response PMID: 19705551 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
involves: 129X1/SvJ
MGI:1341787  MP:0009287 decreased abdominal fat pad weight PMID: 18503767 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1
MGI:1341787  MP:0001364 decreased anxiety-related response PMID: 17251423 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
involves: 129X1/SvJ
MGI:1341787  MP:0003912 decreased drinking behavior PMID: 16943565 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
involves: 129X1/SvJ
MGI:1341787  MP:0009269 decreased fat cell size PMID: 18503767 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0003821 decreased left ventricle diastolic pressure PMID: 16314376 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
involves: 129X1/SvJ
MGI:1341787  MP:0008844 decreased subcutaneous adipose tissue amount PMID: 18503767 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
involves: 129X1/SvJ * C57BL/6
MGI:1341787  MP:0008734 decreased susceptibility to endotoxin shock PMID: 15763167 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0002917 decreased synaptic depression PMID: 18341994 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1
MGI:1341787  MP:0005264 glomerulosclerosis PMID: 19794112 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
involves: 129X1/SvJ
MGI:1341787  MP:0003043 hypoalgesia PMID: 10764638 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
involves: 129X1/SvJ
MGI:1341787  MP:0002578 impaired ability to fire action potentials PMID: 16943565 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0002578 impaired ability to fire action potentials PMID: 15509739 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1
MGI:1341787  MP:0009454 impaired contextual conditioning behavior PMID: 17251423 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0001405 impaired coordination PMID: 19705551 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1
MGI:1341787  MP:0009456 impaired cued conditioning behavior PMID: 17251423 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
involves: 129X1/SvJ * C57BL/6
MGI:1341787  MP:0003829 impaired febrile response PMID: 15763167 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0003545 increased alcohol consumption PMID: 19705551 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0008997 increased blood osmolality PMID: 16327782 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0001260 increased body weight PMID: 17347480 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
involves: 129X1/SvJ
MGI:1341787  MP:0008531 increased chemical nociceptive threshold PMID: 10764638 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0003022 increased coronary flow rate PMID: 16314376 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
involves: 129X1/SvJ * C57BL/6
MGI:1341787  MP:0004499 increased incidence of chemically-induced tumors PMID: 19155296 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1
MGI:1341787  MP:0008705 increased interleukin-6 secretion PMID: 19794112 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0003823 increased left ventricular developed pressure PMID: 16314376 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1
MGI:1341787  MP:0002962 increased protein excretion PMID: 19794112 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
involves: 129X1/SvJ
MGI:1341787  MP:0005659 increased resistance to diet-induced obesity PMID: 18503767 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
involves: 129X1/SvJ
MGI:1341787  MP:0002310 increased resistance to hepatic steatosis PMID: 18503767 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1
MGI:1341787  MP:0005165 increased susceptibility to injury PMID: 19794112 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
involves: 129X1/SvJ
MGI:1341787  MP:0001973 increased thermal nociceptive threshold PMID: 10764638 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0001973 increased thermal nociceptive threshold PMID: 15128844 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1
MGI:1341787  MP:0008560 increased tumor necrosis factor secretion PMID: 19794112 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1
MGI:1341787  MP:0001859 kidney inflammation PMID: 19794112 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1/J
MGI:1341787  MP:0001475 reduced long term depression PMID: 18341994 
Trpv1tm1Jul Trpv1tm1Jul/Trpv1tm1Jul
B6.129X1-Trpv1
MGI:1341787  MP:0001473 reduced long term potentiation PMID: 17251423 
Gene Expression and Pathophysiology
Overexpression
Tissue or cell type:  Bowel, colon.
Pathophysiology:  Inflammatory bowel disease, Crohn's disease and ulcerative colitis.
Species:  Human
Technique: 
References:  15,44
Overexpression
Tissue or cell type:  Vulval vestibulus.
Pathophysiology:  Vulvodynia.
Species:  Human
Technique: 
References:  40
Overexpression.
Tissue or cell type:  Synovia of joints, synoviocytes.
Pathophysiology:  Osteoarthritis.
Species:  Human
Technique: 
References:  13

REFERENCES

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David Julius, David E. Clapham.
Transient Receptor Potential channels: TRPV1. Last modified on 30/05/2014. Accessed on 02/10/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=507.

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