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TRPC5

Family: Transient Receptor Potential channels

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Associated Proteins
Ion Selectivity and Conductance
Activators
Pore Blockers
Tissue Distribution
Physiological Functions
Phenotypes, Alleles and Disease Models
References
Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 973 Xq23 TRPC5 transient receptor potential cation channel, subfamily C, member 5
Mouse 6 1 975 X F2 Trpc5 transient receptor potential cation channel, subfamily C, member 5
Rat 6 1 974 Xq14 Trpc5 transient receptor potential cation channel, subfamily C, member 5
Previous and Unofficial Names
TRP5
CCE2
Trrp5
short transient receptor potential channel 5
transient receptor potential cation channel, subfamily C, member 5
transient receptor protein 5
Database Links
Ensembl ENSG00000072315 (Hs), ENSMUSG00000041710 (Mm), ENSRNOG00000027233 (Rn)
Entrez Gene 7224 (Hs), 22067 (Mm), 140933 (Rn)
GeneCards TRPC5 (Hs)
GenitoUrinary Development Molecular Anatomy Project Trpc5 (Mm)
HomoloGene 74915 (Hs)
Human Protein Reference Database 02273 (Hs)
InterPro Q9UL62 (Hs), Q9QX29 (Mm)
KEGG Gene hsa:7224 (Hs), mmu:22067 (Mm), rno:140933 (Rn)
OMIM 300334 (Hs)
PharmGKB Gene PA37010 (Hs)
PhosphoSitePlus Q9UL62 (Hs), Q9QX29 (Mm)
Protein Ontology (PRO) PRO:000016695 (Hs)
RefSeq Nucleotide NM_012471 (Hs), NM_009428 (Mm), NM_080898 (Rn)
RefSeq Protein NP_036603 (Hs), NP_033454 (Mm), NP_543174 (Rn)
TreeFam ENSG00000072315 (Hs), ENSMUSG00000041710 (Mm), ENSRNOG00000027233 (Rn)
UniGene Hs. 657709 (Hs)
UniProt Q9UL62 (Hs), Q9QX29 (Mm)
Wikipedia TRPC5
Transient Receptor Potential channels
Search for 3D structures on the PDB
Search by keyword: Transient Receptor Potential channels TRPC5 Search by accession number: Q9QX29, Q9UL62
Associated Proteins
Heteromeric Pore-forming Subunits
Name References
TRPC1 11
TRPC3 12
Auxiliary Subunits
Name References
Not determined
Other Associated Proteins
Name References
MxA 6
calmodulin 8
NHERF 13
Ion Selectivity and Conductance
Species:  Mouse
Rank order:  Ca2+ > K+ [35.0 pS] = Cs+ = Na+
References:  10-11
Voltage Dependence
Not Determined
Other chemical activators (Human)
NO-mediated cysteine S-nitrosylation (disputed), potentiation by extracellular protons
Physical activators (Human)
membrane stretch (likely indirect)
Activator Comments
Activated by stimulation of GPCRs coupled to Gq stimulation. Precise pathway is unclear. Also, potentiated by 10-100 μM La3+ and Gd3+ [4,10-11]. When complexed with TRPC1, a current with a unique I-V relationship is formed [11].
Pore Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Affinity Units Concentration range (M) Holding voltage (mV) Reference
La3+ Mm - - 5x10-3 -60.0 4
2-APB Hs 4.7 pIC50 - -80.0 14
View species-specific pore blocker tables

Explore drug-target interactions for this set of compounds using iPHACE

Tissue Distribution
Brain, testes, kidney, uterus.
Species:  Mouse
Technique:  Northern Blot
References:  7
Hippocampus, cerebellar Purkinje neurones, mitral cells of olfactory bulb.
Species:  Mouse
Technique:  In situ hybridisation
References:  9
Hippocampus CA1/3 cells, dentate gyrus cells.
Species:  Rat
Technique:  Immunohistochemistry
References:  1-2
Physiological Functions
Regulation of growth cone extension.
Species:  Rat
Tissue:  Brain
References:  3
Possible component of muscarininc activated current in gastric smooth muscle cells.
Species:  Mouse
Tissue:  Gastric smooth muscle.
References:  5
Phenotypes, Alleles and Disease Models Mouse data from MGI

Click here to show/hide data

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Trpc5tm1.1Clph Trpc5tm1.1Clph/Trpc5tm1.1Clph
involves: 129/Sv		 MGI:109524  MP:0002910 abnormal excitatory postsynaptic currents PMID: 19450521 
Trpc5tm1.1Clph Trpc5tm1.1Clph/Y
involves: 129/Sv		 MGI:109524  MP:0002910 abnormal excitatory postsynaptic currents PMID: 19450521 
Trpc5tm1.1Clph Trpc5tm1.1Clph/Trpc5tm1.1Clph
involves: 129/Sv		 MGI:109524  MP:0001364 decreased anxiety-related response PMID: 19450521 
Trpc5tm1.1Clph Trpc5tm1.1Clph/Y
involves: 129/Sv		 MGI:109524  MP:0001364 decreased anxiety-related response PMID: 19450521 
Trpc5tm1.1Clph Trpc5tm1.1Clph/Trpc5tm1.1Clph
involves: 129/Sv		 MGI:109524  MP:0003460 decreased fear-related response PMID: 19450521 
Trpc5tm1.1Clph Trpc5tm1.1Clph/Y
involves: 129/Sv		 MGI:109524  MP:0003460 decreased fear-related response PMID: 19450521 
Trpc5tm1.1Clph Trpc5tm1.1Clph/Trpc5tm1.1Clph
involves: 129/Sv		 MGI:109524  MP:0003459 increased fear-related response PMID: 19450521 
Trpc5tm1.1Clph Trpc5tm1.1Clph/Y
involves: 129/Sv		 MGI:109524  MP:0003459 increased fear-related response PMID: 19450521 

REFERENCES

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1. Chung, YH; Sun Ahn, H; Kim, D; Hoon Shin, D; Su Kim, S; Yong Kim, K; Bok Lee, W; Ik Cha, C. (2006) Immunohistochemical study on the distribution of TRPC channels in the rat hippocampus. Brain Res., 1085 (1): 132-7. [PMID:16580647]

2. De March, Z; Giampa , C; Patassini, S; Bernardi, G; Fusco, FR. (2006) Cellular localization of TRPC5 in the substantia nigra of rat. Neurosci. Lett., 402 (1-2): 35-9. [PMID:16635549]

3. Greka, A; Navarro, B; Oancea, E; Duggan, A; Clapham, DE. (2003) TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat. Neurosci., 6 (8): 837-45. [PMID:12858178]

4. Jung, S; Muhle, A; Schaefer, M; Strotmann, R; Schultz, G; Plant, TD. (2003) Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouth. J. Biol. Chem., 278 (6): 3562-71. [PMID:12456670]

5. Lee, YM; Kim, BJ; Kim, HJ; Yang, DK; Zhu, MH; Lee, KP; So, I; Kim, KW. (2003) TRPC5 as a candidate for the nonselective cation channel activated by muscarinic stimulation in murine stomach. Am. J. Physiol. Gastrointest. Liver Physiol., 284 (4): G604-16. [PMID:12631560]

6. Lussier, MP; Cayouette, S; Lepage, PK; Bernier, CL; Francoeur, N; St-Hilaire, M; Pinard, M; Boulay, G. (2005) MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC. J. Biol. Chem., 280 (19): 19393-400. [PMID:15757897]

7. Okada, T; Shimizu, S; Wakamori, M; Maeda, A; Kurosaki, T; Takada, N; Imoto, K; Mori, Y. (1998) Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain. J. Biol. Chem., 273 (17): 10279-87. [PMID:9553080]

8. Ordaz, B; Tang, J; Xiao, R; Salgado, A; Sampieri, A; Zhu, MX; Vaca, L. (2005) Calmodulin and calcium interplay in the modulation of TRPC5 channel activity. Identification of a novel C-terminal domain for calcium/calmodulin-mediated facilitation. J. Biol. Chem., 280 (35): 30788-96. [PMID:15987684]

9. Philipp, S; Hambrecht, J; Braslavski, L; Schroth, G; Freichel, M; Murakami, M; Cavalié, A; Flockerzi, V. (1998) A novel capacitative calcium entry channel expressed in excitable cells. EMBO J., 17 (15): 4274-82. [PMID:9687496]

10. Schaefer, M; Plant, TD; Obukhov, AG; Hofmann, T; Gudermann, T; Schultz, G. (2000) Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5. J. Biol. Chem., 275 (23): 17517-26. [PMID:10837492]

11. Strübing, C; Krapivinsky, G; Krapivinsky, L; Clapham, DE. (2001) TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron, 29 (3): 645-55. [PMID:11301024]

12. Strübing, C; Krapivinsky, G; Krapivinsky, L; Clapham, DE. (2003) Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J. Biol. Chem., 278 (40): 39014-9. [PMID:12857742]

13. Tang, Y; Tang, J; Chen, Z; Trost, C; Flockerzi, V; Li, M; Ramesh, V; Zhu, MX. (2000) Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. J. Biol. Chem., 275 (48): 37559-64. [PMID:10980202]

14. Xu, SZ; Zeng, F; Boulay, G; Grimm, C; Harteneck, C; Beech, DJ. (2005) Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. Br. J. Pharmacol., 145 (4): 405-14. [PMID:15806115]

To cite this database page, please use the following:

David E. Clapham, Bernd Nilius, Grzegorz Owsianik.
Transient Receptor Potential channels: TRPC5. Last modified on 07/11/2011. Accessed on 19/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=490.


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