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TRPC4
| Previous and Unofficial Names |
| TRP4 |
| CCE2 |
| Structural Information |
| Species |
TM |
P Loops |
AA |
Chromosomal Location |
Gene Name |
Reference |
| Human |
6 |
1 |
977 |
13q13.1-q13.2 |
TRPC4
|
|
| Rat |
6 |
1 |
977 |
2q26 |
Trpc4
|
|
| Mouse |
6 |
1 |
974 |
3 D |
Trpc4
|
|
|
|
| Database Links |
|
Ensembl |
ENSG00000133107 (Hs), ENSMUSG00000027748 (Mm), ENSRNOG00000011133 (Rn) |
|
Entrez Gene |
7223 (Hs), 22066 (Mm), 84494 (Rn) |
|
GeneCards |
TRPC4 (Hs) |
|
HomoloGene |
22955 (Hs) |
|
OMIM |
603651 (Hs) |
|
PharmGKB Gene |
PA37009 (Hs) |
|
Protein Ontology (PRO) |
PRO:000001075 (Hs) |
|
RefSeq Nucleotide |
NM_016179 (Hs), NM_016984 (Mm), NM_080396 (Rn), NM_001083115 (Rn) |
|
RefSeq Protein |
NP_057263 (Hs), NP_058680 (Mm), NP_536321 (Rn), NP_001076584 (Rn) |
|
UniGene Hs. |
603651 (Hs) |
|
UniProt |
Q9UBN4 (Hs), Q9QUQ5 (Mm), O35119 (Rn) |
|
Wikipedia |
TRPC4 |
| Search for 3D structures on the PDB |
|
Search using keywords: Transient Receptor Potential Channels TRPC4
|
Search using accession numbers: O35119 || Q9QUQ5 || Q9UBN4
|
| Associated Proteins |
| Heteromeric Pore-forming Subunits |
| Name |
References |
| TRPC1 |
38 |
| TRPC3 |
40 |
| TRPC5 |
38 |
|
| Auxiliary Subunits |
| Name |
References |
| Not determined |
|
| Other Associated Proteins |
| Name |
References |
| calmodulin |
73 |
| IP3R |
73 |
| NHERF |
74 |
| MxA |
61 |
|
| Ion Selectivity and Conductance |
| Species: |
Mouse |
| Rank order: |
Ca2+ = Na+ |
| References: |
38,75 |
|
| Voltage Dependence |
|
|
| Tissue Distribution
|
| Inner granule cell layer of olfactory bulb. |
| Species: |
Rat |
| Technique: |
In situ hybridisation |
| References: |
79 |
|
|
| Heart, brain, pancreas, placenta, kidney. |
| Species: |
Human |
| Technique: |
Northern Blot |
| References: |
80 |
|
|
| Hippocampal CA1 & CA3 areas, dentate gyrus. |
| Species: |
Rat |
| Technique: |
Immunohistochemistry |
| References: |
77 |
|
|
| Functional Assays
|
| Nonselective cation current activated by Gq stimulation. |
| Species: |
Mouse |
| Tissue: |
Heterologous expression. |
| Response measured: |
Cation current. |
| References: |
38,75 |
|
|
| Physiological Functions
|
| Mediates agonist dependent vasorelaxation in the vascular endothelium. |
| Species: |
Mouse |
| Tissue: |
Vascular endothelium. |
| References: |
76 |
|
|
| Proposed as a component of muscarinic receptor-activated nonselective current in smooth muscle cells. |
| Species: |
Mouse |
| Tissue: |
Visceral smooth muscle. |
| References: |
77 |
|
|
| Biologically Significant Variants
|
| β-isoform |
| Nucleotide accession: |
NM_001083115
|
| Protein accession: |
NP_001076584
|
| Amino acids: |
893 |
| Type: |
Splice variant |
| Species: |
Rat |
| References: |
|
|
|
| α-isoform |
| Nucleotide accession: |
NM_080396
|
| Protein accession: |
NP_536321
|
| Amino acids: |
977 |
| Type: |
Splice variant |
| Species: |
Rat |
| References: |
|
|
|
|
Subunit Comments |
|
Activated by stimulation of GPCRs coupled to Gq stimulation. Precise pathway is unclear. Also, potentiated by 10-100 μM La3+ and Gd3+. When complexed with TRPC1, a current with a unique I-V relationship is formed [38]. |
To cite this receptor data page, please use the following:
David E. Clapham, Bernd Nilius, Grzegorz Owsianik.
Transient Receptor Potential Channels: TRPC4. Last modified on 2010-07-01. Accessed on 2010-09-10. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=489.
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