Nomenclature: P2X7

Family: P2X receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 595 12q24 P2RX7 purinergic receptor P2X, ligand-gated ion channel, 7 48
Mouse 2 595 5 P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 11
Rat 2 595 12q16 P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 60
Previous and Unofficial Names
P2X7
P2Z
MGC20089
ATP receptor
P2X purinoceptor 7
P2X7 purinoceptor
P2Z receptor
purinergic receptor P2X, ligand-gated ion channel, 7
purinergic receptor P2X7
P2X7 receptor
P2X7R
P2X(7)
AI467586
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
ATP
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
decavanadate Hs Antagonist 7.4 pA2 40
pA2 7.4 pA2 = 7.4 [40]
JNJ-479655 Hs Antagonist 7.9 pKi 5
pKi 7.9 (Ki 1.26x10-8 M) [5]
brilliant blue G Hs Antagonist ~8.0 pIC50 32
pIC50 ~8.0 (IC50 ~1x10-8 M) [32]
A804598 Hs Antagonist ~8.0 pIC50
pIC50 ~8.0 (IC50 ~1x10-8 M)
A839977 Hs Antagonist ~7.7 pIC50 16-17,31
pIC50 ~7.7 (IC50 ~2x10-8 M) [16-17,31]
A740003 Hs Antagonist ~7.4 pIC50
pIC50 ~7.4 (IC50 ~4x10-8 M)
A438079 Hs Antagonist ~6.9 pIC50 16
pIC50 ~6.9 (IC50 ~1.25x10-7 M) [16]
Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Voltage-dependent (mV) Reference
chelerythrine Hs Negative - - - no 51
[51]
Not voltage dependent
ivermectin Hs Positive - - - no 44
[44]
Not voltage dependent
AZ11645373 Hs Negative - - - no 39,58
[39,58]
Not voltage dependent
KN62 Hs Negative - - - no 23,51
[23,51]
Not voltage dependent
Allosteric Modulator Comments
Effects of the allosteric regulators at P2X7 receptors are species-dependent.
Tissue Distribution
Bladder, astrocytes
Expression level:  Low
Species:  Human
Technique:  RT-PCR
References:  42,45
Heart, liver, skeletal muscle, pancreas, thymus, tonsils, monocytes, macrophages, osteoclasts
Expression level:  High
Species:  Human
Technique:  Immunohistochemistry, Northern blot; flow cytometry; RT-PCR
References:  8,24,48
Fibroblasts; dendritic cells, osteoblasts, B lymphocytes, T lymphocytes, keratinocytes, erithrocytes, microglia
Expression level:  Medium
Species:  Human
Technique:  RT-PCR, Western blot, flow cytometry, immunohistochemistry, immunofluorescence
References:  4,8,24,26,54-56,64-65
Brain, lung, prostate, leukocytes
Expression level:  Medium
Species:  Human
Technique:  Northern blot
References:  48
Bone marrow, macrophages, granulocytes, B lymphocytes, mast cells, submandibular glands, lung, microglia, Schwann cells, kidney, osteoclasts, osteoblasts, liver
Expression level:  High
Species:  Mouse
Technique:  In situ hybridisation, RT-PCR, Western blot, Immunofluorescence
References:  9,11,13-14,18,20,27-28,34,52
Bone marrow, macrophages, osteoclasts
Expression level:  High
Species:  Rat
Technique:  in situ hybridization
References:  13,41
New born brain, lung, spleen, bone marrow, spleen, salivary glands, testis, brain (ependyma,neurons from olfactory nucleus, cerebral cortex, piriform cortex, lateral septal nucleus, hippocampal pyramidal cells, oligodendrocytes, microglia), retina, parotid gland, lacrimal glands, pancreas, liver.
Expression level:  High
Species:  Rat
Technique:  in situ hybridization, RT-PCR, Northern Blot, Western blot, Immunofluorescence, Immunohistochemistry
References:  7,13,15,18,21,30,59,62,66
Physiological Consequences of Altering Gene Expression
Decreased proliferation
Species:  Mouse
Tissue:  microglia
Technique:  RNAi
References:  6
Anti-depressant-like behaviour, spatial memory impairment
Species:  Mouse
Tissue:  brain
Technique:  Knock-out
References:  3,36
Reduced long term potentiation and allodynia
Species:  Rat
Tissue:  spinal cord
Technique:  RNAi
References:  12
Defective IL-1 release; defective intraphagosomal killing
Species:  Mouse
Tissue:  macrophages, microglia
Technique:  Knock-out
References:  19,49,57
Reduced experimental arthritis, defective bone homeostasis; reduced neuropathic pain; reduced autoimmune hepatitis, reduced inflammation and fibrosis following ureteral obstruction, reduced experimental glomerulonephritis, defective wound healing, defective experimental encephalitis; reduced smoke-induced lung inflammation
Species:  Mouse
Tissue:  joint tissue, long bones, nervous system; liver, kidney, cornea, brain, lung
Technique:  Knock-out
References:  10,25,33-35,37-38,50,61
Gene Expression and Pathophysiology
Upregulation
Tissue or cell type:  Retina
Pathophysiology:  Retinal degeneration
Species:  Mouse
Technique:  RT-PCR, immunohistochemistry
References:  22
Upregulation
Tissue or cell type:  B lymphocytes
Pathophysiology:  Chronic lymphocytic leukemia
Species:  Human
Technique:  RT-PCR, Western blot
References:  1
Upregulation
Tissue or cell type:  Neuroblastoma cells
Pathophysiology:  Carcinomas
Species:  Human
Technique:  Immunohistochemistry
References:  47
Upregulation
Tissue or cell type:  Kidney
Pathophysiology:  Experimental diabetes/hypertension
Species:  Mouse
Technique:  Immunohistochemistry, Western blotting
References:  63
Upregulation
Tissue or cell type:  Kidney
Pathophysiology:  Autosomal recessive polycystic kidney disease
Species:  Human
Technique:  Immunocytochemistry
References:  29
Upregulation
Tissue or cell type:  Spinal cord
Pathophysiology:  Multiple sclerosis, Amiotrophic lateral sclerosis
Species:  Human
Technique:  Immunocytochemistry, Western blotting
References:  64
Upregulation
Tissue or cell type:  Microglia
Pathophysiology:  Mouse model of Alzheimer's disease
Species:  Mouse
Technique:  Immunofluorescence
References:  46
Biologically Significant Variants
Type:  Single nucletide polymorphisms.
Species:  Human
Description:  Splice site mutation at position +1 in intron 1, SNP 151+1g>t (rs35933842:- null allele)
References:  53
Type:  Single nucleotide polymorphism
Species:  Mouse
Description:  Allelic mutation in the COOH tail of C57BL/6 and DBA mice decreases sensitivity to ATP
References:  2
Type:  Splice variant
Species:  Mouse
Description:  Alternative transmembrane domain 1. This variant escapes gene inactivation in P2X7 knock-out mice
Amino acids:  592
Nucleotide accession: 
Protein accession: 
References:  43
Type:  Splice variant
Species:  Rat
Description:  Alternative transmembrane domain 1
Amino acids:  596
Nucleotide accession: 
Protein accession: 
References:  43

REFERENCES

1. Adinolfi E, Melchiorri L, Falzoni S, Chiozzi P, Morelli A, Tieghi A, Cuneo A, Castoldi G, Di Virgilio F, Baricordi OR. (2002) P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia. Blood99 (2): 706-8. [PMID:11781259]

2. Adriouch S, Dox C, Welge V, Seman M, Koch-Nolte F, Haag F. (2002) Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor. J. Immunol.169 (8): 4108-12. [PMID:12370338]

3. Basso AM, Bratcher NA, Harris RR, Jarvis MF, Decker MW, Rueter LE. (2009) Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: relevance for neuropsychiatric disorders. Behav. Brain Res.198 (1): 83-90. [PMID:18996151]

4. Berchtold S, Ogilvie AL, Bogdan C, Mühl-Zürbes P, Ogilvie A, Schuler G, Steinkasserer A. (1999) Human monocyte derived dendritic cells express functional P2X and P2Y receptors as well as ecto-nucleotidases. FEBS Lett.458 (3): 424-8. [PMID:10570953]

5. Bhattacharya A, Wang Q, Ao H, Shoblock JR, Lord B, Aluisio L, Fraser I, Nepomuceno D, Neff RA, Welty N et al.. (2013) Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567. Br. J. Pharmacol.170 (3): 624-40. [PMID:23889535]

6. Bianco F, Ceruti S, Colombo A, Fumagalli M, Ferrari D, Pizzirani C, Matteoli M, Di Virgilio F, Abbracchio MP, Verderio C. (2006) A role for P2X7 in microglial proliferation. J. Neurochem.99 (3): 745-58. [PMID:16836656]

7. Brändle U, Kohler K, Wheeler-Schilling TH. (1998) Expression of the P2X7-receptor subunit in neurons of the rat retina. Brain Res. Mol. Brain Res.62 (1): 106-9. [PMID:9795168]

8. Buell G, Chessell IP, Michel AD, Collo G, Salazzo M, Herren S, Gretener D, Grahames C, Kaur R, Kosco-Vilbois MH, Humphrey PP. (1998) Blockade of human P2X7 receptor function with a monoclonal antibody. Blood92 (10): 3521-8. [PMID:9808543]

9. Bulanova E, Budagian V, Orinska Z, Hein M, Petersen F, Thon L, Adam D, Bulfone-Paus S. (2005) Extracellular ATP induces cytokine expression and apoptosis through P2X7 receptor in murine mast cells. J. Immunol.174 (7): 3880-90. [PMID:15778342]

10. Chessell IP, Hatcher JP, Bountra C, Michel AD, Hughes JP, Green P, Egerton J, Murfin M, Richardson J, Peck WL, Grahames CB, Casula MA, Yiangou Y, Birch R, Anand P, Buell GN. (2005) Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain114 (3): 386-96. [PMID:15777864]

11. Chessell IP, Simon J, Hibell AD, Michel AD, Barnard EA, Humphrey PP. (1998) Cloning and functional characterisation of the mouse P2X7 receptor. FEBS Lett.439 (1-2): 26-30. [PMID:9849870]

12. Chu YX, Zhang Y, Zhang YQ, Zhao ZQ. (2010) Involvement of microglial P2X7 receptors and downstream signaling pathways in long-term potentiation of spinal nociceptive responses. Brain Behav. Immun.24 (7): 1176-89. [PMID:20554014]

13. Collo G, Neidhart S, Kawashima E, Kosco-Vilbois M, North RA, Buell G. (1997) Tissue distribution of the P2X7 receptor. Neuropharmacology36 (9): 1277-83. [PMID:9364482]

14. Colomar A, Amédée T. (2001) ATP stimulation of P2X(7) receptors activates three different ionic conductances on cultured mouse Schwann cells. Eur. J. Neurosci.14 (6): 927-36. [PMID:11595031]

15. Coutinho-Silva R, Parsons M, Robson T, Lincoln J, Burnstock G. (2003) P2X and P2Y purinoceptor expression in pancreas from streptozotocin-diabetic rats. Mol. Cell. Endocrinol.204 (1-2): 141-54. [PMID:12850289]

16. Donnelly-Roberts DL, Jarvis MF. (2007) Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. Br. J. Pharmacol.151 (5): 571-9. [PMID:17471177]

17. Donnelly-Roberts DL, Namovic MT, Han P, Jarvis MF. (2009) Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors. Br. J. Pharmacol.157 (7): 1203-14. [PMID:19558545]

18. Emmett DS, Feranchak A, Kilic G, Puljak L, Miller B, Dolovcak S, McWilliams R, Doctor RB, Fitz JG. (2008) Characterization of ionotrophic purinergic receptors in hepatocytes. Hepatology47 (2): 698-705. [PMID:18027885]

19. Fairbairn IP, Stober CB, Kumararatne DS, Lammas DA. (2001) ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion. J. Immunol.167 (6): 3300-7. [PMID:11544318]

20. Ferrari D, Chiozzi P, Falzoni S, Dal Susino M, Collo G, Buell G, Di Virgilio F. (1997) ATP-mediated cytotoxicity in microglial cells. Neuropharmacology36 (9): 1295-301. [PMID:9364484]

21. Franke H, Günther A, Grosche J, Schmidt R, Rossner S, Reinhardt R, Faber-Zuschratter H, Schneider D, Illes P. (2004) P2X7 receptor expression after ischemia in the cerebral cortex of rats. J. Neuropathol. Exp. Neurol.63 (7): 686-99. [PMID:15290894]

22. Franke H, Klimke K, Brinckmann U, Grosche J, Francke M, Sperlagh B, Reichenbach A, Liebert UG, Illes P. (2005) P2X(7) receptor-mRNA and -protein in the mouse retina; changes during retinal degeneration in BALBCrds mice. Neurochem. Int.47 (4): 235-42. [PMID:15964665]

23. Gargett CE, Wiley JS. (1997) The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes. Br. J. Pharmacol.120 (8): 1483-90. [PMID:9113369]

24. Gartland A, Buckley KA, Bowler WB, Gallagher JA. (2003) Blockade of the pore-forming P2X7 receptor inhibits formation of multinucleated human osteoclasts in vitro. Calcif. Tissue Int.73 (4): 361-9. [PMID:12874700]

25. Gonçalves RG, Gabrich L, Rosário A, Takiya CM, Ferreira ML, Chiarini LB, Persechini PM, Coutinho-Silva R, Leite M. (2006) The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice. Kidney Int.70 (9): 1599-606. [PMID:16969386]

26. Greig AV, Linge C, Terenghi G, McGrouther DA, Burnstock G. (2003) Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes. J. Invest. Dermatol.120 (6): 1007-15. [PMID:12787128]

27. Grol MW, Panupinthu N, Korcok J, Sims SM, Dixon SJ. (2009) Expression, signaling, and function of P2X7 receptors in bone. Purinergic Signal.5 (2): 205-21. [PMID:19224395]

28. Hillman KA, Johnson TM, Winyard PJ, Burnstock G, Unwin RJ, Woolf AS. (2002) P2X(7) receptors are expressed during mouse nephrogenesis and in collecting duct cysts of the cpk/cpk mouse. Exp. Nephrol.10 (1): 34-42. [PMID:11803203]

29. Hillman KA, Woolf AS, Johnson TM, Wade A, Unwin RJ, Winyard PJ. (2004) The P2X7 ATP receptor modulates renal cyst development in vitro. Biochem. Biophys. Res. Commun.322 (2): 434-9. [PMID:15325248]

30. Hodges RR, Vrouvlianis J, Shatos MA, Dartt DA. (2009) Characterization of P2X7 purinergic receptors and their function in rat lacrimal gland. Invest. Ophthalmol. Vis. Sci.50 (12): 5681-9. [PMID:19608535]

31. Honore P, Donnelly-Roberts D, Namovic M, Zhong C, Wade C, Chandran P, Zhu C, Carroll W, Perez-Medrano A, Iwakura Y et al.. (2009) The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice. Behav. Brain Res.204 (1): 77-81. [PMID:19464323]

32. Jiang LH, Mackenzie AB, North RA, Surprenant A. (2000) Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors. Mol. Pharmacol.58 (1): 82-8. [PMID:10860929]

33. Kawamura H, Aswad F, Minagawa M, Govindarajan S, Dennert G. (2006) P2X7 receptors regulate NKT cells in autoimmune hepatitis. J. Immunol.176 (4): 2152-60. [PMID:16455971]

34. Ke HZ, Qi H, Weidema AF, Zhang Q, Panupinthu N, Crawford DT, Grasser WA, Paralkar VM, Li M, Audoly LP, Gabel CA, Jee WS, Dixon SJ, Sims SM, Thompson DD. (2003) Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption. Mol. Endocrinol.17 (7): 1356-67. [PMID:12677010]

35. Labasi JM, Petrushova N, Donovan C, McCurdy S, Lira P, Payette MM, Brissette W, Wicks JR, Audoly L, Gabel CA. (2002) Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J. Immunol.168 (12): 6436-45. [PMID:12055263]

36. Labrousse VF, Costes L, Aubert A, Darnaudéry M, Ferreira G, Amédée T, Layé S. (2009) Impaired interleukin-1beta and c-Fos expression in the hippocampus is associated with a spatial memory deficit in P2X(7) receptor-deficient mice. PLoS ONE4 (6): e6006. [PMID:19547756]

37. Lucattelli M, S, T, M, G, S, W, M, R, T, G, S, D, F, JC, G, M. (2010) P2X7 Receptor Signalling in the Pathogenesis of Smoke-induced Lung Inflammation and Emphysema. Am J Respir Cell Mol Biol, . [PMID:20508069]

38. Mayo C, Ren R, Rich C, Stepp MA, Trinkaus-Randall V. (2008) Regulation by P2X7: epithelial migration and stromal organization in the cornea. Invest. Ophthalmol. Vis. Sci.49 (10): 4384-91. [PMID:18502993]

39. Michel AD, Ng SW, Roman S, Clay WC, Dean DK, Walter DS. (2009) Mechanism of action of species-selective P2X(7) receptor antagonists. Br. J. Pharmacol.156 (8): 1312-25. [PMID:19309360]

40. Michel AD, Xing M, Thompson KM, Jones CA, Humphrey PP. (2006) Decavanadate, a P2X receptor antagonist, and its use to study ligand interactions with P2X7 receptors. Eur. J. Pharmacol.534 (1-3): 19-29. [PMID:16487507]

41. Naemsch LN, Dixon SJ, Sims SM. (2001) Activity-dependent development of P2X7 current and Ca2+ entry in rabbit osteoclasts. J. Biol. Chem.276 (42): 39107-14. [PMID:11495918]

42. Narcisse L, Scemes E, Zhao Y, Lee SC, Brosnan CF. (2005) The cytokine IL-1beta transiently enhances P2X7 receptor expression and function in human astrocytes. Glia49 (2): 245-58. [PMID:15472991]

43. Nicke A, Kuan YH, Masin M, Rettinger J, Marquez-Klaka B, Bender O, Górecki DC, Murrell-Lagnado RD, Soto F. (2009) A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice. J. Biol. Chem.284 (38): 25813-22. [PMID:19546214]

44. Nörenberg W, Sobottka H, Hempel C, Plötz T, Fischer W, Schmalzing G, Schaefer M. (2012) Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors. Br. J. Pharmacol.167 (1): 48-66. [PMID:22506590]

45. O'Reilly BA, Kosaka AH, Chang TK, Ford AP, Popert R, Rymer JM, McMahon SB. (2001) A quantitative analysis of purinoceptor expression in human fetal and adult bladders. J. Urol.165 (5): 1730-4. [PMID:11342965]

46. Parvathenani LK, Tertyshnikova S, Greco CR, Roberts SB, Robertson B, Posmantur R. (2003) P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease. J. Biol. Chem.278 (15): 13309-17. [PMID:12551918]

47. Raffaghello L, Chiozzi P, Falzoni S, Di Virgilio F, Pistoia V. (2006) The P2X7 receptor sustains the growth of human neuroblastoma cells through a substance P-dependent mechanism. Cancer Res.66 (2): 907-14. [PMID:16424024]

48. Rassendren F, Buell GN, Virginio C, Collo G, North RA, Surprenant A. (1997) The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA. J. Biol. Chem.272 (9): 5482-6. [PMID:9038151]

49. Sanz JM, Chiozzi P, Ferrari D, Colaianna M, Idzko M, Falzoni S, Fellin R, Trabace L, Di Virgilio F. (2009) Activation of microglia by amyloid {beta} requires P2X7 receptor expression. J. Immunol.182 (7): 4378-85. [PMID:19299738]

50. Sharp AJ, Polak PE, Simonini V, Lin SX, Richardson JC, Bongarzone ER, Feinstein DL. (2008) P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis. J Neuroinflammation5: 33. [PMID:18691411]

51. Shemon AN, Sluyter R, Conigrave AD, Wiley JS. (2004) Chelerythrine and other benzophenanthridine alkaloids block the human P2X7 receptor. Br. J. Pharmacol.142 (6): 1015-9. [PMID:15210579]

52. Sim JA, Young MT, Sung HY, North RA, Surprenant A. (2004) Reanalysis of P2X7 receptor expression in rodent brain. J. Neurosci.24 (28): 6307-14. [PMID:15254086]

53. Skarratt KK, Fuller SJ, Sluyter R, Dao-Ung LP, Gu BJ, Wiley JS. (2005) A 5' intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1-2% of the Caucasian population. FEBS Lett.579 (12): 2675-8. [PMID:15862308]

54. Sluyter R, Barden JA, Wiley JS. (2001) Detection of P2X purinergic receptors on human B lymphocytes. Cell Tissue Res.304 (2): 231-6. [PMID:11396717]

55. Sluyter R, Shemon AN, Barden JA, Wiley JS. (2004) Extracellular ATP increases cation fluxes in human erythrocytes by activation of the P2X7 receptor. J. Biol. Chem.279 (43): 44749-55. [PMID:15304508]

56. Solini A, Chiozzi P, Morelli A, Fellin R, Di Virgilio F. (1999) Human primary fibroblasts in vitro express a purinergic P2X7 receptor coupled to ion fluxes, microvesicle formation and IL-6 release. J. Cell. Sci.112 ( Pt 3): 297-305. [PMID:9885283]

57. Solle M, Labasi J, Perregaux DG, Stam E, Petrushova N, Koller BH, Griffiths RJ, Gabel CA. (2001) Altered cytokine production in mice lacking P2X(7) receptors. J. Biol. Chem.276 (1): 125-32. [PMID:11016935]

58. Stokes L, Jiang LH, Alcaraz L, Bent J, Bowers K, Fagura M, Furber M, Mortimore M, Lawson M, Theaker J et al.. (2006) Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373. Br. J. Pharmacol.149 (7): 880-7. [PMID:17031385]

59. Sugiyama T, Oku H, Shibata M, Fukuhara M, Yoshida H, Ikeda T. (2010) Involvement of P2X7 receptors in the hypoxia-induced death of rat retinal neurons. Invest. Ophthalmol. Vis. Sci.51 (6): 3236-43. [PMID:20071682]

60. Surprenant A, Rassendren F, Kawashima E, North RA, Buell G. (1996) The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science272 (5262): 735-8. [PMID:8614837]

61. Taylor SR, Turner CM, Elliott JI, McDaid J, Hewitt R, Smith J, Pickering MC, Whitehouse DL, Cook HT, Burnstock G, Pusey CD, Unwin RJ, Tam FW. (2009) P2X7 deficiency attenuates renal injury in experimental glomerulonephritis. J. Am. Soc. Nephrol.20 (6): 1275-81. [PMID:19389853]

62. Tenneti L, Gibbons SJ, Talamo BR. (1998) Expression and trans-synaptic regulation of P2x4 and P2z receptors for extracellular ATP in parotid acinar cells. Effects of parasympathetic denervation. J. Biol. Chem.273 (41): 26799-808. [PMID:9756924]

63. Vonend O, Turner CM, Chan CM, Loesch A, Dell'Anna GC, Srai KS, Burnstock G, Unwin RJ. (2004) Glomerular expression of the ATP-sensitive P2X receptor in diabetic and hypertensive rat models. Kidney Int.66 (1): 157-66. [PMID:15200422]

64. Yiangou Y, Facer P, Durrenberger P, Chessell IP, Naylor A, Bountra C, Banati RR, Anand P. (2006) COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord. BMC Neurol6: 12. [PMID:16512913]

65. Yip L, Woehrle T, Corriden R, Hirsh M, Chen Y, Inoue Y, Ferrari V, Insel PA, Junger WG. (2009) Autocrine regulation of T-cell activation by ATP release and P2X7 receptors. FASEB J.23 (6): 1685-93. [PMID:19211924]

66. Yu Y, Ugawa S, Ueda T, Ishida Y, Inoue K, Kyaw Nyunt A, Umemura A, Mase M, Yamada K, Shimada S. (2008) Cellular localization of P2X7 receptor mRNA in the rat brain. Brain Res.1194: 45-55. [PMID:18177631]

To cite this database page, please use the following:

Patrizia Pellegatti, Francesco Di Virgilio, John A. Peters.
P2X receptors: P2X7. Last modified on 12/06/2014. Accessed on 24/07/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=484.

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