Nomenclature: P2X6

Family: P2X receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation. 

Contents

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 441 22q11.21 P2RX6 purinergic receptor P2X, ligand-gated ion channel, 6 3
Mouse 2 379 16 A3 P2rx6 purinergic receptor P2X, ligand-gated ion channel, 6 2
Rat 2 379 11q23 P2rx6 purinergic receptor P2X, ligand-gated ion channel, 6 1
Previous and Unofficial Names
P2X6
P2RXL1
P2XM
MGC129625
purinergic receptor P2X-like 1, orphan receptor
RNRNAP2X6
Rnap2x6
ATP receptor
P2X purinoceptor 6
P2X6 receptor
purinergic receptor P2X-like 1
purinergic receptor P2X-like 1 orphan receptor
purinergic receptor P2X6
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligand(s)
ATP

REFERENCES

1. Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G. (1996) Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci.16 (8): 2495-507. [PMID:8786426]

2. Nawa G, Urano T, Tokino T, Ochi T, Miyoshi Y. (1998) Cloning and characterization of the murine P2XM receptor gene. J. Hum. Genet.43 (4): 262-7. [PMID:9852680]

3. Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, Tokino T. (1997) Cloning of P2XM, a novel human P2X receptor gene regulated by p53. Cancer Res.57 (15): 3281-7. [PMID:9242461]

To cite this database page, please use the following:

Francesco Di Virgilio, Richard J Evans, Michael F Jarvis, Charles Kennedy, Baljit S. Khakh, Patrizia Pellegatti, John A. Peters.
P2X receptors: P2X6. Last modified on 14/03/2014. Accessed on 17/04/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=483.

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