Nomenclature: P2X4

Family: P2X receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation. 


Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 388 12q24.32 P2RX4 purinergic receptor P2X, ligand-gated ion channel, 4 3
Mouse 2 388 5 F P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 7
Rat 2 388 12q16 P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 1-2,5-8
Previous and Unofficial Names
ATP receptor
P2X purinoceptor 4
purinergic receptor P2X ligand-gated ion channel 4
purinergic receptor P2X, ligand-gated ion channel 4
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Reference Database
PharmGKB Gene
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
UniGene Hs.
Natural/Endogenous Ligands
Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Voltage-dependent (mV) Reference
ivermectin Rn Positive - - - no 4
Not voltage dependent


1. Bo X, Zhang Y, Nassar M, Burnstock G, Schoepfer R. (1995) A P2X purinoceptor cDNA conferring a novel pharmacological profile. FEBS Lett.375 (1-2): 129-33. [PMID:7498461]

2. Buell G, Lewis C, Collo G, North RA, Surprenant A. (1996) An antagonist-insensitive P2X receptor expressed in epithelia and brain. EMBO J.15 (1): 55-62. [PMID:8598206]

3. Garcia-Guzman M, Soto F, Gomez-Hernandez JM, Lund PE, Stühmer W. (1997) Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. Mol. Pharmacol.51 (1): 109-18. [PMID:9016352]

4. Khakh BS, Proctor WR, Dunwiddie TV, Labarca C, Lester HA. (1999) Allosteric control of gating and kinetics at P2X(4) receptor channels. J. Neurosci.19 (17): 7289-99. [PMID:10460235]

5. Soto F, Garcia-Guzman M, Gomez-Hernandez JM, Hollmann M, Karschin C, Stühmer W. (1996) P2X4: an ATP-activated ionotropic receptor cloned from rat brain. Proc. Natl. Acad. Sci. U.S.A.93 (8): 3684-8. [PMID:8622997]

6. Séguéla P, Haghighi A, Soghomonian JJ, Cooper E. (1996) A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain. J. Neurosci.16 (2): 448-55. [PMID:8551329]

7. Townsend-Nicholson A, King BF, Wildman SS, Burnstock G. (1999) Molecular cloning, functional characterization and possible cooperativity between the murine P2X4 and P2X4a receptors. Brain Res. Mol. Brain Res.64 (2): 246-54. [PMID:9931497]

8. Wang CZ, Namba N, Gonoi T, Inagaki N, Seino S. (1996) Cloning and pharmacological characterization of a fourth P2X receptor subtype widely expressed in brain and peripheral tissues including various endocrine tissues. Biochem. Biophys. Res. Commun.220 (1): 196-202. [PMID:8602843]

To cite this database page, please use the following:

Francesco Di Virgilio, Richard J Evans, Michael F Jarvis, Charles Kennedy, Baljit S. Khakh, Patrizia Pellegatti, John A. Peters.
P2X receptors: P2X4. Last modified on 14/03/2014. Accessed on 31/10/2014. IUPHAR database (IUPHAR-DB),

Contact us | Print | Back to top | Help
Copyright © 2014 IUPHAR