Nomenclature: P2X4

Family: P2X receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation. 

Contents

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 388 12q24.32 P2RX4 purinergic receptor P2X, ligand-gated ion channel, 4 3
Mouse 2 388 5 F P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 7
Rat 2 388 12q16 P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 1-2,5-8
Previous and Unofficial Names
P2X4
ATP receptor
P2X purinoceptor 4
purinergic receptor P2X ligand-gated ion channel 4
purinergic receptor P2X, ligand-gated ion channel 4
D5Ertd444e
AI504491
AW555605
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
ATP
Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Voltage-dependent (mV) Reference
ivermectin Rn Positive - - - no 4
[4]
Not voltage dependent

REFERENCES

1. Bo X, Zhang Y, Nassar M, Burnstock G, Schoepfer R. (1995) A P2X purinoceptor cDNA conferring a novel pharmacological profile. FEBS Lett.375 (1-2): 129-33. [PMID:7498461]

2. Buell G, Lewis C, Collo G, North RA, Surprenant A. (1996) An antagonist-insensitive P2X receptor expressed in epithelia and brain. EMBO J.15 (1): 55-62. [PMID:8598206]

3. Garcia-Guzman M, Soto F, Gomez-Hernandez JM, Lund PE, Stühmer W. (1997) Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. Mol. Pharmacol.51 (1): 109-18. [PMID:9016352]

4. Khakh BS, Proctor WR, Dunwiddie TV, Labarca C, Lester HA. (1999) Allosteric control of gating and kinetics at P2X(4) receptor channels. J. Neurosci.19 (17): 7289-99. [PMID:10460235]

5. Soto F, Garcia-Guzman M, Gomez-Hernandez JM, Hollmann M, Karschin C, Stühmer W. (1996) P2X4: an ATP-activated ionotropic receptor cloned from rat brain. Proc. Natl. Acad. Sci. U.S.A.93 (8): 3684-8. [PMID:8622997]

6. Séguéla P, Haghighi A, Soghomonian JJ, Cooper E. (1996) A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain. J. Neurosci.16 (2): 448-55. [PMID:8551329]

7. Townsend-Nicholson A, King BF, Wildman SS, Burnstock G. (1999) Molecular cloning, functional characterization and possible cooperativity between the murine P2X4 and P2X4a receptors. Brain Res. Mol. Brain Res.64 (2): 246-54. [PMID:9931497]

8. Wang CZ, Namba N, Gonoi T, Inagaki N, Seino S. (1996) Cloning and pharmacological characterization of a fourth P2X receptor subtype widely expressed in brain and peripheral tissues including various endocrine tissues. Biochem. Biophys. Res. Commun.220 (1): 196-202. [PMID:8602843]

To cite this database page, please use the following:

Francesco Di Virgilio, Richard J Evans, Michael F Jarvis, Charles Kennedy, Baljit S. Khakh, Patrizia Pellegatti, John A. Peters.
P2X receptors: P2X4. Last modified on 14/03/2014. Accessed on 02/09/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=481.

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