Nomenclature: α10

Family: Nicotinic acetylcholine receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 450 11p15.5 CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2
Mouse 4 447 7 E3 Chrna10 cholinergic receptor, nicotinic, alpha polypeptide 10
Rat 4 447 1q32 Chrna10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 1
Previous and Unofficial Names
cholinergic receptor, nicotinic, alpha polypeptide 10
acetylcholine receptor, nicotinic, alpha 10 (neuronal)
NACHR alpha 10
NACHR alpha-10
cholinergic receptor, nicotinic, alpha 10
neuronal acetylcholine receptor subunit alpha-10
neuronal nicotinic acetylcholine receptor subunit
nicotinic acetylcholine receptor subunit alpha 10
nicotinic acetylcholine receptor subunit alpha-10
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Functional Characteristics
α9α10: PCa/PNa = 9, Pf = 22%
Natural/Endogenous Ligands
acetylcholine
Commonly used antagonists
α9α10: α-bungarotoxin > tropisetron = strychnine > tubocurarine
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[3H]methyllycaconitine Hs Antagonist 8.12 pKd
pKd 8.12 (Kd 7.5x10-9 M) α9α10
α-bungarotoxin Hs Antagonist - -
α9α10
α-conotoxin RgIA Hs Antagonist - -
α9α10
muscarine Hs Antagonist - -
α9α10
nicotine Hs Antagonist - -
α9α10
strychnine Hs Antagonist - -
α9α10
Tissue Distribution
Pituitary gland, keratinocytes
Species:  Human
Technique:  RT-PCR
References:  3
Pituitary gland (pars tuberalis region), cochlear, vestibular hair cells
Species:  Rat
Technique:  In situ hybridisation, RT-PCR
References:  1,3
Physiological Consequences of Altering Gene Expression
Knockout mice have abnormal innervation, synaptic function and morphology of the cochlear.
Species:  Mouse
Tissue:  in vivo
Technique:  Knockout
References:  4

REFERENCES

1. Elgoyhen AB, Vetter DE, Katz E, Rothlin CV, Heinemann SF, Boulter J. (2001) alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. Proc. Natl. Acad. Sci. U.S.A.98 (6): 3501-6. [PMID:11248107]

2. Lustig LR, Peng H, Hiel H, Yamamoto T, Fuchs PA. (2001) Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10). Genomics73 (3): 272-83. [PMID:11350119]

3. Sgard F, Charpantier E, Bertrand S, Walker N, Caput D, Graham D, Bertrand D, Besnard F. (2002) A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. Mol. Pharmacol.61 (1): 150-9. [PMID:11752216]

4. Vetter DE, Katz E, Maison SF, Taranda J, Turcan S, Ballestero J, Liberman MC, Elgoyhen AB, Boulter J. (2007) The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system. Proc. Natl. Acad. Sci. U.S.A.104 (51): 20594-9. [PMID:18077337]

To cite this database page, please use the following:

Cecilia Gotti, Michael. J. Marks, Neil S. Millar, Susan Wonnacott.
Nicotinic acetylcholine receptors: α10. Last modified on 14/03/2014. Accessed on 20/10/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=470.

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