Nomenclature: GluN1

Family: Ionotropic glutamate receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation. 

Contents

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 3 1 938 9q34.3 GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
Mouse 3 1 938 2 A3 Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1)
Rat 3 1 938 3p13 Grin1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
Previous and Unofficial Names
GLUN1
NMDA-R1
NR1
GluRζ1
NMDAR1
N-methyl-D-aspartate glutamate receptor
N-methyl-D-aspartate receptor
N-methyl-D-aspartate receptor subunit NR1
NMD-R1
NMDA R1 receptor C1 cassette
glutamate [NMDA] receptor subunit zeta-1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
neurotransmitter receptor
Nmdar
M100174
GluRzeta1
Rgsc174
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
Orphanet Gene
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
L-glutamic acid
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
D-aspartate Hs Agonist - -
[Binds to: glutamate site]
homoquinolinic acid Hs Partial agonist - -
[Binds to: glutamate site]
[3H]glycine Hs Full agonist - -
[Binds to: glycine site]
(+)-HA966 Hs Partial agonist - -
[Binds to: glycine site]
NMDA Hs Full agonist - -
[Binds to: glutamate site]
glycine Hs Agonist - -
[Binds to: glycine site]
D-serine Hs Agonist - -
[Binds to: glycine site]
(RS)-(tetrazol-5-yl)glycine Hs Full agonist - -
[Binds to: glutamate site]
L-aspartate Hs Agonist - -
[Binds to: glutamate site]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[3H]L689560 Hs Antagonist - -
[Binds to: glycine site]
[3H]CGP61594 Hs Antagonist - -
[Binds to: glycine site] photoaffinity ligand
GV196771A Hs Antagonist - -
[Binds to: glycine site]
[3H]CGS19755 Hs Antagonist - -
[Binds to: glutamate site]
[3H]CPP Hs Antagonist - -
[Binds to: glutamate site]
L689560 Hs Antagonist - -
[Binds to: glycine site]
L701324 Hs Antagonist - -
[Binds to: glycine site]
[3H]CGP39653 Hs Antagonist - -
[Binds to: glutamate site]
[3H]MK-801 Hs Antagonist - -
[Binds to: cation channel]
[3H]MDL105519 Hs Antagonist - -
[Binds to: glycine site]
5,7-dichlorokynurenic acid Hs Antagonist - -
[Binds to: glycine site]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Mental retardation, autosomal dominant 8
OMIM:  614254
Orphanet:  178469
References: 
Mutations not determined

To cite this database page, please use the following:

John A. Peters, Stephane Peineau, Graham L Collingridge, Robert J. Wenthold.
Ionotropic glutamate receptors: GluN1. Last modified on 17/03/2014. Accessed on 02/09/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=455.

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