Nomenclature: Kir2.4

Family: Inwardly rectifying potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 1 436 19q13.1-13.3 KCNJ14 potassium inwardly-rectifying channel, subfamily J, member 14 2,8
Mouse 2 1 434 7 B4 Kcnj14 potassium inwardly-rectifying channel, subfamily J, member 14 6
Rat 2 1 434 1q22 Kcnj14 potassium inwardly-rectifying channel, subfamily J, member 14 9
Previous and Unofficial Names
IRK4
Kir2.4
ATP-sensitive inward rectifier potassium channel 14
IRK-4
inward rectifier K(+) channel Kir2.4
inwardly rectifying potassium channel Kir2.4
potassium channel, inwardly rectifying subfamily J member 14
potassium inwardly-rectifying channel J14
potassium inwardly-rectifying channel, subfamily J, member 14
A930026G01Rik
Database Links
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Associated Proteins
Heteromeric Pore-forming Subunits
Name References
Kir2.1 5
Auxiliary Subunits
Name References
Not determined
Other Associated Proteins
Name References
Not determined
Functional Characteristics
IK1 in heart, ‘strong’ inward–rectifier current
Ion Selectivity and Conductance
Species:  Rat
Rank order:  K+ [15.0 - 19.4 pS]
References:  7,9
Inhibitors
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
intracellular Mg2+ Hs - - - - -
Gating inhibitors
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
Extracellular H+ Hs Antagonist 7.14 pKi - -120.0 2
pKi 7.14 [2]
Holding voltage: -120.0 mV
Channel Blockers
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
Cs+ Hs Antagonist 3.0 – 4.08 pKd - -60.0 – -100.0 2
pKd 3.0 – 4.08 [2]
Holding voltage: -60.0 – -100.0 mV
Ba2+ Hs Antagonist 3.32 pKd - 0.0 2
pKd 3.32 [2]
Holding voltage: 0.0 mV
Ba2+ Rn Antagonist 3.41 – 4.18 pKi 1x10-6 - 1x10-3 -80.0 – -100.0 7,9
pKi 3.41 – 4.18 Conc range: 1x10-6 - 1x10-3 M [7,9]
Holding voltage: -80.0 – -100.0 mV
Cs+ Rn Antagonist 2.09 pKi - -80.0 9
pKi 2.09 [9]
Holding voltage: -80.0 mV
View species-specific channel blocker tables
Tissue Distribution
Retina.
Species:  Human
Technique:  Northern Blot
References:  2
Cultured pulmonary smooth muscle cells.
Species:  Human
Technique:  RT-PCR
References:  7
Aortic endothelial cells (mRNA, but not protein, can be detected in this tissue).
Species:  Human
Technique:  RT-PCR
References:  1
Cranial nerve motor nuclei in midbrain, pons and medulla (cholinergic neurons).
Species:  Rat
Technique:  In situ hybridisation, immunohistochemistry.
References:  3,9
Striatum (cholinergic interneurons).
Species:  Rat
Technique:  Immunohistochemistry
References:  4
Functional Assays
Kir2.1 and Kir2.4 contribute to inward rectifier potassium current in cultured human pulmonary smooth muscle cells.
Species:  None
Tissue:  Cultured pulmonary smooth muscle cells.
Response measured:  Measurement of K+ current.
References:  7
Control of the excitability of brainstem motorneurons by setting the membrane potential near EK.
Species:  Rat
Tissue:  Hypoglossal motorneurons.
Response measured:  Spike discharge.
References:  9
Physiological Functions
Controls the excitability of brainstem motorneurons by setting the membrane potential near EK.
Species:  Rat
Tissue:  Hypoglossal motorneurons.
References:  9

REFERENCES

1. Fang Y, Schram G, Romanenko VG, Shi C, Conti L, Vandenberg CA, Davies PF, Nattel S, Levitan I. (2005) Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. Am. J. Physiol., Cell Physiol.289 (5): C1134-44. [PMID:15958527]

2. Hughes BA, Kumar G, Yuan Y, Swaminathan A, Yan D, Sharma A, Plumley L, Yang-Feng TL, Swaroop A. (2000) Cloning and functional expression of human retinal kir2.4, a pH-sensitive inwardly rectifying K(+) channel. Am. J. Physiol., Cell Physiol.279 (3): C771-84. [PMID:10942728]

3. Prüss H, Derst C, Lommel R, Veh RW. (2005) Differential distribution of individual subunits of strongly inwardly rectifying potassium channels (Kir2 family) in rat brain. Brain Res. Mol. Brain Res.139 (1): 63-79. [PMID:15936845]

4. Prüss H, Wenzel M, Eulitz D, Thomzig A, Karschin A, Veh RW. (2003) Kir2 potassium channels in rat striatum are strategically localized to control basal ganglia function. Brain Res. Mol. Brain Res.110 (2): 203-19. [PMID:12591157]

5. Schram G, Melnyk P, Pourrier M, Wang Z, Nattel S. (2002) Kir2.4 and Kir2.1 K(+) channel subunits co-assemble: a potential new contributor to inward rectifier current heterogeneity. J. Physiol. (Lond.)544 (Pt 2): 337-49. [PMID:12381809]

6. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF et al.. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A.99 (26): 16899-903. [PMID:12477932]

7. Tennant BP, Cui Y, Tinker A, Clapp LH. (2006) Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: evidence for a major role of Kir2.4 subunits. J. Membr. Biol.213 (1): 19-29. [PMID:17347781]

8. Töpert C, Döring F, Derst C, Daut J, Grzeschik KH, Karschin A. (2000) Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14). Mamm. Genome11 (3): 247-9. [PMID:10723734]

9. Töpert C, Döring F, Wischmeyer E, Karschin C, Brockhaus J, Ballanyi K, Derst C, Karschin A. (1998) Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei. J. Neurosci.18 (11): 4096-105. [PMID:9592090]

To cite this database page, please use the following:

John P. Adelman, David E. Clapham, Hiroshi Hibino, Atsushi Inanobe, Lily Y. Jan, Andreas Karschin, Yoshihiro Kubo, Yoshihisa Kurachi, Michel Lazdunski, Takashi Miki, Colin G. Nichols, Wade L. Pearson, Susumu Seino, Carol A. Vandenberg.
Inwardly rectifying potassium channels: Kir2.4. Last modified on 31/01/2014. Accessed on 18/09/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=433.

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