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α4 (pseudogene in humans)

Family: Glycine receptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Tissue Distribution
General Comments
References
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - q22.2 GLRA4 glycine receptor, alpha 4
Mouse 4 416 X F1 Glra4 glycine receptor, alpha 4 subunit 4
Rat 4 456 Xq35 Glra4 glycine receptor, alpha 4
Previous and Unofficial Names
LOC367912
RGD1564103
RGD1564103_predicted
glycine receptor subunit alpha-4
glycine receptor, alpha 4
glycine receptor, alpha 4 subunit
similar to Glycine receptor alpha-4 chain precursor
similar to Glycine receptor alpha-4 chain precursor (predicted)
Database Links
ChEMBL Target 17118 (Mm)
Ensembl ENSG00000188828 (Hs), ENSMUSG00000018595 (Mm), ENSRNOG00000002391 (Rn)
Entrez Gene 441509 (Hs), 14657 (Mm), 367912 (Rn)
GeneCards GLRA4 (Hs)
GenitoUrinary Development Molecular Anatomy Project Glra4 (Mm)
HomoloGene 69070
Human Protein Reference Database 19610 (Hs)
InterPro Q5JXX5 (Hs), Q61603 (Mm)
KEGG Gene hsa:441509 (Hs), mmu:14657 (Mm), rno:367912 (Rn)
PharmGKB Gene PA142671731 (Hs)
PhosphoSitePlus Q5JXX5 (Hs), Q61603 (Mm)
Protein Ontology (PRO) PRO:000008045 (Hs)
RefSeq Nucleotide NM_001024452 (Hs), NM_010297 (Mm), NM_001191914 (Rn)
RefSeq Protein NP_001019623 (Hs), NP_034427 (Mm), NP_001178843 (Rn)
TreeFam ENSG00000188828 (Hs), ENSMUSG00000018595 (Mm), ENSRNOG00000002391 (Rn)
UniGene Hs. 533289 (Hs)
UniProt Q5JXX5 (Hs), Q61603 (Mm)
Wikipedia α4 (pseudogene in humans)
Glycine receptors
Search for 3D structures on the PDB
Search by keyword: Glycine receptors α4 (pseudogene in humans) Search by accession number: Q61603, Q5JXX5
Natural/Endogenous Ligand(s)
glycine

Explore drug-target interactions for this set of compounds using iPHACE

Tissue Distribution
retina (inner plexiform layer)
Species:  Mouse
Technique:  Immunocytochemistry
References:  3
Kupffer cells, neutrophils and macrophages
Species:  Rat
Technique:  RT-PCR
References:  1
Tissue Distribution Comments
  • Using in situ hybridisation, embryonic chick α4 subunit was found in the following tissues : spinal cord, dorsal root ganglia, sympathetic ganglia, male genital ridge [2].
General Comments
The α4 subunit is likely to be a pseudogene in man. Full length information for the rat α4 subunit is only available as a predicted sequence.

REFERENCES

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1. Froh, M; Thurman, RG; Wheeler, MD. (2002) Molecular evidence for a glycine-gated chloride channel in macrophages and leukocytes. Am. J. Physiol. Gastrointest. Liver Physiol., 283 (4): G856-63. [PMID:12223345]

2. Harvey, RJ; Schmieden, V; Von Holst, A; Laube, B; Rohrer, H; Betz, H. (2000) Glycine receptors containing the alpha4 subunit in the embryonic sympathetic nervous system, spinal cord and male genital ridge. Eur. J. Neurosci., 12 (3): 994-1001. [PMID:10762330]

3. Heinze, L; Harvey, RJ; Haverkamp, S; Wässle, H. (2007) Diversity of glycine receptors in the mouse retina: localization of the alpha4 subunit. J. Comp. Neurol., 500 (4): 693-707. [PMID:17154252]

4. Matzenbach, B; Maulet, Y; Sefton, L; Courtier, B; Avner, P; Guénet, JL; Betz, H. (1994) Structural analysis of mouse glycine receptor alpha subunit genes. Identification and chromosomal localization of a novel variant. J. Biol. Chem., 269 (4): 2607-12. [PMID:7507926]

To cite this database page, please use the following:

Joseph. W. Lynch.
Glycine receptors: α4 (pseudogene in humans). Last modified on 01/03/2012. Accessed on 18/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=426.


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