Nomenclature: α4 (pseudogene in humans)

Family: Glycine receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - q22.2 GLRA4 glycine receptor, alpha 4
Mouse 4 416 X F1 Glra4 glycine receptor, alpha 4 subunit 4
Rat 4 456 Xq35 Glra4 glycine receptor, alpha 4
Previous and Unofficial Names
LOC367912
RGD1564103
RGD1564103_predicted
glycine receptor subunit alpha-4
glycine receptor, alpha 4
glycine receptor, alpha 4 subunit
similar to Glycine receptor alpha-4 chain precursor
similar to Glycine receptor alpha-4 chain precursor (predicted)
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
glycine
Tissue Distribution
Retina (inner plexiform layer)
Species:  Mouse
Technique:  Immunocytochemistry
References:  3
Kupffer cells, neutrophils and macrophages
Species:  Rat
Technique:  RT-PCR
References:  1
Tissue Distribution Comments
  • Using in situ hybridisation, embryonic chick α4 subunit was found in the following tissues: spinal cord, dorsal root ganglia, sympathetic ganglia, male genital ridge [2].
General Comments
The α4 subunit is likely to be a pseudogene in man. Full length information for the rat α4 subunit is only available as a predicted sequence.

REFERENCES

1. Froh M, Thurman RG, Wheeler MD. (2002) Molecular evidence for a glycine-gated chloride channel in macrophages and leukocytes. Am. J. Physiol. Gastrointest. Liver Physiol.283 (4): G856-63. [PMID:12223345]

2. Harvey RJ, Schmieden V, Von Holst A, Laube B, Rohrer H, Betz H. (2000) Glycine receptors containing the alpha4 subunit in the embryonic sympathetic nervous system, spinal cord and male genital ridge. Eur. J. Neurosci.12 (3): 994-1001. [PMID:10762330]

3. Heinze L, Harvey RJ, Haverkamp S, Wässle H. (2007) Diversity of glycine receptors in the mouse retina: localization of the alpha4 subunit. J. Comp. Neurol.500 (4): 693-707. [PMID:17154252]

4. Matzenbach B, Maulet Y, Sefton L, Courtier B, Avner P, Guénet JL, Betz H. (1994) Structural analysis of mouse glycine receptor alpha subunit genes. Identification and chromosomal localization of a novel variant. J. Biol. Chem.269 (4): 2607-12. [PMID:7507926]

To cite this database page, please use the following:

Joseph. W. Lynch.
Glycine receptors: α4 (pseudogene in humans). Last modified on 14/03/2014. Accessed on 30/07/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=426.

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