Nomenclature: ρ2

Family: GABAA receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation. 

Contents

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 490 6q13-q16.3 GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 1
Mouse 4 490 4 A5 Gabrr2 gamma-aminobutyric acid (GABA) C receptor, subunit rho 2 1
Rat 4 465 5q21 Gabrr2 gamma-aminobutyric acid (GABA) A receptor, rho 2 2
Previous and Unofficial Names
gamma-aminobutyric acid (GABA) receptor, rho 2
GABA(A) receptor, rho 2
GABA(A) receptor subunit rho-2
GABA(C) receptor
gamma-aminobutyric acid (GABA-A) receptor subunit rho 2
gamma-aminobutyric acid (GABA-A) receptor, subunit rho 2
gamma-aminobutyric acid (GABA-C) receptor, subunit rho 2
gamma-aminobutyric acid A receptor, rho 2
gamma-aminobutyric acid receptor subunit rho-2
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
GABA
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
5-Me-IAA Hs Full agonist - -
[Binds to: GABA site]
(±)-cis-2-CAMP Hs Full agonist - -
[Binds to: GABA site]
isoguvacine Hs Partial agonist - -
[Binds to: GABA site]
muscimol Hs Partial agonist - -
[Binds to: GABA site]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
trans-3-ACPBPA Hs Antagonist - -
[Binds to: GABA site]
cis-3-ACPBPA Hs Antagonist - -
[Binds to: GABA site]
piperidine-4-sulphonic acid Hs Antagonist - -
[Binds to: GABA site]
TPMPA Hs Antagonist - -
[Binds to: GABA site]
isonipecotic acid Hs Antagonist - -
[Binds to: GABA site]
aza-THIP Hs Antagonist - -
[Binds to: GABA site]
gaboxadol Hs Antagonist - -
[Binds to: GABA site]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Affinity Units Concentration range (M) Voltage-dependent (mV) Reference
TBPS Hs - no - - - no

Not voltage dependent
picrotoxin Hs - no - - - no

Not voltage dependent

REFERENCES

1. Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR. (1992) Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. Genomics12 (4): 801-6. [PMID:1315307]

2. Ogurusu T, Taira H, Shingai R. (1995) Identification of GABAA receptor subunits in rat retina: cloning of the rat GABAA receptor rho 2-subunit cDNA. J. Neurochem.65 (3): 964-8. [PMID:7643126]

To cite this database page, please use the following:

Richard Olsen, John A. Peters, Tim G. Hales, Werner Sieghart, Uwe Rudolph, Jeremy J. Lambert, Delia Belelli, Bernhard Luscher.
GABAA receptors: ρ2. Last modified on 14/03/2014. Accessed on 31/07/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=421.

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