Nomenclature: ρ1

Family: GABAA receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation. 

Contents

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 473 6q13-q16.3 GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 2
Mouse 4 474 4 A5 Gabrr1 gamma-aminobutyric acid (GABA) C receptor, subunit rho 1 3
Rat 4 474 5q21 Gabrr1 gamma-aminobutyric acid (GABA) A receptor, rho 1 1
Previous and Unofficial Names
gamma-aminobutyric acid (GABA) receptor, rho 1
GABA(A) receptor, rho 1
GABA(A) receptor subunit rho-1
GABA(C) receptor
gamma-aminobutyric acid (GABA-A) receptor subunit rho 1
gamma-aminobutyric acid (GABA-A) receptor, subunit rho 1
gamma-aminobutyric acid (GABA-C) receptor, subunit rho 1
gamma-aminobutyric acid A receptor, rho 1
gamma-aminobutyric acid receptor subunit rho-1
GABA-C
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
GABA
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
5-Me-IAA Hs Full agonist - -
[Binds to: GABA site]
(±)-cis-2-CAMP Hs Full agonist - -
[Binds to: GABA site]
isoguvacine Hs Partial agonist - -
[Binds to: GABA site]
muscimol Hs Partial agonist - -
[Binds to: GABA site]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
trans-3-ACPBPA Hs Antagonist - -
[Binds to: GABA site]
cis-3-ACPBPA Hs Antagonist - -
[Binds to: GABA site]
piperidine-4-sulphonic acid Hs Antagonist - -
[Binds to: GABA site]
TPMPA Hs Antagonist - -
[Binds to: GABA site]
aza-THIP Hs Antagonist - -
[Binds to: GABA site]
isonipecotic acid Hs Antagonist - -
[Binds to: GABA site]
gaboxadol Hs Antagonist - -
[Binds to: GABA site]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Affinity Units Concentration range (M) Voltage-dependent (mV) Reference
TBPS Hs - no - - - no

Not voltage dependent
picrotoxin Hs - no - - - no

Not voltage dependent

REFERENCES

1. Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR. (1992) Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. Genomics12 (4): 801-6. [PMID:1315307]

2. Cutting GR, Lu L, O'Hara BF, Kasch LM, Montrose-Rafizadeh C, Donovan DM, Shimada S, Antonarakis SE, Guggino WB, Uhl GR. (1991) Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina. Proc. Natl. Acad. Sci. U.S.A.88 (7): 2673-7. [PMID:1849271]

3. Zhang D, Pan ZH, Zhang X, Brideau AD, Lipton SA. (1995) Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block. Proc. Natl. Acad. Sci. U.S.A.92 (25): 11756-60. [PMID:8524843]

To cite this database page, please use the following:

Richard Olsen, John A. Peters, Tim G. Hales, Werner Sieghart, Uwe Rudolph, Jeremy J. Lambert, Delia Belelli, Bernhard Luscher.
GABAA receptors: ρ1. Last modified on 14/03/2014. Accessed on 30/08/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=420.

Contact us | Print | Back to top | Help
Copyright © 2014 IUPHAR