image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

θ

Family: GABAA receptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Tissue Distribution
References
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 632 Xq28 GABRQ gamma-aminobutyric acid (GABA) A receptor, theta 1
Mouse 4 638 X A6 Gabrq gamma-aminobutyric acid (GABA) A receptor, subunit theta 3
Rat 4 635 Xq37 Gabrq gamma-aminobutyric acid (GABA) A receptor, theta 3
Previous and Unofficial Names
THETA
gamma-aminobutyric acid (GABA) receptor, theta
GABA(A) receptor, theta
gamma-aminobutyric acid A receptor, theta
gamma-aminobutyric acid (GABA) A receptor theta
gamma-aminobutyric acid (GABA-A) receptor, subunit theta
gamma-aminobutyric acid receptor subunit theta
Database Links
ChEMBL Target 11700 (Hs), 11466 (Mm)
Ensembl ENSG00000147402 (Hs), ENSMUSG00000031344 (Mm), ENSRNOG00000016884 (Rn)
Entrez Gene 55879 (Hs), 57249 (Mm), 65187 (Rn)
GeneCards GABRQ (Hs)
GenitoUrinary Development Molecular Anatomy Project Gabrq (Mm)
HomoloGene 10233 (Hs)
Human Protein Reference Database 02284 (Hs)
InterPro Q9UN88 (Hs), Q9JLF1 (Mm)
KEGG Gene hsa:55879 (Hs), mmu:57249 (Mm), rno:65187 (Rn)
OMIM 300349 (Hs)
PharmGKB Gene PA28504 (Hs)
PhosphoSitePlus Q9UN88 (Hs), Q9JLF1 (Mm)
Protein Ontology (PRO) PRO:000007781 (Hs)
RefSeq Nucleotide NM_018558 (Hs), NM_020488 (Mm), NM_031733 (Rn)
RefSeq Protein NP_061028 (Hs), NP_065234 (Mm), NP_113921 (Rn)
TreeFam ENSG00000147402 (Hs), ENSMUSG00000031344 (Mm), ENSRNOG00000016884 (Rn)
UniGene Hs. 283081 (Hs)
UniProt Q9UN88 (Hs), Q9JLF1 (Mm)
Wikipedia θ
GABAA receptors
Search for 3D structures on the PDB
Search by keyword: GABAA receptors θ Search by accession number: Q9JLF1, Q9UN88
Natural/Endogenous Ligand(s)
GABA
Tissue Distribution
Substantia nigra pars compacta, locus coeruleus
Species:  Human
Technique:  In situ hybridization and immunohistochemistry
References:  1
Locus coeruleus, centromedial thalamic region, hypothalamus (dorsomedial and ventromedial regions)
Species:  Rat
Technique:  In situ hybridisation
References:  3
Septum (ventral and intermediate nucleus), bed nuclei and the stria terminalis, amygdala (medial and central nuclei), dentate gyrus, preoptic areas, hypothalamus, thalamus, lateral geniculate nucleus, raphe nuclei, locus coeruleus
Species:  Rat
Technique:  In situ hybridisation
References:  2
Cerebral cortex (cingulate and piriform regions), olfactory tract, nucleus accumbens, hypothalamus (anterior and mammiliary body), amygdala, hippocampus, substantia nigra, pineal gland, pons, dorsal raphe, central grey
Species:  Monkey
Technique:  In situ hybridisation
References:  1
Hypothalamus, cortical pyramidal neurones, substantia nigra pars compacta and associated neurites of the pars reticulata, ventral and lateral tegmental areas, locus coeruleus, recticular pontine nuclei, dorsal raphe
Species:  Monkey
Technique:  Immunohistochemistry
References:  1

REFERENCES

Show »

1. Bonnert, TP; McKernan, RM; Farrar, S; le Bourdellès, B; Heavens, RP; Smith, DW; Hewson, L; Rigby, MR; Sirinathsinghji, DJ; Brown, N; Wafford, KA; Whiting, PJ. (1999) theta, a novel gamma-aminobutyric acid type A receptor subunit. Proc. Natl. Acad. Sci. U.S.A., 96 (17): 9891-6. [PMID:10449790]

2. Moragues, N; Ciofi, P; Tramu, G; Garret, M. (2002) Localisation of GABA(A) receptor epsilon-subunit in cholinergic and aminergic neurones and evidence for co-distribution with the theta-subunit in rat brain. Neuroscience, 111 (3): 657-69. [PMID:12031352]

3. Sinkkonen, ST; Hanna, MC; Kirkness, EF; Korpi, ER. (2000) GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus. J. Neurosci., 20 (10): 3588-95. [PMID:10804200]

To cite this database page, please use the following:

Richard Olsen, John A. Peters, Tim G. Hales, Werner Sieghart.
GABAA receptors: θ. Last modified on 11/10/2012. Accessed on 19/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=418.


Contact us | Print | Back to top | Help