image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation. 

α2

Family: GABAA receptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
References
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 451 4p12 GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 1
Mouse 4 451 5 C3.1 Gabra2 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 2
Rat 4 - 14 Gabra2 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2 2
Previous and Unofficial Names
GABA(A) receptor, alpha 2
GABA(A) receptor subunit alpha-2
gamma-aminobutyric acid A receptor, alpha 2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
gamma-aminobutyric acid (GABA-A) receptor subunit alpha 2
gamma-aminobutyric acid receptor A2 subunit
gamma-aminobutyric acid receptor subunit alpha-2
similar to Gamma-aminobutyric-acid receptor alpha-2 subunit precursor (GABA(A) receptor)
Gabra-2
C630048P16Rik
Database Links
ChEMBL Target 12770 (Hs), 11436 (Mm)
DrugBank Target 423 (Hs)
Ensembl ENSG00000151834 (Hs), ENSMUSG00000000560 (Mm), ENSRNOG00000002349 (Rn)
Entrez Gene 2555 (Hs), 14395 (Mm), 29706 (Rn)
GeneCards GABRA2 (Hs)
GenitoUrinary Development Molecular Anatomy Project Gabra2 (Mm)
HomoloGene 20217 (Hs)
Human Protein Reference Database 11747 (Hs)
InterPro P47869 (Hs), P26048 (Mm), P23576 (Rn)
KEGG Gene hsa:2555 (Hs), mmu:14395 (Mm), rno:29706 (Rn)
OMIM 137140 (Hs)
PharmGKB Gene PA28490 (Hs)
PhosphoSitePlus P47869 (Hs), P26048 (Mm)
Protein Ontology (PRO) PRO:000007767 (Hs)
RefSeq Nucleotide NM_000807 (Hs), NM_008066 (Mm), NM_001135779 (Rn)
RefSeq Protein NP_000798 (Hs), NP_032092 (Mm), NP_001129251 (Rn)
TreeFam ENSG00000151834 (Hs), ENSMUSG00000000560 (Mm), ENSRNOG00000002349 (Rn)
UniGene Hs. 116250 (Hs)
UniProt P47869 (Hs), P26048 (Mm), P23576 (Rn)
Wikipedia α2
GABAA receptors
Search for 3D structures on the PDB
Search by keyword: GABAA receptors α2 Search by accession number: P26048, P47869, P23576
Natural/Endogenous Ligand(s)
GABA

REFERENCES

Show »

1. Hadingham, KL; Wingrove, P; Le Bourdelles, B; Palmer, KJ; Ragan, CI; Whiting, PJ. (1993) Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors. Mol. Pharmacol., 43 (6): 970-5. [PMID:8391122]

2. Khrestchatisky, M; MacLennan, AJ; Tillakaratne, NJ; Chiang, MY; Tobin, AJ. (1991) Sequence and regional distribution of the mRNA encoding the alpha 2 polypeptide of rat gamma-aminobutyric acidA receptors. J. Neurochem., 56 (5): 1717-22. [PMID:1849552]

To cite this database page, please use the following:

Richard Olsen, John A. Peters, Tim G. Hales, Werner Sieghart, Uwe Rudolph, Jeremy J. Lambert, Delia Belelli, Bernhard Luscher.
GABAA receptors: α2. Last modified on 21/06/2012. Accessed on 22/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=405.


Contact us | Print | Back to top | Help