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CNGA4

Family: Cyclic nucleotide-regulated channels

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Associated Proteins
Activators
Tissue Distribution
Physiological Functions
Phenotypes, Alleles and Disease Models
References
Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 575 11p15.4 CNGA4 cyclic nucleotide gated channel alpha 4
Mouse 6 1 575 7 E3 Cnga4 cyclic nucleotide gated channel alpha 4 1
Rat 6 1 575 1q32 Cnga4 cyclic nucleotide gated channel alpha 4 3,8
Previous and Unofficial Names
CNG5
CNGα4
OCNC2
CNGB2
CNCA2
OCNCb
cyclic nucleotide gated channel beta 2
Cgn2
rOCNC2
CNCalpha4, CNG5
CNG channel alpha-4
CNG-4
CNG4
cyclic nucleotide gated cation channel
cyclic nucleotide-gated cation channel alpha 4
cyclic nucleotide-gated cation channel alpha-4
cyclic nucleotide-gated channel alpha-4
cyclic nucleotide-gated olfactory channel subunit OCNC2
olfactory cyclic nucleotide-gated channel
Database Links
Ensembl ENSG00000132259 (Hs), ENSMUSG00000030897 (Mm), ENSRNOG00000017609 (Rn)
Entrez Gene 1262 (Hs), 233649 (Mm), 85258 (Rn)
GeneCards CNGA4 (Hs)
GenitoUrinary Development Molecular Anatomy Project Cnga4 (Mm)
HomoloGene 13579 (Hs)
Human Protein Reference Database 18724 (Hs)
InterPro Q8IV77 (Hs), Q3UW12 (Mm), Q64359 (Rn)
KEGG Gene hsa:1262 (Hs), mmu:233649 (Mm), rno:85258 (Rn)
OMIM 609472 (Hs)
PharmGKB Gene PA26661 (Hs)
PhosphoSitePlus Q8IV77 (Hs), Q3UW12 (Mm)
Protein Ontology (PRO) PRO:000005631 (Hs)
RefSeq Nucleotide NM_001037329 (Hs), NM_001033317 (Mm), NM_053496 (Rn)
RefSeq Protein NP_001032406 (Hs), NP_001028489 (Mm), NP_445948 (Rn)
TreeFam ENSG00000132259 (Hs), ENSMUSG00000030897 (Mm), ENSRNOG00000017609 (Rn)
UniGene Hs. 434618 (Hs)
UniProt Q8IV77 (Hs), Q3UW12 (Mm), Q64359 (Rn)
Wikipedia CNGA4
Cyclic nucleotide-regulated channels
Search for 3D structures on the PDB
Search by keyword: Cyclic nucleotide-regulated channels CNGA4 Search by accession number: Q8IV77, Q64359, Q3UW12
Associated Proteins
Heteromeric Pore-forming Subunits
Name References
Not determined
Auxiliary Subunits
Name References
Not determined
Other Associated Proteins
Name References
Not determined
Activator Comments
CNGA4 confers increased sensitivity to cAMP [3,6,8].
Tissue Distribution
Olfactory epithelium.
Species:  Mouse
Technique:  Immunohistochemistry
References:  2
Vomeronasal organ.
Species:  Mouse
Technique:  Northern Blot
References:  1
Olfactory bulb, brain, cortex, cerebellum.
Species:  Rat
Technique:  RT-PCR
References:  3
Olfactory epithelium.
Species:  Rat
Technique:  Immunohistochemistry
References:  6
Olfactory epithelium.
Species:  Rat
Technique:  In situ hybridisation
References:  3,6,8
Hippocampus.
Species:  Rat
Technique:  In situ hybridisation
References:  5
Functional Assays
Not Determined
Physiological Functions
This subunit increases the cAMP sensitivity of the native olfactory CNG channel.
Species:  None
Tissue:  Olfactory epithelium.
References:  3-4,8,10
Together with CNGB1b, this subunit confers fast odor adaptation in olfactory sensory neurons.
Species:  Mouse
Tissue:  Olfactory epithelium.
References:  3-4,8,10
This subunit is important for odor discrimination and adaptation in mice.
Species:  Mouse
Tissue:  Olfactory epithelium.
References:  7
Together with CNGB1b, this subunit is needed for ciliary targeting of the olfactory CNG channel.
Species:  Mouse
Tissue:  Olfactory epithelium.
References:  9
Phenotypes, Alleles and Disease Models Mouse data from MGI

Click here to show/hide data

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Cnga4tm1Reed Cnga4tm1Reed/Cnga4tm1Reed
involves: 129/Sv		 MGI:2664099  MP:0009562 abnormal odor adaptation PMID: 11739959 
Cnga4tm1Reed Cnga4tm1Reed/Cnga4tm1Reed
involves: 129/Sv		 MGI:2664099  MP:0001983 abnormal olfactory system physiology PMID: 11739959 

REFERENCES

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1. Berghard, A; Buck, LB; Liman, ER. (1996) Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs. Proc. Natl. Acad. Sci. U.S.A., 93 (6): 2365-9. [PMID:8637879]

2. Bradley, J; Bönigk, W; Yau, KW; Frings, S. (2004) Calmodulin permanently associates with rat olfactory CNG channels under native conditions. Nat. Neurosci., 7 (7): 705-10. [PMID:15195096]

3. Bradley, J; Li, J; Davidson, N; Lester, HA; Zinn, K. (1994) Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP. Proc. Natl. Acad. Sci. U.S.A., 91 (19): 8890-4. [PMID:7522325]

4. Bradley, J; Reisert, J; Frings, S. (2005) Regulation of cyclic nucleotide-gated channels. Curr. Opin. Neurobiol., 15 (3): 343-9. [PMID:15922582]

5. Bradley, J; Zhang, Y; Bakin, R; Lester, HA; Ronnett, GV; Zinn, K. (1997) Functional expression of the heteromeric "olfactory" cyclic nucleotide-gated channel in the hippocampus: a potential effector of synaptic plasticity in brain neurons. J. Neurosci., 17 (6): 1993-2005. [PMID:9045728]

6. Bönigk, W; Bradley, J; Müller, F; Sesti, F; Boekhoff, I; Ronnett, GV; Kaupp, UB; Frings, S. (1999) The native rat olfactory cyclic nucleotide-gated channel is composed of three distinct subunits. J. Neurosci., 19 (13): 5332-47. [PMID:10377344]

7. Kelliher, KR; Ziesmann, J; Munger, SD; Reed, RR; Zufall, F. (2003) Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice. Proc. Natl. Acad. Sci. U.S.A., 100 (7): 4299-304. [PMID:12649326]

8. Liman, ER; Buck, LB. (1994) A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP. Neuron, 13 (3): 611-21. [PMID:7522482]

9. Michalakis, S; Reisert, J; Geiger, H; Wetzel, C; Zong, X; Bradley, J; Spehr, M; Hüttl, S; Gerstner, A; Pfeifer, A; Hatt, H; Yau, KW; Biel, M. (2006) Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping. J. Biol. Chem., 281 (46): 35156-66. [PMID:16980309]

10. Munger, SD; Lane, AP; Zhong, H; Leinders-Zufall, T; Yau, KW; Zufall, F; Reed, RR. (2001) Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. Science, 294 (5549): 2172-5. [PMID:11739959]

11. Sautter, A; Zong, X; Hofmann, F; Biel, M. (1998) An isoform of the rod photoreceptor cyclic nucleotide-gated channel beta subunit expressed in olfactory neurons. Proc. Natl. Acad. Sci. U.S.A., 95 (8): 4696-701. [PMID:9539801]

12. Zheng, J; Zagotta, WN. (2004) Stoichiometry and assembly of olfactory cyclic nucleotide-gated channels. Neuron, 42 (3): 411-21. [PMID:15134638]

To cite this database page, please use the following:

Martin Biel, Franz Hofmann, U. Benjamin Kaupp.
Cyclic nucleotide-regulated channels: CNGA4. Last modified on 01/07/2010. Accessed on 21/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=397.


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