Nomenclature: 5-HT3C

Family: 5-HT3 receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 


Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 447 3q27.1 HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 3-5
Previous and Unofficial Names
5-hydroxytryptamine (serotonin) receptor 3, family member C
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Reference Database
PharmGKB Gene
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
UniGene Hs.
Natural/Endogenous Ligands
Tissue Distribution
Brain, colon, intestine, lung, muscle, stomach.
Species:  Human
Technique:  RT-PCR
References:  4
Dorsal root ganglia, lung, duodenum, cecum, brain
Species:  Human
Technique:  RT-PCR
References:  2
Clinically-Relevant Mutations and Pathophysiology
Disease:  Emesis
References:  1
Click column headers to sort
Type Species Molecular location Description Reference
Missense Human K163N 1
General Comments
The HTR3C gene is absent from the rodent genome [2-4]. The human 5-HT3C subunit does not function as a homomer [2,5]. Co-expression with the 5-HT3A subunit has been found to mandatory for the expression of the 5-HT3C subunit at the cell surface in one study [5], but not in a second [2]. Co-assembly of the 5-HT3A and 5-HT3C subunits when heterologously expressed in HEK-293 cells has been demonstrated by immunoprecipitation [5]. Co-expression of the 5-HT3C and 5-HT3A subunits does not alter the potency of agonists and antagonists observed for homopentameric 5-HT3A receptors [2,5].


1. Fasching PA, Kollmannsberger B, Strissel PL, Niesler B, Engel J, Kreis H, Lux MP, Weihbrecht S, Lausen B, Bani MR, Beckmann MW, Strick R. (2008) Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. J. Cancer Res. Clin. Oncol.134 (10): 1079-86. [PMID:18389280]

2. Holbrook JD, Gill CH, Zebda N, Spencer JP, Leyland R, Rance KH, Trinh H, Balmer G, Kelly FM, Yusaf SP, Courtenay N, Luck J, Rhodes A, Modha S, Moore SE, Sanger GJ, Gunthorpe MJ. (2009) Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function. J. Neurochem.108 (2): 384-96. [PMID:19012743]

3. Karnovsky AM, Gotow LF, McKinley DD, Piechan JL, Ruble CL, Mills CJ, Schellin KA, Slightom JL, Fitzgerald LR, Benjamin CW, Roberds SL. (2003) A cluster of novel serotonin receptor 3-like genes on human chromosome 3. Gene319: 137-48. [PMID:14597179]

4. Niesler B, Frank B, Kapeller J, Rappold GA. (2003) Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene310: 101-11. [PMID:12801637]

5. Niesler B, Walstab J, Combrink S, Möller D, Kapeller J, Rietdorf J, Bönisch H, Göthert M, Rappold G, Brüss M. (2007) Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E. Mol. Pharmacol.72 (1): 8-17. [PMID:17392525]

To cite this database page, please use the following:

Nicholas M. Barnes, Tim G. Hales, Sarah C. R. Lummis, Beate Niesler, John A. Peters.
5-HT3 receptors: 5-HT3C. Last modified on 14/03/2014. Accessed on 31/10/2014. IUPHAR database (IUPHAR-DB),

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