IUPHAR DATABASE | 5-HT<sub>3</sub> receptors

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5-HT3C

Family: 5-HT₃ receptors

Contents:

Gene and Protein Information

Previous and Unofficial Names

Database Links

Tissue Distribution

Clinically-Relevant Mutations and Pathophysiology

General Comments

References

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	4	447	3q27.1	HTR3C	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	3-5

Previous and Unofficial Names
5-HT_3C
HTR3C3
5-hydroxytryptamine (serotonin) receptor 3, family member C

Previous and Unofficial Names

5-HT_3C

HTR3C3

5-hydroxytryptamine (serotonin) receptor 3, family member C

Database Links
ChEMBL Target	12117 (Hs)
Ensembl	ENSG00000178084 (Hs)
Entrez Gene	170572 (Hs)
GeneCards	HTR3C (Hs)
HomoloGene	50847 (Hs)
Human Protein Reference Database	17120 (Hs)
InterPro	Q8WXA8 (Hs)
KEGG Gene	hsa:170572 (Hs)
OMIM	610121 (Hs)
PharmGKB Gene	PA134925741 (Hs)
PhosphoSitePlus	Q8WXA8 (Hs)
Protein Ontology (PRO)	PRO:000008835 (Hs)
RefSeq Nucleotide	NM_130770 (Hs)
RefSeq Protein	NP_570126 (Hs)
TreeFam	ENSG00000178084 (Hs)
UniGene Hs.	632579 (Hs)
UniProt	Q8WXA8 (Hs)
Wikipedia	5-HT3C
	5-HT₃ receptors

Search for 3D structures on the PDB
Search by keyword: 5-HT₃ receptors 5-HT3C	Search by accession number: Q8WXA8

Natural/Endogenous Ligand(s)
5-hydroxytryptamine

Tissue Distribution

Brain, colon, intestine, lung, muscle, stomach.

Species:	Human
Technique:	RT-PCR
References:	4

Dorsal root ganglia, lung, duodenum, cecum, brain

Species:	Human
Technique:	RT-PCR
References:	2

Clinically-Relevant Mutations and Pathophysiology

Disease:	Emesis
Comments:	This polymorphism is associated with an increased frequency of vomiting in patients receiving anthracycline chemotherapy.
References:	1

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Type	Species	Molecular location	Description	Reference
Missense	Human	K163N		1

General Comments
The HTR3C gene is absent from the rodent genome [4] [3] [2]. The human 5-HT3C subunit does not function as a homomer [2] [5]. Co-expression with the 5-HT3A subunit has been found to mandatory for the expression of the 5-HT3C subunit at the cell surface in one study[5], but not in a second [2]. Co-assembly of the 5-HT3A and 5-HT3C subunits when heterologously expressed in HEK-293 cells has been demonstrated by immunoprecipitation [5]. Co-expression of the 5-HT3C and 5-HT3A subunits does not alter the potency of agonists and antagonists observed for homopentameric 5-HT3A receptors [2] [5].

General Comments

The HTR3C gene is absent from the rodent genome [4] [3] [2]. The human 5-HT3C subunit does not function as a homomer [2] [5]. Co-expression with the 5-HT3A subunit has been found to mandatory for the expression of the 5-HT3C subunit at the cell surface in one study[5], but not in a second [2]. Co-assembly of the 5-HT3A and 5-HT3C subunits when heterologously expressed in HEK-293 cells has been demonstrated by immunoprecipitation [5]. Co-expression of the 5-HT3C and 5-HT3A subunits does not alter the potency of agonists and antagonists observed for homopentameric 5-HT3A receptors [2] [5].

REFERENCES

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1. Fasching, PA; Kollmannsberger, B; Strissel, PL; Niesler, B; Engel, J; Kreis, H; Lux, MP; Weihbrecht, S; Lausen, B; Bani, MR; Beckmann, MW; Strick, R. (2008) Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. J. Cancer Res. Clin. Oncol., 134 (10): 1079-86. [PMID:18389280]

2. Holbrook, JD; Gill, CH; Zebda, N; Spencer, JP; Leyland, R; Rance, KH; Trinh, H; Balmer, G; Kelly, FM; Yusaf, SP; Courtenay, N; Luck, J; Rhodes, A; Modha, S; Moore, SE; Sanger, GJ; Gunthorpe, MJ. (2009) Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function. J. Neurochem., 108 (2): 384-96. [PMID:19012743]

3. Karnovsky, AM; Gotow, LF; McKinley, DD; Piechan, JL; Ruble, CL; Mills, CJ; Schellin, KA; Slightom, JL; Fitzgerald, LR; Benjamin, CW; Roberds, SL. (2003) A cluster of novel serotonin receptor 3-like genes on human chromosome 3. Gene, 319: 137-48. [PMID:14597179]

4. Niesler, B; Frank, B; Kapeller, J; Rappold, GA. (2003) Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene, 310: 101-11. [PMID:12801637]

5. Niesler, B; Walstab, J; Combrink, S; Möller, D; Kapeller, J; Rietdorf, J; Bönisch, H; Göthert, M; Rappold, G; Brüss, M. (2007) Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E. Mol. Pharmacol., 72 (1): 8-17. [PMID:17392525]

To cite this database page, please use the following:

Nicholas M. Barnes, Tim G. Hales, Sarah C. R. Lummis, Beate Niesler, John A. Peters.
5-HT₃ receptors: 5-HT3C. Last modified on 01/07/2010. Accessed on 23/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=375.