Nomenclature: OT receptor

Family: Vasopressin and oxytocin receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 389 3p25 OXTR oxytocin receptor 50,52-53,61
Mouse 7 388 6 Oxtr oxytocin receptor 54
Rat 7 388 4q42 Oxtr oxytocin receptor 31,74
Previous and Unofficial Names
OT-R
OTR1
OTR
Oxytocin receptor
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
oxytocin {Sp: Human, Mouse, Rat}
vasopressin {Sp: Human, Mouse, Rat}
Comments: oxytocin is the principal endogenous ligand
Rank order of potency (Human)
oxytocin (OXT, P01178) > AVP (AVP, P01178)
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[3H]AVP Hs Partial agonist 8.8 – 8.9 pKd 15,22
pKd 8.8 – 8.9 [15,22]
[3H]OT (human, mouse, rat) Hs Full agonist 8.2 – 9.5 pKd 22,39,48,52
pKd 8.2 – 9.5 (Kd 6.31x10-9 – 3.16x10-10 M) [22,39,48,52]
AVT Hs Full agonist 9.4 pKi 22-23
pKi 9.4 [22-23]
oxytocin {Sp: Human, Mouse, Rat} Hs Full agonist 8.2 – 9.6 pKi 3,22-24,42,48
pKi 8.2 – 9.6 [3,22-24,42,48]
[Phe3]OT Hs Full agonist 8.8 pKi 22-23
pKi 8.8 [22-23]
oxytocin {Sp: Human, Mouse, Rat} Rn Full agonist 8.7 pKi 24
pKi 8.7 [24]
vasopressin {Sp: Human, Mouse, Rat} Hs Partial agonist 7.3 – 9.3 pKi 3,15,21-23,29,42,48
pKi 7.3 – 9.3 [3,15,21-23,29,42,48]
dAVP Hs Full agonist 8.3 pKi 21
pKi 8.3 [21]
[Thr4,Gly7]OT Hs Full agonist 8.2 – 8.4 pKi 23,32,48
pKi 8.2 – 8.4 [23,32,48]
d[Cha4]AVP Hs Full agonist 7.1 – 7.7 pKi 29,42
pKi 7.1 – 7.7 [29,42]
d[Leu4]LVP Rn Full agonist 7.2 pKi 68
pKi 7.2 [68]
desmopressin Hs Full agonist 6.7 – 7.6 pKi 22,48
pKi 6.7 – 7.6 [22,48]
d[Leu4,Dap8]VP Rn Full agonist 6.9 pKi 68
pKi 6.9 [68]
d[Leu4]AVP Hs Full agonist 6.7 pKi 21
pKi 6.7 [21]
d[Cha4,Dab8]VP Rn Full agonist 6.4 pKi 68
pKi 6.4 [68]
d[Cha4]LVP Rn Full agonist 6.2 pKi 68
pKi 6.2 [68]
OPC-21268 Hs Full agonist - -
View species-specific agonist tables
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[35S]non-peptide OT antagonist Hs Antagonist 10.38 pKd 55
pKd 10.38 (Kd 4.2x10-11 M) [55]
d(CH2)5[Tyr(Me)2,Thr4,Tyr(3125I)-NH29]OVT Hs Antagonist 9.7 – 10.0 pKd 15,22-23
pKd 9.7 – 10.0 [15,22-23]
d(CH2)5[Tyr(Me)2,Thr4,Phe(3125I,4N3)-NH29]OVT Hs Antagonist 9.6 pKd 15
pKd 9.6 [15]
d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH29]OVT Hs Antagonist 9.2 – 10.0 pKi 42,59
pKi 9.2 – 10.0 [42,59]
L-366,875 Hs Antagonist 9.5 pKi 48
pKi 9.5 [48]
L023103 Hs Antagonist 9.2 pKi 71
pKi 9.2 [71]
L023103 Rn Antagonist 9.2 pKi 71
pKi 9.2 [71]
d(CH2)5[Tyr(Me)2,Thr4,Phe(3I,4N3)-NH29]OVT Hs Antagonist 9.0 pKi 15
pKi 9.0 [15]
SSR126768A Hs Antagonist 8.82 – 9.05 pKi 75
pKi 8.82 – 9.05 (Ki 1.5x10-9 – 9x10-10 M) [75]
difluorophenyl-dihydro-indenyl isobutyl-dioxopiperazinyl-isopropylethanamide Hs Antagonist 8.9 pKi 13
pKi 8.9 [13]
L-371,257 Hs Antagonist 8.8 pKi 42
pKi 8.8 [42]
L-366,948 Hs Antagonist 8.6 pKi 48
pKi 8.6 [48]
L-369,020 Hs Antagonist 8.5 pKi 48
pKi 8.5 [48]
L-368,930 Hs Antagonist 8.5 pKi 48
pKi 8.5 [48]
L-365,209 Hs Antagonist 8.5 pKi 48
pKi 8.5 [48]
L-372662 Hs Antagonist 8.4 pKi 11
pKi 8.4 [11]
L-368,228 Hs Antagonist 8.4 pKi 48
pKi 8.4 [48]
L-366,682 Hs Antagonist 8.4 pKi 48
pKi 8.4 [48]
d(CH2)5[Tyr(Me)2]AVP Hs Antagonist 8.3 pKi 48
pKi 8.3 [48]
L-368,899 Hs Antagonist 8.1 pKi 48
pKi 8.1 [48]
L-367,938 Hs Antagonist 7.9 pKi 48
pKi 7.9 [48]
nelivaptan Hs Antagonist 6.8 – 8.8 pKi 42,76
pKi 6.8 – 8.8 [42,76]
LS-192629 Hs Antagonist 7.6 – 7.8 pKi 24
pKi 7.6 – 7.8 [24]
L-367,773 Hs Antagonist 7.6 pKi 48
pKi 7.6 [48]
atosiban Rn Antagonist 7.1 pKi 24
pKi 7.1 [24]
LS-192629 Rn Antagonist 6.9 pKi 24
pKi 6.9 [24]
OPC-21268 Hs Antagonist 6.8 pKi 48
pKi 6.8 [48]
atosiban Hs Antagonist 6.0 – 7.6 pKi 3,24,48,59,75
pKi 6.0 – 7.6 [3,24,48,59,75]
relcovaptan Hs Antagonist 6.5 – 7.0 pKi 3,42
pKi 6.5 – 7.0 [3,42]
L-366,509 Hs Antagonist 6.6 pKi 48
pKi 6.6 [48]
[Mpa1,D-Tyr(Et)2,D-Tic7,D-Tic9]OT Hs Antagonist 7.6 pIC50 38
pIC50 7.6 [38]
[Mpa1,D-Tyr(Et)2,D-Tic7]OT Hs Antagonist 7.3 pIC50 38
pIC50 7.3 [38]
[Mpa1,D-Tyr(Et)2,D-Tic7,Aib9]OT Hs Antagonist 7.1 pIC50 38
pIC50 7.1 [38]
View species-specific antagonist tables
Primary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
References:  78,80
Secondary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family Adenylate cyclase inhibition
References:  80-81
Tissue Distribution
Penis.
Species:  Human
Technique:  RT-PCR.
References:  88
Osteoclasts.
Species:  Human
Technique:  Immunofluorescence and Western blotting.
References:  26
Corpus cavernosum
Species:  Human
Technique:  RT-PCR, Northern blotting, immunohistochemistry, Western blotting and radioligand binding.
References:  87
Ovary: cumulus cells.
Species:  Human
Technique:  RT-PCR.
References:  40
Vascular endothelial cells.
Species:  Human
Technique:  RT-PCR.
References:  84
Prostate.
Species:  Human
Technique:  In situ hybridisation and immunohistochemistry.
References:  19
Osteoblasts.
Species:  Human
Technique:  RT-PCR.
References:  27
Brain and spinal cord: brainstem; dorsal horn of upper spinal cord
Species:  Human
Technique:  radioligand binding (autoradiography)
References:  58
Breast tissue.
Species:  Human
Technique:  Immunocytochemistry and RT-PCR.
References:  18
Mammary gland.
Species:  Human
Technique:  Immunohistochemistry.
References:  51
Fetal heart > adult heart.
Species:  Human
Technique:  RT-PCR.
References:  47
Epididymis.
Species:  Human
Technique:  RT-PCR and immunocytochemistry.
References:  37
Thymic epithelial cells.
Species:  Mouse
Technique:  in situ hybridisation.
References:  44
Uterus.
Species:  Mouse
Technique:  Immunohistochemistry.
References:  12
CNS: ventromedial hypothalamus.
Species:  Rat
Technique:  in situ hybridisation.
References:  9
Mammary gland.
Species:  Rat
Technique:  in situ hybridisation.
References:  16
Uterus.
Species:  Rat
Technique:  RT-PCR.
References:  25,56,74
Brain: ventromedial nucleus of the hypothalamus, central amygdaloid nucleus, the islands of Calleja, olfactory nucleus, lateral septum, dorsal motor nucleus of the vagus nerve, taenia tecta, dorsolateral caudate putamen, ventral pallidum, accumbens, bed nucleus of the stria terminalis, thalamic paraventricular nucleus, lateral, basolateral, and medial amygdala, amygdaloid-hippocampal area.
Species:  Rat
Technique:  radioligand binding (autoradiography)
References:  33,85
Cardiomyocytes.
Species:  Rat
Technique:  immunocytochemistry.
References:  47
Testis.
Species:  Rat
Technique:  Radioligand binding.
References:  10
Penis.
Species:  Rat
Technique:  RT-PCR, immunohistochemistry, Western blotting and radioligand binding.
References:  92
Thymus
Species:  Rat
Technique:  Radioligand binding
References:  34
Heart.
Species:  Rat
Technique:  in situ hybridisation.
References:  43
Mammary gland.
Species:  Rat
Technique:  Radioligand binding.
References:  69,79
Pituitary
Species:  Rat
Technique:  Radioligand binding
References:  6
Pituitary
Species:  Rat
Technique:  Northern blotting, RT-PCR and in situ hybridisation
References:  17
Brain, pituitary, mammary glands, uterus.
Brain: ventromedial hypothalamus, bed nucleus of the stria terminalis, ventral pallidum, paraventricular nucleus, dorsal part of the supraoptic nucleus.
Pituitary: anterior and posterior lobes.
Species:  Rat
Technique:  immunocytochemistry.
References:  1
Kidney.
Species:  Rat
Technique:  in situ hybridisation.
References:  67
Brain: ventromedial nucleus of the hypothalamus, anterior olfactory nucleus, intermediate bed nucleus of the stria terminalis, frontal cortex, piriform cortex, supraoptic nucleus, arcuate nucleus, suprachiasmatic nucleus, ventral subiculum, cortical amygdala, subfornical organ, mammillary complex > ateral septal nucleus, medial preoptic area, ventral portions of the bed nucleus of the stria terminalis, paraventricular nucleus of the hypothalamus, dorsal caudoputamen, entorhinal cortex, hippocampus, paraventricular nucleus of the thalamus, dorsal raphe, pontine nuclei, substantia nigra pars compacta, ventral tegmental area.
Species:  Rat
Technique:  in situ hybridisation.
References:  66,86
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Measurement of inositol phosphate accumulation in CHO cells transfected with the rat OT receptor.
Species:  Rat
Tissue:  CHO cells.
Response measured:  Stimulation of IP accumulation.
References:  49
Measurement of calcium levels in CHO cells transfected with the rat OT receptor.
Species:  Rat
Tissue:  CHO cells.
Response measured:  Stimulation of calcium mobilisation.
References:  49,78
Measurement of arachidonic acid and PGE2 levels in CHO cells transfected with the rat OT receptor.
Species:  Rat
Tissue:  CHO cells.
Response measured:  Stimulation of arachidonic acid release followed by PGE2 synthesis.
References:  49
Measurement of ERK2 phosphorylation in CHO cells transfected with the rat OT receptor.
Species:  Rat
Tissue:  CHO cells.
Response measured:  Stimulation of ERK2 phosphorylation.
References:  80
Physiological Functions
Noradrenaline release.
Species:  Rat
Tissue:  In vivo (supraoptic nucleus).
References:  65
Inhibition of food and water intake.
Species:  Rat
Tissue:  In vivo.
References:  7,64
Milk ejection.
Species:  Mouse
Tissue:  In vivo.
References:  63,91
Stimulation of parturition.
Species:  Rat
Tissue:  In vivo.
References:  5,20,72
Uterine contractions.
Species:  Rat
Tissue:  In vivo.
References:  2,60
Muscle contractions.
Species:  Human
Tissue:  Myometrium strips.
References:  70,89
Muscle contractions.
Species:  Rat
Tissue:  Myometrium strips.
References:  8,35
Modulation of exercise-induced tachycardia.
Species:  Rat
Tissue:  In vivo (heart).
References:  14
Cardiomyogenesis.
Species:  Rat
Tissue:  Heart.
References:  47
Facilitation of sperm transport during ejaculation.
Species:  Human
Tissue:  In vivo (epididymis).
References:  37
Stimulation of renin secretion.
Species:  Rat
Tissue:  In vivo (kidney).
References:  45,57,77
Stimulation of urinary Na+ excretion in response to continual (not pulsatile) administration of oxytocin.
Species:  Rat
Tissue:  In vivo (kidney).
References:  77
Regulation of stress-induced antinociception.
Species:  Mouse
Tissue:  Dorsal horn neurones in spinal slices.
References:  73
Attenuation of stress-induced hypothalamic-pituitary-adrenal axis activity.
Species:  Rat
Tissue:  In vivo.
References:  62,90
Development of social memory.
Species:  Mouse
Tissue:  In vivo.
References:  28,36
Physiological Consequences of Altering Gene Expression
Female OT receptor knockout mice exhibit defects in lactation and maternal nuturing; male OT receptor knockout mice have deficits in social discrimination and elevated aggressive behaviour.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  82
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Oxtrtm1Wsy Oxtrtm1Wsy/Oxtrtm1Wsy
involves: 129S1/Sv * 129X1/SvJ
MGI:109147  MP:0002152 abnormal brain morphology PMID: 18356275 
Oxtrtm1.1Knis Oxtrtm1.1Knis/Oxtrtm1.1Knis
involves: 129P2/OlaHsd * C57BL/6J
MGI:109147  MP:0001386 abnormal maternal nurturing PMID: 16249339 
Oxtrtm1.2Wsy Oxtrtm1.2Wsy/Oxtrtm1.2Wsy
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL
MGI:109147  MP:0003838 abnormal milk ejection PMID: 18356275 
Oxtrtm1.1Knis Oxtrtm1.1Knis/Oxtrtm1.1Knis
involves: 129P2/OlaHsd * C57BL/6J
MGI:109147  MP:0001384 abnormal pup retrieval PMID: 16249339 
Oxtrtm1.1Knis Oxtrtm1.1Knis/Oxtrtm1.1Knis
involves: 129P2/OlaHsd * C57BL/6J
MGI:109147  MP:0001360 abnormal social investigation PMID: 16249339 
Oxtrtm1.1Wsy|Tg(Camk2a-cre)1Szi Oxtrtm1.1Wsy/Oxtrtm1.1Wsy,Tg(Camk2a-cre)1Szi/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL
MGI:109147  MGI:2177766  MP:0001360 abnormal social investigation PMID: 18356275 
Oxtrtm1.2Wsy Oxtrtm1.2Wsy/Oxtrtm1.2Wsy
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL
MGI:109147  MP:0001360 abnormal social investigation PMID: 18356275 
Oxtrtm1.1Knis Oxtrtm1.1Knis/Oxtrtm1.1Knis
involves: 129P2/OlaHsd * C57BL/6J
MGI:109147  MP:0001529 abnormal vocalization PMID: 16249339 
Oxtrtm1.1Knis Oxtrtm1.1Knis/Oxtrtm1.1Knis
involves: 129P2/OlaHsd * C57BL/6J
MGI:109147  MP:0009326 absent maternal crouching PMID: 16249339 
Oxtrtm1.1Wsy|Tg(Camk2a-cre)1Szi Oxtrtm1.1Wsy/Oxtrtm1.1Wsy,Tg(Camk2a-cre)1Szi/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL
MGI:109147  MGI:2177766  MP:0001262 decreased body weight PMID: 18356275 
Oxtr+|Oxtrtm1.2Wsy Oxtrtm1.2Wsy/Oxtr+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL
MGI:109147  MP:0001935 decreased litter size PMID: 18356275 
Oxtrtm1.1Knis Oxtrtm1.1Knis/Oxtrtm1.1Knis
involves: 129P2/OlaHsd * C57BL/6J
MGI:109147  MP:0001399 hyperactivity PMID: 16249339 
Oxtrtm1.1Knis Oxtrtm1.1Knis/Oxtrtm1.1Knis
involves: 129P2/OlaHsd * C57BL/6J
MGI:109147  MP:0001353 increased aggression towards mice PMID: 16249339 
Oxtrtm1.1Knis Oxtrtm1.1Knis/Oxtrtm1.1Knis
involves: 129P2/OlaHsd * C57BL/6J
MGI:109147  MP:0010249 lactation failure PMID: 16249339 
Oxtrtm1.1Wsy Oxtrtm1.1Wsy/Oxtrtm1.1Wsy
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
MGI:109147  MP:0002169 no abnormal phenotype detected PMID: 18356275 
Biologically Significant Variants
Type:  Single nucleotide polymorphism.
Species:  Human
Description:  SNPs in the OT receptor gene may be linked to autism.
References:  46
General Comments
The number of OT receptors in the uterus increases near to parturition [25].

The neurohypophysial hormone oxytocin (OT) was the first peptide hormone to have its structure determined and the first to be chemically synthesised in biologically active form [30]. Circulating OT is associated chiefly with the contraction of uterine smooth muscle at term and of myoepithelial cells that surround the alveoli of the mammary gland during lactation through its action on OT receptors. Today, it is recognised that OT exerts a wide spectrum of central and peripheral effects. These actions of OT range from the modulation of neuroendocrine reflexes to the establishment of complex social and bonding behaviours related to the reproduction and care of the offspring [41]. OT receptors form homodimers in vitro and may heterodimerise with vasopressin V1A and V2 receptors [83].

A peptide antagonist, [1-deamino,D-Tyr(Et)2,Thr4,Orn8]vasotocin (atosiban), shown to inhibit uterine contractions in women, threatened and established pre-term labour [4], has been approved for clinical use in Europe.
Available Assays
DiscoveRx PathHunter® CHO-K1 OXTR β-Arrestin Cell Line (Cat no. 93-0261C2)
PathHunter® eXpress OXTR CHO-K1 β-Arrestin GPCR Assay (Cat no. 93-0261E2CP2M)
more info

REFERENCES

1. Adan RA, Van Leeuwen FW, Sonnemans MA, Brouns M, Hoffman G, Verbalis JG, Burbach JP. (1995) Rat oxytocin receptor in brain, pituitary, mammary gland, and uterus: partial sequence and immunocytochemical localization. Endocrinology136: 4022-4028. [PMID:7649111]

2. Ahn TG, Han SJ, Cho YS, An TH, Pak SC, Flouret G. (2004) In vivo activity of the potent oxytocin antagonist on uterine activity in the rat. In Vivo18: 763-766. [PMID:15646817]

3. Akerlund M, Bossmar T, Brouard R, Kostrzewska A, Laudanski T, Lemancewicz A, Serradeil-Le Gal C, Steinwall M. (1999) Receptor binding of oxytocin and vasopressin antagonists and inhibitory effects on isolated myometrium from preterm and term pregnant women. Br J Obstet Gynaecol106: 1047-1053. [PMID:10519430]

4. Akerlund M, Carlsson AM, Melin P, Trojnar J. (1985) The effect on the human uterus of two newly developed competitive inhibitors of oxytocin and vasopressin. Acta obstetricia et gynecologica Scandinavica64: 499-504. [PMID:4061066]

5. Alexandrova M, Soloff MS. (1980) Oxytocin receptors and parturition. I. Control of oxytocin receptor concentration in the rat myometrium at term. Endocrinology106: 730-735. [PMID:6243547]

6. Antoni FA. (1986) Oxytocin receptors in rat adenohypophysis: evidence from radioligand binding studies. Endocrinology119: 2393-2395. [PMID:3021442]

7. Arletti R, Benelli A, Bertolini A. (1990) Oxytocin inhibits food and fluid intake in rats. Physiol Behav48: 825-830. [PMID:2087513]

8. Atke A, Vilhardt H. (1987) Uterotonic activity and myometrial receptor affinity of 1-deamino-1-carba-2-tyrosine(O-methyl)-oxytocin. Acta Endocrinol (Copenh)115: 155-160. [PMID:3035851]

9. Bale TL, Pedersen CA, Dorsa DM. (1995) CNS oxytocin receptor mRNA expression and regulation by gonadal steroids. Adv Exp Med Biol395: 269-280. [PMID:8713977]

10. Bathgate RA, Sernia C. (1994) Characterization and localization of oxytocin receptors in the rat testis. J Endocrinol141: 343-352. [PMID:8046305]

11. Bell IM, Erb JM, Freidinger RM, Gallicchio SN, Guare JP, Guidotti MT, Halpin RA, Hobbs DW, Homnick CF, Kuo MS, Lis EV, Mathre DJ, Michelson SR, Pawluczyk JM, Pettibone DJ, Reiss DR, Vickers S, Williams PD, Woyden CJ. (1998) Development of orally active oxytocin antagonists: studies on 1-(1-[4-[1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl]piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines. J Med Chem41: 2146-2163. [PMID:9622556]

12. Beretsos P, Loutradis D, Koussoulakos S, Margaritis LH, Kiapekou E, Mastorakos G, Papaspirou I, Makris N, Makrigiannakis A, Antsaklis A. (2006) Oxytocin receptor is differentially expressed in mouse endometrium and embryo during blastocyst implantation. Ann N Y Acad Sci1092: 466-479. [PMID:17308174]

13. Borthwick AD, Davies DE, Exall AM, Livermore DG, Sollis SL, Nerozzi F, Allen MJ, Perren M, Shabbir SS, Woollard PM, Wyatt PG. (2005) 2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 2. Synthesis, chirality, and pharmacokinetics. J Med Chem48: 6956-6969. [PMID:16250654]

14. Braga DC, Mori E, Higa KT, Morris M, Michelini LC. (2000) Central oxytocin modulates exercise-induced tachycardia. Am J Physiol Regul Integr Comp Physiol278: R1474-R1482. [PMID:10848513]

15. Breton C, Chellil H, Kabbaj-Benmansour M, Carnazzi E, Seyer R, Phalipou S, Morin D, Durroux T, Zingg HH, Barberis C, Mouillac B. (2001) Direct identification of human oxytocin receptor-binding domains using a photoactivatable cyclic peptide antagonist: comparison with the human V1a vasopressin receptor. J Biol Chem276: 26931-26941. [PMID:11337500]

16. Breton C, Di Scala-Guenot D, Zingg HH. (2001) Oxytocin receptor gene expression in rat mammary gland: structural characterization and regulation. J Mol Endocrinol27: 175-189. [PMID:11564602]

17. Breton C, Pechoux C, Morel G, Zingg HH. (1995) Oxytocin receptor messenger ribonucleic acid: characterization, regulation, and cellular localization in the rat pituitary gland. Endocrinology136: 2928-2936. [PMID:7540544]

18. Bussolati G, Cassoni P, Ghisolfi G, Negro F, Sapino A. (1996) Immunolocalization and gene expression of oxytocin receptors in carcinomas and non-neoplastic tissues of the breast. Am J Pathol148: 1895-1903. [PMID:8669475]

19. Cassoni P, Marrocco T, Sapino A, Allia E, Bussolati G. (2004) Evidence of oxytocin/oxytocin receptor interplay in human prostate gland and carcinomas. Int J Oncol25: 899-904. [PMID:15375538]

20. Chan WY, Chen DL. (1992) Myometrial oxytocin receptors and prostaglandin in the parturition process in the rat. Biol Reprod46: 58-64. [PMID:1312364]

21. Cheng LL, Stoev S, Manning M, Derick S, Pena A, Mimoun MB, Guillon G. (2004) Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J Med Chem47: 2375-2388. [PMID:15084136]

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To cite this database page, please use the following:

Daniel Bichet, Michel Bouvier, Bice Chini, Gerald Gimpl, Gilles Guillon, Tadashi Kimura, Mark Knepper, Stephen Lolait, Maurice Manning, Bernard Mouillac, Claudine Serradeil-Le Gal, Melvyn Soloff, Joseph G. Verbalis, Mark Wheatley, Hans H. Zingg.
Vasopressin and oxytocin receptors: OT receptor. Last modified on 12/02/2014. Accessed on 01/10/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=369.

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