Nomenclature: V1A receptor

Family: Vasopressin and oxytocin receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 418 12q14-q15 AVPR1A arginine vasopressin receptor 1A 70-71
Mouse 7 423 10 D3 Avpr1a arginine vasopressin receptor 1A 34
Rat 7 424 7q21 Avpr1a arginine vasopressin receptor 1A 42
Previous and Unofficial Names
V1
V1aR
arginine vasopressin receptor 1A
AVPR1
AVPR
MGC108538
V1a
Vasopressin receptor V1a
antidiuretic hormone receptor 1a
arginine vasopressin receptor V1a
vascular/hepatic-type arginine vasopressin receptor
vasopressin V1a receptor
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
oxytocin {Sp: Human, Mouse, Rat}
vasopressin {Sp: Human, Mouse, Rat}
Comments: vasopressin is the principal endogenous agonist
Rank order of potency (Human)
AVP (AVP, P01178) > oxytocin (OXT, P01178)
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[3H]AVP Hs Full agonist 8.6 – 10.2 pKd 9,16,19-20,46,51,53,62-63,70,72,75,78
pKd 8.6 – 10.2 (Kd 2.51x10-9 – 6.3x10-11 M) [9,16,19-20,46,51,53,62-63,70,72,75,78]
F180 Hs Full agonist 7.9 – 8.3 pKd 2,19
pKd 7.9 – 8.3 [2,19]
[3H]OT (human, mouse, rat) Hs Full agonist 6.9 pKd 51
pKd 6.9 [51]
d[D-Phe2]AVP Hs Full agonist 9.2 pKi 21
pKi 9.2 [21]
vasopressin {Sp: Human, Mouse, Rat} Hs Full agonist 8.5 – 9.3 pKi 1,15,19,21,46,51,53,62-63,70,72,78
pKi 8.5 – 9.3 [1,15,19,21,46,51,53,62-63,70,72,78]
LVP {Sp: Pig} Hs Full agonist 8.6 pKi 72
pKi 8.6 [72]
AVT Rn Full agonist 8.5 pKi 16
pKi 8.5 [16]
vasopressin {Sp: Human, Mouse, Rat} Rn Full agonist 8.4 pKi 16
pKi 8.4 [16]
dAVP Hs Full agonist 8.4 pKi 15,21
pKi 8.4 [15,21]
AVT Hs Full agonist 8.3 pKi 72
pKi 8.3 [72]
dVDAVP Hs Full agonist 7.6 – 8.0 pKi 21,72
pKi 7.6 – 8.0 [21,72]
oxytocin {Sp: Human, Mouse, Rat} Hs Full agonist 6.9 – 8.3 pKi 1,17,51,53,62-63,70,72
pKi 6.9 – 8.3 [1,17,51,53,62-63,70,72]
d[D-Pal2]AVP Hs Full agonist 7.5 pKi 15,21
pKi 7.5 [15,21]
[Val4]AVP Hs Full agonist 7.5 pKi 21
pKi 7.5 [21]
d[Leu4]AVP Hs Full agonist 7.4 pKi 15
pKi 7.4 [15]
desmopressin Hs Full agonist 7.0 – 7.7 pKi 15,46,51,53,62,72
pKi 7.0 – 7.7 [15,46,51,53,62,72]
d[Cha4]AVP Hs Full agonist 7.1 pKi 21
pKi 7.1 [21]
[Thr4,Gly7]OT Hs Full agonist 6.5 – 6.8 pKi 51,62
pKi 6.5 – 6.8 [51,62]
[Phe3]OT Rn Full agonist 6.3 pKi 16
pKi 6.3 [16]
DAVP Rn Full agonist 6.1 pKi 16
pKi 6.1 [16]
OPC-51803 Hs Full agonist 6.1 pKi 46
pKi 6.1 [46]
oxytocin {Sp: Human, Mouse, Rat} Rn Full agonist 6.1 pKi 16
pKi 6.1 [16]
desmopressin Rn Full agonist 5.6 pKi 16
pKi 5.6 [16]
d[Leu4,Dap8]VP Rn Full agonist 5.5 pKi 50
pKi 5.5 [50]
d[Leu4]LVP Rn Full agonist 5.4 pKi 50
pKi 5.4 [50]
d[Cha4,Dab8]VP Rn Full agonist 5.4 pKi 50
pKi 5.4 [50]
d[Cha4]LVP Rn Full agonist 5.0 pKi 50
pKi 5.0 [50]
View species-specific agonist tables
Agonist Comments
The binding affinities at the V1A receptor found in study [50] are from native tissues.
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[125I]OH-LVA Hs Antagonist 10.3 – 10.4 pKd 16,19,51
pKd 10.3 – 10.4 (Kd 3.99x10-11 – 5x10-11 M) [16,19,51]
[125I]3-N3-Phpa-LVA Hs Antagonist 9.9 pKd 51
pKd 9.9 [51]
d(CH2)5[Tyr(Me)2,Thr4,Phe(3125I,4N3)-NH29]OVT Hs Antagonist 9.3 pKd 9
pKd 9.3 [9]
d(CH2)5[Tyr(Me)2,Thr4,Tyr(3125I)-NH29]OVT Hs Antagonist 9.0 pKd 9
pKd 9.0 [9]
3-N3-Phpa-LVA Hs Antagonist 9.6 pKi 51
pKi 9.6 [51]
YM 218 Hs Antagonist 9.5 pKi 66
pKi 9.5 [66]
OH-LVA Hs Antagonist 9.3 pKi 72
pKi 9.3 [72]
YM 471 Hs Antagonist 9.2 pKi 75
pKi 9.2 [75]
[Phaa1,D-Tyr2,Val4,Arg6,Arg-NH29]AVP Hs Antagonist 9.2 pKi 72
pKi 9.2 [72]
[Phaa1,D-Tyr(Me)2,Arg6,Tyr-NH29]AVP Hs Antagonist 9.1 pKi 72
pKi 9.1 [72]
d(CH2)5[Tyr(Et)2,Val4,des-Gly9]AVP Hs Antagonist 9.1 pKi 62
pKi 9.1 [62]
d(CH2)5[D-Tyr(Et)2,Val4,Tyr-NH29]AVP Hs Antagonist 9.1 pKi 19
pKi 9.1 [19]
[tBaa1,D-Tyr(Et)2,Val4,Lys6,Arg-NH28,des-Gly9]AVP Hs Antagonist 9.1 pKi 72
pKi 9.1 [72]
d[Pen1,Tyr(Me)2]AVP Hs Antagonist 9.1 pKi 62
pKi 9.1 [62]
[Phaa1,D-Tyr(Et)2,Lys6,des-Gly9]AVP Hs Antagonist 8.9 – 9.1 pKi 70,72
pKi 8.9 – 9.1 [70,72]
d(CH2)5[Tyr(Me)2,Thr4,Phe(3I,4N3)-NH29]OVT Hs Antagonist 8.9 pKi 9
pKi 8.9 [9]
d(CH2)5[Tyr(Me)2]AVP Hs Antagonist 8.4 – 9.2 pKi 19,51,53,62-63,72
pKi 8.4 – 9.2 [19,51,53,62-63,72]
relcovaptan Hs Antagonist 8.1 – 9.3 pKi 1,19,26,51,55,62,70,72,75
pKi 8.1 – 9.3 [1,19,26,51,55,62,70,72,75]
[Phaa1,D-Tyr(Et)2,Val4,Lys6,Tyr-NH28,des-Gly9]AVP Hs Antagonist 8.5 – 8.6 pKi 70,72
pKi 8.5 – 8.6 [70,72]
d[D-Pal2]AVP Hs Antagonist 8.4 pKi 72
pKi 8.4 [72]
atosiban Hs Antagonist 8.3 – 8.5 pKi 1,17,40,56
pKi 8.3 – 8.5 [1,17,40,56]
d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH29]OVT Hs Antagonist 8.3 – 8.4 pKi 40,72
pKi 8.3 – 8.4 [40,72]
conivaptan Hs Antagonist 8.2 – 8.4 pKi 62-63
pKi 8.2 – 8.4 [62-63]
d(CH2)5[Tyr(Me)2,Thr4]OVT Hs Antagonist 8.1 pKi 72
pKi 8.1 [72]
tolvaptan Hs Antagonist 7.9 pKi 78
pKi 7.9 [78]
RWJ-351647 Hs Antagonist 7.6 pKi 28
pKi 7.6 [28]
d(CH2)5[D-Ile2,Ile4,Ala-NH29]AVP Hs Antagonist 7.5 pKi 72
pKi 7.5 [72]
L023103 Hs Antagonist 7.4 pKi 52
pKi 7.4 [52]
d(CH2)5[D-Ile2,Ile4,Ala-NH2]AVP Hs Antagonist 7.2 – 7.3 pKi 70,72
pKi 7.2 – 7.3 [70,72]
nelivaptan Hs Antagonist 7.0 pKi 58
pKi 7.0 [58]
mozavaptan Hs Antagonist 6.8 – 7.1 pKi 62,72,78
pKi 6.8 – 7.1 [62,72,78]
SSR126768A Hs Antagonist 6.8 pKi 56
pKi 6.8 [56]
LS-192629 Hs Antagonist 6.7 pKi 17
pKi 6.7 [17]
satavaptan Hs Antagonist 6.5 pKi 62,75
pKi 6.5 [62,75]
tolvaptan Rn Antagonist 6.5 pKi 78
pKi 6.5 [78]
mozavaptan Rn Antagonist 6.3 pKi 78
pKi 6.3 [78]
OPC-21268 Hs Antagonist 5.1 pKi 72
pKi 5.1 [72]
View species-specific antagonist tables
Primary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
References:  54
Tissue Distribution
Liver > heart, kidney, skeletal muscle.
Species:  Human
Technique:  Northern blotting.
References:  71
Myometrium.
Species:  Human
Technique:  in situ hybridisation.
References:  73
Adrenal gland (medulla and cortex).
Species:  Human
Technique:  RT-PCR.
References:  25,27
Platelets.
Species:  Human
Technique:  RT-PCR.
References:  29
Uterus.
Species:  Rat
Technique:  RT-PCR.
References:  18
Liver.
Species:  Rat
Technique:  in situ hybridisation.
References:  49
Adrenal gland.
Species:  Rat
Technique:  RT-PCR.
References:  27,74
CNS: frontal cortex, piriform cortex, internal granular layer and the medial, dorsal, ventral and lateral portion of the anterior olfactory nucleus, zona limitans of the islands of Calleja, suprachiasmatic nucleus, CA1, CA2, CA3 and dentate gyrus of the hippocampus, paraventricular hypothalamic nucleus, ventromedial hypothalamic nucleus, arcuate nucleus, lateral habenular nucleus, molecular and granular cell layers of the cerebellum.
Species:  Rat
Technique:  in situ hybridisation.
References:  48,60
Lung.
Species:  Rat
Technique:  Radioligand binding.
References:  65
Testis.
Species:  Rat
Technique:  Radioligand binding.
References:  41
Kidney.
Species:  Rat
Technique:  in situ hybridisation.
References:  49
Vascular smooth muscle cells.
Species:  Rat
Technique:  Northern blotting.
References:  44
Adult: brain, lung, liver, kidney.
Newborn: brain, liver, heart, kidney.
Species:  Rat
Technique:  RT-PCR.
References:  30
Cardiomyocytes.
Species:  Rat
Technique:  RT-PCR.
References:  13
Kidney: glomerulus, initial cortical collecting duct, cortical collecting duct, outer medullary collecting duct, inner medullary collecting duct, arcuate artery > proximal convoluted and straight tubules, inner medullary thin limbs, medullary thick ascending limbs.
Species:  Rat
Technique:  RT-PCR.
References:  67
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Measurement of inositol phosphate accumulation in CHO cells transfected with the human V1A receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Stimulation of IP accumulation.
References:  70
Measurement of inositol phosphate accumulation in COS-7 cells transfected with the human V1A receptor.
Species:  Human
Tissue:  COS-7 cells.
Response measured:  Stimulation of IP accumulation.
References:  70
Measurement of calcium levels in CHO cells transfected with the rat V1A receptor.
Species:  Rat
Tissue:  CHO cells.
Response measured:  Stimulation of calcium mobilisation.
References:  10
Measurement of arachidonic acid levels in CHO cells transfected with the rat V1A receptor.
Species:  Rat
Tissue:  CHO cells.
Response measured:  Stimulation arachidonic acid release.
References:  10
Measurement of calcium levels in CHO cells transfected with the human V1A receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Stimulation of calcium mobilisation.
References:  62
Measurement of MAP kinase activation in CHO cells transfected with the human V1A receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Stimulation of MAP kinase activation.
References:  64
Physiological Functions
Vasoconstriction.
Species:  Rat
Tissue:  Isolated uterine resistance arteries.
References:  14
Vasoconstriction.
Species:  Rat
Tissue:  Isolated perfused kidney.
References:  39
Vasoconstriction.
Species:  Rat
Tissue:  Isolated mesenteric artery rings.
References:  59
Vasoconstriction.
Species:  Human
Tissue:  In vivo.
References:  11
Hypertension.
Species:  Rat
Tissue:  In vivo.
References:  45,61
Tissue regeneration.
Species:  Rat
Tissue:  Adrenal gland.
References:  74
Aldosterone and corticosterone secretion.
Species:  Rat
Tissue:  Adrenal gland.
References:  24
Platelet aggregation.
Species:  Human
Tissue:  Platelets.
References:  29,57
Glucose homeostasis.
Species:  Mouse
Tissue:  In vivo.
References:  3
Regulation of heart rate.
Species:  Mouse
Tissue:  In vivo.
References:  47
Cardiomyocyte hypertrophy.
Species:  Mouse
Tissue:  Isolated cardiomyocytes.
References:  33
Myometrial contraction.
Species:  Human
Tissue:  Myometrial strips.
References:  73
Physiological Consequences of Altering Gene Expression
V1A receptor knockout mice exhibit subtle olfactory deficit but normal aggression.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  77
V1A receptor knockout mice exhibit a decrease in anxiety-like behaviour and impaired social recognition. This effect was seen in both male and female receptor knockout mice suggesting that there is no sexual dimorphism involved.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  23
V1A receptor knockout mice exhibit altered lipid metabolism.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  31
V1A receptor knockout mice exhibit altered glucose homeostasis.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  3
V1A receptor knockout mice exhibit a decrease in blood pressure and circulating blood volume.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  37
V1A receptor knockout mice exhibit altered reflex changes in heart rate.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  47
V1A receptor knockout mice exhibit attenuated cardiac hypertrophy in response to pressure overload.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  33
Male V1A receptor knockout mice exhibit a decrease in anxiety-like behaviour and impaired social recognition. No such effects were observed in female V1A knockout mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  6-7
Re-expressing the V1A receptor in the lateral septum of V1A receptor knockout mice restores impaired social memory; mice overexpressing the V1A receptor exhibit potentiation of social recognition and a slight increase in anxiety-related behaviour.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells; viral gene transfer.
References:  5
V1A receptor knockout mice exhibit impaired spacial memory.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  22
V1A receptor knockout mice exhibit enhanced proteolysis and gluconeogenesis.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  32
V1A receptor (and V1B receptor) knockout mice exhibit normal, acute intoxicating behavioural effects following ethanol ingestion.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  12
V1A receptor knockout mice exhibit impaired aldosterone secretion.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  8
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Avpr1atm1Gzt Avpr1atm1Gzt/Avpr1atm1Gzt
involves: 129/Sv * C57BL/6J
MGI:1859216  MP:0000639 abnormal adrenal gland morphology PMID: 16682631 
Avpr1atm1Gzt Avpr1atm1Gzt/Avpr1atm1Gzt
involves: 129/Sv * C57BL/6J
MGI:1859216  MP:0004184 abnormal baroreceptor physiology PMID: 16682631 
Avpr1atm1Sbhu Avpr1atm1Sbhu/Avpr1atm1Sbhu
involves: C57BL/6
MGI:1859216  MP:0002144 abnormal B cell differentiation PMID: 12576226 
Avpr1atm1Gzt Avpr1atm1Gzt/Avpr1atm1Gzt
involves: 129/Sv * C57BL/6J
MGI:1859216  MP:0005345 abnormal circulating corticosterone level PMID: 16682631 
Avpr1atm1Gzt Avpr1atm1Gzt/Avpr1atm1Gzt
involves: 129/Sv * C57BL/6J
MGI:1859216  MP:0001629 abnormal heart rate PMID: 16682631 
Avpr1atm1Sbhu Avpr1atm1Sbhu/Avpr1atm1Sbhu
involves: C57BL/6
MGI:1859216  MP:0002490 abnormal immunoglobulin level PMID: 12576226 
Avpr1atm1Gzt Avpr1atm1Gzt/Avpr1atm1Gzt
involves: C57BL/6
MGI:1859216  MP:0001449 abnormal learning/ memory PMID: 15036628 
Avpr1atm1Sbhu Avpr1atm1Sbhu/Avpr1atm1Sbhu
129X1.Cg-Avpr1a
MGI:1859216  MP:0001360 abnormal social investigation PMID: 14647484 
Avpr1atm1Gzt Avpr1atm1Gzt/Avpr1atm1Gzt
involves: 129/Sv * C57BL/6J
MGI:1859216  MP:0000250 abnormal vasoconstriction PMID: 16682631 
Avpr1atm1Sbhu Avpr1atm1Sbhu/Avpr1atm1Sbhu
129X1.Cg-Avpr1a
MGI:1859216  MP:0001364 decreased anxiety-related response PMID: 14647484  16046007 
Avpr1atm1Gzt Avpr1atm1Gzt/Avpr1atm1Gzt
involves: 129/Sv * C57BL/6J
MGI:1859216  MP:0005523 decreased circulating atrial natriuretic factor PMID: 16682631 
Avpr1atm1Sbhu Avpr1atm1Sbhu/Avpr1atm1Sbhu
involves: C57BL/6
MGI:1859216  MP:0008497 decreased IgG2b level PMID: 12576226 
Avpr1atm1Dgen Avpr1atm1Dgen/Avpr1atm1Dgen
involves: 129P2/OlaHsd * C57BL/6
MGI:1859216  MP:0009142 decreased prepulse inhibition
Avpr1atm1Gzt Avpr1atm1Gzt/Avpr1atm1Gzt
involves: 129/Sv * C57BL/6J
MGI:1859216  MP:0001596 hypotension PMID: 16682631 
Avpr1atm1Sbhu Avpr1atm1Sbhu/Avpr1atm1Sbhu
involves: C57BL/6
MGI:1859216  MP:0008167 increased B-1a cell number PMID: 12576226 
Avpr1atm1Sbhu Avpr1atm1Sbhu/Avpr1atm1Sbhu
involves: C57BL/6
MGI:1859216  MP:0008500 increased IgG2a level PMID: 12576226 
Avpr1atm1Gzt Avpr1atm1Gzt/Avpr1atm1Gzt
involves: 129/Sv * C57BL/6J
MGI:1859216  MP:0001633 poor circulation PMID: 16682631 
Biologically Significant Variants
Type:  Single nucleotide polymorphisms.
Species:  Human
Description:  Four SNPs in the promotor region of the V1A receptor gene have been found in human platelets.
References:  29
General Comments
V1A vasopressin receptors modulate the vasopressor actions of arginine vasopressin (AVP). They have been shown to be present in many tissues including the brain. They mediate vascular smooth muscle cell contraction and proliferation, liver glycogenolysis, platelet aggregation, aldosterone secretion by the adrenals, and subserve neurotransmitter-like actions of AVP in the central nervous system.

Overexpression of the V1A receptor has been found in adrenocorticotropin-independent macromodular adrenal hyperplasia [43,76]. Vasopressin V1A receptors form homodimers in vitro and may heterodimerise with vasopressin V2 and oxytocin receptors [68-69].

The pattern of V1A receptor expression in the brain may be associated with species-typical social behaviours (e.g., affiliative behaviour) in rodents [38,80]. Polymorphisms in the promoter region of the V1A receptor gene have been associated with decision making in a dictator game [36] and creative dance performance [4] in humans. An association between polymorphisms in the V1A receptor gene and autism has been found in some [79] but not all [35] studies.
Available Assays
DiscoveRx PathHunter® eXpress AVPR1A U2OS β-Arrestin GPCR Assay (Cat no. 93-0587E3CP0M)
PathHunter® U2OS AVPR1A β-Arrestin Cell Line (Cat no. 93-0587C3)
more info

REFERENCES

1. Akerlund M, Bossmar T, Brouard R, Kostrzewska A, Laudanski T, Lemancewicz A, Serradeil-Le Gal C, Steinwall M. (1999) Receptor binding of oxytocin and vasopressin antagonists and inhibitory effects on isolated myometrium from preterm and term pregnant women. Br J Obstet Gynaecol106: 1047-1053. [PMID:10519430]

2. Andres M, Trueba M, Guillon G. (2002) Pharmacological characterization of F-180: a selective human V1a vasopressin receptor agonist of higly affinity. Br J Pharmacol135: 1828-1836. [PMID:11934825]

3. Aoyagi T, Birumachi J, Hiroyama M, Fujiwara Y, Sanbe A, Yamauchi J, Tanoue A. (2007) Alteration of glucose homeostasis in V1a vasopressin receptor-deficient mice. Endocrinology148: 2075-2084. [PMID:17303660]

4. Bachner-Melman R, Dina C, Zohar AH, Constantini N, Lerer E, Hoch S, Sella S, Nemanov L, Gritsenko I, Lichtenberg P, Granot R, Ebstein RP. (2005) AVPR1a and SLC6A4 gene polymorphisms are associated with creative dance performance. PLoS Genet1: e42-e42. [PMID:16205790]

5. Bielsky IF, Hu SB, Ren X, Terwilliger EF, Young LJ. (2005) The V1a vasopressin receptor is necessary and sufficient for normal social recognition: a gene replacement study. Neuron47: 503-513. [PMID:16102534]

6. Bielsky IF, Hu SB, Szegda KL, Westphal H, Young LJ. (2004) Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice. Neuropsychopharmacology29: 483-493. [PMID:14647484]

7. Bielsky IF, Hu SB, Young LJ. (2005) Sexual dimorphism in the vasopressin system: lack of an altered behavioral phenotype in female V1a receptor knockout mice. Behav Brain Res164: 132-136. [PMID:16046007]

8. Birumachi J, Hiroyama M, Fujiwara Y, Aoyagi T, Sanbe A, Tanoue A. (2007) Impaired arginine-vasopressin-induced aldosterone release from adrenal gland cells in mice lacking the vasopressin V1A receptor. Eur J Pharmacol566: 226-230. [PMID:17449028]

9. Breton C, Chellil H, Kabbaj-Benmansour M, Carnazzi E, Seyer R, Phalipou S, Morin D, Durroux T, Zingg HH, Barberis C, Mouillac B. (2001) Direct identification of human oxytocin receptor-binding domains using a photoactivatable cyclic peptide antagonist: comparison with the human V1a vasopressin receptor. J Biol Chem276: 26931-26941. [PMID:11337500]

10. Briley EM, Lolait SJ, Axelrod J, Felder CC. (1994) The cloned vasopressin V1a receptor stimulates phospholipase A2, phospholipase C, and phospholipase D through activation of receptor-operated calcium channels. Neuropeptides27: 63-74. [PMID:7969820]

11. Brouard R, Laporte V, Serradeil Le Gal C, Pignol R, Jang H, Donat F, Lockwood G, Fournie D, Dreux F. (1998) Safety, tolerability, and pharmacokinetics of SR 49059, a V1a vasopressin receptor antagonist, after repeated oral administration in healthy volunteers. Adv Exp Med Biol449: 455-465. [PMID:10026839]

12. Caldwell HK, Stewart J, Wiedholz LM, Millstein RA, Iacangelo A, Holmes A, Young WS, Wersinger SR. (2006) The acute intoxicating effects of ethanol are not dependent on the vasopressin 1a or 1b receptors. Neuropeptides40: 325-337. [PMID:17049983]

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To cite this database page, please use the following:

Daniel Bichet, Michel Bouvier, Bice Chini, Gerald Gimpl, Gilles Guillon, Tadashi Kimura, Mark Knepper, Stephen Lolait, Maurice Manning, Bernard Mouillac, Claudine Serradeil-Le Gal, Melvyn Soloff, Joseph G. Verbalis, Mark Wheatley, Hans H. Zingg.
Vasopressin and oxytocin receptors: V1A receptor. Last modified on 17/12/2013. Accessed on 24/09/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=366.

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