Nomenclature: NK2 receptor

Family: Tachykinin receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 398 10q11-q21 TACR2 tachykinin receptor 2 25
Mouse 7 384 10 B4 Tacr2 tachykinin receptor 2 61
Rat 7 390 20 Tacr2 tachykinin receptor 2 56
Previous and Unofficial Names
Neurokinin B receptor
Substance K receptor
Substance K
TAC2R
NKNAR
SKR
NK2R
NK-2 receptor
NK-2R
Tachykinin 2 (substance K) receptor
neurokinin A receptor
substance-K receptor
tachykinin receptor 2
SP-E receptor
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
neurokinin A {Sp: Human, Mouse, Rat}
neurokinin B {Sp: Human, Mouse, Rat, Pig}
substance P {Sp: Human, Mouse, Rat}
Comments: neurokinin A is the principal endogenous agonist
Rank order of potency (Human)
neurokinin A (TAC1, P20366) > neurokinin B (TAC3, Q9UHF0) >> substance P (TAC1, P20366)
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[βAla8]neurokinin A-(4-10) Hs Full agonist 6.0 pKd 23
pKd 6.0 [23]
neurokinin A {Sp: Human, Mouse, Rat} Hs Full agonist 8.0 – 9.1 pKi 6,23,55,66
pKi 8.0 – 9.1 [6,23,55,66]
[Phe(Me)7]neurokinin B Hs Full agonist 6.9 pKi 55
pKi 6.9 [55]
substance P {Sp: Human, Mouse, Rat} Hs Full agonist 5.9 – 6.9 pKi 6,23,55
pKi 5.9 – 6.9 [6,23,55]
neurokinin B {Sp: Human, Mouse, Rat, Pig} Hs Full agonist 5.0 – 7.7 pKi 23,55
pKi 5.0 – 7.7 [23,55]
hemokinin 1 {Sp: Mouse} Hs Full agonist 6.3 pKi 6
pKi 6.3 [6]
neuropeptide γ {Sp: Human, Mouse, Rat} Cp Agonist 9.5 pEC50 63
pEC50 9.5 (EC50 3.16x10-10 M) [63]
neurokinin A {Sp: Human, Mouse, Rat} Cp Agonist 8.89 pEC50 18
pEC50 8.89 (EC50 1.3x10-9 M) [18]
neuropeptide K {Sp: Human, Rat} Cp Agonist 8.8 pEC50 63
pEC50 8.8 (EC50 1.58x10-9 M) [63]
GR64349 Rn Full agonist 8.4 pEC50 19
pEC50 8.4 (EC50 3.7x10-9 M) [19]
[Lys5,Me-Leu9,Nle10]NKA-(4-10) Rn Full agonist 8.8 – 9.4 pIC50 46
pIC50 8.8 – 9.4 [46]
View species-specific agonist tables
Agonist Comments
Affinity data for guinea pig tachykinin receptors has been included as this species more closely mimics human tachykinin receptor expression pattern, gene sequence, and receptor function than do the rat or mouse.
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[3H]SR48,968 Rn Antagonist 9.7 pKd 31
pKd 9.7 (Kd 2x10-10 M) [31]
GR159897 Hs Antagonist 7.8 – 9.5 pKd 8,23,59
pKd 7.8 – 9.5 [8,23,59]
ibodutant Hs Antagonist 9.8 – 10.3 pKi 15
pKi 9.8 – 10.3 [15]
YM44781 Hs Antagonist 9.9 pKi 14
pKi 9.9 [14]
GR94800 Hs Antagonist 9.8 pKi 10
pKi 9.8 [10]
saredutant Hs Antagonist 9.4 – 9.7 pKi 4,23,55
pKi 9.4 – 9.7 [4,23,55]
SCH 206272 Hs Antagonist 9.4 pKi 4
pKi 9.4 [4]
saredutant Rn Antagonist 9.2 – 9.4 pKi 24
pKi 9.2 – 9.4 (Ki 6x10-10 – 4.2x10-10 M) [24]
SB 414240 Hs Antagonist 9.0 pKi 9
pKi 9.0 (Ki 1x10-9 M) [9]
ZM-274773 Hs Antagonist 8.62 pKi 3
pKi 8.62 (Ki 2.4x10-9 M) [3]
nepadutant Hs Antagonist 8.5 – 8.7 pKi 11,15
pKi 8.5 – 8.7 [11,15]
YM44778 Hs Antagonist 8.6 pKi 14
pKi 8.6 [14]
MEN 10376 Hs Antagonist 8.1 pKi 23
pKi 8.1 [23]
osanetant Hs Antagonist 7.3 – 7.8 pKi 4,55
pKi 7.3 – 7.8 [4,55]
talnetant Hs Antagonist 6.8 – 6.9 pKi 55
pKi 6.8 – 6.9 [55]
YM49598 Hs Antagonist 6.8 pKi 14
pKi 6.8 [14]
R396 Hs Antagonist 6.5 pKi 23
pKi 6.5 [23]
FK888 Hs Antagonist 6.1 pKi 14
pKi 6.1 [14]
ZM 253270 Cp Antagonist 5.05 pKi 2
pKi 5.05 (Ki 9x10-6 M) [2]
ZM 253270 Hs Antagonist 3.8 pKi 2
pKi 3.8 (Ki 1.5x10-4 M) [2]
saredutant Cp Antagonist 10.25 pIC50 45
pIC50 10.25 (IC50 5.6x10-11 M) [45]
View species-specific antagonist tables
Antagonist Comments
Affinity data for guinea pig tachykinin receptors has been included as this species more closely mimics human tachykinin receptor expression pattern, gene sequence, and receptor function than do the rat or mouse.
Primary Transduction Mechanisms
Transducer Effector/Response
Gs family
Gq/G11 family
Adenylate cyclase stimulation
Phospholipase C stimulation
References:  12,51,60
Tissue Distribution
Hippocampus.
Species:  Human
Technique:  RT-PCR.
References:  7
Substantia nigra
Species:  Human
Technique:  RT-PCR
References:  7
Caudate nucleus.
Species:  Human
Technique:  RT-PCR.
References:  7
Cerebral cortex.
Species:  Human
Technique:  RT-PCR.
References:  7
Mouse ileum; inner portion of the circular muscle layer.
Species:  Mouse
Technique:  Immunohistochemistry.
References:  64
Substantia nigra.
Species:  Rat
Technique:  Radioligand binding.
References:  20
Brainstem auditory nuclei; cochlear nucleus, lateral superior olive, the medial nucleus of the trapezoid body, and inferior colliculus.
Species:  Rat
Technique:  Immunohistochemistry.
References:  32
Dorsal and ventral hippocampus, septum, thalamus and prefrontal cortex.
Species:  Rat
Technique:  Autoradiography.
References:  54
Gastrointestinal tract; circular and longitudinal muscle cells, nerve endings in the plexuses.
Species:  Rat
Technique:  Immunohistochemistry.
References:  30
Kidney.
Species:  Rat
Technique:  Autoradiography.
References:  13
Uterus.
Species:  Rat
Technique:  Radioligand binding.
References:  5
Expression Datasets

Show »

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Bronchospasm.
Species:  Guinea pig
Tissue:  Trachea.
Response measured:  Administration of NKA(4-10) or NKA produced a dose-dependent increase in tracheal insufflation pressure.
References:  44
Airway microvascular leakage.
Species:  Guinea pig
Tissue:  Lungs.
Response measured:  Treatment with sardutant reduced airway microvascular leakage.
References:  52
Urinary bladder contractions.
Species:  Rat
Tissue:  Bladder.
Response measured: 
References:  27
Fecal excretion.
Species:  Rat
Tissue: 
Response measured: 
References:  22
Smooth muscle contraction induced by electric field stimulation.
Species:  Human
Tissue:  Colon.
Response measured:  Contraction.
References:  37
Induction of tracheal smooth muscle contraction.
Species:  Rabbit
Tissue:  Trachea.
Response measured:  Contraction of trachea.
References:  58
Measurement of cAMP accumulation in COS cells transfected with the human NK2 receptor.
Species:  Human
Tissue:  COS cells.
Response measured:  Stimulation of cAMP accumulation and IP3 turnover.
References:  12
Measurement of intracellular IP3 levels in CHO cells transfected with the human NK2 recetor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Increase in intracellular IP3.
References:  12
Measurement of PGE2 levels in CHO cells transfected with the human NK2 receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Increase in PGE2 levels.
References:  12
Induction of tracheal smooth muscle contraction.
Species:  Guinea pig
Tissue:  Trachea.
Response measured:  Contraction of trachea.
References:  58
Smooth muscle contraction induced by electric field stimulation.
Species:  Human
Tissue:  Small intestine.
Response measured:  Contraction.
References:  37
Bronchoconstriction.
Species:  Rat
Tissue:  Lungs.
Response measured:  Inhibition of NKA by sardutant.
References:  24
Dopamine induced contralateral rotational activity (turning behavior).
Species:  Rat
Tissue: 
Response measured:  Activation of the nigro-striatal DA pathway by NK2 selective agonists (Ava (D-Pro9) SP (7-11) [GR51667] or [Lys3,Gly8,R-Lac-Leu9]NKA (3-10) [GR64349]) elicit contralateral rotational activity.
References:  20
Physiological Functions
Stimulation of contractions in rat urinary bladder.
Species:  Rat
Tissue:  In vivo
References:  1,14,38,42
Mediation of contraction of circular muscle of human colon.
Species:  Human
Tissue:  Colon
References:  26
Mediation of contractions in oestrogen-primed rat uterus.
Species:  Rat
Tissue:  In vivo
References:  43
Mediation of irregular spiking activity in the small intestine of the rat.
Species:  Rat
Tissue:  In vivo
References:  40
Mediation of duodenum contractions in rat.
Species:  Rat
Tissue:  In vivo
References:  28
Stimulation of contractile response of isolated mouse stomach and bladder.
Species:  Mouse
Tissue:  Stomach and bladder
References:  50
Mediation of contractions of isolated colonic circular smooth muscle.
Species:  Human
Tissue:  Isolated colonic circular smooth muscle.
References:  47-48,65
Involvement in supraspinal cardiovascular regulation
Species:  Human
Tissue:  In vivo
References:  16
Mediation of noncholinergic excitatory neural responses in the circular muscle of rat proximal colon.
Species:  Rat
Tissue:  In vivo
References:  57
Modulation of intestinal motility.
Species:  Rat
Tissue:  In vivo
References:  53
Modulation of mouse gastric mechanical activity.
Species:  Mouse
Tissue:  In vivo
References:  49
Involvement in oedema formation and plasma extravasation in mouse ear.
Species:  Mouse
Tissue:  In vivo
References:  35
Stimulation of contraction of the circular muslce of human esophageal body.
Species:  Human
Tissue:  In vivo
References:  33
Mediation of non-adrenergic non-cholinergic excitatory neuromuscular transmission in the human ileum.
Species:  Human
Tissue:  In vivo
References:  67
Mediation of contraction of the lower esophageal sphincter.
Species:  Human
Tissue:  In vivo
References:  34
Excitation of colonic motility.
Species:  Rat
Tissue:  In vivo
References:  39
Inhaled NK2 protects against bradykinin-induced bronchoconstriction and cough in asthmatics.
Species:  Human
Tissue:  In vivo.
References:  36
Control of presynaptic dopamine release.
Species:  Rat
Tissue:  In vivo.
References:  29,62
Modulation of resting tone in rat small intestine.
Species:  Rat
Tissue:  Small intestine
References:  41
Modulation of motor responses of human colonic muscle strips.
Species:  Human
Tissue:  In vivo
References:  17
NK2 receptor anatgonist SR 144190 blocks [Nle10] neurokinin A-(4-10)-induced bronchoconstriction in guinea pigs.
Species:  Guinea pig
Tissue:  In vivo.
References:  21
Available Assays
DiscoveRx PathHunter® CHO-K1 TACR2 β-Arrestin Cell Line (Cat no. 93-0238C2)
PathHunter® eXpress TACR2 CHO-K1 β-Arrestin GPCR Assay (Cat no. 93-0238E2CP0M)
more info

REFERENCES

1. Abdel-Gawad M, Dion SB, Elhilali MM. (2001) Evidence of a peripheral role of neurokinins in detrusor hyperreflexia: a further study of selective tachykinin antagonists in chronic spinal injured rats. J Urol165: 1739-1744. [PMID:11342967]

2. Aharony D, Buckner CK, Ellis JL, Ghanekar SV, Graham A, Kays JS, Little J, Meeker S, Miller SC, Undem BJ. (1995) Pharmacological characterization of a new class of nonpeptide neurokinin A antagonists that demonstrate species selectivity. J. Pharmacol. Exp. Ther.274 (3): 1216-21. [PMID:7562491]

3. Altamura M. (2012) Tachykinin NK2 receptor antagonists. A patent review (2006 - 2010). Expert Opin Ther Pat22 (1): 57-77. [PMID:22149761]

4. Anthes JC, Chapman RW, Richard C, Eckel S, Corboz M, Hey JA, Fernandez X, Greenfeder S, McLeod R, Sehring S, Rizzo C, Crawley Y, Shih NY, Piwinski J, Reichard G, Ting P, Carruthers N, Cuss FM, Billah M, Kreutner W, Egan RW. (2002) SCH 206272: a potent, orally active tachykinin NK(1), NK(2), and NK(3) receptor antagonist. Eur J Pharmacol450: 191-202. [PMID:12206858]

5. Barr AJ, Watson SP, Bernal AL, Nimmo AJ. (1991) The presence of NK3 tachykinin receptors on rat uterus. Eur J Pharmacol203: 287-290. [PMID:1724757]

6. Bellucci F, Carini F, Catalani C, Cucchi P, Lecci A, Meini S, Patacchini R, Quartara L, Ricci R, Tramontana M, Giuliani S, Maggi CA. (2002) Pharmacological profile of the novel mammalian tachykinin, hemokinin 1. Br J Pharmacol135: 266-274. [PMID:11786503]

7. Bensaid M, Faucheux BA, Hirsch E, Agid Y, Soubrié P, Oury-Donat F. (2001) Expression of tachykinin NK2 receptor mRNA in human brain. Neurosci. Lett.303 (1): 25-8. [PMID:11297815]

8. Beresford IJ, Sheldrick RL, Ball DI, Turpin MP, Walsh DM, Hawcock AB, Coleman RA, Hagan RM, Tyers MB. (1995) GR159897, a potent non-peptide antagonist at tachykinin NK2 receptors. Eur. J. Pharmacol.272 (2-3): 241-8. [PMID:7713168]

9. Blaney FE, Raveglia LF, Artico M, Cavagnera S, Dartois C, Farina C, Grugni M, Gagliardi S, Luttmann MA, Martinelli M et al.. (2001) Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity and selectivity in quinoline tachykinin receptor antagonists. J. Med. Chem.44 (11): 1675-89. [PMID:11356103]

10. Bradshaw CG, Ceszkowski K, Turcatti G, Beresford IJ, Chollet A. (1994) Synthesis and characterization of selective fluorescent ligands for the neurokinin NK2 receptor. J. Med. Chem.37 (13): 1991-5. [PMID:8027981]

11. Catalioto RM, Criscuoli M, Cucchi P, Giachetti A, Gianotti D, Giuliani S, Lecci A, Lippi A, Patacchini R, Quartara L et al.. (1998) MEN 11420 (Nepadutant), a novel glycosylated bicyclic peptide tachykinin NK2 receptor antagonist. Br. J. Pharmacol.123 (1): 81-91. [PMID:9484857]

12. Catalioto RM, Cucchi P, Renzetti AR, Criscuoli M, Maggi CA. (1998) Independent coupling of the human tachykinin NK2 receptor to phospholipases C and A2 in transfected Chinese hamster ovary cells. Naunyn Schmiedebergs Arch Pharmacol358: 395-403. [PMID:9826060]

13. Chen Y, Hoover DB. (1995) Autoradiographic localization of NK1 and NK3 tachykinin receptors in rat kidney. Peptides16: 673-681. [PMID:7479302]

14. Choppin A, Groke G, Bringas A, Stepan G, Dillon MP. (2002) Effect of YM-44781, YM-44778 and YM-49598, novel tachykinin antagonists, in a drug-induced bladder contraction model. Pharmacology65: 96-102. [PMID:11937780]

15. Cialdai C, Tramontana M, Patacchini R, Lecci A, Catalani C, Catalioto RM, Meini S, Valenti C, Altamura M, Giuliani S, Maggi CA. (2006) MEN15596, a novel nonpeptide tachykinin NK2 receptor antagonist. Eur J Pharmacol549: 140-148. [PMID:16979621]

16. Couture R, Picard P, Poulat P, Prat A. (1995) Characterization of the tachykinin receptors involved in spinal and supraspinal cardiovascular regulation. Can J Physiol Pharmacol73: 892-902. [PMID:8846427]

17. Croci T, Aureggi G, Manara L, Emonds-Alt X, Le Fur G, Maffrand JP, Mukenge S, Ferla G. (1998) In vitro characterization of tachykinin NK2-receptors modulating motor responses of human colonic muscle strips. Br J Pharmacol124: 1321-1327. [PMID:9720807]

18. D'Orléans-Juste P, Dion S, Drapeau G, Regoli D. (1986) Different receptors are involved in the endothelium-mediated relaxation and the smooth muscle contraction of the rabbit pulmonary artery in response to substance P and related neurokinins. Eur. J. Pharmacol.125 (1): 37-44. [PMID:2426129]

19. Deal MJ, Hagan RM, Ireland SJ, Jordan CC, McElroy AB, Porter B, Ross BC, Stephens-Smith M, Ward P. (1992) Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists. J. Med. Chem.35 (22): 4195-204. [PMID:1331460]

20. Elliott PJ, Mason GS, Stephens-Smith M, Hagan RM. (1991) Behavioural and biochemical responses following activation of midbrain dopamine pathways by receptor selective neurokinin agonists. Neuropeptides19 (2): 119-26. [PMID:1719444]

21. Emonds-Alt X, Advenier C, Cognon C, Croci T, Daoui S, Ducoux JP, Landi M, Naline E, Neliat G, Poncelet M et al.. (1997) Biochemical and pharmacological activities of SR 144190, a new potent non-peptide tachykinin NK2 receptor antagonist. Neuropeptides31 (5): 449-58. [PMID:9413022]

22. Emonds-Alt X, Advenier C, Croci T, Manara L, Neliat G, Poncelet M, Proietto V, Santucci V, Soubrié P, Van Broeck D. (1993) SR 48968, a neurokinin A (NK2) receptor antagonist. Regul. Pept.46 (1-2): 31-6. [PMID:8210494]

23. Emonds-Alt X, Golliot F, Pointeau P, Le Fur G, Breliere JC. (1993) Characterization of the binding sites of [3H]SR 48968, a potent nonpeptide radioligand antagonist of the neurokinin-2 receptor. Biochem Biophys Res Commun191: 1172-1177. [PMID:7682062]

24. Emonds-Alt X, Vilain P, Goulaouic P, Proietto V, Van Broeck D, Advenier C, Naline E, Neliat G, Le Fur G, Brelière JC. (1992) A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor. Life Sci.50 (15): PL101-6. [PMID:1313515]

25. Gerard NP, Eddy RL, Shows TB, Gerard C. (1990) The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues. J Biol Chem265: 20455-20462. [PMID:2173708]

26. Giuliani S, Barbanti G, Turini D, Quartara L, Rovero P, Giachetti A, Maggi CA. (1991) NK2 tachykinin receptors and contraction of circular muscle of the human colon: characterization of the NK2 receptor subtype. Eur J Pharmacol203: 365-370. [PMID:1723045]

27. Giuliani S, Patacchini R, Giachetti A, Maggi CA. (1993) In vivo and in vitro activity of SR 48,968, a non-peptide tachykinin NK-2 receptor antagonist. Regul. Pept.46 (1-2): 314-6. [PMID:7692525]

28. Giuliani S, Tramontana M, Lecci A, Maggi CA. (1996) Tachykinin receptors mediate atropine-resistant rat duodenal reflex contractions in vivo. Naunyn Schmiedebergs Arch Pharmacol354: 327-335. [PMID:8878063]

29. Glowinski J, Kemel ML, Desban M, Gauchy C, Lavielle S, Chassaing G, Beaujouan JC, Tremblay L. (1993) Distinct presynaptic control of dopamine release in striosomal- and matrix-enriched areas of the rat striatum by selective agonists of NK1, NK2 and NK3 tachykinin receptors. Regul Pept46: 124-128. [PMID:7692480]

30. Grady EF, Baluk P, Böhm S, Gamp PD, Wong H, Payan DG, Ansel J, Portbury AL, Furness JB, McDonald DM, Bunnett NW. (1996) Characterization of antisera specific to NK1, NK2, and NK3 neurokinin receptors and their utilization to localize receptors in the rat gastrointestinal tract. J Neurosci16: 6975-6986. [PMID:8824334]

31. Grisshammer R, Little J, Aharony D. (1994) Expression of rat NK-2 (neurokinin A) receptor in E. coli. Recept. Channels2 (4): 295-302. [PMID:7719707]

32. Hafidi A, Beurg M, Bouleau Y, Dulon D. (2002) Comparative distribution of NK1, NK2, and NK3 receptors in the rat brainstem auditory nuclei. Brain Res947: 299-306. [PMID:12176174]

33. Huber O, Bertrand C, Bunnett NW, Pellegrini CA, Nadel JA, Debas HT, Geppetti P. (1993) Tachykinins contract the circular muscle of the human esophageal body in vitro via NK2 receptors. Gastroenterology105: 981-987. [PMID:7691676]

34. Huber O, Bertrand C, Bunnett NW, Pellegrini CA, Nadel JA, Nakazato P, Debas HT, Geppetti P. (1993) Tachykinins mediate contraction of the human lower esophageal sphincter in vitro via activation of NK2 receptors. Eur J Pharmacol239: 103-109. [PMID:8223885]

35. Inoue H, Nagata N, Koshihara Y. (1996) Involvement of tachykinin receptors in oedema formation and plasma extravasation induced by substance P, neurokinin A, and neurokinin B in mouse ear. Inflamm Res45: 316-323. [PMID:8841832]

36. Joos GF, Van Schoor J, Kips JC, Pauwels RA. (1996) The effect of inhaled FK224, a tachykinin NK-1 and NK-2 receptor antagonist, on neurokinin A-induced bronchoconstriction in asthmatics. Am J Respir Crit Care Med153: 1781-1784. [PMID:8665034]

37. Lecci A, Capriati A, Altamura M, Maggi CA. (2006) Tachykinins and tachykinin receptors in the gut, with special reference to NK2 receptors in human. Auton Neurosci126-127: 232-49. [PMID:16616700]

38. Lecci A, Giuliani S, Tramontana M, Meini S, Santicioli P, Maggi CA. (2000) Tachykinin-mediated effect of nociceptin in the rat urinary bladder in vivo. Eur J Pharmacol389: 99-102. [PMID:10686301]

39. Lecci A, Tramontana M, Giuliani S, Maggi CA. (1997) Role of tachykinin NK1 and NK2 receptors on colonic motility in anesthetized rats: effect of agonists. Can J Physiol Pharmacol75: 582-586. [PMID:9276132]

40. Lördal M, Bränström R, Hellström PM. (1998) Mediation of irregular spiking activity by multiple neurokinin-receptors in the small intestine of the rat. Br J Pharmacol123: 63-70. [PMID:9484855]

41. Maggi CA, Giuliani S. (1996) Evidence that tachykinin NK2 receptors modulate resting tone in the rat isolated small intestine. Br J Pharmacol118: 1262-1268. [PMID:8818352]

42. Maggi CA, Giuliani S, Santicioli P, Abelli L, Giachetti A. (1991) Facilitation of reflex micturition by intravesical administration of [beta Ala8]-neurokinin A (4-10), a selective NK-2 tachykinin receptor agonist. J Urol145: 184-187. [PMID:1845772]

43. Magraner J, Pinto FM, Anselmi E, Hernandez M, Perez-Afonso R, Martin JD, Advenier C, Candenas ML. (1998) Characterization of tachykinin receptors in the uterus of the oestrogen-primed rat. Br J Pharmacol123: 259-268. [PMID:9489614]

44. Manzini S, Conti S, Maggi CA, Rovero P, Ballati L. (1988) Neurokinin A-(4-10): a potent bronchospastic agent virtually devoid of sialologic properties in anaesthetized guinea-pigs. Eur. J. Pharmacol.148 (3): 475-8. [PMID:2454832]

45. Martin CA, Naline E, Emonds-Alt X, Advenier C. (1992) Influence of (+/-)-CP-96,345 and SR 48968 on electrical field stimulation of the isolated guinea-pig main bronchus. Eur. J. Pharmacol.224 (2-3): 137-43. [PMID:1334836]

46. Matuszek MA, Zeng XP, Strigas J, Burcher E. (1998) An investigation of tachykinin NK2 receptor subtypes in the rat. Eur. J. Pharmacol.352 (1): 103-9. [PMID:9718274]

47. Menzies JR, McKee R, Corbett AD. (2001) Differential alterations in tachykinin NK2 receptors in isolated colonic circular smooth muscle in inflammatory bowel disease and idiopathic chronic constipation. Regul Pept99: 151-156. [PMID:11384776]

48. Mitolo-Chieppa D, Mansi G, Nacci C, De Salvia MA, Montagnani M, Potenza MA, Rinaldi R, Lerro G, Siro-Brigiani G, Mitolo CI, Rinaldi M, Altomare DF, Memeo V. (2001) Idiopathic chronic constipation: tachykinins as cotransmitters in colonic contraction. Eur J Clin Invest31: 349-355. [PMID:11298783]

49. Mulè F, Amato A, Vannucchi MG, Faussone-Pellegrini MS, Serio R. (2006) Role of NK1 and NK2 receptors in mouse gastric mechanical activity. Br J Pharmacol147: 430-436. [PMID:16402037]

50. Nsa Allogho S, Nguyen-Le XK, Gobeil F, Pheng LH, Regoli D. (1997) Neurokinin receptors (NK1, NK2) in the mouse: a pharmacological study. Can J Physiol Pharmacol75: 552-557. [PMID:9276127]

51. Palanche T, Ilien B, Zoffmann S, Reck MP, Bucher B, Edelstein SJ, Galzi JL. (2001) The neurokinin A receptor activates calcium and cAMP responses through distinct conformational states. J Biol Chem276: 34853-34861. [PMID:11459843]

52. Qian Y, Emonds-Alt X, Advenier C. (1993) Effects of capsaicin, (+/-)-CP-96,345 and SR 48968 on the bradykinin-induced airways microvascular leakage in guinea-pigs. Pulm Pharmacol6 (1): 63-7. [PMID:7682876]

53. Rahman M, Lördal M, al-Saffar A, Hellström PM. (1994) Intestinal motility responses to neuropeptide gamma in vitro and in vivo in the rat: comparison with neurokinin 1 and neurokinin 2 receptor agonists. Acta Physiol Scand151: 497-505. [PMID:7976423]

54. Saffroy M, Torrens Y, Glowinski J, Beaujouan JC. (2003) Autoradiographic distribution of tachykinin NK2 binding sites in the rat brain: comparison with NK1 and NK3 binding sites. Neuroscience116: 761-773. [PMID:12573718]

55. Sarau HM, Griswold DE, Potts W, Foley JJ, Schmidt DB, Webb EF, Martin LD, Brawner ME, Elshourbagy NA, Medhurst AD, Giardina GA, Hay DW. (1997) Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist. J Pharmacol Exp Ther281: 1303-1311. [PMID:9190866]

56. Sasai Y, Nakanishi S. (1989) Molecular characterization of rat substance K receptor and its mRNAs. Biochem Biophys Res Commun165: 695-702. [PMID:2480781]

57. Serio R, Mulè F, Bonvissuto F, Postorino A. (1998) Tachykinins mediate noncholinergic excitatory neural responses in the circular muscle of rat proximal colon. Can J Physiol Pharmacol76: 684-689. [PMID:9923407]

58. Sheldrick RL, Ball DI, Coleman RA. (1990) Characterisation of the neurokinin receptors mediating contraction of isolated tracheal preparations from a variety of species. Agents Actions Suppl.31: 205-9. [PMID:1706905]

59. Smith PW, Cooper AW, Bell R, Beresford IJ, Gore PM, McElroy AB, Pritchard JM, Saez V, Taylor NR, Sheldrick RL. (1995) New spiropiperidines as potent and selective non-peptide tachykinin NK2 receptor antagonists. J. Med. Chem.38 (19): 3772-9. [PMID:7562907]

60. Stratowa C, Machat H, Burger E, Himmler A, Schafer R, Spevak W, Weyer U, Wiche-Castanon M, Czernilofsky AP. (1995) Functional characterization of the human neurokinin receptors NK1, NK2, and NK3 based on a cellular assay system. J Recept Signal Transduct Res15: 617-630. [PMID:8903968]

61. Sundelin JB, Provvedini DM, Wahlestedt CR, Laurell H, Pohl JS, Peterson PA. (1992) Molecular cloning of the murine substance K and substance P receptor genes. Eur J Biochem203: 625-631. [PMID:1370937]

62. Tremblay L, Kemel ML, Desban M, Gauchy C, Glowinski J. (1992) Distinct presynaptic control of dopamine release in striosomal- and matrix-enriched areas of the rat striatum by selective agonists of NK1, NK2, and NK3 tachykinin receptors. Proc Natl Acad Sci U S A89: 11214-11218. [PMID:1280822]

63. van Giersbergen PL, Shatzer SA, Burcher E, Buck SH. (1992) Comparison of the effects of neuropeptide K and neuropeptide gamma with neurokinin A at NK2 receptors in the hamster urinary bladder. Naunyn Schmiedebergs Arch. Pharmacol.345 (1): 51-6. [PMID:1311427]

64. Vannucchi MG, Faussone-Pellegrini MS. (2000) NK1, NK2 and NK3 tachykinin receptor localization and tachykinin distribution in the ileum of the mouse. Anat Embryol (Berl)202: 247-255. [PMID:10994997]

65. Warner FJ, Liu L, Lubowski DZ, Burcher E. (2000) Circular muscle contraction, messenger signalling and localization of binding sites for neurokinin A in human sigmoid colon. Clin Exp Pharmacol Physiol27: 928-933. [PMID:11071312]

66. Warner FJ, Mack P, Comis A, Miller RC, Burcher E. (2001) Structure-activity relationships of neurokinin A (4-10) at the human tachykinin NK(2) receptor: the role of natural residues and their chirality. Biochem Pharmacol61: 55-60. [PMID:11137709]

67. Zagorodnyuk V, Santicioli P, Turini D, Maggi CA. (1997) Tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitatory neuromuscular transmission in the human ileum. Neuropeptides31: 265-271. [PMID:9243524]

To cite this database page, please use the following:

Steven D. Douglas, Susan E. Leeman, Jeffrey Barrett, Erin Dombrowsky, Christa Y. Heyward, Pranela Remeshwar.
Tachykinin receptors: NK2 receptor. Last modified on 25/04/2014. Accessed on 01/08/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=361.

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