Nomenclature: sst3 receptor

Family: Somatostatin receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 418 22q13.1 SSTR3 somatostatin receptor 3 6,42-43
Mouse 7 428 15 E1 Sstr3 somatostatin receptor 3 45
Rat 7 428 7q34 Sstr3 somatostatin receptor 3 23
Previous and Unofficial Names
SSTR3
SRIF1
SRIF1C
SSTR
Smstr28
SS-3-R
SS3-R
SS3R
SSR-28
somatostatin receptor 28
somatostatin receptor 3
somatostatin receptor subtype 3
somatostatin receptor type 3
sst3
Smstr-3
Smstr3
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligand(s)
CST-14 {Sp: Mouse, Rat}
CST-17 {Sp: Human}
SRIF-14 {Sp: Human, Mouse, Rat}
SRIF-28 {Sp: Human, Mouse, Rat}
Comments: SRIF-14 and SRIF-28 are the active fragments of precursor somatostatin
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[125I]Tyr10-CST14 Hs Full agonist 10.1 pKd 37-38
pKd 10.1 [37-38]
[125I]LTT-SRIF-28 Hs Full agonist 9.4 – 10.3 pKd 6,31,37-38
pKd 9.7 – 10.3 [6,37-38]
pKd 9.4 [31]
[125I]CGP 23996 Hs Full agonist 9.8 pKd 38
pKd 9.8 [38]
[125I]Tyr7-Sst3-ODN-8 Hs Full agonist 9.6 pKd 30
pKd 9.6 [30]
[125I]CGP 23996 Mm Full agonist 9.4 pKd 27
pKd 9.4 [27]
NC 8-12 Hs Full agonist 10.0 pKi 25
pKi 10.0 [25]
CST-14 {Sp: Mouse, Rat} Hs Full agonist 9.1 – 9.9 pKi 37-38
pKi 9.1 – 9.9 [37-38]
SRIF-14 {Sp: Human, Mouse, Rat} Hs Full agonist 8.7 – 10.0 pKi 4,6,8,25-26,31,37-38,44
pKi 8.7 – 10.0 [4,6,8,25-26,31,37-38,44]
CST-17 {Sp: Human} Hs Full agonist 8.7 – 9.9 pKi 8,37-38
pKi 8.7 – 9.9 [8,37-38]
BN-81,644 Hs Full agonist 9.2 pKi 26
pKi 9.2 [26]
SRIF-28 {Sp: Human, Mouse, Rat} Rn Full agonist 9.1 pKi 22
pKi 9.1 [22]
CGP 23996 Hs Full agonist 8.8 – 9.3 pKi 37-38
pKi 8.8 – 9.3 [37-38]
BIM 23052 Hs Full agonist 8.4 – 9.7 pKi 4,37-38
pKi 8.4 – 9.7 [4,37-38]
BN-81,674 Hs Full agonist 9.0 pKi 26
pKi 9.0 [26]
SRIF-28 {Sp: Human, Mouse, Rat} Hs Full agonist 8.1 – 9.9 pKi 4,6,8,22,25,37-38
pKi 8.1 – 9.9 [4,6,8,22,25,37-38]
SRIF-14 {Sp: Human, Mouse, Rat} Rn Full agonist 8.9 pKi 22
pKi 8.9 [22]
BIM 23058 Hs Full agonist 8.8 pKi 25
pKi 8.8 [25]
BIM 23068 Hs Full agonist 8.8 pKi 25
pKi 8.8 [25]
BIM 23052 Rn Full agonist 8.5 pKi 22
pKi 8.5 [22]
BIM 23068 Rn Full agonist 8.4 pKi 22
pKi 8.4 [22]
BIM 23295 Rn Full agonist 8.2 pKi 22
pKi 8.2 [22]
BIM 23023 Hs Full agonist 8.1 pKi 25
pKi 8.1 [25]
BIM 23034 Hs Full agonist 8.1 pKi 25
pKi 8.1 [25]
octreotide Hs Full agonist 7.4 – 8.6 pKi 4,6,25,37-38,44
pKi 7.4 – 8.6 [4,6,25,37-38,44]
NC 4-28B Hs Full agonist 8.0 pKi 25
pKi 8.0 [25]
L-362,855 Hs Full agonist 7.6 – 8.3 pKi 37-38
pKi 7.6 – 8.3 [37-38]
octreotide Rn Full agonist 7.8 pKi 22
pKi 7.8 [22]
BIM 23050 Hs Full agonist 7.8 pKi 25
pKi 7.8 [25]
vapreotide Hs Full agonist 7.4 – 7.9 pKi 4,25,37
pKi 7.4 – 7.9 [4,25,37]
lanreotide Hs Full agonist 7.2 – 8.0 pKi 4,25,37-38
pKi 7.2 – 8.0 [4,25,37-38]
L-796,778 Hs Full agonist 7.6 pKi 31
pKi 7.6 [31]
BIM 23030 Hs Full agonist 7.2 – 7.8 pKi 37-38
pKi 7.2 – 7.8 [37-38]
MK-678 Rn Full agonist 7.4 pKi 22
pKi 7.4 [22]
MK-678 Hs Full agonist 6.6 – 7.9 pKi 4,25,37-38,44
pKi 6.6 – 7.9 [4,25,37-38,44]
vapreotide Rn Full agonist 7.1 pKi 22
pKi 7.1 [22]
BIM 23056 Hs Full agonist 6.9 – 7.2 pKi 37-38
pKi 6.9 – 7.2 [37-38]
BIM 23023 Rn Full agonist 7.0 pKi 22
pKi 7.0 [22]
lanreotide Rn Full agonist 6.9 pKi 22
pKi 6.9 [22]
L-363,301 Hs Full agonist 6.3 – 7.0 pKi 37-38
pKi 6.3 – 7.0 [37-38]
BIM 23056 Mm Full agonist 10.7 pIC50 27
pIC50 10.7 [27]
BIM 23058 Mm Full agonist 10.4 pIC50 27
pIC50 10.4 [27]
SRIF-28 {Sp: Human, Mouse, Rat} Mm Full agonist 10.2 pIC50 27
pIC50 10.2 [27]
L-362,823 Mm Full agonist 10.1 pIC50 27
pIC50 10.1 [27]
SRIF-14 {Sp: Human, Mouse, Rat} Mm Full agonist 10.1 pIC50 27
pIC50 10.1 [27]
BIM 23052 Mm Full agonist 9.4 pIC50 27
pIC50 9.4 [27]
BIM 23068 Mm Full agonist 9.1 pIC50 27
pIC50 9.1 [27]
BIM 23066 Mm Full agonist 9.0 pIC50 27
pIC50 9.0 [27]
pasireotide Hs Full agonist 8.8 pIC50 33
pIC50 8.8 [33]
KE 108 Hs Full agonist 8.8 pIC50 29
pIC50 8.8 [29]
octreotide Mm Full agonist 8.5 pIC50 27
pIC50 8.5 [27]
Des-AA5-[D-Trp8]SRIF Hs Full agonist 8.4 – 8.5 pIC50 10
pIC50 8.4 – 8.5 [10]
[111In]DOTA-BOC-ATE Hs Full agonist 8.3 pIC50 12
pIC50 8.3 [12]
BIM 23050 Mm Full agonist 8.3 pIC50 27
pIC50 8.3 [27]
lanreotide Mm Full agonist 8.2 pIC50 27
pIC50 8.2 [27]
BIM 23059 Mm Full agonist 8.2 pIC50 27
pIC50 8.2 [27]
[111In]DOTA-NOC Hs Full agonist 8.1 pIC50 41
pIC50 8.1 [41]
[111In]DOTA-NOC-ATE Hs Full agonist 7.9 pIC50 12
pIC50 7.9 [12]
MK-678 Mm Full agonist 7.9 pIC50 27
pIC50 7.9 [27]
BIM 23023 Mm Full agonist 7.9 pIC50 27
pIC50 7.9 [27]
[111In,90Y]DOTA-NOC Hs Full agonist 7.6 pIC50 41
pIC50 7.6 [41]
BIM 23197 Hs Full agonist 7.6 pIC50 34
pIC50 7.6 [34]
[111In,90Y]DOTA-OC Hs Full agonist 7.6 pIC50 41
pIC50 7.6 [41]
BOC-ATE Hs Full agonist 7.5 pIC50 12
pIC50 7.5 [12]
BIM 23034 Mm Full agonist 7.2 pIC50 27
pIC50 7.2 [27]
NC 4-28B Mm Full agonist 7.0 pIC50 27
pIC50 7.0 [27]
BIM 23056 Rn Full agonist 6.5 pIC50 40
pIC50 6.5 [40]
[111In,90Y]DOTA-LAN Hs Full agonist 6.5 pIC50 41
pIC50 6.5 [41]
NOC-ATE Hs Full agonist 6.5 pIC50 12
pIC50 6.5 [12]
[111In,90Y]DOTA-TOC Hs Full agonist 6.4 pIC50 41
pIC50 6.4 [41]
View species-specific agonist tables
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
NVP ACQ090 Hs Antagonist 7.9 pKi 15
pKi 7.9 [15]
PRL-2915 Hs Antagonist 7.0 pKi 14
pKi 7.0 [14]
PRL-2970 Hs Antagonist 7.0 pKi 14
pKi 7.0 [14]
[L-Tyr8]CYN 154806 Hs Antagonist 6.2 – 6.8 pKi 11
pKi 6.2 – 6.8 [11]
[D-Tyr8]CYN 154806 Hs Antagonist 6.2 – 6.7 pKi 11
pKi 6.2 – 6.7 [11]
sst3-ODN-8 Hs Antagonist 8.2 pIC50 30
pIC50 8.2 [30]
BIM 23627 Hs Antagonist 7.4 pIC50 39
pIC50 7.4 [39]
BIM 23454 Hs Antagonist 7.3 pIC50 39
pIC50 7.3 [39]
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family Adenylate cyclase inhibition
References:  16,35,45
Secondary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family
G protein (identity unknown)
Phospholipase C stimulation
Comments:  Stimulation of PLC is via the Gq G-protein. There is also inhibition of the Na+/H+ exchanger (NHE1) and activation of protein tyrosine phosphatases via unknown G-proteins.
References:  1,21,28,36
Tissue Distribution
Poorly expressed in pancreatic islets, mainly in beta-cells.
Species:  Human
Technique:  immunocytochemistry.
References:  19
T cells (Jurkat).
Species:  Human
Technique:  RT-PCR.
References:  5
Cerebellum (Purkinje cells and Golgi cells), frontal cortex (pyramidal cells), hippocampus (CA1-4 subfields and some granule cells of the dentate gyrus).
Species:  Human
Technique:  RT-PCR and in situ hybridisation.
References:  32
Pituitary.
Species:  Rat
Technique:  Nuclease protection analysis.
References:  3
Fundic gastric mucosa of the stomach.
Species:  Rat
Technique:  RT-PCT.
References:  20
Spleen, kidney, liver.
Species:  Rat
Technique:  Nuclease protection analysis.
References:  3
Cortex, hippocampus (indeseum griseum, granular layer of the dentate gyrus, piriform cortex, amygdaloid nuclei), amygdala, habenula, hypothalamus, cerebellum (granular cell layer and interpositus cerebellar nuclei).
Species:  Rat
Technique:  immunocytochemistry.
References:  13
Pituitary.
Species:  Rat
Technique:  RT-PCR.
References:  7,9
Aorta.
Species:  Rat
Technique:  RT-PCR and immunocytochemistry.
References:  17
High levels in the cerebellum, amygdala, hippocampus, striatum, olfactory bulb and cortex. Medium levels in the hypothalamus, thalamus, midbrain and preoptic area.
Species:  Rat
Technique:  Nuclease protection analysis.
References:  3
Expression Datasets

Show »

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Functional Assays
Measurement of cAMP accumulation (AC activity) in CHO-K1 cells stably transfected with human sst3 receptors.
Species:  Human
Tissue:  CHO-K1 cells.
Response measured:  Inhibition of cAMP accumulation.
References:  26
Measurement of NHE1 (Na-H exchanger) activity (pH recovery) in Ltk- cells stably expressing rat sst3 receptors.
Species:  Rat
Tissue:  Mouse fibroblast Ltk- cells.
Response measured:  Inhibition of NHE1 activity.
References:  21
Measurement of PLC activity in CCL39 cells stably transfected with human sst3 receptors.
Species:  Human
Tissue:  CCL39 cells.
Response measured:  Stimulation of PLC activity.
References:  36
Measurement of protein tyrosine phosphatase and Raf-1 activity in NIH 3T3 cells stably transfected with human sst3 receptors.
Species:  Human
Tissue:  NIH 3T3 cells.
Response measured:  Activation of protein tyrosine phosphatase, inactivation of Raf-1 serine kinase.
References:  28
Measurement of cAMP accumulation (AC activity) in HEK 293 cells stably transfected with human sst3 receptors.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Inhibition of cAMP accumulation.
References:  16
Measurement of AC activity (cAMP levels) in CCL39 cells stably transfected with human sst3 receptors.
Species:  Human
Tissue:  CCL39 cells.
Response measured:  Inhibition of AC activity.
References:  35
Measurement of GIRK currents (inward potassium currents) in Xenopus oocyte cells stably transfected with rat sst3 receptors and GIRK1 channels.
Species:  Rat
Tissue:  Xenopus oocytes.
Response measured:  Activation of GIRK current.
References:  18
Measurement of AC activity (cAMP accumulation) in COS-1 cells stably expressing mouse sst3 receptors.
Species:  Mouse
Tissue:  COS-1 cells.
Response measured:  Inhibition of AC activity.
References:  45
Measurement of NOS activity (NO production) in CHO-K1 cells stably transfected with rat sst3 receptors.
Species:  Rat
Tissue:  CHO-K1 cells.
Response measured:  Inhibition of NO production.
References:  2
Physiological Functions
Inhibition of IL-2 secretion and cell proliferation.
Species:  Human
Tissue:  T cells (Jurkat)
References:  5
Inhibition of GH release (with sst2).
Species:  Rat
Tissue:  Hepatocytes (liver cells).
References:  24
Available Assays
DiscoveRx PathHunter® CHO-K1 SSTR3 β-Arrestin Cell Line (Cat no. 93-0244C2)
PathHunter® eXpress SSTR3 CHO-K1 β-Arrestin GPCR Assay (Cat no. 93-0244E2CP0M)
PathHunter® HEK 293 SSTR3 β-Arrestin Cell Line (Cat no. 93-0244C1)
more info

REFERENCES

1. Akbar M, Okajima F, Tomura H, Majid MA, Yamada Y, Seino S, Kondo Y. (1994) Phospholipase C activation and Ca2+ mobilization by cloned human somatostatin receptor subtypes 1-5, in transfected COS-7 cells. FEBS Lett348: 192-196. [PMID:8034040]

2. Arena S, Pattarozzi A, Corsaro A, Schettini G, Florio T. (2005) Somatostatin receptor subtype-dependent regulation of nitric oxide release: involvement of different intracellular pathways. Mol Endocrinol19: 255-267. [PMID:15388796]

3. Bruno JF, Xu Y, Song J, Berelowitz M. (1993) Tissue distribution of somatostatin receptor subtype messenger ribonucleic acid in the rat. Endocrinology133: 2561-2567. [PMID:8243278]

4. Bruns C, Raulf F, Hoyer D, Schloos J, Lubbert H, Weckbecker G. (1996) Binding properties of somatostatin receptor subtypes. Metabolism45: 17-20. [PMID:8769372]

5. Cardoso A, el Ghamrawy C, Gautron JP, Horvat B, Gautier N, Enjalbert A, Krantic S. (1998) Somatostatin increases mitogen-induced IL-2 secretion and proliferation of human Jurkat T cells via sst3 receptor isotype. J Cell Biochem68: 62-73. [PMID:9407314]

6. Corness JD, Demchyshyn LL, Seeman P, Van Tol HH, Srikant CB, Kent G, Patel YC, Niznik HB. (1993) A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides. FEBS Lett321: 279-284. [PMID:8097479]

7. Day R, Dong W, Panetta R, Kraicer J, Greenwood MT, Patel YC. (1995) Expression of mRNA for somatostatin receptor (sstr) types 2 and 5 in individual rat pituitary cells. A double labeling in situ hybridization analysis. Endocrinology136: 5232-5235. [PMID:7588263]

8. Engstrom M, Tomperi J, El-Darwish K, Ahman M, Savola JM, Wurster S. (2005) Superagonism at the human somatostatin receptor subtype 4. J Pharmacol Exp Ther312: 332-338. [PMID:15333679]

9. Epelbaum J, Briard N, Djordjijevic D, Dutour A, Meyerhoff W, Oliver C, Slama A, Viollet C, Zhang J. (1998) Characterization of somatostatin receptor subtypes in mammalian pituitary. Ann N Y Acad Sci839: 249-253. [PMID:9629161]

10. Erchegyi J, Hoeger CA, Low W, Hoyer D, Waser B, Eltschinger V, Schaer JC, Cescato R, Reubi JC, Rivier JE. (2005) Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem48: 507-514. [PMID:15658864]

11. Feuerbach D, Fehlmann D, Nunn C, Siehler S, Langenegger D, Bouhelal R, Seuwen K, Hoyer D. (2000) Cloning, expression and pharmacological characterisation of the mouse somatostatin sst(5) receptor. Neuropharmacology39: 1451-1462. [PMID:10818261]

12. Ginj M, Chen J, Walter MA, Eltschinger V, Reubi JC, Maecke HR. (2005) Preclinical evaluation of new and highly potent analogues of octreotide for predictive imaging and targeted radiotherapy. Clin Cancer Res11: 1136-1145. [PMID:15709181]

13. Hervieu G, Emson PC. (1999) Visualisation of somatostatin receptor sst(3) in the rat central nervous system. Brain Res Mol Brain Res71: 290-303. [PMID:10521583]

14. Hocart SJ, Jain R, Murphy WA, Taylor JE, Morgan B, Coy DH. (1998) Potent antagonists of somatostatin: synthesis and biology. J Med Chem41: 1146-1154. [PMID:9544214]

15. Hoyer D, Vassout A, Gentsch C, Enz A, Vigouret JM, Jaton A, Schoeffter P, Kelly P, Wrynn A, Hurth K, Troxler T. (2004) Functional characterization of NVP ACQ090, a somatostatin sst3 receptor antagonist. Soc Neuroscience Abs, : -.

16. Kaupmann K, Bruns C, Hoyer D, Seuwen K, Lubbert H. (1993) Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain. FEBS Lett331: 53-59. [PMID:8405411]

17. Khare S, Kumar U, Sasi R, Puebla L, Calderon L, Lemstrom K, Hayry P, Patel AY. (1999) Differential regulation of somatostatin receptor types 1-5 in rat aorta after angioplasty. Faseb J13: 387-394. [PMID:9973327]

18. Kreienkamp HJ, Honck HH, Richter D. (1997) Coupling of rat somatostatin receptor subtypes to a G-protein gated inwardly rectifying potassium channel (GIRK1). FEBS Lett419: 92-94. [PMID:9426226]

19. Kumar U, Sasi R, Suresh S, Patel A, Thangaraju M, Metrakos P, Patel SC, Patel YC. (1999) Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis. Diabetes48: 77-85. [PMID:9892225]

20. Le Romancer M, Cherifi Y, Levasseur S, Laigneau JP, Peranzi G, Jais P, Lewin MJ, Reyl-Desmars F. (1996) Messenger RNA expression of somatostatin receptor subtypes in human and rat gastric mucosae. Life Sci58: 1091-1098. [PMID:8622562]

21. Lin CY, Varma MG, Joubel A, Madabushi S, Lichtarge O, Barber DL. (2003) Conserved motifs in somatostatin, D2-dopamine, and alpha 2B-adrenergic receptors for inhibiting the Na-H exchanger, NHE1. J Biol Chem278: 15128-15135. [PMID:12566440]

22. Meyerhof W. (1998) The elucidation of somatostatin receptor functions: a current view. Rev Physiol Biochem Pharmacol133: 55-108. [PMID:9600011]

23. Meyerhof W, Wulfsen I, Schonrock C, Fehr S, Richter D. (1992) Molecular cloning of a somatostatin-28 receptor and comparison of its expression pattern with that of a somatostatin-14 receptor in rat brain. Proc Natl Acad Sci U S A89: 10267-10271. [PMID:1279674]

24. Murray RD, Kim K, Ren SG, Chelly M, Umehara Y, Melmed S. (2004) Central and peripheral actions of somatostatin on the growth hormone-IGF-I axis. J Clin Invest114: 349-356. [PMID:15286801]

25. Patel YC, Srikant CB. (1994) Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). Endocrinology135: 2814-2817. [PMID:7988476]

26. Poitout L, Roubert P, Contour-Galcera MO, Moinet C, Lannoy J, Pommier J, Plas P, Bigg D, Thurieau C. (2001) Identification of potent non-peptide somatostatin antagonists with sst(3) selectivity. J Med Chem44: 2990-3000. [PMID:11520208]

27. Raynor K, Murphy WA, Coy DH, Taylor JE, Moreau JP, Yasuda K, Bell GI, Reisine T. (1993) Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides. Mol Pharmacol43: 838-844. [PMID:8100350]

28. Reardon DB, Wood SL, Brautigan DL, Bell GI, Dent P, Sturgill TW. (1996) Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin. Biochem J314: 401-404. [PMID:8670047]

29. Reubi JC, Eisenwiener KP, Rink H, Waser B, Macke HR. (2002) A new peptidic somatostatin agonist with high affinity to all five somatostatin receptors. Eur J Pharmacol456: 45-49. [PMID:12450568]

30. Reubi JC, Schaer JC, Wenger S, Hoeger C, Erchegyi J, Waser B, Rivier J. (2000) SST3-selective potent peptidic somatostatin receptor antagonists. Proc Natl Acad Sci U S A97: 13973-13978. [PMID:11095748]

31. Rohrer SP, Birzin ET, Mosley RT, Berk SC, Hutchins SM, Shen DM, Xiong Y, Hayes EC, Parmar RM, Foor F, Mitra SW, Degrado SJ, Shu M, Klopp JM, Cai SJ, Blake A, Chan WW, Pasternak A, Yang L, Patchett AA, Smith RG, Chapman KT, Schaeffer JM. (1998) Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science282: 737-740. [PMID:9784130]

32. Schindler M, Harrington KA, Humphrey PP, Emson PC. (1995) Cellular localisation and co-expression of somatostatin receptor messenger RNAs in the human brain. Brain Res Mol Brain Res34: 321-326. [PMID:8750836]

33. Schmid HA, Schoeffter P. (2004) Functional activity of the multiligand analog SOM230 at human recombinant somatostatin receptor subtypes supports its usefulness in neuroendocrine tumors. Neuroendocrinology80: 47-50. [PMID:15477717]

34. Shimon I, Taylor JE, Dong JZ, Bitonte RA, Kim S, Morgan B, Coy DH, Culler MD, Melmed S. (1997) Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation. J Clin Invest99: 789-798. [PMID:9045884]

35. Siehler S, Hoyer D. (1999) Characterisation of human recombinant somatostatin receptors. 3. Modulation of adenylate cyclase activity. Naunyn Schmiedebergs Arch Pharmacol360: 510-521. [PMID:10598790]

36. Siehler S, Hoyer D. (1999) Characterisation of human recombinant somatostatin receptors. 4. Modulation of phospholipase C activity. Naunyn Schmiedebergs Arch Pharmacol360: 522-532. [PMID:10598791]

37. Siehler S, Seuwen K, Hoyer D. (1998) [125I]Tyr10-cortistatin14 labels all five somatostatin receptors. Naunyn Schmiedebergs Arch Pharmacol357: 483-489. [PMID:9650799]

38. Siehler S, Seuwen K, Hoyer D. (1999) Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies. Naunyn Schmiedebergs Arch Pharmacol360: 488-499. [PMID:10598788]

39. Tulipano G, Soldi D, Bagnasco M, Culler MD, Taylor JE, Cocchi D, Giustina A. (2002) Characterization of new selective somatostatin receptor subtype-2 (sst2) antagonists, BIM-23627 and BIM-23454. Effects of BIM-23627 on GH release in anesthetized male rats after short-term high-dose dexamethasone treatment. Endocrinology143: 1218-1224. [PMID:11897676]

40. Viollet C, Bodenant C, Prunotto C, Roosterman D, Schaefer J, Meyerhof W, Epelbaum J, Vaudry H, Leroux P. (1997) Differential expression of multiple somatostatin receptors in the rat cerebellum during development. J Neurochem68: 2263-2272. [PMID:9166718]

41. Wild D, Schmitt JS, Ginj M, Macke HR, Bernard BF, Krenning E, De Jong M, Wenger S, Reubi JC. (2003) DOTA-NOC, a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5 for labelling with various radiometals. Eur J Nucl Med Mol Imaging30: 1338-1347. [PMID:12937948]

42. Yamada Y, Reisine T, Law SF, Ihara Y, Kubota A, Kagimoto S, Seino M, Seino Y, Bell GI, Seino S. (1992) Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase. Mol Endocrinol6: 2136-2142. [PMID:1337145]

43. Yamada Y, Stoffel M, Espinosa R3rd, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI. (1993) Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. Genomics15: 449-452. [PMID:8449518]

44. Yang L, Berk SC, Rohrer SP, Mosley RT, Guo L, Underwood DJ, Arison BH, Birzin ET, Hayes EC, Mitra SW, Parmar RM, Cheng K, Wu TJ, Butler BS, Foor F, Pasternak A, Pan Y, Silva M, Freidinger RM, Smith RG, Chapman K, Schaeffer JM, Patchett AA. (1998) Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2. Proc Natl Acad Sci U S A95: 10836-10841. [PMID:9724791]

45. Yasuda K, Rens-Domiano S, Breder CD, Law SF, Saper CB, Reisine T, Bell GI. (1992) Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase. J Biol Chem267: 20422-20428. [PMID:1328199]

To cite this database page, please use the following:

Jacques Epelbaum, Wasyl Feniuk, Anthony Harmar, Rebecca Hills, Daniel Hoyer, Patrick P. A. Humphrey, Wolfgang Meyerhof, Anne-Marie O'Carroll, Yogesh C. Patel, Terry Reisine, Jean-Claude Reubi, Marcus Schindler, Agnes Schonbrunn, John E. Taylor, Annamaria Vezzani.
Somatostatin receptors: sst3 receptor. Last modified on 07/01/2014. Accessed on 19/04/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=357.

Contact us | Print | Back to top | Help
Copyright © 2014 IUPHAR