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RXFP4

Previous and Unofficial Names
GPR100
GPCR142
RLN3R2
Structural Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Name Reference
Human 7 374 1q22 RXFP4 53
Mouse 7 414 3 F1 Rxfp4 47
Contents:
Previous and Unofficial Names
Structural Information
Database Links
Agonists
Transduction Mechanisms
Tissue Distribution
Functional Assays
Database Links
Ensembl ENSG00000173080 (Hs), ENSMUSG00000049741 (Mm)
Entrez Gene 339403 (Hs), 242093 (Mm)
GeneCards RXFP4 (Hs)
HomoloGene 18775 (Hs)
OMIM 609043 (Hs)
PharmGKB Gene PA28848 (Hs)
Protein Ontology (PRO) PRO:000001553 (Hs)
RefSeq Nucleotide NM_181885 (Hs), NM_181817 (Mm)
RefSeq Protein NP_871001 (Hs), NP_861538 (Mm)
UniGene Hs. 449914 (Hs)
UniProt Q8TDU9 (Hs), Q7TQP4 (Mm)
Wikipedia RXFP4
Search for 3D structures on the PDB
Search using keywords: Relaxin family peptide receptors RXFP4 Search using accession numbers: Q8TDU9 || Q7TQP4
Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[125I]H3 relaxin Hs Full agonist 8.7 pKd 53
[125I]INSL5 Hs Full agonist 8.6 pKd 50
H3 relaxin Hs Full agonist 9.0 pKi 53
INSL5 Hs Full agonist 8.8 pKi 50
Agonist Comments
Affinity values were determined in COS-7 cells expressing human RXFP4.
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family
References:  48,50,53
Tissue Distribution
Colon, thyroid, salivary gland, prostate, placenta, thymus, testis, kidney, brain.
Species:  Human
Technique:  RT-PCR.
References:  53
Ovary, uterus, testis, prostate, brain, heart, intestine, colon, adrenal, thyroid, thymus, salivary gland, muscle, peripheral blood cells, bone marrow.
Species:  Human
Technique:  Multi-tissue expression array.
References:  54
Stomach, fetal brain, brain, leukocytes, kidney, colon, prostate, lung, ovary, thymus, thyroid, placenta, spleen, pituitary, heart.
Species:  Human
Technique:  RT-PCR.
References:  50
Functional Assays
Measurement of cAMP levels in COS-7 cells stably transfected with RXFP4 receptors.
Species:  Human
Tissue:  COS-7 cells.
Response measured:  Inhibition of cAMP accumulation.
References:  48,50,53

To cite this receptor data page, please use the following:

Ross Bathgate, Richard Ivell, Barbara Sanborn, David Sherwood, Roger Summers.
Relaxin family peptide receptors: RXFP4. Last modified on 2010-07-01. Accessed on 2010-09-09. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=354.


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