Nomenclature: AT2 receptor

Family: Angiotensin receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 363 Xq22-q23 AGTR2 angiotensin II receptor, type 2 46,80
Mouse 7 363 X12.5cM Agtr2 angiotensin II receptor, type 2 31
Rat 7 363 Xq34 Agtr2 angiotensin II receptor, type 2 80
Previous and Unofficial Names
AII-2
AII β
AII-A
AT2
MRX88
angiotensin receptor 2
AT2-R
AT2R
AT2R
angiotensin II receptor, type 2
angiotensin II type 2 receptor
angiotensin II type-2 receptor
type-2 angiotensin II receptor
AT2 receptor
AI316812
AW107640
AT-2
ATGR2
Agtr2
AGTR2
ATR2
ATII type 2
angiotensin subtype-2
angiotensin II – subtype 2 receptor
type 2 angiotensin receptor
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
Orphanet Gene
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligand(s)
angiotensin II {Sp: Human, Mouse, Rat}
angiotensin III {Sp: Human, Mouse, Rat}
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[125I]CGP42112 Hs Full agonist 10.6 pKd 19,86-87
pKd 10.6 (Kd 2.51x10-11 M) [19,86-87]
angiotensin III {Sp: Human, Mouse, Rat} Hs Full agonist 10.4 pKd 16,19,86
pKd 10.4 [16,19,86]
angiotensin II {Sp: Human, Mouse, Rat} Hs Full agonist 10.2 pKd 19,75,86
pKd 10.2 [19,75,86]
[p-aminoPhe6]ang II Rn Full agonist 9.1 – 9.4 pKd 19,76
pKd 9.1 – 9.4 [19,76]
[125I][Sar1,Ile8]Ang-II Rn Full agonist 7.76 – 8.77 pKd 78
pKd 7.76 – 8.77 (Kd 1.7x10-9 – 1.74x10-8 M) [78]
angiotensin A {Sp: Human} Hs Agonist 8.64 pKi 97
pKi 8.64 (Ki 2.3x10-9 M) [97]
novokinin Hs Agonist 8.13 pKi 96
pKi 8.13 (Ki 7.35x10-9 M) [96]
compound 21 [PMID: 22802221] Rn Full agonist 5.6 – 5.8 pEC50 84
pEC50 5.6 – 5.8 [84]
compound 21 [PMID: 22802221] Hs Full agonist 4.8 pEC50 84
pEC50 4.8 [84]
angiotensin A {Sp: Human} Hs Agonist 9.92 pIC50 41
pIC50 9.92 [41]
CGP42112 Hs Full agonist 9.63 pIC50 8
pIC50 9.63 (IC50 2.33x10-10 M) [8]
View species-specific agonist tables
Agonist Comments
The natural ligands Ang II and Ang III do not distinguish between the AT1 and AT2 receptors. CGP42112 behaves like an AT1 antagonist at high concentration (Ki 1.7 µM) [10,16]. It was previously thought that Ang I was a natural ligand for AT2R, but this is incorrect. The binding of tissue expressing exclusively the AT2 receptor is not affected by GTP or its analogues [9]. In contrast, an AT2 receptor sensitive to GTPgS and pertussis toxin has been identified in rat brain [81].
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
PD123319 Hs Antagonist 8.7 – 9.2 pKd 19,21,89
pKd 8.7 – 9.2 [19,21,89]
saralasin Rn Antagonist 9.0 pIC50 15
pIC50 9.0 [15]
PD123177 Rn Antagonist 8.5 – 9.5 pIC50 14-15,22
pIC50 8.5 – 9.5 [14-15,22]
View species-specific antagonist tables
Antagonist Comments
Saralasin is a non specific antagonist, which does not distinguish the AT1 and AT2 receptors [15].
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family Phospholipase A2 stimulation
Other - See Comments
Comments:  The AT2 receptor appear to bind to Gia2 or Gia3 [103].
Depending on the tissues, activation of the AT2 receptor
1) stimulates Tyr and Ser/Thr phosphatases (MKP-1, PP2A, SHP-1) and protein dephosphorylation,
2) regulates the nitric-oxide-cGMP system
3) stimulates phospholipase A2, release arachidonic acid and activates the Na+/HCO3 symporter [17,36,62]
4) inhibits autophagy [66]
5) modulates sympatho-excitation in hypertrophy-heart failure model [26].

Ligand-independent AT2 action results in the induction of apoptosis.

Constitutive signal transduction of AT2 [58]:
1) increased bradykinin and iNOS protein expression in VSMCs [42]
2) stimulation of apoptosis in prostate cancer cells [51]
3) increased bradykinin release in mouse coronary artery endothelial cells [106].

G-protein independent signalling: AT2 does not require phosphorylation or heterotrimeric Gαβγ protein to be active [23].
References:  29,52,103
Secondary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family Other - See Comments
Comments:  Activation of the AT2 receptor leads to MAP kinase inactivation, opening of delayed-rectifier K channel and closing of T-type Ca channels [12,107]

Intracellular storage of AT2R [58].

While antagonism of AT1 mediated signal and function were generally observed, there are several exceptions and conflicting findings (cardiac hypertrophy, etc). Potential mechanisms of the interference include interaction and/or binding between AT2 and AT1 or competing AngII binding.
References: 
Tissue Distribution
Non pregnant uterus, heart, lung, kidney, brain, spinal cord, failing heart, remodeling vessels, skin, atretic ovarian follicle
Species:  Human
Technique:  Immunocytochemistry, RT-PCR, microarray expression
References:  13,17,32,39,45,65
The expression is developmentally regulated: foetus >> adult; adrenal medulla > inferior olive, brain >>heart, kidney, ovary, myometrium, endothelial cells, adventitia, pancreas.
Expression in adult brainstem> fetus; fetus skin > adult.
Expression is largely in the cerebellum.

Liver and pituitary appear devoid of AT2 receptors.
Species:  Rat
Technique:  Northern blotting.
References:  17,21,49,85,102
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Functional Assays
Nitric oxide formation and increased cGMP
Species:  Rat
Tissue:  Kidney, heart
Response measured:  cGMP
References:  28,71-72
Inhibition of cell growth leading to apoptosis
Species:  Rat
Tissue:  Confluent and quiescent neonatal cardiomyocyte, R3T3 fibroblast or PC12W pheochromocytoma cell lines
Response measured:  Radiolabelled thymidine incorporation, DNA fragmentation, Bcl2/Bax;
References:  22,35,95
Physiological Functions
Vasodilation (still controversial)
Species:  Rat
Tissue:  Vessel
References:  17,33,44,54,57
Vascular hypertrophy and fibrosis (controversial)
Species:  Rat
Tissue:  Not specified
References:  17,33,54,57
Neuronal cell differentiation and nerve regeneration
Species:  Rat
Tissue:  NG108-15, PC12W
References:  17,25,53
Diuresis and natriuresis (controversial)
Species:  Mouse
Tissue:  AT2 KO mice
References:  74
Increased cGMP and NO
Species:  Human
Tissue:  Kidney, coronary artery, aorta, heart, neurite
References:  17,27-28,33,44,48,54,57,70-73,88,98,104
Inhibition of cell growth and stimulation of apoptosis in vitro and in vivo
Species:  Human
Tissue:  PC12W, VSMC, endothelial cells, cardiomyocytes, R3T3 fibroblast, heart (contraversial), kidney
References:  7,11,17,20,33,54,57,59,63,77,83,94-95
AT2R and MTUS1 cooperate to trans-inactivate receptor tyrosine kinases (inhibition of insulin, FGF, EGF-induced ERK2, DNA synthesis, insulin receptor autophosphorylation) (controversial)
Species:  Mouse
Tissue:  CHO cells, VSMCs, Cos-1 cells
References:  61
AT2 receptor stimulation counteracts AT1 receptor-mediated vasoconstriction
Species:  Human
Tissue:  Coronary microarteries
References:  5
Decrease of dopamine synthesis
Species:  Rat
Tissue:  Striatum
References:  55
Physiological Consequences of Altering Gene Expression
AGTR2 overexpression:
No effect on cardiac hypertrophy or attenuation of cardiac remodeling and of perivascular fibrosis, stimulation of collagen synthesis in SMC and mesangial cells but inhibition in fibroblasts, increased bradykinin and nitric oxide formation. Over expression of the AT2 receptor down-regulated the AT1 receptor.
Species:  Rat
Tissue: 
Technique:  Transgenesis.
References:  1-2,30,37-38,40,56,68-69,74,79,90-93
AGTR2 deletion:
No gross anatomical defect or deformity; increase in basal blood pressure, increased sensitivity (vasopressor response) to injected Ang II, delay in vascular smooth muscle differentiation, attenuation of exploratory behavior, stimulation of dipsogenesis, reduced fibrosis and collagen expression, increased or reduced cardiac and vascular remodeling, anti-diuresis and anti-natriuresis, increased anti-inflammatory and pro-atherosclerotic mediators.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  42,48,56,82,98
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003962 abnormal adrenaline level PMID: 12218346 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003962 abnormal adrenaline level PMID: 12218346 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0000818 abnormal amygdala morphology PMID: 11384784 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0004184 abnormal baroreceptor physiology PMID: 12154115 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0000130 abnormal cancellous bone morphology PMID: 19004830 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0001560 abnormal circulating insulin level PMID: 15793237 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0005667 abnormal circulating leptin level PMID: 15793237 
Agtr1atm1Unc|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87966  MP:0005416 abnormal circulating protein level PMID: 18497303 
Agtr1atm1Unc|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87966  MP:0005416 abnormal circulating protein level PMID: 18497303 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003963 abnormal corticosterone level PMID: 12218346 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003963 abnormal corticosterone level PMID: 12218346 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0006319 abnormal epididymal fat pad morphology PMID: 15793237 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0002078 abnormal glucose homeostasis PMID: 15793237 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0004082 abnormal habenula morphology PMID: 11384784 
Agtr2tm1Tin Agtr2tm1Tin/Y
B6.129P2-Agtr2
MGI:87966  MP:0003921 abnormal heart left ventricle morphology PMID: 12390955 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0001629 abnormal heart rate PMID: 18497303 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0001629 abnormal heart rate PMID: 18497303 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0001629 abnormal heart rate PMID: 18497303 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0001629 abnormal heart rate PMID: 18497303 
Agtr1atm1Unc|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87966  MP:0001629 abnormal heart rate PMID: 18497303 
Agtr1atm1Unc|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87966  MP:0001629 abnormal heart rate PMID: 18497303 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0008263 abnormal hippocampus CA1 region morphology PMID: 11384784 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0008265 abnormal hippocampus CA2 region morphology PMID: 11384784 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0008267 abnormal hippocampus CA3 region morphology PMID: 11384784 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003953 abnormal hormone level PMID: 12218346 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003953 abnormal hormone level PMID: 12218346 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0000521 abnormal kidney cortex PMID: 9551401 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0000527 abnormal kidney development PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0000527 abnormal kidney development PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0005555 abnormal kidney excretion PMID: 10620200 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd
MGI:87966  MP:0005555 abnormal kidney excretion PMID: 10620200 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0002135 abnormal kidney morphology PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0002135 abnormal kidney morphology PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0002136 abnormal kidney physiology PMID: 10620200  9551401 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd
MGI:87966  MP:0002136 abnormal kidney physiology PMID: 10620200 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0006312 abnormal kidney sodium excretion PMID: 10620200 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd
MGI:87966  MP:0006312 abnormal kidney sodium excretion PMID: 10620200 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0002118 abnormal lipid homeostasis PMID: 15793237 
Agtr2tm1Tin Agtr2tm1Tin/Y
B6.129P2-Agtr2
MGI:87966  MP:0000278 abnormal myocardial fiber morphology PMID: 10930448 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003964 abnormal noradrenaline level PMID: 12218346 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003964 abnormal noradrenaline level PMID: 12218346 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0001944 abnormal pancreas morphology PMID: 19033539 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0001944 abnormal pancreas morphology PMID: 19033539 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0008872 abnormal physiological response to xenobiotic PMID: 18497303 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0008872 abnormal physiological response to xenobiotic PMID: 18497303 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0010009 abnormal piriform cortex morphology PMID: 11384784 
Agtr1btm1Cof|Agtr2tm1Tin Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87965  MGI:87966  MP:0005325 abnormal renal glomerulus morphology PMID: 18497303 
Agtr1btm1Cof|Agtr2tm1Tin Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87965  MGI:87966  MP:0005325 abnormal renal glomerulus morphology PMID: 18497303 
Agtr1atm1Unc|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87966  MP:0005325 abnormal renal glomerulus morphology PMID: 18497303 
Agtr1atm1Unc|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87966  MP:0005325 abnormal renal glomerulus morphology PMID: 18497303 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0005529 abnormal renal vascular resistance PMID: 10620200 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd
MGI:87966  MP:0005529 abnormal renal vascular resistance PMID: 10620200 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0004129 abnormal respiratory quotient PMID: 15793237 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 18497303 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 15793237 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 18497303 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 18497303 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 18497303 
Agtr1atm1Unc|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87966  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 18497303 
Agtr1atm1Unc|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87966  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 18497303 
Agtr2tm1Gsb Agtr2tm1Gsb/Y
involves: 129S1/Sv * 129X1/SvJ * FVB/N
MGI:87966  MP:0000230 abnormal systemic arterial blood pressure PMID: 7477266 
Agtr2tm1Gsb Agtr2tm1Gsb/Y
FVB.129/Sv-Agtr2
MGI:87966  MP:0000230 abnormal systemic arterial blood pressure PMID: 10373225 
Agtr1atm1Afu|Agtr2tm1Gsb Agtr1atm1Afu/Agtr1atm1Afu,Agtr2tm1Gsb/Y
mixed
MGI:87964  MGI:87966  MP:0000230 abnormal systemic arterial blood pressure PMID: 12388241 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0000230 abnormal systemic arterial blood pressure PMID: 15793237 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0000230 abnormal systemic arterial blood pressure PMID: 18497303 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0000230 abnormal systemic arterial blood pressure PMID: 18497303 
Agtr1atm1Unc|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87966  MP:0000230 abnormal systemic arterial blood pressure PMID: 18497303 
Agtr1atm1Unc|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87966  MP:0000230 abnormal systemic arterial blood pressure PMID: 18497303 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0000832 abnormal thalamus morphology PMID: 11384784 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0000187 abnormal triglyceride level PMID: 15793237 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003672 abnormal ureter development PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003672 abnormal ureter development PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0000534 abnormal ureter morphology PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0000534 abnormal ureter morphology PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0000516 abnormal urinary system morphology PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0000516 abnormal urinary system morphology PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0005502 abnormal urinary system physiology PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0005502 abnormal urinary system physiology PMID: 10024874 
Agtr2tm1Gsb Agtr2tm1Gsb/Y
FVB.129/Sv-Agtr2
MGI:87966  MP:0005592 abnormal vascular smooth muscle morphology PMID: 10373225 
Agtr2tm1Gsb Agtr2tm1Gsb/Y
FVB.129/Sv-Agtr2
MGI:87966  MP:0001622 abnormal vasculogenesis PMID: 10373225 
Agtr2tm1Gsb Agtr2tm1Gsb/Y
FVB.129/Sv-Agtr2
MGI:87966  MP:0000250 abnormal vasoconstriction PMID: 10373225 
Agtr2tm1Gsb Agtr2tm1Gsb/Y
FVB.129/Sv-Agtr2
MGI:87966  MP:0000343 altered response to myocardial infarction PMID: 12624001 
Agtr2tm1Tin Agtr2tm1Tin/Y
B6.129P2-Agtr2
MGI:87966  MP:0000343 altered response to myocardial infarction PMID: 12390955 
Agtr2tm1Tin Agtr2tm1Tin/Y
B6.129P2-Agtr2
MGI:87966  MP:0003141 cardiac fibrosis PMID: 10930448  12390955 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0005602 decreased angiogenesis PMID: 14597675 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0005534 decreased body temperature PMID: 7477267 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0001262 decreased body weight PMID: 18497303 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0001262 decreased body weight PMID: 18497303 
Agtr1btm1Cof|Agtr2tm1Tin Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87965  MGI:87966  MP:0001262 decreased body weight PMID: 18497303 
Agtr1btm1Cof|Agtr2tm1Tin Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87965  MGI:87966  MP:0001262 decreased body weight PMID: 18497303 
Agtr2tm1Gsb Agtr2tm1Gsb/Y
involves: 129S1/Sv * 129X1/SvJ * FVB/N
MGI:87966  MP:0003912 decreased drinking behavior PMID: 7477266 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0003910 decreased eating behavior PMID: 15793237 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0001417 decreased exploration in new environment PMID: 7477267 
Agtr2tm1Tin Agtr2tm1Tin/Y
B6.129P2-Agtr2
MGI:87966  MP:0003916 decreased heart left ventricle weight PMID: 12390955 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0005333 decreased heart rate PMID: 18497303 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0005333 decreased heart rate PMID: 18497303 
Agtr1atm1Unc|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87966  MP:0005333 decreased heart rate PMID: 18497303 
Agtr1atm1Unc|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87966  MP:0005333 decreased heart rate PMID: 18497303 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0002834 decreased heart weight PMID: 18497303 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0002834 decreased heart weight PMID: 18497303 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0002834 decreased heart weight PMID: 18497303 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0002834 decreased heart weight PMID: 18497303 
Agtr1atm1Unc|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87966  MP:0002834 decreased heart weight PMID: 18497303 
Agtr1atm1Unc|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87966  MP:0002834 decreased heart weight PMID: 18497303 
Agtr2tm1Tin Agtr2tm1Tin/Y
SWR.129P2-Agtr2
MGI:87966  MP:0004502 decreased incidence of chemically-induced tumors PMID: 16140932 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003918 decreased kidney weight PMID: 18497303 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003918 decreased kidney weight PMID: 18497303 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0003918 decreased kidney weight PMID: 18497303 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0003918 decreased kidney weight PMID: 18497303 
Agtr1btm1Cof|Agtr2tm1Tin Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87965  MGI:87966  MP:0003918 decreased kidney weight PMID: 18497303 
Agtr1btm1Cof|Agtr2tm1Tin Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87965  MGI:87966  MP:0003918 decreased kidney weight PMID: 18497303 
Agtr1atm1Unc|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87966  MP:0003918 decreased kidney weight PMID: 18497303 
Agtr1atm1Unc|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87966  MP:0003918 decreased kidney weight PMID: 18497303 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0004876 decreased mean systemic arterial blood pressure PMID: 18497303 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0004876 decreased mean systemic arterial blood pressure PMID: 18497303 
Agtr1atm1Unc|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87966  MP:0004876 decreased mean systemic arterial blood pressure PMID: 18497303 
Agtr1atm1Unc|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87966  MP:0004876 decreased mean systemic arterial blood pressure PMID: 18497303 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0009109 decreased pancreas weight PMID: 19033539 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0009109 decreased pancreas weight PMID: 19033539 
Agtr2tm1Tin Agtr2tm1Tin/Y
B6.129P2-Agtr2
MGI:87966  MP:0004486 decreased response of heart to induced stress PMID: 10930448 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0001489 decreased startle reflex PMID: 7477267 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0010182 decreased susceptibility to weight gain PMID: 15793237 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0009133 decreased white fat cell size PMID: 15793237 
Agtr2tm1Gsb Agtr2tm1Gsb/Y
FVB.129/Sv-Agtr2
MGI:87966  MP:0002753 dilated heart left ventricle PMID: 12624001 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0000519 hydronephrosis PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0000519 hydronephrosis PMID: 10024874 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0000519 hydronephrosis PMID: 18497303 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0000519 hydronephrosis PMID: 18497303 
Agtr2tm1Gsb Agtr2tm1Gsb/Y
involves: 129S1/Sv * 129X1/SvJ * FVB/N
MGI:87966  MP:0001402 hypoactivity PMID: 7477266 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003043 hypoalgesia PMID: 7477267 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0005601 increased angiogenesis PMID: 14597675 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0005605 increased bone mass PMID: 19004830 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0009347 increased cancellous bone thickness PMID: 19004830 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0001748 increased circulating adrenocorticotropin level PMID: 12218346 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0001748 increased circulating adrenocorticotropin level PMID: 12218346 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0001745 increased circulating corticosterone level PMID: 12218346 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0001745 increased circulating corticosterone level PMID: 12218346 
Agtr2tm1Gsb Agtr2tm1Gsb/Y
involves: 129S1/Sv * 129X1/SvJ * FVB/N
MGI:87966  MP:0003911 increased drinking behavior PMID: 12388241 
Agtr1atm1Afu|Agtr2tm1Gsb Agtr1atm1Afu/Agtr1atm1Afu,Agtr2tm1Gsb/Y
mixed
MGI:87964  MGI:87966  MP:0003911 increased drinking behavior PMID: 12388241 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0004889 increased energy expenditure PMID: 15793237 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003459 increased fear-related response PMID: 7477267 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0002891 increased insulin sensitivity PMID: 15793237 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0004875 increased mean systemic arterial blood pressure PMID: 18497303 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0004875 increased mean systemic arterial blood pressure PMID: 12154115 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0004875 increased mean systemic arterial blood pressure PMID: 18497303 
Agtr1btm1Cof|Agtr2tm1Tin Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87965  MGI:87966  MP:0004875 increased mean systemic arterial blood pressure PMID: 18497303 
Agtr1btm1Cof|Agtr2tm1Tin Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87965  MGI:87966  MP:0004875 increased mean systemic arterial blood pressure PMID: 18497303 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0008873 increased physiological sensitivity to xenobiotic PMID: 19033539 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0008873 increased physiological sensitivity to xenobiotic PMID: 12154115 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0008873 increased physiological sensitivity to xenobiotic PMID: 19033539 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0005659 increased resistance to diet-induced obesity PMID: 15793237 
Agtr2tm1Gsb Agtr2tm1Gsb/Y
FVB.129/Sv-Agtr2
MGI:87966  MP:0009763 increased sensitivity to induced morbidity/mortality PMID: 12624001 
Agtr2tm1Tin Agtr2tm1Tin/Y
B6.129P2-Agtr2
MGI:87966  MP:0009763 increased sensitivity to induced morbidity/mortality PMID: 12390955 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0002842 increased systemic arterial blood pressure PMID: 7477267 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0002842 increased systemic arterial blood pressure PMID: 12154115 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0006143 increased systemic arterial diastolic blood pressure PMID: 7477267 
Agtr2tm1Gsb Agtr2tm1Gsb/Y
involves: 129S1/Sv * 129X1/SvJ * FVB/N
MGI:87966  MP:0006144 increased systemic arterial systolic blood pressure PMID: 12388241 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0006144 increased systemic arterial systolic blood pressure PMID: 7477267 
Agtr2tm1Gsb Agtr2tm1Gsb/Y
FVB.129/Sv-Agtr2
MGI:87966  MP:0003025 increased vasoconstriction PMID: 11714657 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0009130 increased white fat cell number PMID: 15793237 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003585 large ureter PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003585 large ureter PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003334 pancreas fibrosis PMID: 19033539 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003334 pancreas fibrosis PMID: 19033539 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0009150 pancreatic acinar cell atrophy PMID: 19033539 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0009150 pancreatic acinar cell atrophy PMID: 19033539 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0008528 polycystic kidney PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0008528 polycystic kidney PMID: 10024874 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0002082 postnatal lethality PMID: 18497303 
Agtr1atm1Unc|Agtr1btm1Cof|Agtr2tm1Tin Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87964  MGI:87965  MGI:87966  MP:0002082 postnatal lethality PMID: 18497303 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003446 renal hypoplasia PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003446 renal hypoplasia PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd
MGI:87966  MP:0003215 renal interstitial fibrosis PMID: 9551401 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003604 single kidney PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003604 single kidney PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Y
B6.129P2-Agtr2
MGI:87966  MP:0010725 thin interventricular septum PMID: 10930448 
Agtr2tm1Tin Agtr2tm1Tin/Y
B6.129P2-Agtr2
MGI:87966  MP:0000280 thin ventricular wall PMID: 10930448 
Agtr2tm1Tin Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003588 ureter stenosis PMID: 10024874 
Agtr2tm1Tin Agtr2tm1Tin/Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6
MGI:87966  MP:0003588 ureter stenosis PMID: 10024874 
Agtr2tm1Gsb Agtr2tm1Gsb/Y
FVB.129/Sv-Agtr2
MGI:87966  MP:0002975 vascular smooth muscle hypertrophy PMID: 11714657 
Clinically-Relevant Mutations and Pathophysiology
Disease:  X-linked nonsyndromic intellectual deficit
OMIM:  300852
Orphanet:  777
Comments: 
References:  6,67,85
Click column headers to sort
Type Species Molecular location Description Reference
Frameshift Human F133 85
single nucleotide polymorphism Human R324Q 85
single nucleotide polymorphism Human I337V 85
single nucleotide polymorphism Human G21V 85
single nucleotide polymorphism Human I53F 100
Biologically Significant Variants
Type:  Single nucleotide polymorphism.
Species:  Human
Description:  Ala1332Gly. Association with congenital anomalies of the kidney and urinary tract. This however was not confirmed in the pathogenesis of primary familial vesicoureteral reflux
Ala1675Gly was associated with coronary risk especially in hypertensive patients. The G allele carriers appears protected.
References:  43,60,99,101
Type:  Single nucleotide polymorphism
Species:  Human
Description:  Ala1675Gly was associated with coronary risk especially in hypertensive patients. The G allele carriers appear protected. A1675G was associated with left ventricular hypertrophy in hypertensive subjects. Left ventricular mass is influenced by the G allele
References:  3,64
Type:  Single nucleotide polymorphism
Species:  Human
Description:  C4599A. Association with preeclampsia in pregnancies in which the woman had a BMI > 25kg/m(2). This suggests a gene-environment interaction.
References:  105
Type:  Single nucleotide polymorphism
Species:  Human
Description:  C3123A. The A-allele carriers showed significantly lower high-density lipoprotein cholesterol (HDL-C) levels than the non-A-allele carriers among nonhypertensive subjects. However, this association was not observed among hypertensive subjects. The AT2R A/C3123 polymorphism could be a polymorphic marker related to glycemic control.
References:  4,47
Biologically Significant Variant Comments
For other AGTR2 SNPs, please see the entry for this gene on dbSNP.
General Comments
The ATGR2 appears to be re-expressed or up-regulated after vascular injury, myocardial infarction, cardiac failure or wound healing, possibly reflecting re-activation of a foetal genetic programme [17-18,34,54]

Preclinical in vitro and in vivo studies indicated that the AT2 receptor counterbalances the effect of the AT1 receptor [17,33,54,57,59].

The most relevant transcription factor binding sites in the AGTR2 gene promoter:
Most relevant TFs: AP-1, ATF-2, IRF-1, CREB, PPAR-γ1, δCREB, PPAR-γ2, c-Jun.

MiRNAs Predicted to Target AGTR2 3’-UTR:
Predicted miRNAs. Both conserved and poorly conserved sites are shown [24,50].

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To cite this database page, please use the following:

Jacqueline Kemp, Sadashiva Karnik, Walter (Wally) Thomas, Satoru Eguchi, Patrick Vanderheyden, Wayne Alexander, Kenneth E. Bernstein, Kevin J. Catt, Marc de Gasparo, Theodore L. Goodfriend, Mastgugu Horiuchi, Ahsan Husain, Tadashi Inagami, Pieter B. M. W. M. Timmermans, Thomas Unger.
Angiotensin receptors: AT2 receptor. Last modified on 07/03/2014. Accessed on 20/04/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=35.

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