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PAR3

Family: Protease-activated receptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Expression Datasets
Phenotypes, Alleles and Disease Models
Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 374 5q13 F2RL2 coagulation factor II (thrombin) receptor-like 2
Mouse 7 369 13 D1 F2rl2 coagulation factor II (thrombin) receptor-like 2
Rat 7 368 2q12 F2rl2 coagulation factor II (thrombin) receptor-like 2
Previous and Unofficial Names
Thrombin receptor
PAR-3
proteinase-activated receptor-3
coagulation factor II receptor-like 2
protease-activated receptor 3
proteinase-activated receptor 3
thrombin receptor-like 2
Database Links
ChEMBL Target 101205 (Hs)
Ensembl ENSG00000164220 (Hs), ENSMUSG00000021675 (Mm), ENSRNOG00000018054 (Rn)
Entrez Gene 2151 (Hs), 14064 (Mm), 29636 (Rn)
GeneCards F2RL2 (Hs)
GenitoUrinary Development Molecular Anatomy Project F2rl2 (Mm)
HomoloGene 36151 (Hs)
Human Protein Reference Database 03561 (Hs)
InterPro O00254 (Hs), O08675 (Mm), Q920E1 (Rn)
KEGG Gene hsa:2151 (Hs), mmu:14064 (Mm), rno:29636 (Rn)
OMIM 601919 (Hs)
PharmGKB Gene PA27948 (Hs)
PhosphoSitePlus O00254 (Hs), O08675 (Mm), Q920E1 (Rn)
Protein Ontology (PRO) PRO:000001663 (Hs)
RefSeq Nucleotide NM_004101 (Hs), NM_010170 (Mm), NM_053313 (Rn)
RefSeq Protein NP_004092 (Hs), NP_034300 (Mm), NP_445765 (Rn)
TreeFam ENSG00000164220 (Hs), ENSMUSG00000021675 (Mm), ENSRNOG00000018054 (Rn)
UniGene Hs. 42502 (Hs)
UniProt O00254 (Hs), O08675 (Mm), Q920E1 (Rn)
Wikipedia PAR3
Protease-activated receptors
Search for 3D structures on the PDB
Search by keyword: Protease-activated receptors PAR3 Search by accession number: Q920E1, O00254, O08675
Natural/Endogenous Ligand(s)
thrombin {Sp: Human} , thrombin {Sp: Mouse} , thrombin {Sp: Rat}
Agonist proteases (Human)
thrombin
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
F2rl2tm1Cgh F2rl2tm1Cgh/F2rl2tm1Cgh
involves: 129S4/SvJae * C57BL/6		 MGI:1298208  MP:0005464 abnormal platelet physiology PMID: 9716134 
F2rl2tm1Cgh F2rl2tm1Cgh/F2rl2tm1Cgh
involves: 129S4/SvJae * C57BL/6		 MGI:1298208  MP:0005606 increased bleeding time PMID: 12384423 
F2rl2tm1Cgh F2rl2tm1Cgh/F2rl2tm1Cgh
involves: 129S4/SvJae * C57BL/6		 MGI:1298208  MP:0005048 thrombosis PMID: 12384423 

To cite this database page, please use the following:

Protease-activated receptors: PAR3. Last modified on 18/09/2012. Accessed on 22/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=349.


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