Nomenclature: PAR3

Family: Proteinase-activated receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation. 

Contents

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 374 5q13 F2RL2 coagulation factor II (thrombin) receptor-like 2
Mouse 7 369 13 D1 F2rl2 coagulation factor II (thrombin) receptor-like 2
Rat 7 368 2q12 F2rl2 coagulation factor II (thrombin) receptor-like 2
Previous and Unofficial Names
Thrombin receptor
PAR-3
proteinase-activated receptor-3
coagulation factor II receptor-like 2
protease-activated receptor 3
proteinase-activated receptor 3
thrombin receptor-like 2
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
thrombin {Sp: Human} , thrombin {Sp: Mouse} , thrombin {Sp: Rat}
Agonist proteases (Human)
thrombin (F2, P00734)
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
F2rl2tm1Cgh F2rl2tm1Cgh/F2rl2tm1Cgh
involves: 129S4/SvJae * C57BL/6
MGI:1298208  MP:0005464 abnormal platelet physiology PMID: 9716134 
F2rl2tm1Cgh F2rl2tm1Cgh/F2rl2tm1Cgh
involves: 129S4/SvJae * C57BL/6
MGI:1298208  MP:0005606 increased bleeding time PMID: 12384423 
F2rl2tm1Cgh F2rl2tm1Cgh/F2rl2tm1Cgh
involves: 129S4/SvJae * C57BL/6
MGI:1298208  MP:0005048 thrombosis PMID: 12384423 

To cite this database page, please use the following:

Morley D. Hollenberg, JoAnn Trejo.
Proteinase-activated receptors: PAR3. Last modified on 18/09/2012. Accessed on 31/10/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=349.

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