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DARC

Family: Chemokine receptors

Contents:
Gene and Protein Information
Previous and Unofficial Names
Database Links
Expression Datasets
Phenotypes, Alleles and Disease Models
Gene and Protein Information
class A G protein-coupled receptor: Non-signalling 7TM chemokine-binding protein
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 336 1q21-q22 DARC Duffy blood group, chemokine receptor
Mouse 7 334 1 H3 Darc Duffy blood group, chemokine receptor
Previous and Unofficial Names
FY
Dfy
GPD
CCBP1
CD234
Duffy blood group, chemokine receptor
Non-signalling 7TM chemokine-binding protein
Duffy blood group
chemokine receptor
Plasmodium vivax receptor
Glycoprotein D
GpFy
Fy glycoprotein
WBCQ1
Duffy antigen/chemokine receptor
Duffy blood group antigen
CD234 antigen
ESTM35
AA162249
atypical chemokine receptor 1
Database Links
Ensembl ENSG00000213088 (Hs), ENSMUSG00000037872 (Mm)
Entrez Gene 2532 (Hs), 13349 (Mm)
GeneCards DARC (Hs)
GenitoUrinary Development Molecular Anatomy Project Darc (Mm)
HomoloGene 48067 (Hs)
Human Protein Reference Database 00192 (Hs)
InterPro Q16570 (Hs), Q9QUI6 (Mm)
KEGG Gene hsa:2532 (Hs), mmu:13349 (Mm)
OMIM 110700 (Hs)
PharmGKB Gene PA28451 (Hs)
PhosphoSitePlus Q16570 (Hs), Q9QUI6 (Mm)
Protein Ontology (PRO) PRO:000001132 (Hs)
RefSeq Nucleotide NM_002036 (Hs), NM_010045 (Mm)
RefSeq Protein NP_002027 (Hs), NP_034175 (Mm)
TreeFam ENSG00000213088 (Hs), ENSMUSG00000037872 (Mm)
UniGene Hs. 153381 (Hs)
UniProt Q16570 (Hs), Q9QUI6 (Mm)
Wikipedia DARC
Chemokine receptors
Search for 3D structures on the PDB
Search by keyword: Chemokine receptors DARC Search by accession number: Q16570, Q9QUI6
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Darctm1Pogo Darctm1Pogo/Darctm1Pogo
involves: 129P2/OlaHsd * C57BL/6J		 MGI:1097689  MP:0000065 abnormal bone marrow cavity morphology PMID: 17416748 
Darctm1Pogo Darctm1Pogo/Darctm1Pogo
involves: 129P2/OlaHsd * C57BL/6J		 MGI:1097689  MP:0000130 abnormal cancellous bone morphology PMID: 17416748 
Darctm1Skmz Darctm1Skmz/Darctm1Skmz
involves: 129P2/OlaHsd * C57BL/6J		 MGI:1097689  MP:0008721 abnormal chemokine level PMID: 12646177 
Darctm1Scp Darctm1Scp/Darctm1Scp
involves: 129P2/OlaHsd		 MGI:1097689  MP:0010209 abnormal circulating chemokine level PMID: 20643340 
Cxcl5tm1Gscw|Darctm1Scp Cxcl5tm1Gscw/Cxcl5tm1Gscw,Darctm1Scp/Darctm1Scp
involves: 129/Sv * 129P2/OlaHsd * C57BL/6		 MGI:1096868  MGI:1097689  MP:0010209 abnormal circulating chemokine level PMID: 20643340 
Darctm1Skmz Darctm1Skmz/Darctm1Skmz
involves: 129P2/OlaHsd * C57BL/6J		 MGI:1097689  MP:0001764 abnormal homeostasis PMID: 12646177 
Darctm1Pogo Darctm1Pogo/Darctm1Pogo
involves: 129P2/OlaHsd * C57BL/6J		 MGI:1097689  MP:0010120 increased bone mineral density PMID: 17416748 
Darctm1Scp Darctm1Scp/Darctm1Scp
involves: 129P2/OlaHsd * C57BL/6		 MGI:1097689  MP:0001846 increased inflammatory response PMID: 10961863 

To cite this database page, please use the following:

Chemokine receptors: DARC. Last modified on 31/01/2013. Accessed on 20/05/2013. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=316.


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