Nomenclature: ACKR1

Family: Chemokine receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation. 

Contents

Gene and Protein Information
class A G protein-coupled receptor: Non-signalling 7TM chemokine-binding protein
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 336 1q21-q22 DARC Duffy blood group, atypical chemokine receptor
Mouse 7 334 1 H3 Darc Duffy blood group, chemokine receptor
Rat - - 13q24 Darc Duffy blood group, atypical chemokine receptor
Previous and Unofficial Names
FY
Dfy
GPD
CCBP1
CD234
Duffy blood group, chemokine receptor
Non-signalling 7TM chemokine-binding protein
Duffy blood group
chemokine receptor
Plasmodium vivax receptor
Glycoprotein D
GpFy
Fy glycoprotein
WBCQ1
Duffy antigen/chemokine receptor
Duffy blood group antigen
CD234 antigen
ESTM35
AA162249
DARC
atypical chemokine receptor 1
CTA-134P22.3
Database Links
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Endogenous ligands (Human)
CXCL5 (CXCL5, P42830), CXCL6 (CXCL6, P80162), CXCL8 (IL8, P10145), CXCL11 (CXCL11, O14625), CCL2 (CCL2, P13500), CCL5 (CCL5, P13501), CCL7 (CCL7, P80098), CCL11 (CCL11, P51671), CCL14 (CCL14, Q16627), CCL17 (CCL17, Q92583)
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Darctm1Pogo Darctm1Pogo/Darctm1Pogo
involves: 129P2/OlaHsd * C57BL/6J
MGI:1097689  MP:0000065 abnormal bone marrow cavity morphology PMID: 17416748 
Darctm1Pogo Darctm1Pogo/Darctm1Pogo
involves: 129P2/OlaHsd * C57BL/6J
MGI:1097689  MP:0000130 abnormal cancellous bone morphology PMID: 17416748 
Darctm1Skmz Darctm1Skmz/Darctm1Skmz
involves: 129P2/OlaHsd * C57BL/6J
MGI:1097689  MP:0008721 abnormal chemokine level PMID: 12646177 
Darctm1Scp Darctm1Scp/Darctm1Scp
involves: 129P2/OlaHsd
MGI:1097689  MP:0010209 abnormal circulating chemokine level PMID: 20643340 
Cxcl5tm1Gscw|Darctm1Scp Cxcl5tm1Gscw/Cxcl5tm1Gscw,Darctm1Scp/Darctm1Scp
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
MGI:1096868  MGI:1097689  MP:0010209 abnormal circulating chemokine level PMID: 20643340 
Darctm1Skmz Darctm1Skmz/Darctm1Skmz
involves: 129P2/OlaHsd * C57BL/6J
MGI:1097689  MP:0001764 abnormal homeostasis PMID: 12646177 
Darctm1Pogo Darctm1Pogo/Darctm1Pogo
involves: 129P2/OlaHsd * C57BL/6J
MGI:1097689  MP:0010120 increased bone mineral density PMID: 17416748 
Darctm1Scp Darctm1Scp/Darctm1Scp
involves: 129P2/OlaHsd * C57BL/6
MGI:1097689  MP:0001846 increased inflammatory response PMID: 10961863 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Malaria, vivax, protection against
OMIM:  611162
References: 
Mutations not determined
Biologically Significant Variant Comments
The Duffy blood group system, associated with complete resistance to the malarial parasite Plasmodium vivax, and white blood cell count as a quantitative trait are based on variation in the DARC gene. For more information see OMIM entries 110700 and 611862.
Available Assays
DiscoveRx PathHunter® CHO-K1 DARC β-Arrestin Orphan GPCR Cell Line (Cat no. 93-0548C2)
PathHunter® eXpress DARC CHO-K1 β-Arrestin Orphan GPCR Assay (Cat no. 93-0548E2CP1M)
more info

To cite this database page, please use the following:

Francoise Bachelerie, Adit Ben-Baruch, Christophe Combadiere, Joshua M. Farber, Gerard J. Graham, Richard Horuk, Massimo Locati, Andrew D. Luster, Alberto Mantovani, Kouji Matsushima, Philip M. Murphy, Robert J. B. Nibbs, Hisayuki Nomiyama, Christine A. Power, Amanda E. I. Proudfoot , Mette M. Rosenkilde, Antal Rot, Silvano Sozzani, Marcus Thelen, Osamu Yoshie, Albert Zlotnik.
Chemokine receptors: ACKR1. Last modified on 24/03/2014. Accessed on 27/08/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=316.

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