Nomenclature: Y5 receptor

Family: Neuropeptide Y receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates. 

Contents

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 455 4q31-q32 NPY5R neuropeptide Y receptor Y5 4,16
Mouse 7 466 8 B3-C2 Npy5r neuropeptide Y receptor Y5 4,28
Rat 7 456 16p14 Npy5r neuropeptide Y receptor Y5 12,16
Previous and Unofficial Names
Y1-like
food intake receptor
NPYR5
NPY-Y5 receptor
NPY5-R
NPYY5-R
Neuropeptide Y5 receptor
Y5 receptor
neuropeptide Y receptor Y5
neuropeptide Y receptor type 5
Y5R
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
neuropeptide Y {Sp: Human, Mouse, Rat}
pancreatic polypeptide {Sp: Human} , pancreatic polypeptide {Sp: Rat} , pancreatic polypeptide {Sp: Mouse}
peptide YY {Sp: Human} , peptide YY {Sp: Mouse, Rat, Pig}
Comments: neuropeptide Y is the principal endogenous agonist
Rank order of potency (Human)
NPY (NPY, P01303) > PYY (PYY, P10082) > PP (PPY, P01298)
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[125I][cPP(1-7), NPY(19-23), Ala31, Aib32, Gln34]hPP Rn Agonist 9.2 – 9.3 pKd 10
pKd 9.2 – 9.3 (Kd 5x10-10 – 7x10-10 M) [10]
[125I][PP1-17,Ala31,Aib32]NPY (human) Rn Full agonist 8.9 pKd 9
pKd 8.9 [9]
neuropeptide Y {Sp: Human, Mouse, Rat} Rn Full agonist 9.3 pKi 16
pKi 9.3 [16]
neuropeptide Y {Sp: Human, Mouse, Rat} Hs Full agonist 9.1 pKi 16
pKi 9.1 [16]
[Leu31,Pro34]NPY (pig) Hs Full agonist 9.1 pKi 16
pKi 9.1 [16]
peptide YY {Sp: Mouse, Rat, Pig} Rn Full agonist 9.0 pKi 16
pKi 9.0 [16]
[Leu31,Pro34]NPY (pig) Rn Full agonist 8.6 – 9.3 pKi 9,16
pKi 8.6 – 9.3 [9,16]
NPY-(2-36) Hs Full agonist 8.9 pKi 16
pKi 8.9 [16]
NPY-(2-36) Rn Full agonist 8.9 pKi 16
pKi 8.9 [16]
peptide YY {Sp: Mouse, Rat, Pig} Hs Full agonist 8.9 pKi 16
pKi 8.9 [16]
pancreatic polypeptide {Sp: Human} Rn Full agonist 8.4 – 9.3 pKi 9,16
pKi 8.4 – 9.3 [9,16]
[PP1-17,Ala31,Aib32]NPY (human) Hs Full agonist 8.8 pKi 9
pKi 8.8 [9]
[Leu31,Pro34]PYY (human) Hs Full agonist 8.8 pKi 16
pKi 8.8 [16]
NPY-(3-36) (pig) Rn Full agonist 8.7 pKi 16
pKi 8.7 [16]
[Leu31,Pro34]PYY (human) Rn Full agonist 8.7 pKi 16
pKi 8.7 [16]
[Ala31,Aib32]NPY Rn Full agonist 8.4 pKi 9
pKi 8.4 [9]
PYY-(3-36) {Sp: Mouse, Rat} Rn Full agonist 8.4 pKi 16
pKi 8.4 [16]
[D-Trp32]NPY Rn Full agonist 8.2 pKi 16
pKi 8.2 [16]
[D-Trp32]NPY Hs Full agonist 8.1 pKi 16
pKi 8.1 [16]
NPY-(3-36) (pig) Hs Full agonist 8.0 pKi 16
pKi 8.0 [16]
PYY-(3-36) {Sp: Mouse, Rat} Hs Full agonist 8.0 pKi 16
pKi 8.0 [16]
pancreatic polypeptide {Sp: Human} Hs Full agonist 8.0 pKi 16
pKi 8.0 [16]
NPY-(13-36) (pig) Rn Full agonist 7.7 pKi 16
pKi 7.7 [16]
NPY-(13-36) (pig) Hs Full agonist 7.3 pKi 16
pKi 7.3 [16]
PYY-(13-36) (mouse, rat, pig) Hs Full agonist 7.1 pKi 16
pKi 7.1 [16]
PYY-(13-36) (mouse, rat, pig) Rn Full agonist 7.1 pKi 16
pKi 7.1 [16]
NPY-(18-36) (human, pig) Rn Full agonist 6.7 pKi 16
pKi 6.7 [16]
pancreatic polypeptide {Sp: Rat} Rn Full agonist 6.5 pKi 16
pKi 6.5 [16]
GR231118 Rn Full agonist 6.4 pKi 9
pKi 6.4 [9]
pancreatic polypeptide {Sp: Rat} Hs Full agonist 6.4 pKi 16
pKi 6.4 [16]
NPY-(18-36) (human, pig) Hs Full agonist 6.2 pKi 16
pKi 6.2 [16]
[Ala31,Aib32]NPY (pig) Hs Full agonist 8.2 pIC50 5
pIC50 8.2 [5]
[Ala31,Aib32]NPY (pig) Rn Full agonist 8.2 pIC50 5
pIC50 8.2 [5]
View species-specific agonist tables
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
CGP 71683A Rn Antagonist 9.5 pKi 9
pKi 9.5 [9]
JCF 109 Rn Antagonist 8.3 pKi 9
pKi 8.3 [9]
L-152,804 Hs Antagonist 7.6 pKi 20
pKi 7.6 [20]
L-152,804 Rn Antagonist 7.5 pKi 20
pKi 7.5 [20]
FMS586 Hs Antagonist 8.4 pIC50 19
pIC50 8.4 [19]
View species-specific antagonist tables
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family Adenylate cyclase inhibition
References:  3
Tissue Distribution
Small intestine (epithelial crypts), colon (nonepithelial tissue).
Species:  Rat
Technique:  RT-PCR.
References:  13
Ventrolateral portion of the suprachiasmatic nucleus.
Species:  Rat
Technique:  in situ hybridisation.
References:  23
Brain: hippocampus, hypothalamus, cortex, amygdala.
Species:  Rat
Technique:  in situ hybridisation.
References:  29
CNS: olfactory bulb, lateral septum, anteroventral thalamic nucleus, CA3 subfield of the ventral hippocampus, nucleus tractus solitarius, area postrema.
Species:  Rat
Technique:  Radioligand binding.
References:  8
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Functional Assays
Measurement of cAMP levels in HEK 293 cells transfected with the rat Y5 receptor.
Species:  Rat
Tissue:  HEK 293 cells.
Response measured:  Inhibition of cAMP accumulation.
References:  12
Measurement of cAMP levels in HEK 293 cells transfected with the human Y5 receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Inhibition of cAMP accumulation.
References:  19
Measurement of cAMP levels in HEC-1B cells transfected with the human Y5 receptor.
Species:  Human
Tissue:  HEC-1B cells.
Response measured:  Inhibition of cAMP accumulation.
References:  3
Physiological Functions
Hyperinsulinemia dependent of food ingestion.
Species:  Rat
Tissue:  In vivo.
References:  11
Modulation of anxiety-related behaviour.
Species:  Rat
Tissue:  In vivo.
References:  34
Sedation.
Species:  Rat
Tissue:  In vivo.
References:  34
Modulation of food intake.
Species:  Rat
Tissue:  In vivo.
References:  6-7,15,17,22,30,32,35,37,39-40
Regulation of the gonadotropic axis.
Species:  Rat
Tissue:  In vivo.
References:  31
Regulation of energy homeostasis.
Species:  Rat
Tissue:  In vivo.
References:  27
Modulation of ethanol consumption.
Species:  Rat
Tissue:  In vivo.
References:  33
Supression of reproduction.
Species:  Rat
Tissue:  In vivo.
References:  36
Physiological Consequences of Altering Gene Expression
Y5 receptor knockout mice exhibit more severe systemic kainate-induced seizures compared to wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  38
Y5 receptor knockout mice do not exhibit spontaneous seizure-like activity, but do exhibit an increased sensitivity to kainic acid-induced seizures.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  25
Hippocampal slices from Y5 receptor knockout mice do not exhibit inhibition of excitatory synaptic transmission as seen in slices fromwild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  1,14
Y5 receptor knockout mice do not exhibit an antagonist-induced decrease in diet-induced obesity, as seen in wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  18
Y5 receptor knockout mice exhibit increases in body weight, food intake and adiposity.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  26
Y5 receptor knockout mice exhibit altered Y5 agonist-induced food intake.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  21
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Npy5rtm1Rpa Npy5rtm1Rpa/Npy5rtm1Rpa
involves: 129S7/SvEvBrd * C57BL/6
MGI:108082  MP:0001259 abnormal body weight PMID: 9623983 
Lepob|Npy5rtm1Rpa Lepob/Lepob,Npy5rtm1Rpa/Npy5rtm1Rpa
involves: 129S7/SvEvBrd * C57BL/6
MGI:104663  MGI:108082  MP:0001259 abnormal body weight PMID: 9623983 
Npy5rtm1Aka Npy5rtm1Aka/Npy5rtm1Aka
involves: C57BL/6 * CBA
MGI:108082  MP:0003910 decreased eating behavior PMID: 10698177 
Npy5rtm1Rpa Npy5rtm1Rpa/Npy5rtm1Rpa
involves: 129S7/SvEvBrd * C57BL/6
MGI:108082  MP:0002628 hepatic steatosis PMID: 9623983 
Npy5rtm1Rpa Npy5rtm1Rpa/Npy5rtm1Rpa
involves: 129S7/SvEvBrd
MGI:108082  MP:0001745 increased circulating corticosterone level PMID: 14525913 
Npy5rtm1Rpa Npy5rtm1Rpa/Npy5rtm1Rpa
involves: 129S7/SvEvBrd
MGI:108082  MP:0002079 increased circulating insulin level PMID: 14525913 
Npy5rtm1Rpa Npy5rtm1Rpa/Npy5rtm1Rpa
involves: 129S7/SvEvBrd
MGI:108082  MP:0005669 increased circulating leptin level PMID: 14525913 
Npy5rtm1Rpa Npy5rtm1Rpa/Npy5rtm1Rpa
involves: 129S7/SvEvBrd
MGI:108082  MP:0009304 increased retroperitoneal fat pad weight PMID: 14525913 
Npy5rtm1Aka Npy5rtm1Aka/Npy5rtm1Aka
involves: C57BL/6 * CBA
MGI:108082  MP:0005658 increased susceptibility to diet-induced obesity PMID: 16636293 
Npy5rtm1Rpa Npy5rtm1Rpa/Npy5rtm1Rpa
involves: 129S7/SvEvBrd * C57BL/6
MGI:108082  MP:0010024 increased total body fat amount PMID: 9623983 
Lepob|Npy5rtm1Rpa Lepob/Lepob,Npy5rtm1Rpa/Npy5rtm1Rpa
involves: 129S7/SvEvBrd * C57BL/6
MGI:104663  MGI:108082  MP:0008908 increased total fat pad weight PMID: 9623983 
Npy5rtm1Rpa Npy5rtm1Rpa/Npy5rtm1Rpa
involves: 129S7/SvEvBrd * C57BL/6
MGI:108082  MP:0001261 obese PMID: 9623983 
Lepob|Npy5rtm1Rpa Lepob/Lepob,Npy5rtm1Rpa/Npy5rtm1Rpa
involves: 129S7/SvEvBrd * C57BL/6
MGI:104663  MGI:108082  MP:0001261 obese PMID: 9623983 
Npy5rtm1Aka Npy5rtm1Aka/Npy5rtm1Aka
involves: C57BL/6 * CBA
MGI:108082  MP:0001261 obese PMID: 10698177 
Npy5rtm1Rpa Npy5rtm1Rpa/Npy5rtm1Rpa
involves: 129S7/SvEvBrd
MGI:108082  MP:0001261 obese PMID: 14525913 
Npy5rtm1Rpa Npy5rtm1Rpa/Npy5rtm1Rpa
involves: 129S7/SvEvBrd * C57BL/6
MGI:108082  MP:0001433 polyphagia PMID: 9623983 
Lepob|Npy5rtm1Rpa Lepob/Lepob,Npy5rtm1Rpa/Npy5rtm1Rpa
involves: 129S7/SvEvBrd * C57BL/6
MGI:104663  MGI:108082  MP:0001433 polyphagia PMID: 9623983 
General Comments
For a review on the functions of Y5 receptors see [2].
For a review on NPY receptor knockout mice see [24].

REFERENCES

1. Baraban SC. (2002) Antiepileptic actions of neuropeptide Y in the mouse hippocampus require Y5 receptors. Epilepsia43 Suppl 5: 9-13. [PMID:12121287]

2. Bischoff A, Michel MC. (1999) Emerging functions for Y5 neuropeptide Y receptors. Trends Pharmacol. Sci.20: 104-106. [PMID:10203865]

3. Bischoff A, Püttmann K, Kötting A, Moser C, Buschauer A, Michel MC. (2001) Limited signal transduction repertoire of human Y(5) neuropeptide Y receptors expressed in HEC-1B cells. Peptides22: 387-394. [PMID:11287093]

4. Borowsky B, Walker MW, Bard J, Weinshank RL, Laz TM, Vaysse P, Branchek TA, Gerald C. (1998) Molecular biology and pharmacology of multiple NPY Y5 receptor species homologs. Regul Pept75-76: 45-53. [PMID:9802393]

5. Cabrele C, Wieland HA, Koglin N, Stidsen C, Beck-Sickinger AG. (2002) Ala31-Aib32: identification of the key motif for high affinity and selectivity of neuropeptide Y at the Y5-receptor. Biochemistry41: 8043-8049. [PMID:12069595]

6. Criscione L, Rigollier P, Batzl-Hartmann C, Rueger H, Stricker-Krongrad A, Wyss P, Brunner L, Whitebread S, Yamaguchi Y, Gerald C, Heurich RO, Walker MW, Chiesi M, Schilling W, Hofbauer KG, Levens N. (1998) Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor. J. Clin. Invest.102: 2136-2145. [PMID:9854049]

7. Daniels AJ, Grizzle MK, Wiard RP, Matthews JE, Heyer D. (2002) Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul Pept106: 47-54. [PMID:12047910]

8. Dumont Y, Fournier A, Quirion R. (1998) Expression and characterization of the neuropeptide Y Y5 receptor subtype in the rat brain. J Neurosci18: 5565-5574. [PMID:9671648]

9. Dumont Y, Thakur M, Beck-Sickinger A, Fournier A, Quirion R. (2003) Development and characterization of a highly selective neuropeptide Y Y5 receptor agonist radioligand: [125I][hPP1-17, Ala31, Aib32]NPY. Br J Pharmacol139: 1360-1368. [PMID:12890716]

10. Dumont Y, Thakur M, Beck-Sickinger A, Fournier A, Quirion R. (2004) Characterization of a new neuropeptide Y Y5 agonist radioligand: [125I][cPP(1-7), NPY(19-23), Ala31, Aib32, Gln34]hPP. Neuropeptides38 (4): 163-74. [PMID:15337369]

11. Gao J, Ghibaudi L, Hwa JJ. (2004) Selective activation of central NPY Y1 vs. Y5 receptor elicits hyperinsulinemia via distinct mechanisms. Am J Physiol Endocrinol Metab287: E706-E711. [PMID:15187000]

12. Gerald C, Walker MW, Criscione L, Gustafson EL, Batzl-Hartmann C, Smith KE, Vaysse P, Durkin MM, Laz TM, Linemeyer DL, Schaffhauser AO, Whitebread S, Hofbauer KG, Taber RI, Branchek TA, Weinshank RL. (1996) A receptor subtype involved in neuropeptide-Y-induced food intake. Nature382: 168-171. [PMID:8700207]

13. Goumain M, Voisin T, Lorinet AM, Laburthe M. (1998) Identification and distribution of mRNA encoding the Y1, Y2, Y4, and Y5 receptors for peptides of the PP-fold family in the rat intestine and colon. Biochem Biophys Res Commun247: 52-56. [PMID:9636652]

14. Guo H, Castro PA, Palmiter RD, Baraban SC. (2002) Y5 receptors mediate neuropeptide Y actions at excitatory synapses in area CA3 of the mouse hippocampus. J Neurophysiol87: 558-566. [PMID:11784771]

15. Haynes AC, Arch JR, Wilson S, McClue S, Buckingham RE. (1998) Characterisation of the neuropeptide Y receptor that mediates feeding in the rat: a role for the Y5 receptor?. Regul Pept75-76: 355-361. [PMID:9802429]

16. Hu Y, Bloomquist BT, Cornfield LJ, DeCarr LB, Flores-Riveros JR, Friedman L, Jiang P, Lewis-Higgins L, Sadlowski Y, Schaefer J, Velazquez N, McCaleb ML. (1996) Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. J Biol Chem271: 26315-26319. [PMID:8824284]

17. Hwa JJ, Witten MB, Williams P, Ghibaudi L, Gao J, Salisbury BG, Mullins D, Hamud F, Strader CD, Parker EM. (1999) Activation of the NPY Y5 receptor regulates both feeding and energy expenditure. Am J Physiol277: R1428-R1434. [PMID:10564216]

18. Ishihara A, Kanatani A, Mashiko S, Tanaka T, Hidaka M, Gomori A, Iwaasa H, Murai N, Egashira S, Murai T, Mitobe Y, Matsushita H, Okamoto O, Sato N, Jitsuoka M, Fukuroda T, Ohe T, Guan X, MacNeil DJ, Van der Ploeg LH, Nishikibe M, Ishii Y, Ihara M, Fukami T. (2006) A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice. Proc Natl Acad Sci U S A103: 7154-7158. [PMID:16636293]

19. Kakui N, Tanaka J, Tabata Y, Asai K, Masuda N, Miyara T, Nakatani Y, Ohsawa F, Nishikawa N, Sugai M, Suzuki M, Aoki K, Kitaguchi H. (2006) Pharmacological characterization and feeding-suppressive property of FMS586 [3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin-4-yl-ethyl)-urea hydrochloride], a novel, selective, and orally active antagonist for neuropeptide Y Y5 receptor. J Pharmacol Exp Ther317: 562-570. [PMID:16436501]

20. Kanatani A, Ishihara A, Iwaasa H, Nakamura K, Okamoto O, Hidaka M, Ito J, Fukuroda T, MacNeil DJ, Van der Ploeg LH, Ishii Y, Okabe T, Fukami T, Ihara M. (2000) L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem Biophys Res Commun272: 169-173. [PMID:10872822]

21. Kanatani A, Mashiko S, Murai N, Sugimoto N, Ito J, Fukuroda T, Fukami T, Morin N, MacNeil DJ, Van der Ploeg LH, Saga Y, Nishimura S, Ihara M. (2000) Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice. Endocrinology141: 1011-1016. [PMID:10698177]

22. Kask A, Vasar E, Heidmets LT, Allikmets L, Wikberg JE. (2001) Neuropeptide Y Y(5) receptor antagonist CGP71683A: the effects on food intake and anxiety-related behavior in the rat. Eur J Pharmacol414: 215-224. [PMID:11239922]

23. Larsen PJ, Kristensen P. (1998) Distribution of neuropeptide Y receptor expression in the rat suprachiasmatic nucleus. Brain Res Mol Brain Res60: 69-76. [PMID:9748510]

24. Lin S, Boey D, Herzog H. (2004) NPY and Y receptors: lessons from transgenic and knockout models. Neuropeptides38: 189-200. [PMID:15337371]

25. Marsh DJ, Baraban SC, Hollopeter G, Palmiter RD. (1999) Role of the Y5 neuropeptide Y receptor in limbic seizures. Proc. Natl. Acad. Sci. U.S.A.96: 13518-13523. [PMID:10557353]

26. Marsh DJ, Hollopeter G, Kafer KE, Palmiter RD. (1998) Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nat. Med.4: 718-721. [PMID:9623983]

27. Mashiko S, Ishihara A, Iwaasa H, Sano H, Oda Z, Ito J, Yumoto M, Okawa M, Suzuki J, Fukuroda T, Jitsuoka M, Morin NR, MacNeil DJ, Van der Ploeg LH, Ihara M, Fukami T, Kanatani A. (2003) Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: chronic intracerebroventricular infusion of D-Trp(34)NPY. Endocrinology144: 1793-1801. [PMID:12697685]

28. Nakamura M, Yokoyama M, Watanabe H, Matsumoto T. (1997) Molecular cloning, organization and localization of the gene for the mouse neuropeptide Y-Y5 receptor. Biochim Biophys Acta1328: 83-89. [PMID:9315606]

29. Parker RM, Herzog H. (1999) Regional distribution of Y-receptor subtype mRNAs in rat brain. Eur J Neurosci11: 1431-1448. [PMID:10103138]

30. Polidori C, Ciccocioppo R, Regoli D, Massi M. (2000) Neuropeptide Y receptor(s) mediating feeding in the rat: characterization with antagonists. Peptides21: 29-35. [PMID:10704716]

31. Raposinho PD, Broqua P, Pierroz DD, Hayward A, Dumont Y, Quirion R, Junien JL, Aubert ML. (1999) Evidence that the inhibition of luteinizing hormone secretion exerted by central administration of neuropeptide Y (NPY) in the rat is predominantly mediated by the NPY-Y5 receptor subtype. Endocrinology140: 4046-4055. [PMID:10465275]

32. Schaffhauser AO, Stricker-Krongrad A, Brunner L, Cumin F, Gerald C, Whitebread S, Criscione L, Hofbauer KG. (1997) Inhibition of food intake by neuropeptide Y Y5 receptor antisense oligodeoxynucleotides. Diabetes46: 1792-1798. [PMID:9356028]

33. Schroeder JP, Overstreet DH, Hodge CW. (2005) The neuropeptide-Y Y5 receptor antagonist L-152,804 decreases alcohol self-administration in inbred alcohol-preferring (iP) rats. Alcohol36: 179-186. [PMID:16377459]

34. Sørensen G, Lindberg C, Wörtwein G, Bolwig TG, Woldbye DP. (2004) Differential roles for neuropeptide Y Y1 and Y5 receptors in anxiety and sedation. J Neurosci Res77: 723-729. [PMID:15352219]

35. Tang-Christensen M, Kristensen P, Stidsen CE, Brand CL, Larsen PJ. (1998) Central administration of Y5 receptor antisense decreases spontaneous food intake and attenuates feeding in response to exogenous neuropeptide Y. J Endocrinol159: 307-312. [PMID:9795372]

36. Toufexis DJ, Kyriazis D, Woodside B. (2002) Chronic neuropeptide Y Y5 receptor stimulation suppresses reproduction in virgin female and lactating rats. J Neuroendocrinol14: 492-497. [PMID:12047724]

37. Turnbull AV, Ellershaw L, Masters DJ, Birtles S, Boyer S, Carroll D, Clarkson P, Loxham SJ, McAulay P, Teague JL, Foote KM, Pease JE, Block MH. (2002) Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes51: 2441-2449. [PMID:12145156]

38. Woldbye DP, Nanobashvili A, Sørensen AT, Husum H, Bolwig TG, Sørensen G, Ernfors P, Kokaia M. (2005) Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors. Neurobiol Dis20: 760-772. [PMID:15979311]

39. Wyss P, Levens N, Stricker-Krongrad A. (1998) Stimulation of feeding in lean but not in obese Zucker rats by a selective neuropeptide Y Y5 receptor agonist. Neuroreport9: 2675-2677. [PMID:9721954]

40. Wyss P, Stricker-Krongrad A, Brunner L, Miller J, Crossthwaite A, Whitebread S, Criscione L. (1998) The pharmacology of neuropeptide Y (NPY) receptor-mediated feeding in rats characterizes better Y5 than Y1, but not Y2 or Y4 subtypes. Regul Pept75-76: 363-371. [PMID:9802430]

To cite this database page, please use the following:

Annette Beck-Sickinger, William F. Colmers, Helen M. Cox, Henri N. Doods, Herbert Herzog, Dan Larhammar, Martin C. Michel, Remi Quirion, Thue Schwartz, Thomas Westfall.
Neuropeptide Y receptors: Y5 receptor. Last modified on 12/03/2013. Accessed on 02/10/2014. IUPHAR database (IUPHAR-DB), http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=308.

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